Development Level

Tbio 360 | 10,625
Tchem 159 | 1,890
Tdark 90 | 7,003
Tclin 60 | 602

Collection

Eligible Kinase Proteins 5 | 134
Eligible Ion Channel Proteins 3 | 117

IMPC Term

preweaning lethality, complete... 22 | 633
preweaning lethality, incomple... 18 | 260
decreased lean body mass 9 | 195
increased or absent threshold ... 8 | 128
abnormal behavior 7 | 226
abnormal bone mineralization 7 | 55
decreased body weight 7 | 174
decreased bone mineral density 7 | 126
decreased circulating triglyce... 7 | 83
decreased total body fat amoun... 7 | 186
embryonic lethality prior to t... 7 | 187
enlarged heart 7 | 111
abnormal bone structure 6 | 131
decreased bone mineral content 6 | 157
abnormal lens morphology 5 | 73
decreased body length 5 | 108
decreased circulating insulin ... 5 | 75
increased total body fat amoun... 5 | 57
abnormal embryo size 4 | 112
abnormal retina morphology 4 | 100
abnormal retinal pigmentation 4 | 61
abnormal seminal vesicle morph... 4 | 47
decreased circulating glucose ... 4 | 121
decreased grip strength 4 | 123
decreased prepulse inhibition 4 | 52
increased circulating HDL chol... 4 | 63
increased circulating alkaline... 4 | 119
increased circulating sodium l... 4 | 71
increased heart weight 4 | 37
increased mean corpuscular vol... 4 | 91
male infertility 4 | 62
abnormal heart morphology 3 | 51
abnormal sleep behavior 3 | 63
decreased circulating alanine ... 3 | 53
decreased circulating amylase ... 3 | 24
decreased circulating serum al... 3 | 79
decreased lumbar vertebrae num... 3 | 62
decreased startle reflex 3 | 48
embryonic lethality prior to o... 3 | 148
hydrops fetalis 3 | 22
hyperactivity 3 | 108
increased circulating choleste... 3 | 53
increased circulating potassiu... 3 | 31
increased fasted circulating g... 3 | 68
increased grip strength 3 | 83
increased lean body mass 3 | 107
increased mean corpuscular hem... 3 | 93
short tibia 3 | 82
thrombocytopenia 3 | 46
tremors 3 | 34
abnormal QRS complex 2 | 25
abnormal coat/hair pigmentatio... 2 | 54
abnormal coping response 2 | 12
abnormal epididymis morphology 2 | 31
abnormal femur morphology 2 | 14
abnormal humerus morphology 2 | 11
abnormal locomotor activation 2 | 26
abnormal testis morphology 2 | 30
abnormal vibrissa morphology 2 | 17
absent vibrissae 2 | 14
cataract 2 | 26
decreased circulating aspartat... 2 | 27
decreased circulating bilirubi... 2 | 14
decreased circulating choleste... 2 | 85
decreased circulating creatini... 2 | 31
decreased circulating free fat... 2 | 39
decreased circulating glycerol... 2 | 19
decreased circulating phosphat... 2 | 15
decreased circulating total pr... 2 | 41
decreased eosinophil cell numb... 2 | 41
decreased fasted circulating g... 2 | 49
decreased hemoglobin content 2 | 53
decreased mean corpuscular vol... 2 | 50
decreased rib number 2 | 59
enlarged lymph nodes 2 | 27
impaired glucose tolerance 2 | 52
improved glucose tolerance 2 | 56
increased bone mineral content 2 | 92
increased circulating chloride... 2 | 43
increased erythrocyte cell num... 2 | 26
increased hematocrit 2 | 36
increased hemoglobin content 2 | 45
increased leukocyte cell numbe... 2 | 37
increased sacral vertebrae num... 2 | 62
mydriasis 2 | 9
small heart 2 | 8
small kidney 2 | 10
small liver 2 | 8
small lung 2 | 5
small spleen 2 | 11
small testis 2 | 37
vertebral fusion 2 | 23
vertebral transformation 2 | 12
abnormal neural tube closure 1 | 37
abnormal thoracic vertebrae mo... 1 | 16
decreased circulating magnesiu... 1 | 11
decreased circulating sodium l... 1 | 18
decreased pulmonary respirator... 1 | 4
prenatal lethality prior to he... 1 | 64
small thymus 1 | 11

Disease

osteosarcoma 334 | 7,933
ovarian cancer 325 | 8,484
glioblastoma 273 | 5,572
psoriasis 273 | 6,685
medulloblastoma, large-cell 272 | 6,234
lung cancer 240 | 4,466
Cancer 238 | 2,346
atypical teratoid / rhabdoid tumor 190 | 4,369
invasive ductal carcinoma 182 | 2,950
lung carcinoma 176 | 2,844
malignant mesothelioma 174 | 3,162
pilocytic astrocytoma 173 | 3,086
non-small cell lung cancer 162 | 2,798
intraductal papillary-mucinous neoplasm (IPMN) 159 | 3,289
pediatric high grade glioma 158 | 2,712
lung adenocarcinoma 157 | 2,713
pancreatic cancer 156 | 2,300
Breast cancer 152 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 152 | 2,988
interstitial cystitis 148 | 2,299
ulcerative colitis 146 | 2,087
intraductal papillary-mucinous adenoma (IPMA) 144 | 2,956
oligodendroglioma 130 | 2,849
primitive neuroectodermal tumor 124 | 3,031
subependymal giant cell astrocytoma 122 | 2,287
Carcinoma 110 | 2,147
ductal carcinoma in situ 104 | 1,745
tuberculosis 102 | 1,557
ependymoma 101 | 2,514
colon cancer 100 | 1,475
cystic fibrosis 99 | 1,665
diabetes mellitus 97 | 1,663
astrocytoma 92 | 1,493
breast carcinoma 91 | 1,614
pituitary cancer 91 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 86 | 1,795
posterior fossa group A ependymoma 82 | 1,511
group 4 medulloblastoma 81 | 1,875
primary pancreatic ductal adenocarcinoma 81 | 1,271
group 3 medulloblastoma 80 | 2,254
adult high grade glioma 79 | 2,148
astrocytic glioma 78 | 2,241
cutaneous lupus erythematosus 76 | 1,056
Pick disease 74 | 1,893
Rheumatoid Arthritis 73 | 1,160
juvenile dermatomyositis 71 | 1,189
primary Sjogren syndrome 68 | 789
adrenocortical carcinoma 66 | 1,427
sonic hedgehog group medulloblastoma 64 | 1,482
gastric carcinoma 59 | 832
Multiple myeloma 54 | 1,327
posterior fossa group B ependymoma 53 | 1,530
medulloblastoma 52 | 1,524
Kidney disease 51 | 396
dermatomyositis 51 | 933
Duchenne muscular dystrophy 50 | 602
pancreatic carcinoma 50 | 567
IGA Glomerulonephritis 49 | 454
Obesity 48 | 616
Vascular disease 48 | 281
nasopharyngeal carcinoma 48 | 1,056
Atherosclerosis 47 | 275
Atopic dermatitis 47 | 944
acute quadriplegic myopathy 46 | 1,157
esophageal adenocarcinoma 46 | 737
Asthma 45 | 349
Coronary artery disease 45 | 240
Cerebrovascular disease 44 | 231
atypical teratoid/rhabdoid tumor 44 | 1,095
Waldenstrons macroglobulinemia 43 | 765
mucosa-associated lymphoid tissue lymphoma 42 | 480
spina bifida 41 | 1,064
Mammary Neoplasms 40 | 410
active Crohn's disease 40 | 918
Heart disease 39 | 279
acute myeloid leukemia 39 | 780
Hypertension 38 | 287
Thrombocytopenia 37 | 105
Anemia 36 | 252
Down syndrome 36 | 548
non-small cell lung carcinoma 36 | 413
Alzheimer's disease 35 | 644
Hypertensive disease 35 | 193
Multiple Sclerosis 35 | 498
autosomal dominant Emery-Dreifuss muscular dystrophy 35 | 499
fibroadenoma 35 | 557
Prostatic Neoplasms 34 | 471
periodontitis 34 | 269
Arthritis 33 | 248
Endometriosis 32 | 535
Neoplasm Invasiveness 29 | 127
Neurodegenerative disease 29 | 383
Crohn's disease 28 | 304
Hypersensitivity reaction type II disease 28 | 235
Liver disease 28 | 219
Lung disease 28 | 132
non primary Sjogren syndrome sicca 28 | 840
sarcoidosis 28 | 358
Stomach Neoplasms 27 | 282
Schizophrenia 26 | 501

Tissue

Female tissues 644 | 18,647
Nervous System 643 | 18,561
Digestive Tract 641 | 18,473
Urinary Tract 640 | 18,444
Liver and Pancreas 638 | 18,136
Skin and soft tissues 634 | 18,115
Blood and immune system 632 | 17,995
Endocrine System 632 | 18,512
Cardiovascular System 629 | 17,958
Respiratory system 620 | 17,484
Male tissues 618 | 17,969

Target Family

Non-IDG 429 | 11,971
Enzyme 106 | 4,146
Kinase 50 | 634
Transporter 25 | 473
Transcription Factor 20 | 1,400
Ion Channel 19 | 341
Epigenetic 10 | 242
GPCR 10 | 406

Reactome Pathway

Hemostasis 669 | 669
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Immunoglobulin kappa variable 3-11 IGKV3-11 Tdark Non-IDG 0.00000 0
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Natural killer cell receptor 2B4 CD244 Tbio Non-IDG -2.27438 190.1 418
Coagulation factor XI F11 Tchem Enzyme -2.65863 487.3 216
Plasma kallikrein KLKB1 Tclin Enzyme -2.88472 708.0 231
SH2B adapter protein 3 SH2B3 Tbio Non-IDG -2.46631 317.6 137
Kinesin-like protein KIF1C KIF1C Tbio Non-IDG -1.21884 20.0 95
F-actin-capping protein subunit alpha-1 CAPZA1 Tbio Non-IDG -1.28182 20.1 139