Development Level

Tbio 66 | 11,445
Tchem 8 | 1,598
Tclin 6 | 613
Tdark 6 | 6,588

Collection

GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 8 | 979
abnormal behavior 3 | 298
decreased circulating alkaline... 3 | 46
embryonic lethality prior to t... 3 | 278
preweaning lethality, incomple... 3 | 499
abnormal embryo size 2 | 220
decreased circulating glucose ... 2 | 126
decreased circulating total pr... 2 | 49
decreased mean corpuscular vol... 2 | 79
enlarged lymph nodes 2 | 37
increased circulating phosphat... 2 | 26
increased circulating triglyce... 2 | 42
increased heart weight 2 | 62
thrombocytopenia 2 | 56
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal embryo development 1 | 7
abnormal embryo turning 1 | 31
abnormal esophagus morphology 1 | 5
abnormal eye morphology 1 | 68
abnormal eyelid morphology 1 | 7
abnormal forebrain development 1 | 20
abnormal head size 1 | 6
abnormal hindbrain development 1 | 16
abnormal iris morphology 1 | 13
abnormal kidney morphology 1 | 65
abnormal limb bud morphology 1 | 17
abnormal liver size 1 | 5
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal placement of pupils 1 | 6
abnormal placenta size 1 | 20
abnormal retinal inner nuclear... 1 | 8
abnormal spleen morphology 1 | 55
abnormal stomach morphology 1 | 10
abnormal tooth morphology 1 | 24
abnormal vertebral arch morpho... 1 | 9
corneal opacity 1 | 32
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
enlarged gallbladder 1 | 2
enlarged kidney 1 | 14
enlarged spleen 1 | 41
enlarged urinary bladder 1 | 8
impaired glucose tolerance 1 | 75
increased body weight 1 | 25
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating serum al... 1 | 22
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased eosinophil cell numb... 1 | 11
increased fasted circulating g... 1 | 76
increased heart rate variabili... 1 | 7
increased large unstained cell... 1 | 5
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
irregularly shaped pupil 1 | 7
limb grasping 1 | 41
narrow eye opening 1 | 12
pale liver 1 | 6
pale yolk sac 1 | 25
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small adrenal glands 1 | 16
small thymus 1 | 16
tremors 1 | 39
trunk curl 1 | 16

Disease

ovarian cancer 56 | 8,520
Carcinoma 49 | 11,493
osteosarcoma 40 | 7,950
lung cancer 34 | 4,740
psoriasis 34 | 6,694
glioblastoma 29 | 5,792
Multiple myeloma 28 | 1,332
atypical teratoid / rhabdoid tumor 22 | 5,112
Cancer 21 | 2,499
ependymoma 19 | 4,679
medulloblastoma, large-cell 18 | 6,241
Breast cancer 17 | 3,578
HIV Infections 16 | 102
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,291
malignant mesothelioma 16 | 3,232
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
Polydactyly 13 | 107
Gastrointestinal Stromal Tumors 12 | 48
oligodendroglioma 12 | 2,850
subependymal giant cell astrocytoma 12 | 2,287
Kidney cancer 11 | 2,613
group 3 medulloblastoma 11 | 4,104
lung carcinoma 11 | 2,843
non-small cell lung cancer 11 | 2,890
adult high grade glioma 10 | 3,801
astrocytoma 10 | 1,146
dermatomyositis 10 | 966
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
Nevoid basal cell carcinoma syndrome 9 | 16
Pick disease 9 | 1,894
Waldenstrons macroglobulinemia 9 | 765
invasive ductal carcinoma 9 | 2,951
pancreatic cancer 9 | 2,398
Holoprosencephaly 8 | 56
medulloblastoma 8 | 720
non primary Sjogren syndrome sicca 8 | 891
Abnormally small eyeball 7 | 97
Cleft Lip 7 | 141
Decreased size of eyeball 7 | 97
Microphthalmos 7 | 100
astrocytic glioma 7 | 2,597
interstitial cystitis 7 | 2,312
spina bifida 7 | 1,074
tuberculosis 7 | 2,010
Astrocytoma, Pilocytic 6 | 3,081
Cleft Palate 6 | 271
Highly variable severity 6 | 157
Short stature 6 | 531
Variable expressivity 6 | 157
acute myeloid leukemia 6 | 783
diabetes mellitus 6 | 1,728
lung adenocarcinoma 6 | 2,716
primary pancreatic ductal adenocarcinoma 6 | 1,109
primitive neuroectodermal tumor 6 | 3,035
Alobar Holoprosencephaly 5 | 14
Basal cell carcinoma 5 | 54
Brachydactyly 5 | 156
Carcinoma, Basal Cell 5 | 28
Epilepsy 5 | 792
Intellectual disability 5 | 1,016
Liver Cirrhosis, Experimental 5 | 769
Lobar Holoprosencephaly 5 | 20
Mantle cell lymphoma 5 | 23
Orbital separation diminished 5 | 23
Orbital separation excessive 5 | 244
Osteoporosis 5 | 363
Seizures 5 | 596
Semilobar Holoprosencephaly 5 | 14
Short ribs 5 | 30
Strabismus 5 | 270
acute quadriplegic myopathy 5 | 1,158
breast carcinoma 5 | 1,638
cystic fibrosis 5 | 1,696
Acquired scoliosis 4 | 281
Autosomal recessive predisposition 4 | 1,442
Big calvaria 4 | 147
Broad flat nasal bridge 4 | 236
Cognitive delay 4 | 608
Congenital hypoplasia of penis 4 | 176
Curvature of spine 4 | 282
Failure to gain weight 4 | 365
Frontal bossing 4 | 157
Global developmental delay 4 | 608
Hydrocephalus 4 | 152
Increased head circumference 4 | 147
Increased size of cranium 4 | 147
Increased size of skull 4 | 147
Mental and motor retardation 4 | 608
Nasal bridge wide 4 | 236
Parkinson's disease 4 | 392
Pediatric failure to thrive 4 | 365
Ulnar polydactyly of fingers 4 | 47
Uranostaphyloschisis 4 | 167
adrenocortical carcinoma 4 | 1,428
colon cancer 4 | 1,478
esophageal adenocarcinoma 4 | 737
pediatric high grade glioma 4 | 1,064
primary Sjogren syndrome 4 | 735
progressive supranuclear palsy 4 | 676

Tissue

Endocrine System 85 | 18,159
Digestive Tract 84 | 17,369
Female tissues 84 | 17,400
Male tissues 84 | 17,142
Nervous System 84 | 16,725
Respiratory system 84 | 16,393
Urinary Tract 84 | 16,678
Liver and Pancreas 83 | 16,750
Skin and soft tissues 83 | 17,230
Blood and immune system 82 | 16,909
Cardiovascular System 80 | 15,192

Target Family

Enzyme 43 | 4,145
Non-IDG 35 | 12,091
Kinase 3 | 634
Transcription Factor 3 | 1,400
GPCR 2 | 408

Reactome Pathway

Hedgehog 'on' state 86 | 86
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Hedgehog-interacting protein HHIP Tbio Non-IDG -1.83526 65.4 193
Growth arrest-specific protein 8 GAS8 Tbio Non-IDG -1.20822 17.3 102
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
Smoothened homolog SMO Tclin GPCR -1.17466 14.5 415
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Zinc finger protein DZIP1 DZIP1 Tbio Non-IDG -1.05223 12.5 101
Protein patched homolog 2 PTCH2 Tbio Non-IDG -1.80541 50.4 92
Proteasome activator complex subunit 4 PSME4 Tdark Non-IDG -1.60128 39.3 43