Development Level

Tbio 16 | 11,445
Tchem 3 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

decreased circulating serum al... 2 | 82
preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
cataract 1 | 92
decreased exploration in new e... 1 | 11
decreased lymphocyte cell numb... 1 | 83
decreased red blood cell distr... 1 | 41
decreased total body fat amoun... 1 | 207
hypoactivity 1 | 132
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating creatini... 1 | 38
increased circulating potassiu... 1 | 29
increased circulating triglyce... 1 | 42
increased neutrophil cell numb... 1 | 46
mydriasis 1 | 6
short tibia 1 | 97
small adrenal glands 1 | 16
small kidney 1 | 16
thrombocytosis 1 | 27

Disease

Carcinoma 17 | 11,493
psoriasis 13 | 6,694
glioblastoma 12 | 5,792
atypical teratoid / rhabdoid tumor 11 | 5,112
ovarian cancer 11 | 8,520
medulloblastoma, large-cell 9 | 6,241
Breast cancer 8 | 3,578
Coarse facial features 8 | 108
Congenital deafness 8 | 185
Deafness 8 | 198
Hearing Loss, Partial 8 | 185
Hepatomegaly 8 | 285
Short neck 8 | 140
Splenomegaly 8 | 190
Thickened facial skin with coarse facial features 8 | 108
hearing impairment 8 | 199
invasive ductal carcinoma 8 | 2,951
malignant mesothelioma 8 | 3,232
osteosarcoma 8 | 7,950
primitive neuroectodermal tumor 8 | 3,035
Astrocytoma, Pilocytic 7 | 3,081
Autosomal recessive predisposition 7 | 1,442
Hernia, Inguinal 7 | 89
Umbilical hernia 7 | 93
ependymoma 7 | 4,679
group 3 medulloblastoma 7 | 4,104
Acquired scoliosis 6 | 281
Cancer 6 | 2,499
Curvature of spine 6 | 282
Dull intelligence 6 | 645
Intellectual disability 6 | 1,016
Joint stiffness 6 | 84
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Mucopolysaccharidosis 6 | 26
Poor school performance 6 | 645
adult high grade glioma 6 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
Big calvaria 5 | 147
Broad flat nasal bridge 5 | 236
Hydrocephalus 5 | 152
Increased head circumference 5 | 147
Increased size of cranium 5 | 147
Increased size of skull 5 | 147
Kidney cancer 5 | 2,613
Nasal bridge wide 5 | 236
Pfaundler-Hurler Syndrome 5 | 12
Short stature 5 | 531
Simpson-Golabi-Behmel syndrome 5 | 19
ductal carcinoma in situ 5 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
lung cancer 5 | 4,740
non-small cell lung cancer 5 | 2,890
Atrial Septal Defects 4 | 85
Class III malocclusion 4 | 78
Concave bridge of nose 4 | 195
Cryptorchidism 4 | 296
Death in early childhood 4 | 82
Death in infancy 4 | 82
Depressed nasal bridge 4 | 195
Depressed nasal root/bridge 4 | 195
Flared iliac wings 4 | 13
Heart valve disease 4 | 39
Hirsutism 4 | 47
Hyperkyphosis 4 | 111
Hypertrophy of lower jaw 4 | 78
Increased size of mandible 4 | 78
Kyphosis deformity of spine 4 | 114
Macroglossia 4 | 65
Mandibular hyperplasia 4 | 78
Multiple myeloma 4 | 1,332
Muscle hypotonia 4 | 571
Osteoporosis 4 | 363
VALVULAR ABNORMALITY 4 | 12
adrenocortical carcinoma 4 | 1,428
cutaneous lupus erythematosus 4 | 1,057
group 4 medulloblastoma 4 | 1,855
interstitial cystitis 4 | 2,312
lung carcinoma 4 | 2,843
mandibular excess (physical finding) 4 | 78
pancreatic cancer 4 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
pediatric high grade glioma 4 | 1,064
subependymal giant cell astrocytoma 4 | 2,287
Atopic dermatitis 3 | 952
Duchenne muscular dystrophy 3 | 601
Epilepsy 3 | 792
Seizures 3 | 596
Small nose 3 | 132
Ventricular Septal Defects 3 | 119
astrocytoma 3 | 1,146
cystic fibrosis 3 | 1,696
diabetes mellitus 3 | 1,728
lung adenocarcinoma 3 | 2,716
pituitary cancer 3 | 1,972
sonic hedgehog group medulloblastoma 3 | 467
spina bifida 3 | 1,074
tuberculosis 3 | 2,010

Tissue

Blood and immune system 20 | 16,909
Digestive Tract 20 | 17,369
Endocrine System 20 | 18,159
Female tissues 20 | 17,400
Liver and Pancreas 20 | 16,750
Male tissues 20 | 17,142
Nervous System 20 | 16,725
Respiratory system 20 | 16,393
Skin and soft tissues 20 | 17,230
Urinary Tract 20 | 16,678
Cardiovascular System 18 | 15,192

Target Family

Enzyme 10 | 4,145
Non-IDG 10 | 12,091

Reactome Pathway

HS-GAG degradation 20 | 20
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Glypican-6 GPC6 Tbio Non-IDG -1.33560 21.9 125
Alpha-N-acetylglucosaminidase NAGLU Tbio Enzyme -2.18649 159.9 64
Syndecan-3 SDC3 Tbio Non-IDG -1.86172 78.8 179
Alpha-L-iduronidase IDUA Tbio Enzyme -2.45679 291.5 129
Beta-galactosidase-1-like protein GLB1L Tdark Enzyme 0.23 0.30 58
Glypican-2 GPC2 Tbio Non-IDG -1.10212 12.9 106
Glypican-5 GPC5 Tbio Non-IDG -1.65766 45.7 200
Syndecan-4 SDC4 Tbio Non-IDG -2.39649 274.8 297
Inactive heparanase-2 HPSE2 Tbio Enzyme -2.52081 326.4 137
Glypican-1 GPC1 Tbio Non-IDG -2.38207 232.3 202