Development Level

Tbio 66 | 10,625
Tchem 25 | 1,890
Tclin 7 | 602
Tdark 3 | 7,003

Collection

Kinase: IDG Consortium (Targets) 2 | 125
GPCR: IDG Consortium (Complete/Control) 1 | 26

IMPC Phenotype

preweaning lethality, complete... 8 | 633
abnormal bone structure 6 | 131
increased heart weight 5 | 37
abnormal bone mineralization 4 | 55
decreased lean body mass 3 | 195
embryonic lethality prior to t... 3 | 187
abnormal behavior 2 | 226
abnormal embryo size 2 | 112
abnormal embryo turning 2 | 15
decreased bone mineral content 2 | 157
decreased fasted circulating g... 2 | 49
decreased mean corpuscular vol... 2 | 50
increased mean corpuscular vol... 2 | 91
increased total body fat amoun... 2 | 57
abnormal QRS complex 1 | 25
abnormal cervical vertebrae mo... 1 | 4
abnormal embryo development 1 | 2
abnormal eye morphology 1 | 38
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal limb bud morphology 1 | 15
abnormal liver size 1 | 4
abnormal midbrain development 1 | 22
abnormal nail morphology 1 | 7
abnormal neural tube closure 1 | 37
abnormal pericardium morpholog... 1 | 11
abnormal placenta size 1 | 10
abnormal rib morphology 1 | 28
abnormal spinal cord morpholog... 1 | 8
abnormal stomach morphology 1 | 4
abnormal tooth morphology 1 | 24
absent heartbeat 1 | 6
anophthalmia 1 | 20
decreased body length 1 | 108
decreased body weight 1 | 174
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating alkaline... 1 | 41
decreased circulating chloride... 1 | 32
decreased circulating choleste... 1 | 85
decreased circulating fructosa... 1 | 31
decreased circulating glucose ... 1 | 121
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 34
decreased prepulse inhibition 1 | 52
decreased total body fat amoun... 1 | 186
embryonic growth retardation 1 | 28
enlarged lymph nodes 1 | 27
hyperactivity 1 | 108
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
increased body weight 1 | 42
increased circulating LDL chol... 1 | 15
increased circulating alkaline... 1 | 119
increased circulating aspartat... 1 | 17
increased circulating calcium ... 1 | 32
increased circulating phosphat... 1 | 24
increased circulating total pr... 1 | 20
increased heart rate variabili... 1 | 4
increased or absent threshold ... 1 | 128
increased sacral vertebrae num... 1 | 62
pale liver 1 | 5
pale yolk sac 1 | 12
pallor 1 | 13
preweaning lethality, incomple... 1 | 260
tremors 1 | 34

Disease

ovarian cancer 68 | 8,491
osteosarcoma 46 | 7,933
psoriasis 41 | 6,685
glioblastoma 36 | 5,572
lung cancer 34 | 4,473
Multiple myeloma 27 | 1,327
medulloblastoma, large-cell 27 | 6,234
atypical teratoid / rhabdoid tumor 25 | 4,369
Cancer 21 | 2,346
Carcinoma 19 | 2,147
malignant mesothelioma 19 | 3,163
Breast cancer 17 | 3,098
ependymoma 17 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,988
Polydactyly 16 | 93
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,956
HIV Infections 15 | 99
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,289
pancreatic cancer 15 | 2,300
pediatric high grade glioma 15 | 2,712
oligodendroglioma 14 | 2,849
Pick disease 13 | 1,893
astrocytoma 13 | 1,493
invasive ductal carcinoma 13 | 2,950
lung carcinoma 13 | 2,844
group 3 medulloblastoma 12 | 2,254
posterior fossa group B ependymoma 12 | 1,530
primitive neuroectodermal tumor 12 | 3,031
astrocytic glioma 11 | 2,241
medulloblastoma 11 | 1,524
non-small cell lung cancer 11 | 2,798
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,795
pilocytic astrocytoma 11 | 3,086
Carney complex 10 | 23
Ciliopathy 10 | 57
Obesity 10 | 616
Waldenstrons macroglobulinemia 10 | 764
dermatomyositis 10 | 966
interstitial cystitis 10 | 2,299
subependymal giant cell astrocytoma 10 | 2,287
chronic rhinosinusitis 9 | 512
primary pancreatic ductal adenocarcinoma 9 | 1,271
Asphyxiating thoracic dystrophy 8 | 34
Primary pigmented nodular adrenocortical disease 8 | 13
Sensenbrenner syndrome 8 | 15
diabetes mellitus 8 | 1,663
lung adenocarcinoma 8 | 2,714
non primary Sjogren syndrome sicca 8 | 840
pituitary cancer 8 | 1,972
Nephronophthisis 7 | 74
Retinitis pigmentosa 7 | 156
group 4 medulloblastoma 7 | 1,875
progressive supranuclear palsy 7 | 674
sonic hedgehog group medulloblastoma 7 | 1,482
tuberculosis 7 | 1,563
ulcerative colitis 7 | 2,087
Acquired metabolic disease 6 | 267
Adenoma 6 | 165
Alzheimer's disease 6 | 644
Brachydactyly 6 | 52
Cushing's syndrome 6 | 47
Ellis-Van Creveld syndrome 6 | 19
Parkinson's disease 6 | 364
Substance Withdrawal Syndrome 6 | 55
adult high grade glioma 6 | 2,148
cutaneous lupus erythematosus 6 | 1,056
Acrodysostosis 5 | 9
Acromegaly 5 | 40
Bardet-Biedl Syndrome 5 | 40
Fibrous dysplasia 5 | 15
Intellectual disability 5 | 573
Jeune thoracic dystrophy 5 | 9
Kidney cancer 5 | 121
Mantle cell lymphoma 5 | 20
McCune Albright syndrome 5 | 19
Multiple Endocrine Neoplasia Type 1 5 | 30
Nevoid basal cell carcinoma syndrome 5 | 9
Pituitary adenoma 5 | 35
Pseudohypoparathyroidism 5 | 17
Senior-Loken syndrome 5 | 22
active Crohn's disease 5 | 918
atypical teratoid/rhabdoid tumor 5 | 1,095
cystic fibrosis and chronic rhinosinusitis 5 | 213
Holoprosencephaly 4 | 52
Hypothyroidism 4 | 89
Kidney Diseases 4 | 86
Kidney disease 4 | 397
Osteoporosis 4 | 259
Polycystic Ovary Syndrome 4 | 334
Polycystic kidney disease 4 | 54
Synostosis 4 | 18
acute myeloid leukemia 4 | 785
acute quadriplegic myopathy 4 | 1,157
breast carcinoma 4 | 1,614
colon cancer 4 | 1,475
esophageal adenocarcinoma 4 | 737
gastric carcinoma 4 | 832
juvenile dermatomyositis 4 | 1,189
posterior fossa group A ependymoma 4 | 1,511
sarcoidosis 4 | 368

Tissue

Blood and immune system 100 | 17,994
Digestive Tract 100 | 18,472
Endocrine System 100 | 18,511
Female tissues 100 | 18,646
Liver and Pancreas 100 | 18,135
Male tissues 100 | 17,968
Nervous System 100 | 18,560
Urinary Tract 100 | 18,443
Cardiovascular System 99 | 17,957
Respiratory system 99 | 17,483
Skin and soft tissues 97 | 18,114

Target Family

Enzyme 55 | 4,146
Non-IDG 35 | 11,969
Kinase 5 | 634
Transcription Factor 4 | 1,400
GPCR 2 | 408

Reactome Pathway

Hedgehog 'off' state 101 | 101
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.29669 19.6 50
Adenylate cyclase type 10 ADCY10 Tchem Enzyme -3.12717 1279.3 98
Intraflagellar transport protein 140 homolog IFT140 Tbio Non-IDG -1.28967 18.3 40
26S proteasome non-ATPase regulatory subunit 13 PSMD13 Tchem Enzyme -1.05639 9.70 94
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS Tbio Non-IDG -2.60782 1308.3 400
S-phase kinase-associated protein 1 SKP1 Tbio Enzyme -2.54884 305.8 337
Adenylate cyclase type 6 ADCY6 Tchem Enzyme -2.03355 100.9 102
Suppressor of fused homolog SUFU Tbio Non-IDG -2.28664 185.5 162
26S proteasome non-ATPase regulatory subunit 3 PSMD3 Tbio Enzyme -1.21151 15.4 162
Neuroendocrine secretory protein 55 GNAS Tbio Non-IDG -2.60782 1308.3 400