Development Level

Tbio 28 | 11,651
Tchem 7 | 1,388
Tdark 1 | 6,593

IMPC Phenotype

preweaning lethality, complete... 7 | 979
embryonic lethality prior to o... 5 | 239
embryonic lethality prior to t... 5 | 278
abnormal blood vessel morpholo... 2 | 5
abnormal embryo size 2 | 220
abnormal embryo turning 2 | 31
decreased circulating glucose ... 2 | 126
abnormal bone structure 1 | 187
abnormal chorioallantoic fusio... 1 | 8
abnormal embryo development 1 | 7
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pharyngeal arch morph... 1 | 8
abnormal somite shape 1 | 5
abnormal spinal cord morpholog... 1 | 9
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
cardiovascular system phenotyp... 1 | 36
decreased fasted circulating g... 1 | 65
decreased heart rate variabili... 1 | 13
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased heart weight 1 | 62
increased mean corpuscular vol... 1 | 92
pale yolk sac 1 | 25
pallor 1 | 34

Disease

Carcinoma 25 | 11,493
ovarian cancer 25 | 8,520
osteosarcoma 24 | 7,950
lung cancer 20 | 4,740
Cancer 19 | 2,499
group 3 medulloblastoma 19 | 4,104
malignant mesothelioma 19 | 3,232
Breast cancer 15 | 3,578
medulloblastoma, large-cell 15 | 6,241
non-small cell lung cancer 15 | 2,890
psoriasis 15 | 6,694
glioblastoma 14 | 5,792
atypical teratoid / rhabdoid tumor 13 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
Short stature 12 | 531
primitive neuroectodermal tumor 12 | 3,035
Autosomal recessive predisposition 11 | 1,442
Bloom syndrome 11 | 29
Small head 10 | 374
colon cancer 10 | 1,478
nasopharyngeal carcinoma 10 | 1,058
Ataxia telangiectasia 9 | 34
Fanconi anemia 9 | 56
Nijmegen breakage syndrome 9 | 24
Xeroderma pigmentosum 9 | 43
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
invasive ductal carcinoma 9 | 2,951
Dull intelligence 8 | 645
Intellectual disability 8 | 1,016
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Poor school performance 8 | 645
adult high grade glioma 8 | 3,801
ductal carcinoma in situ 8 | 1,745
ependymoma 8 | 4,679
Hereditary Breast and Ovarian Cancer Syndrome 7 | 14
Werner syndrome 7 | 29
diabetes mellitus 7 | 1,728
Breast Neoplasms 6 | 445
Chromosome Breakage 6 | 36
Hypoplastic mandible condyle 6 | 275
Kidney cancer 6 | 2,613
Mammary Neoplasms 6 | 425
Mandibular hypoplasia 6 | 275
Micrognathism 6 | 275
Seckel syndrome 6 | 34
adrenocortical carcinoma 6 | 1,428
non primary Sjogren syndrome sicca 6 | 891
Cockayne syndrome 5 | 60
Convex nasal ridge 5 | 37
Fetal Growth Retardation 5 | 189
Increased chromosomal breakage 5 | 27
Infant, Small for Gestational Age 5 | 176
Intrauterine retardation 5 | 176
Microcephaly 5 | 166
Narrow face 5 | 54
Thin face 5 | 54
astrocytic glioma 5 | 2,597
lung adenocarcinoma 5 | 2,716
oligodendroglioma 5 | 2,850
pituitary cancer 5 | 1,972
Bilateral fifth finger clinodactyly 4 | 110
Cachexia 4 | 50
Cataract 4 | 297
Chronic Lymphocytic Leukemia 4 | 262
Cognitive delay 4 | 608
Curvature of little finger 4 | 110
Global developmental delay 4 | 608
Hyperplasia of nose 4 | 23
Hypertrophy of nose 4 | 23
Large nose 4 | 23
Malignant neoplasm of breast 4 | 15
Mental and motor retardation 4 | 608
Muscle Spasticity 4 | 195
Prostatic Neoplasms 4 | 495
Rothmund-Thomson syndrome 4 | 19
Sinusitis 4 | 65
Strabismus 4 | 270
Waldenstrons macroglobulinemia 4 | 765
breast carcinoma 4 | 1,638
Acquired scoliosis 3 | 281
Anemia 3 | 365
Astrocytoma, Pilocytic 3 | 3,081
Craniosynostosis 3 | 74
Curvature of spine 3 | 282
Delayed bone age 3 | 136
Epilepsy 3 | 792
Impaired cognition 3 | 96
Liver cancer 3 | 604
Low Vision 3 | 174
Melanoma 3 | 711
Multiple Sclerosis 3 | 540
Pick disease 3 | 1,894
Prostate cancer 3 | 175
Seizures 3 | 596
cutaneous lupus erythematosus 3 | 1,057
dermatomyositis 3 | 966
hepatocellular carcinoma 3 | 547
lung carcinoma 3 | 2,843

Tissue

Blood and immune system 36 | 16,909
Cardiovascular System 36 | 15,192
Digestive Tract 36 | 17,369
Endocrine System 36 | 18,159
Female tissues 36 | 17,400
Liver and Pancreas 36 | 16,750
Male tissues 36 | 17,142
Nervous System 36 | 16,725
Respiratory system 36 | 16,393
Skin and soft tissues 36 | 17,230
Urinary Tract 36 | 16,678

Target Family

Non-IDG 26 | 12,091
Enzyme 7 | 4,145
Kinase 2 | 634
Epigenetic 1 | 242

Reactome Pathway

HDR through Single Strand Anne... 36 | 36
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cell cycle checkpoint control protein RAD9B RAD9B Tdark Non-IDG -0.07767 1.44 35
ATR-interacting protein ATRIP Tbio Non-IDG -1.60828 43.0 359
Breast cancer type 1 susceptibility protein BRCA1 Tchem Non-IDG -3.76784 6081.3 1542
Cell cycle checkpoint control protein RAD9A RAD9A Tbio Non-IDG -2.15330 141.0 919
BRCA1-associated RING domain protein 1 BARD1 Tbio Non-IDG -2.09264 120.7 236
Replication protein A 70 kDa DNA-binding subunit RPA1 Tchem Non-IDG -2.48277 297.9 350
Replication factor C subunit 4 RFC4 Tbio Non-IDG -1.17661 13.7 195
Replication factor C subunit 5 RFC5 Tbio Non-IDG -1.06074 11.3 79
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.79461 61.4 510
DNA replication ATP-dependent helicase/nuclease DNA2 DNA2 Tbio Enzyme -2.42159 256.1 101