Development Level

Tbio 39 | 11,178
Tdark 8 | 6,569
Tclin 5 | 612
Tchem 4 | 1,885

IMPC Phenotype

preweaning lethality, complete... 6 | 979
abnormal behavior 2 | 298
decreased bone mineral density 2 | 126
hypoactivity 2 | 132
increased circulating alkaline... 2 | 122
abnormal bone mineralization 1 | 38
abnormal lens morphology 1 | 81
abnormal maxilla morphology 1 | 17
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal tooth morphology 1 | 24
aorta stenosis 1 | 2
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased heart rate 1 | 18
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased lumbar vertebrae num... 1 | 2
decreased mean platelet volume 1 | 25
decreased sacral vertebrae num... 1 | 1
decreased threshold for audito... 1 | 26
embryonic lethality prior to o... 1 | 239
increased body temperature 1 | 9
increased body weight 1 | 25
increased circulating HDL chol... 1 | 80
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating glycerol... 1 | 9
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased hemoglobin content 1 | 45
increased lumbar vertebrae num... 1 | 1
increased prepulse inhibition 1 | 32
increased sacral vertebrae num... 1 | 1
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
preweaning lethality, incomple... 1 | 499
small heart 1 | 10
small kidney 1 | 16
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 19
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56
trunk curl 1 | 16

Disease

Carcinoma 32 | 11,192
ovarian cancer 28 | 8,297
psoriasis 21 | 6,514
osteosarcoma 20 | 7,766
glioblastoma 17 | 5,635
lung cancer 16 | 4,607
Breast cancer 14 | 3,469
Cancer 14 | 2,388
atypical teratoid / rhabdoid tumor 14 | 4,971
lung adenocarcinoma 14 | 2,627
Multiple myeloma 12 | 1,296
medulloblastoma, large-cell 12 | 6,086
invasive ductal carcinoma 11 | 2,867
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,902
adult high grade glioma 9 | 3,701
breast carcinoma 9 | 1,589
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,204
non-small cell lung cancer 9 | 2,799
ependymoma 8 | 4,559
group 3 medulloblastoma 8 | 4,002
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,872
subependymal giant cell astrocytoma 8 | 2,230
Peripheral T-cell lymphoma 7 | 25
Primary cutaneous T-cell lymphoma 7 | 29
Schizophrenia 7 | 1,136
astrocytoma 7 | 1,113
ductal carcinoma in situ 7 | 1,686
non-small cell lung carcinoma 7 | 302
pancreatic cancer 7 | 2,322
primitive neuroectodermal tumor 7 | 2,957
Intellectual disability 6 | 998
Kidney cancer 6 | 2,548
malignant mesothelioma 6 | 3,135
Endometriosis 5 | 521
Rheumatoid arthritis 5 | 1,156
cutaneous lupus erythematosus 5 | 1,016
cystic fibrosis 5 | 1,629
gastric cancer 5 | 445
pituitary cancer 5 | 1,915
Pick disease 4 | 1,856
acute myeloid leukemia 4 | 760
colon cancer 4 | 1,428
dermatomyositis 4 | 941
group 4 medulloblastoma 4 | 1,806
juvenile dermatomyositis 4 | 1,147
sonic hedgehog group medulloblastoma 4 | 459
Astrocytoma, Pilocytic 3 | 3,006
Breast Neoplasms 3 | 423
Cleft Palate 3 | 265
Connective tissue disease 3 | 59
Lupus erythematosus 3 | 56
Mammary Neoplasms 3 | 403
acute quadriplegic myopathy 3 | 1,133
gastric carcinoma 3 | 781
hepatocellular carcinoma 3 | 536
lung carcinoma 3 | 2,755
medulloblastoma 3 | 702
pancreatic carcinoma 3 | 555
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,911
pediatric high grade glioma 3 | 1,035
Autistic Disorder 2 | 358
Bipolar Disorder 2 | 646
Carcinoma, Squamous Cell 2 | 107
Colonic Neoplasms 2 | 133
Down syndrome 2 | 480
Epilepsy 2 | 775
Heart Diseases 2 | 41
Mood Disorders 2 | 181
Neoplasm Invasiveness 2 | 151
Nephroblastoma 2 | 50
Neuronal ceroid lipofuscinosis 2 2 | 16
Primary ciliary dyskinesia 2 | 75
Retinitis pigmentosa 20 2 | 5
Retinoblastoma 2 | 18
Seizures 2 | 584
Squamous cell carcinoma 2 | 125
Thyroiditis 2 | 28
Waldenstrons macroglobulinemia 2 | 742
active ulcerative colitis 2 | 736
astrocytic glioma 2 | 2,530
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 492
diabetes mellitus 2 | 1,683
inflammatory breast cancer 2 | 272
interstitial cystitis 2 | 2,237
non primary Sjogren syndrome sicca 2 | 861
oligodendroglioma 2 | 2,768
primary pancreatic ductal adenocarcinoma 2 | 1,071
spina bifida 2 | 1,053
tuberculosis 2 | 1,963
Abdominal Pain 1 | 95
Endometrial Neoplasms 1 | 54
Globe disease 1 | 65
Influenza 1 | 136
Liver neoplasms 1 | 126
Microsatellite Instability 1 | 12
Neoplasm Metastasis 1 | 160
Pallister-Hall syndrome 1 | 10
Rubinstein-Taybi syndrome 1 | 10
Sensorineural hearing loss 1 | 102
drug-induced hepatitis 1 | 44

Tissue

Endocrine System 56 | 18,159
Blood and immune system 55 | 16,909
Cardiovascular System 55 | 15,192
Digestive Tract 55 | 17,369
Female tissues 55 | 17,400
Liver and Pancreas 55 | 16,750
Male tissues 55 | 17,142
Nervous System 55 | 16,725
Respiratory system 55 | 16,393
Skin and soft tissues 55 | 17,230
Urinary Tract 55 | 16,678

Target Family

Non-IDG 32 | 12,091
Transcription Factor 10 | 1,400
Epigenetic 9 | 242
Enzyme 4 | 4,145
TF/Epigenetic 1 | 38

Reactome Pathway

HDACs deacetylate histones 56 | 56
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Histone H2A type 2-C HIST2H2AC Tbio Non-IDG -3.03938 994.7 101
Histone H2B type 2-E HIST2H2BE Tbio Non-IDG -3.48425 2920.0 135
Histone H2B type 3-B HIST3H2BB Tbio Non-IDG -0.72238 5.02 53
AT-rich interactive domain-containing protein 4B ARID4B Tbio TF/Epigenetic -1.25831 18.5 133
Histone H2A type 1-D HIST1H2AD Tdark Non-IDG 0.17 0.32 11
Histone H2B type 2-F HIST2H2BF Tdark Non-IDG 0.52 0.19 121
Histone H2B type 1-K HIST1H2BK Tbio Non-IDG -0.50219 4.04 29
Histone H2A type 3 HIST3H2A Tbio Non-IDG 0.00000 35
Histone H2A type 1-J HIST1H2AJ Tdark Non-IDG -0.13212 1.19 16