Development Level

Tbio 66 | 10,625
Tchem 26 | 1,890
Tclin 7 | 602
Tdark 3 | 7,003

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 8 | 633
abnormal bone structure 6 | 131
increased heart weight 5 | 37
abnormal bone mineralization 4 | 55
decreased lean body mass 3 | 195
embryonic lethality prior to t... 3 | 187
abnormal behavior 2 | 226
abnormal embryo size 2 | 112
abnormal embryo turning 2 | 15
decreased bone mineral content 2 | 157
decreased fasted circulating g... 2 | 49
decreased mean corpuscular vol... 2 | 50
increased mean corpuscular vol... 2 | 91
increased total body fat amoun... 2 | 57
abnormal QRS complex 1 | 25
abnormal cervical vertebrae mo... 1 | 4
abnormal embryo development 1 | 2
abnormal eye morphology 1 | 38
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal limb bud morphology 1 | 15
abnormal liver size 1 | 4
abnormal midbrain development 1 | 22
abnormal nail morphology 1 | 7
abnormal neural tube closure 1 | 37
abnormal pericardium morpholog... 1 | 11
abnormal placenta size 1 | 10
abnormal rib morphology 1 | 28
abnormal spinal cord morpholog... 1 | 8
abnormal stomach morphology 1 | 4
abnormal tooth morphology 1 | 24
absent heartbeat 1 | 6
anophthalmia 1 | 20
decreased body length 1 | 108
decreased body weight 1 | 174
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating alkaline... 1 | 41
decreased circulating chloride... 1 | 32
decreased circulating choleste... 1 | 85
decreased circulating fructosa... 1 | 31
decreased circulating glucose ... 1 | 121
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 34
decreased prepulse inhibition 1 | 52
decreased total body fat amoun... 1 | 186
embryonic growth retardation 1 | 28
enlarged lymph nodes 1 | 27
hyperactivity 1 | 108
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
increased body weight 1 | 42
increased circulating LDL chol... 1 | 15
increased circulating alkaline... 1 | 119
increased circulating aspartat... 1 | 17
increased circulating calcium ... 1 | 32
increased circulating phosphat... 1 | 24
increased circulating total pr... 1 | 20
increased heart rate variabili... 1 | 4
increased or absent threshold ... 1 | 128
increased sacral vertebrae num... 1 | 62
pale liver 1 | 5
pale yolk sac 1 | 12
pallor 1 | 13
preweaning lethality, incomple... 1 | 260
tremors 1 | 34

Disease

ovarian cancer 69 | 8,484
osteosarcoma 46 | 7,933
psoriasis 41 | 6,685
glioblastoma 36 | 5,572
lung cancer 34 | 4,466
Multiple myeloma 28 | 1,327
medulloblastoma, large-cell 27 | 6,234
atypical teratoid / rhabdoid tumor 25 | 4,369
Cancer 21 | 2,346
Carcinoma 19 | 2,147
malignant mesothelioma 19 | 3,162
Breast cancer 18 | 3,094
ependymoma 17 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,988
HIV Infections 16 | 100
Polydactyly 16 | 93
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,289
pancreatic cancer 15 | 2,300
pediatric high grade glioma 15 | 2,712
oligodendroglioma 14 | 2,849
Pick disease 13 | 1,893
astrocytoma 13 | 1,493
invasive ductal carcinoma 13 | 2,950
lung carcinoma 13 | 2,844
group 3 medulloblastoma 12 | 2,254
posterior fossa group B ependymoma 12 | 1,530
primitive neuroectodermal tumor 12 | 3,031
Waldenstrons macroglobulinemia 11 | 765
astrocytic glioma 11 | 2,241
dermatomyositis 11 | 933
medulloblastoma 11 | 1,524
non-small cell lung cancer 11 | 2,798
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,795
pilocytic astrocytoma 11 | 3,086
Carney complex 10 | 23
Ciliopathy 10 | 57
Obesity 10 | 616
interstitial cystitis 10 | 2,299
subependymal giant cell astrocytoma 10 | 2,287
chronic rhinosinusitis 9 | 512
primary pancreatic ductal adenocarcinoma 9 | 1,271
Sensenbrenner syndrome 8 | 15
diabetes mellitus 8 | 1,663
lung adenocarcinoma 8 | 2,713
non primary Sjogren syndrome sicca 8 | 840
pituitary cancer 8 | 1,972
Asphyxiating thoracic dystrophy 7 | 32
Nephronophthisis 7 | 74
Primary pigmented nodular adrenocortical disease 7 | 12
Retinitis pigmentosa 7 | 153
group 4 medulloblastoma 7 | 1,875
progressive supranuclear palsy 7 | 674
sonic hedgehog group medulloblastoma 7 | 1,482
tuberculosis 7 | 1,557
ulcerative colitis 7 | 2,087
Acquired metabolic disease 6 | 267
Adenoma 6 | 165
Alzheimer's disease 6 | 644
Brachydactyly 6 | 52
Cushing's syndrome 6 | 47
Ellis-Van Creveld syndrome 6 | 18
Parkinson's disease 6 | 364
adult high grade glioma 6 | 2,148
cutaneous lupus erythematosus 6 | 1,056
Acrodysostosis 5 | 9
Acromegaly 5 | 40
Bardet-Biedl Syndrome 5 | 40
Fibrous dysplasia 5 | 15
Intellectual disability 5 | 573
Jeune thoracic dystrophy 5 | 9
Kidney cancer 5 | 118
Mantle cell lymphoma 5 | 18
McCune Albright syndrome 5 | 19
Multiple Endocrine Neoplasia Type 1 5 | 30
Nevoid basal cell carcinoma syndrome 5 | 9
Pituitary adenoma 5 | 35
Pseudohypoparathyroidism 5 | 17
Senior-Loken syndrome 5 | 21
active Crohn's disease 5 | 918
atypical teratoid/rhabdoid tumor 5 | 1,095
cystic fibrosis and chronic rhinosinusitis 5 | 213
primary Sjogren syndrome 5 | 789
Holoprosencephaly 4 | 52
Hypothyroidism 4 | 89
Joubert syndrome 4 | 61
Kidney Diseases 4 | 86
Kidney disease 4 | 396
Osteoporosis 4 | 257
Polycystic kidney disease 4 | 54
Synostosis 4 | 18
acute myeloid leukemia 4 | 780
acute quadriplegic myopathy 4 | 1,157
breast carcinoma 4 | 1,614
colon cancer 4 | 1,475
esophageal adenocarcinoma 4 | 737
gastric carcinoma 4 | 832
juvenile dermatomyositis 4 | 1,189
posterior fossa group A ependymoma 4 | 1,511
sarcoidosis 4 | 358

Tissue

Blood and immune system 101 | 17,995
Digestive Tract 101 | 18,473
Endocrine System 101 | 18,512
Female tissues 101 | 18,647
Liver and Pancreas 101 | 18,136
Male tissues 101 | 17,969
Nervous System 101 | 18,561
Urinary Tract 101 | 18,444
Cardiovascular System 100 | 17,958
Respiratory system 100 | 17,484
Skin and soft tissues 98 | 18,115

Target Family

Enzyme 56 | 4,146
Non-IDG 35 | 11,971
Kinase 5 | 634
Transcription Factor 4 | 1,400
GPCR 2 | 406

Reactome Pathway

Hedgehog 'off' state 102 | 102
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -2.94349 567.7 767
Adenylate cyclase type 1 ADCY1 Tchem Enzyme -1.58202 42.2 123
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
26S proteasome non-ATPase regulatory subunit 8 PSMD8 Tbio Enzyme -1.35900 20.6 94
Transcriptional activator GLI3 GLI3 Tbio Transcription Factor -3.17963 1388.1 188
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
Zinc finger protein GLI2 GLI2 Tchem Transcription Factor -2.51321 325.2 174
cAMP-dependent protein kinase type II-alpha regulatory subunit PRKAR2A Tbio Enzyme -0.84292 6.74 237
E3 ubiquitin-protein ligase RBX1 RBX1 Tbio Enzyme -1.88715 67.2 211
Cytoplasmic dynein 2 heavy chain 1 DYNC2H1 Tbio Non-IDG -1.59494 38.2 10