Development Level

Tbio 22 | 11,445
Tchem 11 | 1,598
Tclin 1 | 613
Tdark 1 | 6,588

IMPC Phenotype

embryonic lethality prior to t... 2 | 278
preweaning lethality, complete... 2 | 979
abnormal embryo size 1 | 220
abnormal retina morphology 1 | 71
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
abnormal tail morphology 1 | 25
decreased blood urea nitrogen ... 1 | 51
decreased circulating LDL chol... 1 | 38
embryonic lethality prior to o... 1 | 239
increased circulating LDL chol... 1 | 13
increased grip strength 1 | 41
increased mean corpuscular hem... 1 | 96
male infertility 1 | 123
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 21 | 11,493
ovarian cancer 21 | 8,520
medulloblastoma, large-cell 17 | 6,241
Breast cancer 15 | 3,578
osteosarcoma 14 | 7,950
glioblastoma 13 | 5,792
lung cancer 12 | 4,740
atypical teratoid / rhabdoid tumor 11 | 5,112
psoriasis 11 | 6,694
Cancer 10 | 2,499
adult high grade glioma 10 | 3,801
Astrocytoma, Pilocytic 9 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
ependymoma 8 | 4,679
group 3 medulloblastoma 8 | 4,104
oligodendroglioma 8 | 2,850
pancreatic cancer 8 | 2,398
Kidney cancer 7 | 2,613
Major Depressive Disorder 7 | 301
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
lung adenocarcinoma 7 | 2,716
malignant mesothelioma 7 | 3,232
non-small cell lung cancer 7 | 2,890
pituitary cancer 7 | 1,972
subependymal giant cell astrocytoma 7 | 2,287
tuberculosis 7 | 2,010
Schizophrenia 6 | 1,160
Unipolar Depression 6 | 250
Waldenstrons macroglobulinemia 6 | 765
astrocytoma 6 | 1,146
cystic fibrosis 6 | 1,696
esophageal adenocarcinoma 6 | 737
interstitial cystitis 6 | 2,312
invasive ductal carcinoma 6 | 2,951
Huntington's disease 5 | 76
Multiple myeloma 5 | 1,332
astrocytic glioma 5 | 2,597
colon cancer 5 | 1,478
ductal carcinoma in situ 5 | 1,745
primitive neuroectodermal tumor 5 | 3,035
Acquired scoliosis 4 | 281
Amyotrophic lateral sclerosis 4 | 451
Bipolar Disorder 4 | 666
Carcinoma, Squamous Cell 4 | 110
Cataract 4 | 297
Curvature of spine 4 | 282
Epilepsy 4 | 792
Hypoplastic mandible condyle 4 | 275
Lens Opacities 4 | 231
Mandibular hypoplasia 4 | 275
Micrognathism 4 | 275
Prostatic Neoplasms 4 | 495
Squamous cell carcinoma 4 | 129
breast carcinoma 4 | 1,638
cystic fibrosis and chronic rhinosinusitis 4 | 214
juvenile dermatomyositis 4 | 1,187
lung carcinoma 4 | 2,843
non primary Sjogren syndrome sicca 4 | 891
pancreatic carcinoma 4 | 562
Autistic Disorder 3 | 364
Breast Neoplasms 3 | 445
Congenital deafness 3 | 185
Contracture 3 | 96
Contracture of joint 3 | 93
Deafness 3 | 198
Endometrial cancer 3 | 311
Flexion contracture 3 | 93
Flexion contractures of joints 3 | 93
HIV Infections 3 | 102
Hearing Loss, Partial 3 | 185
Intellectual disability 3 | 1,016
Joint laxity 3 | 54
Kennedy's disease 3 | 11
Liver Cirrhosis, Experimental 3 | 769
Mammary Neoplasms 3 | 425
Myopathy 3 | 185
Neurodegenerative disease 3 | 414
Parkinson's disease 3 | 392
Pick disease 3 | 1,894
Renal Cell Carcinoma 3 | 214
Rheumatoid arthritis 3 | 1,191
Seizures 3 | 596
Short stature 3 | 531
Vascular disease 3 | 319
acute quadriplegic myopathy 3 | 1,158
chronic rhinosinusitis 3 | 512
diabetes mellitus 3 | 1,728
fibroadenoma 3 | 559
hearing impairment 3 | 199
primary pancreatic ductal adenocarcinoma 3 | 1,109
Decreased projection of maxilla 2 | 66
Deficiency of upper jaw bones 2 | 66
Dental caries 2 | 164
Hypotrophic maxilla 2 | 66
Low posterior hairline 2 | 52
Maxillary retrognathia 2 | 66
Retrusion of upper jaw bones 2 | 66
Spina bifida occulta 2 | 19
Sunken eyes 2 | 63

Tissue

Blood and immune system 35 | 16,909
Endocrine System 35 | 18,159
Digestive Tract 34 | 17,369
Male tissues 34 | 17,142
Respiratory system 33 | 16,393
Urinary Tract 33 | 16,678
Female tissues 32 | 17,400
Nervous System 32 | 16,725
Skin and soft tissues 32 | 17,230
Cardiovascular System 31 | 15,192
Liver and Pancreas 31 | 16,750

Target Family

Non-IDG 25 | 12,091
Kinase 5 | 634
Enzyme 2 | 4,145
Epigenetic 2 | 242
Transcription Factor 1 | 1,400

Reactome Pathway

HSF1-dependent transactivation 35 | 35
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA-binding death effector domain-containing protein 2 DEDD2 Tbio Non-IDG -0.55115 3.37 164
Heat shock-related 70 kDa protein 2 HSPA2 Tbio Non-IDG -1.98655 104.3 162
Calcium/calmodulin-dependent protein kinase type II subunit gamma CAMK2G Tchem Kinase -0.94556 7.03 308
Calcium/calmodulin-dependent protein kinase type II subunit beta CAMK2B Tchem Kinase -1.14550 13.6 344
Heat shock 70 kDa protein 1A HSPA1B Tchem Non-IDG -3.10995 0.00000 1174
Heat shock 70 kDa protein 1B HSPA1B Tbio Non-IDG -1.61862 0.00000 60
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Serpin H1 SERPINH1 Tbio Non-IDG -3.18763 1526.9 346
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.82317 50.9 620
Heat shock 70 kDa protein 6 HSPA6 Tbio Non-IDG -1.75259 92.5 173