Development Level

Tbio 401 | 11,445
Tchem 121 | 1,598
Tdark 94 | 6,588
Tclin 50 | 613

Collection

RFA-RM-18-021 5 | 328
Kinase: IDG Consortium (Target... 3 | 125
Ion Channel: IDG Consortium (T... 2 | 99

IMPC Phenotype

preweaning lethality, complete... 39 | 979
preweaning lethality, incomple... 32 | 499
embryonic lethality prior to t... 11 | 278
abnormal behavior 10 | 298
abnormal bone structure 10 | 187
abnormal embryo size 10 | 220
decreased vertical activity 10 | 208
enlarged heart 9 | 210
decreased lean body mass 8 | 135
increased startle reflex 8 | 112
cataract 7 | 92
decreased total body fat amoun... 7 | 207
increased lean body mass 7 | 172
increased total body fat amoun... 7 | 134
abnormal seminal vesicle morph... 6 | 114
short tibia 6 | 97
abnormal retina morphology 5 | 71
abnormal sleep behavior 5 | 70
decreased body weight 5 | 161
decreased bone mineral content 5 | 151
decreased circulating triglyce... 5 | 79
decreased prepulse inhibition 5 | 82
edema 5 | 59
embryonic growth retardation 5 | 106
embryonic lethality prior to o... 5 | 239
hyperactivity 5 | 148
increased circulating choleste... 5 | 66
increased heart weight 5 | 62
male infertility 5 | 123
thrombocytopenia 5 | 56
abnormal eye morphology 4 | 68
abnormal gait 4 | 69
abnormal lens morphology 4 | 81
abnormal testis morphology 4 | 43
decreased bone mineral density 4 | 126
decreased circulating glucose ... 4 | 126
decreased circulating insulin ... 4 | 76
decreased startle reflex 4 | 75
hypoactivity 4 | 132
increased circulating alkaline... 4 | 122
increased circulating sodium l... 4 | 71
increased erythrocyte cell num... 4 | 39
increased neutrophil cell numb... 4 | 46
increased or absent threshold ... 4 | 101
abnormal heart morphology 3 | 162
absent vibrissae 3 | 12
decreased circulating amylase ... 3 | 28
decreased circulating bilirubi... 3 | 19
decreased circulating creatini... 3 | 39
decreased circulating serum al... 3 | 82
decreased fasted circulating g... 3 | 65
decreased grip strength 3 | 116
decreased heart left ventricle... 3 | 28
decreased heart weight 3 | 27
decreased hemoglobin content 3 | 68
decreased mean corpuscular hem... 3 | 50
decreased mean corpuscular vol... 3 | 79
enlarged lymph nodes 3 | 37
enlarged spleen 3 | 41
increased bone mineral content 3 | 108
increased circulating HDL chol... 3 | 80
increased circulating glucose ... 3 | 24
increased mean corpuscular hem... 3 | 96
increased spleen weight 3 | 10
prenatal lethality prior to he... 3 | 87
small testis 3 | 58
abnormal coat-hair pigmentatio... 2 | 64
abnormal cornea morphology 2 | 31
abnormal epididymis morphology 2 | 42
cardiovascular system phenotyp... 2 | 36
corneal opacity 2 | 32
decreased body length 2 | 101
decreased circulating alkaline... 2 | 46
decreased circulating aspartat... 2 | 34
decreased circulating calcium ... 2 | 36
decreased circulating free fat... 2 | 31
decreased circulating glycerol... 2 | 16
decreased circulating phosphat... 2 | 27
decreased circulating total pr... 2 | 49
decreased eosinophil cell numb... 2 | 24
decreased erythrocyte cell num... 2 | 62
decreased hematocrit 2 | 46
decreased mean corpuscular hem... 2 | 31
decreased red blood cell distr... 2 | 41
impaired glucose tolerance 2 | 75
improved glucose tolerance 2 | 79
increased blood urea nitrogen ... 2 | 48
increased circulating aspartat... 2 | 15
increased circulating calcium ... 2 | 34
increased circulating chloride... 2 | 41
increased circulating triglyce... 2 | 42
increased fasted circulating g... 2 | 76
increased hematocrit 2 | 46
increased hemoglobin content 2 | 45
increased mean corpuscular vol... 2 | 92
small kidney 2 | 16
small spleen 2 | 19
small superior vagus ganglion 2 | 74
tremors 2 | 39
vertebral fusion 2 | 23

Disease

Carcinoma 404 | 11,493
osteosarcoma 328 | 7,950
ovarian cancer 324 | 8,520
glioblastoma 279 | 5,792
psoriasis 268 | 6,694
medulloblastoma, large-cell 264 | 6,241
lung cancer 249 | 4,740
Cancer 238 | 2,499
atypical teratoid / rhabdoid tumor 220 | 5,112
ependymoma 197 | 4,679
Breast cancer 185 | 3,578
invasive ductal carcinoma 179 | 2,951
adult high grade glioma 177 | 3,801
malignant mesothelioma 176 | 3,232
lung carcinoma 171 | 2,843
non-small cell lung cancer 167 | 2,890
Astrocytoma, Pilocytic 164 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 159 | 3,291
group 3 medulloblastoma 157 | 4,104
pancreatic cancer 156 | 2,398
lung adenocarcinoma 152 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 149 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 143 | 2,955
interstitial cystitis 140 | 2,312
oligodendroglioma 130 | 2,850
primitive neuroectodermal tumor 123 | 3,035
ulcerative colitis 121 | 1,819
subependymal giant cell astrocytoma 119 | 2,287
tuberculosis 114 | 2,010
Kidney cancer 105 | 2,613
diabetes mellitus 104 | 1,728
astrocytic glioma 103 | 2,597
ductal carcinoma in situ 102 | 1,745
cystic fibrosis 99 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 98 | 1,962
colon cancer 97 | 1,478
breast carcinoma 93 | 1,638
pituitary cancer 91 | 1,972
Autosomal recessive predisposition 86 | 1,442
Pick disease 73 | 1,894
group 4 medulloblastoma 72 | 1,855
Liver Cirrhosis, Experimental 71 | 769
cutaneous lupus erythematosus 71 | 1,057
juvenile dermatomyositis 70 | 1,187
primary pancreatic ductal adenocarcinoma 69 | 1,109
Rheumatoid arthritis 66 | 1,191
astrocytoma 66 | 1,146
Schizophrenia 65 | 1,160
adrenocortical carcinoma 65 | 1,428
primary Sjogren syndrome 61 | 735
Hypertension 59 | 396
pediatric high grade glioma 55 | 1,064
Coronary artery disease 53 | 268
Kidney disease 53 | 430
Multiple myeloma 53 | 1,332
gastric carcinoma 53 | 807
Vascular disease 52 | 319
Duchenne muscular dystrophy 51 | 601
Obesity 50 | 678
dermatomyositis 49 | 966
Thrombocytopenia 48 | 197
Atherosclerosis 47 | 291
Atopic dermatitis 47 | 952
Hypertensive disease 47 | 292
Cerebrovascular disease 46 | 238
acute quadriplegic myopathy 46 | 1,158
nasopharyngeal carcinoma 46 | 1,058
pancreatic carcinoma 46 | 562
esophageal adenocarcinoma 45 | 737
active ulcerative colitis 44 | 764
Anemia 43 | 365
mucosa-associated lymphoid tissue lymphoma 43 | 484
Bipolar Disorder 42 | 666
Heart disease 41 | 306
Waldenstrons macroglobulinemia 41 | 765
Asthma 40 | 385
spina bifida 40 | 1,074
Breast Neoplasms 39 | 445
Epilepsy 39 | 792
Intellectual disability 39 | 1,016
Mammary Neoplasms 39 | 425
active Crohn's disease 39 | 922
Depressive disorder 38 | 409
Arthritis 37 | 290
Seizures 37 | 596
acute myeloid leukemia 37 | 783
Alzheimer's disease 36 | 658
Down syndrome 36 | 499
autosomal dominant Emery-Dreifuss muscular dystrophy 36 | 510
Short stature 35 | 531
Endometriosis 34 | 540
fibroadenoma 34 | 559
periodontitis 34 | 293
Cognitive delay 33 | 608
Global developmental delay 33 | 608
Mental and motor retardation 33 | 608
Neurodegenerative disease 33 | 414
Prostatic Neoplasms 33 | 495
Liver cancer 32 | 604
Melanoma 32 | 711

Tissue

Endocrine System 561 | 18,159
Digestive Tract 557 | 17,369
Female tissues 555 | 17,400
Skin and soft tissues 555 | 17,230
Blood and immune system 550 | 16,909
Male tissues 549 | 17,142
Urinary Tract 547 | 16,678
Liver and Pancreas 543 | 16,750
Respiratory system 539 | 16,393
Nervous System 533 | 16,725
Cardiovascular System 508 | 15,192

Target Family

Non-IDG 432 | 12,091
Enzyme 105 | 4,145
Kinase 45 | 634
Transporter 25 | 473
Transcription Factor 20 | 1,400
Ion Channel 19 | 344
Epigenetic 10 | 242
GPCR 10 | 408

Reactome Pathway

Hemostasis 666 | 666
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
Kinesin-like protein KIF25 KIF25 Tbio Non-IDG -0.75019 5.59 191
Sorcin SRI Tbio Non-IDG -2.69915 481.5 119
Thrombopoietin THPO Tbio Non-IDG -3.23551 1632.3 440
CDK5 and ABL1 enzyme substrate 2 CABLES2 Tdark Non-IDG 0.08 1.29 75
CD109 antigen CD109 Tbio Non-IDG -1.85817 77.8 239
Calcium-activated potassium channel subunit beta-2 KCNMB2 Tbio Ion Channel 1.28 0.09 191
Kinesin-like protein KIF18B KIF18B Tbio Non-IDG -0.83463 5.23 17
Bromodomain and PHD finger-containing protein 3 BRPF3 Tchem Epigenetic -0.46982 2.70 64
Monoacylglycerol lipase ABHD6 ABHD6 Tchem Enzyme -1.37418 26.1 71