Development Level

Tchem 15 | 1,598
Tbio 7 | 11,445

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal behavior 2 | 298
abnormal retinal blood vessel ... 2 | 26
hypoactivity 2 | 132
increased body length 2 | 32
abnormal glucose homeostasis 1 | 4
abnormal iris pigmentation 1 | 4
abnormal response to tactile s... 1 | 17
abnormal retinal vasculature m... 1 | 27
decreased basophil cell number 1 | 16
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased hemoglobin content 1 | 68
decreased red blood cell distr... 1 | 41
decreased spleen weight 1 | 10
embryonic lethality prior to t... 1 | 278
increased body weight 1 | 25
increased circulating creatini... 1 | 38
increased lean body mass 1 | 172
increased startle reflex 1 | 112
preweaning lethality, incomple... 1 | 499
small heart 1 | 10
small kidney 1 | 16
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 19
vertebral transformation 1 | 12

Disease

Carcinoma 20 | 11,493
osteosarcoma 13 | 7,950
ovarian cancer 11 | 8,520
psoriasis 10 | 6,694
Cancer 9 | 2,499
glioblastoma 9 | 5,792
group 3 medulloblastoma 9 | 4,104
medulloblastoma, large-cell 9 | 6,241
Kidney cancer 7 | 2,613
malignant mesothelioma 7 | 3,232
astrocytoma 6 | 1,146
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
lung cancer 6 | 4,740
Intellectual disability 5 | 1,016
atypical teratoid / rhabdoid tumor 5 | 5,112
ependymoma 5 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
oligodendroglioma 4 | 2,850
tuberculosis 4 | 2,010
Cryptorchidism 3 | 296
dermatomyositis 3 | 966
juvenile dermatomyositis 3 | 1,187
lung adenocarcinoma 3 | 2,716
non-small cell lung cancer 3 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
primitive neuroectodermal tumor 3 | 3,035
subependymal giant cell astrocytoma 3 | 2,287
Adenoid Cystic Carcinoma 2 | 99
Alzheimer's disease 2 | 658
Amyotrophic lateral sclerosis 2 | 451
Autistic Disorder 2 | 364
Breast cancer 2 | 3,578
Broad nasal tip 2 | 28
Carcinoma, Adenoid Cystic 2 | 99
Cleft Palate 2 | 271
Colonic Neoplasms 2 | 142
Congenital hypoplasia of penis 2 | 176
Dull intelligence 2 | 645
Epilepsy 2 | 792
Kabuki syndrome 2 | 27
Large auricle 2 | 87
Large dysplastic ears 2 | 87
Large hand 2 | 18
Large pinnae 2 | 87
Large prominent ears 2 | 87
Large protruding ears 2 | 87
Large, floppy ears 2 | 87
Liver cancer 2 | 604
Low intelligence 2 | 645
Macrotia 2 | 87
Male infertility 2 | 206
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Pick disease 2 | 1,894
Poor school performance 2 | 645
Rheumatoid arthritis 2 | 1,191
Seizures 2 | 596
Short stature 2 | 531
acute myeloid leukemia 2 | 783
acute quadriplegic myopathy 2 | 1,158
adrenocortical carcinoma 2 | 1,428
adult high grade glioma 2 | 3,801
group 4 medulloblastoma 2 | 1,855
invasive ductal carcinoma 2 | 2,951
medulloblastoma 2 | 720
non diabetic and post-ischemic heart failure 2 | 200
non primary Sjogren syndrome sicca 2 | 891
pancreatic cancer 2 | 2,398
pediatric high grade glioma 2 | 1,064
primary pancreatic ductal adenocarcinoma 2 | 1,109
sonic hedgehog group medulloblastoma 2 | 467
spina bifida 2 | 1,074
Carcinoma, Non-Small-Cell Lung 1 | 107
Carcinoma, Renal Cell 1 | 124
Congenital hemivertebra 1 | 25
Decreased projection of maxilla 1 | 66
Deficiency of upper jaw bones 1 | 66
Dental abnormalities 1 | 60
Dental caries 1 | 164
Hypodontia 1 | 81
Hypoplastic feet 1 | 66
Malocclusion 1 | 57
Microdontia (disorder) 1 | 59
Obstruction of pelviureteric junction 1 | 8
Periodontal disease 1 | 40
Preauricular Fistulae, Congenital 1 | 27
Preauricular dimple 1 | 27
Preauricular sinus 1 | 27
Progressive mental retardation 1 | 37
Recurrent infections 1 | 48
Recurrent otitis media 1 | 42
Renal Cell Carcinoma 1 | 214
Small testicle 1 | 75
Spermatogenic Failure, Nonobstructive, Y-Linked 1 | 15
Tooth Abnormalities 1 | 69
Trigeminal Neuralgia 1 | 24
Underweight 1 | 17
Weight less than 3rd percentile 1 | 17
X- linked recessive 1 | 110

Tissue

Blood and immune system 22 | 16,909
Cardiovascular System 22 | 15,192
Digestive Tract 22 | 17,369
Endocrine System 22 | 18,159
Female tissues 22 | 17,400
Liver and Pancreas 22 | 16,750
Male tissues 22 | 17,142
Nervous System 22 | 16,725
Respiratory system 22 | 16,393
Skin and soft tissues 22 | 17,230
Urinary Tract 22 | 16,678

Target Family

Epigenetic 17 | 242
TF/Epigenetic 4 | 38
Enzyme 1 | 4,145

Reactome Pathway

HDMs demethylate histones 22 | 22
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Lysine-specific demethylase 3A KDM3A Tchem Epigenetic -1.83544 74.7 253
Lysine-specific demethylase 2A KDM2A Tchem Epigenetic -1.51861 36.3 183
Lysine-specific demethylase 5C KDM5C Tchem TF/Epigenetic -1.94004 86.4 135
Lysine-specific demethylase 6B KDM6B Tchem Epigenetic -2.22888 174.2 272
Lysine-specific demethylase 4D KDM4D Tchem Epigenetic -1.51327 28.3 162
Lysine-specific demethylase 6A KDM6A Tchem Epigenetic -2.27999 176.8 119
Lysine-specific histone demethylase 1B KDM1B Tbio Epigenetic -1.45110 27.6 106
Lysine-specific demethylase 3B KDM3B Tbio Epigenetic -1.04920 11.3 286
Lysine-specific demethylase 4A KDM4A Tchem Epigenetic -3.06159 1089.8 271
Lysine-specific demethylase 2B KDM2B Tchem Epigenetic -1.56328 41.7 248