Development Level

Tbio 27 | 10,625
Tchem 7 | 1,890
Tclin 1 | 602
Tdark 1 | 7,003

IMPC Term

preweaning lethality, complete... 5 | 633
embryonic lethality prior to o... 3 | 148
embryonic lethality prior to t... 2 | 187
abnormal behavioral response t... 1 | 52
abnormal blood vessel morpholo... 1 | 2
abnormal bone structure 1 | 131
cardiovascular system phenotyp... 1 | 35
decreased circulating glucose ... 1 | 121
decreased fasted circulating g... 1 | 49
decreased heart rate variabili... 1 | 11
increased circulating sodium l... 1 | 71
increased exploration in new e... 1 | 56
increased heart weight 1 | 37
increased mean corpuscular vol... 1 | 91

Disease

ovarian cancer 25 | 8,484
osteosarcoma 24 | 7,933
Cancer 19 | 2,346
malignant mesothelioma 19 | 3,162
lung cancer 18 | 4,466
non-small cell lung cancer 15 | 2,798
psoriasis 15 | 6,685
glioblastoma 14 | 5,572
medulloblastoma, large-cell 14 | 6,234
Breast cancer 13 | 3,094
group 3 medulloblastoma 13 | 2,254
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,289
primitive neuroectodermal tumor 12 | 3,031
Bloom syndrome 11 | 30
nasopharyngeal carcinoma 10 | 1,056
Fanconi's anemia 9 | 50
Nijmegen breakage syndrome 9 | 23
atypical teratoid/rhabdoid tumor 9 | 1,095
colon cancer 9 | 1,475
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,988
invasive ductal carcinoma 9 | 2,950
Carcinoma 8 | 2,147
ductal carcinoma in situ 8 | 1,745
Ataxia telangiectasia 7 | 31
Mammary Neoplasms 7 | 410
Neoplastic Syndromes, Hereditary 7 | 48
Peripheral Neuropathy 7 | 303
Werner syndrome 7 | 29
diabetes mellitus 7 | 1,663
pediatric high grade glioma 7 | 2,712
Hereditary Breast and Ovarian Cancer Syndrome 6 | 14
Seckel syndrome 6 | 34
adrenocortical carcinoma 6 | 1,427
atypical teratoid / rhabdoid tumor 6 | 4,369
ependymoma 6 | 2,514
non primary Sjogren syndrome sicca 6 | 840
sonic hedgehog group medulloblastoma 6 | 1,482
Breast Cancer, Familial 5 | 12
Cockayne syndrome 5 | 54
lung adenocarcinoma 5 | 2,713
oligodendroglioma 5 | 2,849
pituitary cancer 5 | 1,972
Chronic Lymphocytic Leukemia 4 | 242
Malignant neoplasm of breast 4 | 63
Microcephaly 4 | 149
Photosensitive trichothiodystrophy 4 | 24
Rothmund-Thomson syndrome 4 | 22
Waldenstrons macroglobulinemia 4 | 765
Xeroderma pigmentosum 4 | 41
astrocytic glioma 4 | 2,241
astrocytoma 4 | 1,493
posterior fossa group A ependymoma 4 | 1,511
Anemia 3 | 252
Intellectual disability 3 | 573
Pick disease 3 | 1,893
Prostate cancer 3 | 172
Prostatic Neoplasms 3 | 471
adult high grade glioma 3 | 2,148
breast carcinoma 3 | 1,614
cutaneous lupus erythematosus 3 | 1,056
dermatomyositis 3 | 933
lung carcinoma 3 | 2,844
Adenoid Cystic Carcinoma 2 | 99
Alzheimer's disease 2 | 644
Aplastic anemia 2 | 18
Arsenic Poisoning 2 | 59
Asthma 2 | 349
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1 2 | 7
Baller-Gerold syndrome 2 | 14
Bladder Neoplasm 2 | 109
Cataract 2 | 104
Fanconi Anemia 2 | 19
Immune system cancer 2 | 38
Lynch syndrome 2 | 33
Malignant neoplasm of ovary 2 | 13
Melanoma 2 | 261
Multiple Sclerosis 2 | 498
Neoplasm Metastasis 2 | 138
Neoplasms, Germ Cell and Embryonal 2 | 13
Pancreatic Neoplasm 2 | 79
Progeria 2 | 22
Stomach Neoplasms 2 | 282
Testicular Neoplasms 2 | 5
acute quadriplegic myopathy 2 | 1,157
hepatocellular carcinoma 2 | 532
inflammatory breast cancer 2 | 404
interstitial cystitis 2 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,956
juvenile dermatomyositis 2 | 1,189
non-small cell lung carcinoma 2 | 413
ovarian neoplasm 2 | 97
pancreatic cancer 2 | 2,300
pancreatic carcinoma 2 | 567
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
pilocytic astrocytoma 2 | 3,086
posterior fossa group B ependymoma 2 | 1,530
progressive supranuclear palsy 2 | 674
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 1,557
ulcerative colitis 2 | 2,087

Tissue

Blood and immune system 36 | 17,995
Cardiovascular System 36 | 17,958
Digestive Tract 36 | 18,473
Endocrine System 36 | 18,512
Female tissues 36 | 18,647
Liver and Pancreas 36 | 18,136
Male tissues 36 | 17,969
Nervous System 36 | 18,561
Respiratory system 36 | 17,484
Skin and soft tissues 36 | 18,115
Urinary Tract 36 | 18,444

Target Family

Non-IDG 25 | 11,971
Enzyme 7 | 4,146
Kinase 3 | 634
Epigenetic 1 | 242

Reactome Pathway

HDR through Single Strand Anne... 36 | 36
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.76828 59.7 468
Replication factor C subunit 3 RFC3 Tbio Non-IDG -1.28299 19.5 161
Replication factor C subunit 5 RFC5 Tbio Non-IDG -1.02728 11.1 64
Replication factor C subunit 2 RFC2 Tbio Non-IDG -1.34287 19.7 194
Replication protein A 14 kDa subunit RPA3 Tbio Non-IDG -1.80635 59.3 127
Tyrosine-protein kinase ABL1 ABL1 Tclin Kinase -3.47805 3222.2 1533
Replication factor C subunit 4 RFC4 Tbio Non-IDG -1.13105 13.0 167
Cell cycle checkpoint control protein RAD9B RAD9B Tdark Non-IDG -0.05859 1.38 29
DNA replication ATP-dependent helicase/nuclease DNA2 DNA2 Tbio Enzyme -2.37310 239.3 81
Exonuclease 1 EXO1 Tbio Enzyme -2.58414 403.9 226