Development Level

Tbio 51 | 10,625
Tchem 9 | 1,890
Tclin 2 | 602
Tdark 2 | 7,003

IMPC Term

preweaning lethality, complete... 10 | 633
embryonic lethality prior to o... 6 | 148
embryonic lethality prior to t... 4 | 187
increased exploration in new e... 2 | 56
abnormal behavioral response t... 1 | 52
abnormal blood vessel morpholo... 1 | 2
abnormal bone structure 1 | 131
abnormal cornea morphology 1 | 24
abnormal cranium morphology 1 | 32
abnormal embryo size 1 | 112
abnormal embryo turning 1 | 15
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal pharyngeal arch morph... 1 | 2
abnormal placement of pupils 1 | 4
abnormal spleen morphology 1 | 36
anophthalmia 1 | 20
cardiovascular system phenotyp... 1 | 35
corneal opacity 1 | 25
decreased body weight 1 | 174
decreased circulating glucose ... 1 | 121
decreased fasted circulating g... 1 | 49
decreased heart rate variabili... 1 | 11
embryonic growth retardation 1 | 28
hypoactivity 1 | 89
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating sodium l... 1 | 71
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
narrow eye opening 1 | 15
polydactyly 1 | 22
prenatal lethality prior to he... 1 | 64
thrombocytopenia 1 | 46

Disease

ovarian cancer 43 | 8,484
osteosarcoma 36 | 7,933
lung cancer 28 | 4,466
malignant mesothelioma 28 | 3,162
Breast cancer 26 | 3,094
Cancer 24 | 2,346
medulloblastoma, large-cell 24 | 6,234
psoriasis 24 | 6,685
group 3 medulloblastoma 23 | 2,254
non-small cell lung cancer 21 | 2,798
glioblastoma 20 | 5,572
primitive neuroectodermal tumor 20 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,289
Bloom syndrome 15 | 30
Fanconi's anemia 15 | 50
invasive ductal carcinoma 15 | 2,950
ductal carcinoma in situ 14 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,988
nasopharyngeal carcinoma 14 | 1,056
Carcinoma 13 | 2,147
Mammary Neoplasms 13 | 410
colon cancer 13 | 1,475
atypical teratoid/rhabdoid tumor 12 | 1,095
pediatric high grade glioma 12 | 2,712
Neoplastic Syndromes, Hereditary 11 | 48
lung adenocarcinoma 11 | 2,713
non primary Sjogren syndrome sicca 11 | 840
Hereditary Breast and Ovarian Cancer Syndrome 10 | 14
adrenocortical carcinoma 10 | 1,427
Ataxia telangiectasia 9 | 31
Nijmegen breakage syndrome 9 | 23
Seckel syndrome 9 | 34
atypical teratoid / rhabdoid tumor 9 | 4,369
oligodendroglioma 9 | 2,849
sonic hedgehog group medulloblastoma 9 | 1,482
astrocytic glioma 8 | 2,241
Breast Cancer, Familial 7 | 12
Peripheral Neuropathy 7 | 303
diabetes mellitus 7 | 1,663
ependymoma 7 | 2,514
posterior fossa group A ependymoma 7 | 1,511
Anemia 6 | 252
Malignant neoplasm of breast 6 | 63
Waldenstrons macroglobulinemia 6 | 765
Werner syndrome 6 | 29
acute myeloid leukemia 6 | 780
breast carcinoma 6 | 1,614
lung carcinoma 6 | 2,844
ovarian neoplasm 6 | 97
pituitary cancer 6 | 1,972
Fanconi Anemia 5 | 19
Lynch syndrome 5 | 33
Prostate cancer 5 | 172
adult high grade glioma 5 | 2,148
astrocytoma 5 | 1,493
pancreatic cancer 5 | 2,300
ulcerative colitis 5 | 2,087
Aplastic anemia 4 | 18
Chronic Lymphocytic Leukemia 4 | 242
Cockayne syndrome 4 | 54
Colorectal Neoplasms 4 | 217
IGA Glomerulonephritis 4 | 454
Microcephaly 4 | 149
Pancreatic Neoplasm 4 | 79
Pick disease 4 | 1,893
Prostatic Neoplasms 4 | 471
Rheumatoid Arthritis 4 | 1,160
Rothmund-Thomson syndrome 4 | 22
Xeroderma pigmentosum 4 | 41
dermatomyositis 4 | 933
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,956
progressive supranuclear palsy 4 | 674
tuberculosis and treatment for 6 months 4 | 686
Alzheimer's disease 3 | 644
Cowden disease 3 | 16
Endometriosis 3 | 535
Hereditary breast ovarian cancer 3 | 6
Intellectual disability 3 | 573
Li-Fraumeni Syndrome 3 | 13
Malignant neoplasm of ovary 3 | 13
Malignant neoplasm of prostate 3 | 67
Multiple myeloma 3 | 1,327
Pancreatic carcinoma, familial 3 | 8
Prostate cancer, familial 3 | 13
acute quadriplegic myopathy 3 | 1,157
cutaneous lupus erythematosus 3 | 1,056
interstitial cystitis 3 | 2,299
juvenile dermatomyositis 3 | 1,189
pilocytic astrocytoma 3 | 3,086
posterior fossa group B ependymoma 3 | 1,530
tuberculosis 3 | 1,557
Atopic dermatitis 2 | 944
Multiple Sclerosis 2 | 498
cystic fibrosis 2 | 1,665
glioblastoma multiforme 2 | 347
inflammatory breast cancer 2 | 404
non-small cell lung carcinoma 2 | 413
pancreatic carcinoma 2 | 567
primary pancreatic ductal adenocarcinoma 2 | 1,271
subependymal giant cell astrocytoma 2 | 2,287

Tissue

Blood and immune system 64 | 17,995
Cardiovascular System 64 | 17,958
Digestive Tract 64 | 18,473
Endocrine System 64 | 18,512
Female tissues 64 | 18,647
Liver and Pancreas 64 | 18,136
Male tissues 64 | 17,969
Nervous System 64 | 18,561
Respiratory system 64 | 17,484
Skin and soft tissues 64 | 18,115
Urinary Tract 64 | 18,444

Target Family

Non-IDG 38 | 11,971
Enzyme 22 | 4,146
Kinase 3 | 634
Epigenetic 1 | 242

Reactome Pathway

HDR through Homologous Recombi... 64 | 64
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.76828 59.7 468
Replication factor C subunit 3 RFC3 Tbio Non-IDG -1.28299 19.5 161
Replication factor C subunit 5 RFC5 Tbio Non-IDG -1.02728 11.1 64
Probable crossover junction endonuclease EME2 EME2 Tbio Enzyme -1.53403 32.3 56
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
Replication factor C subunit 2 RFC2 Tbio Non-IDG -1.34287 19.7 194
Replication factor C subunit 1 RFC1 Tbio Non-IDG -1.40675 26.5 184
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
Replication protein A 14 kDa subunit RPA3 Tbio Non-IDG -1.80635 59.3 127