Development Level

Tbio 19 | 11,445
Tchem 7 | 1,598
Tclin 1 | 613
Tdark 1 | 6,588

IMPC Phenotype

embryonic lethality prior to t... 2 | 278
preweaning lethality, complete... 2 | 979
abnormal embryo size 1 | 220
abnormal retina morphology 1 | 71
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
abnormal tail morphology 1 | 25
decreased circulating glucose ... 1 | 126
embryonic lethality prior to o... 1 | 239
increased grip strength 1 | 41
increased heart weight 1 | 62
increased mean corpuscular vol... 1 | 92
male infertility 1 | 123
preweaning lethality, incomple... 1 | 499

Disease

ovarian cancer 19 | 8,520
Carcinoma 16 | 11,493
Breast cancer 11 | 3,578
medulloblastoma, large-cell 11 | 6,241
osteosarcoma 11 | 7,950
lung cancer 9 | 4,740
Cancer 8 | 2,499
Waldenstrons macroglobulinemia 8 | 765
pancreatic cancer 8 | 2,398
psoriasis 8 | 6,694
Multiple myeloma 7 | 1,332
astrocytoma 7 | 1,146
atypical teratoid / rhabdoid tumor 6 | 5,112
glioblastoma 6 | 5,792
non-small cell lung cancer 6 | 2,890
oligodendroglioma 6 | 2,850
Astrocytoma, Pilocytic 5 | 3,081
ependymoma 5 | 4,679
interstitial cystitis 5 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
invasive ductal carcinoma 5 | 2,951
lung adenocarcinoma 5 | 2,716
Major Depressive Disorder 4 | 301
Pick disease 4 | 1,894
Unipolar Depression 4 | 250
adult high grade glioma 4 | 3,801
breast carcinoma 4 | 1,638
group 3 medulloblastoma 4 | 4,104
malignant mesothelioma 4 | 3,232
pancreatic carcinoma 4 | 562
tuberculosis 4 | 2,010
Depressive disorder 3 | 409
HIV Infections 3 | 102
Huntington's disease 3 | 76
Neurodegenerative disease 3 | 414
Prostatic Neoplasms 3 | 495
Rheumatoid arthritis 3 | 1,191
Schizophrenia 3 | 1,160
acute quadriplegic myopathy 3 | 1,158
astrocytic glioma 3 | 2,597
dermatomyositis 3 | 966
esophageal adenocarcinoma 3 | 737
juvenile dermatomyositis 3 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pituitary cancer 3 | 1,972
subependymal giant cell astrocytoma 3 | 2,287
Amyotrophic lateral sclerosis 2 | 451
Becker muscular dystrophy 2 | 191
Bipolar Disorder 2 | 666
Breast Neoplasms 2 | 445
Creatine phosphokinase serum increased 2 | 110
Difficulty walking up stairs 2 | 12
Elevated creatine kinase 2 | 110
Epilepsy 2 | 792
Frontal bossing 2 | 157
High forehead 2 | 102
Hypoplastic mandible condyle 2 | 275
Low set ears 2 | 181
Machado-Joseph disease 2 | 18
Mammary Neoplasms 2 | 425
Mandibular hypoplasia 2 | 275
Mental Depression 2 | 333
Micrognathism 2 | 275
Myopathy 2 | 185
Neoplasm Metastasis 2 | 168
Pelvic girdle weakness 2 | 7
Platyspondyly 2 | 56
Rimmed vacuoles on biopsy 2 | 15
Seizures 2 | 596
Short nose 2 | 132
Short stature 2 | 531
Shoulder girdle weakness 2 | 10
Shoulder weakness 2 | 10
Single major depressive episode 2 | 8
Small nose 2 | 132
Tall forehead 2 | 102
Thin rib 2 | 21
Xeroderma pigmentosum 2 | 43
chronic rhinosinusitis 2 | 512
colon cancer 2 | 1,478
cutaneous lupus erythematosus 2 | 1,057
cystic fibrosis 2 | 1,696
cystic fibrosis and chronic rhinosinusitis 2 | 214
diabetes mellitus 2 | 1,728
ductal carcinoma in situ 2 | 1,745
gastric cancer 2 | 459
group 4 medulloblastoma 2 | 1,855
hereditary spastic paraplegia 2 | 318
interstitial lung disease 2 | 298
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
lung carcinoma 2 | 2,843
medulloblastoma 2 | 720
non primary Sjogren syndrome sicca 2 | 891
posterior fossa group B ependymoma 2 | 416
primary pancreatic ductal adenocarcinoma 2 | 1,109
primitive neuroectodermal tumor 2 | 3,035
progressive supranuclear palsy 2 | 676
Echolalia 1 | 12
Inclusion body myopathy with Paget disease of bone and frontotemporal dementia 1 | 13

Tissue

Blood and immune system 28 | 16,909
Endocrine System 28 | 18,159
Digestive Tract 27 | 17,369
Male tissues 27 | 17,142
Respiratory system 26 | 16,393
Urinary Tract 26 | 16,678
Female tissues 25 | 17,400
Nervous System 25 | 16,725
Skin and soft tissues 25 | 17,230
Cardiovascular System 24 | 15,192
Liver and Pancreas 24 | 16,750

Target Family

Non-IDG 23 | 12,091
Enzyme 3 | 4,145
Epigenetic 1 | 242
Transcription Factor 1 | 1,400

Reactome Pathway

HSF1 activation 28 | 28
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA-binding death effector domain-containing protein 2 DEDD2 Tbio Non-IDG -0.55115 3.37 164
Heat shock 70 kDa protein 1A HSPA1B Tchem Non-IDG -3.10995 0.00000 1174
Heat shock 70 kDa protein 1B HSPA1B Tbio Non-IDG -1.61862 0.00000 60
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Serpin H1 SERPINH1 Tbio Non-IDG -3.18763 1526.9 346
Replication protein A 14 kDa subunit RPA3 Tbio Non-IDG -1.85941 67.1 171
Heat shock 70 kDa protein 6 HSPA6 Tbio Non-IDG -1.75259 92.5 173
Heat shock factor-binding protein 1 HSBP1 Tbio Non-IDG -0.97962 10.1 68
Tumor necrosis factor receptor superfamily member 21 TNFRSF21 Tbio Non-IDG -2.23109 178.7 413
Heat shock protein 105 kDa HSPH1 Tbio Non-IDG -1.69371 52.4 316