Development Level

Tbio 20 | 11,445
Tchem 7 | 1,598
Tdark 6 | 6,588
Tclin 4 | 613

IMPC Phenotype

preweaning lethality, complete... 6 | 979
preweaning lethality, incomple... 5 | 499
decreased total body fat amoun... 2 | 207
increased grip strength 2 | 41
abnormal behavior 1 | 298
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal snout morphology 1 | 23
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
corneal opacity 1 | 32
decreased caudal vertebrae num... 1 | 53
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating sodium l... 1 | 22
decreased hematocrit 1 | 46
enlarged lymph nodes 1 | 37
impaired glucose tolerance 1 | 75
increased circulating creatini... 1 | 38
increased hematocrit 1 | 46
increased lean body mass 1 | 172
male infertility 1 | 123
microphthalmia 1 | 26
prenatal lethality prior to he... 1 | 87
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

ovarian cancer 24 | 8,520
Carcinoma 23 | 11,493
psoriasis 18 | 6,694
lung cancer 16 | 4,740
osteosarcoma 16 | 7,950
Breast cancer 15 | 3,578
medulloblastoma, large-cell 14 | 6,241
atypical teratoid / rhabdoid tumor 12 | 5,112
glioblastoma 12 | 5,792
group 3 medulloblastoma 10 | 4,104
invasive ductal carcinoma 10 | 2,951
Multiple myeloma 9 | 1,332
malignant mesothelioma 9 | 3,232
interstitial cystitis 8 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
pancreatic cancer 8 | 2,398
Cancer 7 | 2,499
Major Depressive Disorder 7 | 301
Unipolar Depression 7 | 250
Waldenstrons macroglobulinemia 7 | 765
adult high grade glioma 7 | 3,801
astrocytoma 7 | 1,146
ependymoma 7 | 4,679
juvenile dermatomyositis 7 | 1,187
lung adenocarcinoma 7 | 2,716
non-small cell lung cancer 7 | 2,890
subependymal giant cell astrocytoma 7 | 2,287
Depressive disorder 6 | 409
Kidney cancer 6 | 2,613
Rheumatoid arthritis 6 | 1,191
acute quadriplegic myopathy 6 | 1,158
colon cancer 6 | 1,478
diabetes mellitus 6 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
oligodendroglioma 6 | 2,850
Astrocytoma, Pilocytic 5 | 3,081
Bipolar Disorder 5 | 666
Endometriosis 5 | 540
Mood Disorders 5 | 184
chronic rhinosinusitis 5 | 512
dermatomyositis 5 | 966
ductal carcinoma in situ 5 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
posterior fossa group B ependymoma 5 | 416
primitive neuroectodermal tumor 5 | 3,035
tuberculosis 5 | 2,010
Breast Neoplasms 4 | 445
Kennedy's disease 4 | 11
Mammary Neoplasms 4 | 425
Mental Depression 4 | 333
Neurodegenerative disease 4 | 414
Pick disease 4 | 1,894
Schizophrenia 4 | 1,160
astrocytic glioma 4 | 2,597
breast carcinoma 4 | 1,638
cutaneous lupus erythematosus 4 | 1,057
cystic fibrosis 4 | 1,696
hepatocellular carcinoma 4 | 547
non primary Sjogren syndrome sicca 4 | 891
tuberculosis and treatment for 6 months 4 | 409
Acne vulgaris 3 | 14
Alcoholic Intoxication, Chronic 3 | 289
Amyotrophic lateral sclerosis 3 | 451
Atopic dermatitis 3 | 952
Duchenne muscular dystrophy 3 | 601
Huntington's disease 3 | 76
Hypertension 3 | 396
Hypertensive disease 3 | 292
Male infertility 3 | 206
Menopausal flushing 3 | 17
Neuropathy 3 | 261
Parkinson's disease 3 | 392
Prostatic Neoplasms 3 | 495
Slow progression 3 | 89
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
esophageal adenocarcinoma 3 | 737
gastric cancer 3 | 459
pancreatic carcinoma 3 | 562
pituitary cancer 3 | 1,972
post-traumatic stress disorder 3 | 40
Atrophic vaginitis 2 | 14
Contact Dermatitis 2 | 81
Contraception 2 | 15
Decreased tendon reflex 2 | 122
Distal limb muscle weakness due to peripheral neuropathy 2 | 62
Distal muscle weakness 2 | 62
Endometrial cancer 2 | 311
Highly variable clinical phenotype 2 | 150
Highly variable phenotype and severity 2 | 150
Highly variable phenotype, even within families 2 | 150
Hyperandrogenism 2 | 34
Kidney disease 2 | 430
Melanoma 2 | 711
Phenotypic variability 2 | 150
Psychotic Disorders 2 | 151
Vascular disease 2 | 319
adrenocortical carcinoma 2 | 1,428
medulloblastoma 2 | 720
pediatric high grade glioma 2 | 1,064

Tissue

Digestive Tract 37 | 17,369
Endocrine System 37 | 18,159
Female tissues 37 | 17,400
Male tissues 37 | 17,142
Skin and soft tissues 37 | 17,230
Urinary Tract 37 | 16,678
Blood and immune system 36 | 16,909
Liver and Pancreas 36 | 16,750
Respiratory system 36 | 16,393
Cardiovascular System 35 | 15,192
Nervous System 35 | 16,725

Target Family

Non-IDG 30 | 12,091
Nuclear Receptor 4 | 48
Enzyme 3 | 4,145

Reactome Pathway

HSP90 chaperone cycle for ster... 37 | 37
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DnaJ homolog subfamily A member 4 DNAJA4 Tbio Non-IDG -0.52235 2.67 120
Peptidyl-prolyl cis-trans isomerase FKBP5 FKBP5 Tchem Enzyme -2.52114 348.1 299
Heat shock-related 70 kDa protein 2 HSPA2 Tbio Non-IDG -1.98655 104.3 162
Cytoplasmic dynein 1 light intermediate chain 2 DYNC1LI2 Tbio Non-IDG -0.61455 3.87 95
Heat shock 70 kDa protein 1B HSPA1B Tbio Non-IDG -1.61862 0.00000 60
Heat shock 70 kDa protein 1A HSPA1B Tchem Non-IDG -3.10995 0.00000 1174
Mineralocorticoid receptor NR3C2 Tclin Nuclear Receptor -3.08863 1005.8 203
Progesterone receptor PGR Tclin Nuclear Receptor -3.94412 7951.2 2098
Cytoplasmic dynein 1 heavy chain 1 DYNC1H1 Tbio Non-IDG -1.80946 62.1 94
Androgen receptor AR Tclin Nuclear Receptor -3.82874 7137.7 1609