Development Level

Tbio 127 | 11,445
Tchem 12 | 1,598
Tdark 9 | 6,588
Tclin 3 | 613

IMPC Phenotype

preweaning lethality, complete... 26 | 979
embryonic lethality prior to o... 9 | 239
embryonic lethality prior to t... 8 | 278
abnormal embryo size 5 | 220
hypoactivity 4 | 132
abnormal heart morphology 3 | 162
abnormal retina morphology 3 | 71
enlarged heart 3 | 210
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
abnormal body wall morphology 2 | 9
abnormal craniofacial morpholo... 2 | 33
abnormal skin morphology 2 | 50
decreased vertical activity 2 | 208
increased circulating potassiu... 2 | 29
abnormal epididymis morphology 1 | 42
abnormal forebrain morphology 1 | 10
abnormal hindbrain morphology 1 | 10
abnormal kidney morphology 1 | 65
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal placenta size 1 | 20
abnormal retinal inner nuclear... 1 | 8
abnormal vibrissa morphology 1 | 25
absent startle reflex 1 | 24
brachydactyly 1 | 19
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating alkaline... 1 | 46
decreased circulating sodium l... 1 | 22
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased total retina thickne... 1 | 17
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged spleen 1 | 41
female infertility 1 | 60
hemorrhage 1 | 23
increased anti-nuclear antigen... 1 | 19
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased heart rate 1 | 23
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
male infertility 1 | 123
prenatal lethality prior to he... 1 | 87
protruding tongue 1 | 3
short tibia 1 | 97
shortened RR interval 1 | 17

Disease

Carcinoma 91 | 11,493
ovarian cancer 90 | 8,520
osteosarcoma 64 | 7,950
lung cancer 62 | 4,740
psoriasis 44 | 6,694
medulloblastoma, large-cell 42 | 6,241
glioblastoma 38 | 5,792
group 3 medulloblastoma 36 | 4,104
atypical teratoid / rhabdoid tumor 35 | 5,112
Multiple myeloma 33 | 1,332
Breast cancer 30 | 3,578
Cancer 29 | 2,499
malignant mesothelioma 26 | 3,232
primitive neuroectodermal tumor 26 | 3,035
Kidney cancer 25 | 2,613
ependymoma 25 | 4,679
adult high grade glioma 23 | 3,801
dermatomyositis 21 | 966
oligodendroglioma 21 | 2,850
Waldenstrons macroglobulinemia 20 | 765
astrocytic glioma 19 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,291
invasive ductal carcinoma 18 | 2,951
non-small cell lung cancer 18 | 2,890
Pick disease 17 | 1,894
acute quadriplegic myopathy 17 | 1,158
Cockayne syndrome 16 | 60
diabetes mellitus 16 | 1,728
Astrocytoma, Pilocytic 14 | 3,081
tuberculosis 14 | 2,010
acute myeloid leukemia 13 | 783
breast carcinoma 13 | 1,638
lung adenocarcinoma 13 | 2,716
Intellectual disability 12 | 1,016
Photosensitive trichothiodystrophy 12 | 30
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
subependymal giant cell astrocytoma 12 | 2,287
astrocytoma 11 | 1,146
pediatric high grade glioma 11 | 1,064
Xeroderma pigmentosum group B 10 | 20
colon cancer 10 | 1,478
group 4 medulloblastoma 10 | 1,855
pancreatic cancer 10 | 2,398
Autosomal recessive predisposition 9 | 1,442
ductal carcinoma in situ 9 | 1,745
juvenile dermatomyositis 9 | 1,187
ulcerative colitis 9 | 1,819
Dull intelligence 8 | 645
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Poor school performance 8 | 645
Rheumatoid arthritis 8 | 1,191
Xeroderma pigmentosum 8 | 43
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
progressive supranuclear palsy 8 | 676
Atopic dermatitis 7 | 952
Hypoplastic mandible condyle 7 | 275
Mandibular hypoplasia 7 | 275
Micrognathism 7 | 275
Schizophrenia 7 | 1,160
Xeroderma pigmentosum group D 7 | 33
hepatocellular carcinoma 7 | 547
lung carcinoma 7 | 2,843
medulloblastoma 7 | 720
primary pancreatic ductal adenocarcinoma 7 | 1,109
spina bifida 7 | 1,074
Cognitive delay 6 | 608
Failure to gain weight 6 | 365
Global developmental delay 6 | 608
Mental and motor retardation 6 | 608
Pediatric failure to thrive 6 | 365
Short stature 6 | 531
Small head 6 | 374
adrenocortical carcinoma 6 | 1,428
interstitial cystitis 6 | 2,312
nasopharyngeal carcinoma 6 | 1,058
pituitary cancer 6 | 1,972
primary Sjogren syndrome 6 | 735
Acquired immunodeficiency syndrome 5 | 197
Cryptorchidism 5 | 296
Epidermodysplasia verruciformis 5 | 21
Fetal Growth Retardation 5 | 189
Infant, Small for Gestational Age 5 | 176
Intrauterine retardation 5 | 176
Muscle Spasticity 5 | 195
Amyotrophic lateral sclerosis 4 | 451
Asthma 4 | 385
Broad flat nasal bridge 4 | 236
Dementia 4 | 175
Dystonia 4 | 164
Epilepsy 4 | 792
Hypersensitivity reaction type II disease 4 | 253
Multiple Sclerosis 4 | 540
Nasal bridge wide 4 | 236
Seizures 4 | 596
aldosterone-producing adenoma 4 | 665
cutaneous lupus erythematosus 4 | 1,057
cystic fibrosis 4 | 1,696

Tissue

Endocrine System 147 | 18,159
Blood and immune system 146 | 16,909
Digestive Tract 146 | 17,369
Female tissues 146 | 17,400
Liver and Pancreas 146 | 16,750
Nervous System 146 | 16,725
Respiratory system 146 | 16,393
Skin and soft tissues 146 | 17,230
Urinary Tract 146 | 16,678
Male tissues 145 | 17,142
Cardiovascular System 144 | 15,192

Target Family

Non-IDG 104 | 12,091
Enzyme 37 | 4,145
Epigenetic 3 | 242
Kinase 3 | 634
GPCR 2 | 408
Transcription Factor 2 | 1,400

Reactome Pathway

HIV Life Cycle 151 | 151
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nucleoporin NDC1 NDC1 Tbio Non-IDG -0.66901 4.57 46
Negative elongation factor B NELFB Tbio Non-IDG -1.16040 16.4 158
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.49730 299.8 149
Charged multivesicular body protein 7 CHMP7 Tbio Non-IDG -0.61033 3.61 30
Tumor susceptibility gene 101 protein TSG101 Tbio Non-IDG -2.47780 298.9 332
Charged multivesicular body protein 3 CHMP3 Tbio Non-IDG -1.39658 35.6 64
Transcription initiation factor TFIID subunit 9B TAF9B Tbio Non-IDG -1.38372 23.5 105
Programmed cell death 6-interacting protein PDCD6IP Tbio Non-IDG -1.59404 35.1 216
Nucleoprotein TPR TPR Tbio Non-IDG -2.11491 135.6 161
DNA-directed RNA polymerases I, II, and III subunit RPABC2 POLR2F Tbio Enzyme -1.13403 13.9 68