Development Level

Tbio 370 | 11,178
Tchem 153 | 1,885
Tdark 93 | 6,569
Tclin 50 | 612

Collection

Kinase: IDG Consortium (Target... 3 | 125
Ion Channel: IDG Consortium (T... 2 | 99

IMPC Phenotype

preweaning lethality, complete... 39 | 979
preweaning lethality, incomple... 32 | 499
embryonic lethality prior to t... 11 | 278
abnormal behavior 10 | 298
abnormal bone structure 10 | 187
abnormal embryo size 10 | 220
decreased vertical activity 10 | 208
enlarged heart 9 | 210
decreased lean body mass 8 | 135
increased startle reflex 8 | 112
cataract 7 | 92
decreased total body fat amoun... 7 | 207
increased lean body mass 7 | 172
increased total body fat amoun... 7 | 134
abnormal seminal vesicle morph... 6 | 114
short tibia 6 | 97
abnormal retina morphology 5 | 71
abnormal sleep behavior 5 | 70
decreased body weight 5 | 161
decreased bone mineral content 5 | 151
decreased circulating triglyce... 5 | 79
decreased prepulse inhibition 5 | 82
edema 5 | 59
embryonic growth retardation 5 | 106
embryonic lethality prior to o... 5 | 239
hyperactivity 5 | 148
increased circulating choleste... 5 | 66
increased heart weight 5 | 62
male infertility 5 | 123
thrombocytopenia 5 | 56
abnormal eye morphology 4 | 68
abnormal gait 4 | 69
abnormal lens morphology 4 | 81
abnormal testis morphology 4 | 43
decreased bone mineral density 4 | 126
decreased circulating glucose ... 4 | 126
decreased circulating insulin ... 4 | 76
decreased startle reflex 4 | 75
hypoactivity 4 | 132
increased circulating alkaline... 4 | 122
increased circulating sodium l... 4 | 71
increased erythrocyte cell num... 4 | 39
increased neutrophil cell numb... 4 | 46
increased or absent threshold ... 4 | 101
abnormal heart morphology 3 | 162
absent vibrissae 3 | 12
decreased circulating amylase ... 3 | 28
decreased circulating bilirubi... 3 | 19
decreased circulating creatini... 3 | 39
decreased circulating serum al... 3 | 82
decreased fasted circulating g... 3 | 65
decreased grip strength 3 | 116
decreased heart left ventricle... 3 | 28
decreased heart weight 3 | 27
decreased hemoglobin content 3 | 68
decreased mean corpuscular hem... 3 | 50
decreased mean corpuscular vol... 3 | 79
enlarged lymph nodes 3 | 37
enlarged spleen 3 | 41
increased bone mineral content 3 | 108
increased circulating HDL chol... 3 | 80
increased circulating glucose ... 3 | 24
increased mean corpuscular hem... 3 | 96
increased spleen weight 3 | 10
prenatal lethality prior to he... 3 | 87
small testis 3 | 58
abnormal coat-hair pigmentatio... 2 | 64
abnormal cornea morphology 2 | 31
abnormal epididymis morphology 2 | 42
cardiovascular system phenotyp... 2 | 36
corneal opacity 2 | 32
decreased body length 2 | 101
decreased circulating alkaline... 2 | 46
decreased circulating aspartat... 2 | 34
decreased circulating calcium ... 2 | 36
decreased circulating free fat... 2 | 31
decreased circulating glycerol... 2 | 16
decreased circulating phosphat... 2 | 27
decreased circulating total pr... 2 | 49
decreased eosinophil cell numb... 2 | 24
decreased erythrocyte cell num... 2 | 62
decreased hematocrit 2 | 46
decreased mean corpuscular hem... 2 | 31
decreased red blood cell distr... 2 | 41
impaired glucose tolerance 2 | 75
improved glucose tolerance 2 | 79
increased blood urea nitrogen ... 2 | 48
increased circulating aspartat... 2 | 15
increased circulating calcium ... 2 | 34
increased circulating chloride... 2 | 41
increased circulating triglyce... 2 | 42
increased fasted circulating g... 2 | 76
increased hematocrit 2 | 46
increased hemoglobin content 2 | 45
increased mean corpuscular vol... 2 | 92
small kidney 2 | 16
small spleen 2 | 19
small superior vagus ganglion 2 | 74
tremors 2 | 39
vertebral fusion 2 | 23

Disease

Carcinoma 391 | 11,192
osteosarcoma 322 | 7,766
ovarian cancer 313 | 8,297
glioblastoma 275 | 5,635
medulloblastoma, large-cell 260 | 6,086
psoriasis 258 | 6,514
lung cancer 239 | 4,607
Cancer 228 | 2,388
atypical teratoid / rhabdoid tumor 217 | 4,971
ependymoma 194 | 4,559
Breast cancer 180 | 3,469
adult high grade glioma 174 | 3,701
invasive ductal carcinoma 172 | 2,867
malignant mesothelioma 170 | 3,135
lung carcinoma 163 | 2,755
non-small cell lung cancer 162 | 2,799
Astrocytoma, Pilocytic 161 | 3,006
group 3 medulloblastoma 155 | 4,002
intraductal papillary-mucinous neoplasm (IPMN) 154 | 3,204
pancreatic cancer 150 | 2,322
lung adenocarcinoma 144 | 2,627
intraductal papillary-mucinous carcinoma (IPMC) 143 | 2,902
interstitial cystitis 136 | 2,237
intraductal papillary-mucinous adenoma (IPMA) 136 | 2,872
oligodendroglioma 128 | 2,768
primitive neuroectodermal tumor 122 | 2,957
subependymal giant cell astrocytoma 117 | 2,230
ulcerative colitis 117 | 1,765
tuberculosis 111 | 1,963
Kidney cancer 104 | 2,548
astrocytic glioma 100 | 2,530
diabetes mellitus 98 | 1,683
cystic fibrosis 96 | 1,629
ductal carcinoma in situ 96 | 1,686
colon cancer 95 | 1,428
pancreatic ductal adenocarcinoma liver metastasis 93 | 1,911
pituitary cancer 91 | 1,915
breast carcinoma 89 | 1,589
Autosomal recessive predisposition 79 | 1,407
Pick disease 72 | 1,856
cutaneous lupus erythematosus 70 | 1,016
group 4 medulloblastoma 70 | 1,806
juvenile dermatomyositis 67 | 1,147
primary pancreatic ductal adenocarcinoma 66 | 1,071
astrocytoma 65 | 1,113
Liver Cirrhosis, Experimental 64 | 733
Rheumatoid arthritis 64 | 1,156
Schizophrenia 64 | 1,136
adrenocortical carcinoma 61 | 1,385
primary Sjogren syndrome 60 | 710
pediatric high grade glioma 54 | 1,035
Multiple myeloma 52 | 1,296
Hypertension 51 | 372
Kidney disease 50 | 411
gastric carcinoma 50 | 781
dermatomyositis 48 | 941
Coronary artery disease 47 | 253
Duchenne muscular dystrophy 47 | 587
Obesity 46 | 655
Thrombocytopenia 46 | 193
pancreatic carcinoma 46 | 555
nasopharyngeal carcinoma 45 | 1,024
Atopic dermatitis 44 | 915
Vascular disease 44 | 294
acute quadriplegic myopathy 44 | 1,133
mucosa-associated lymphoid tissue lymphoma 43 | 473
Anemia 42 | 353
Atherosclerosis 42 | 276
Hypertensive disease 42 | 278
active ulcerative colitis 42 | 736
esophageal adenocarcinoma 42 | 696
Bipolar Disorder 40 | 646
Cerebrovascular disease 40 | 223
Waldenstrons macroglobulinemia 40 | 742
spina bifida 40 | 1,053
Asthma 37 | 370
Depressive disorder 37 | 401
Epilepsy 37 | 775
Intellectual disability 37 | 998
active Crohn's disease 37 | 882
Breast Neoplasms 36 | 423
Heart disease 36 | 288
Mammary Neoplasms 36 | 403
acute myeloid leukemia 36 | 760
Seizures 35 | 584
Short stature 35 | 514
Alzheimer's disease 34 | 640
Arthritis 33 | 276
Prostatic Neoplasms 33 | 472
periodontitis 33 | 280
Down syndrome 32 | 480
Endometriosis 32 | 521
Liver cancer 32 | 589
Neurodegenerative disease 32 | 402
autosomal dominant Emery-Dreifuss muscular dystrophy 32 | 492
Cognitive delay 31 | 596
Global developmental delay 31 | 596
Melanoma 31 | 689
Mental and motor retardation 31 | 596
fibroadenoma 31 | 538

Tissue

Endocrine System 561 | 18,159
Digestive Tract 557 | 17,369
Female tissues 555 | 17,400
Skin and soft tissues 555 | 17,230
Blood and immune system 550 | 16,909
Male tissues 549 | 17,142
Urinary Tract 547 | 16,678
Liver and Pancreas 543 | 16,750
Respiratory system 539 | 16,393
Nervous System 533 | 16,725
Cardiovascular System 508 | 15,192

Target Family

Non-IDG 432 | 12,091
Enzyme 105 | 4,145
Kinase 45 | 634
Transporter 25 | 473
Transcription Factor 20 | 1,400
Ion Channel 19 | 344
Epigenetic 10 | 242
GPCR 10 | 408

Reactome Pathway

Hemostasis 666 | 666
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protocadherin-7 PCDH7 Tbio Non-IDG -1.42056 26.3 248
Vinculin VCL Tbio Non-IDG -3.34872 2107.1 637
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 GNG7 Tbio Non-IDG -0.76260 5.38 63
Immunoglobulin kappa variable 3D-20 IGKV3D-20 Tdark Non-IDG 0.00000 0
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform PPP2R5B Tbio Enzyme -0.59131 2.64 81
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform PPP2R5A Tchem Enzyme -0.54568 3.09 202
Transcription factor NF-E2 45 kDa subunit NFE2 Tbio Transcription Factor -2.36469 209.0 110
C-type lectin domain family 1 member B CLEC1B Tbio Non-IDG -1.92806 93.6 224
Alpha-2B adrenergic receptor ADRA2B Tclin GPCR -2.15839 139.8 0
Thromboxane A2 receptor TBXA2R Tclin GPCR -2.17674 123.4 112