Development Level

Tbio 37 | 10,625
Tdark 11 | 7,003
Tclin 5 | 602
Tchem 4 | 1,890

IMPC Term

preweaning lethality, complete... 3 | 633
decreased bone mineral density 2 | 126
decreased lean body mass 2 | 195
increased circulating alkaline... 2 | 119
abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal maxilla morphology 1 | 16
abnormal respiratory quotient 1 | 9
abnormal tooth morphology 1 | 24
aorta dilation 1 | 3
decreased body length 1 | 108
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased caudal vertebrae num... 1 | 49
decreased circulating LDL chol... 1 | 37
decreased grip strength 1 | 123
decreased hemoglobin content 1 | 53
decreased lumbar vertebrae num... 1 | 62
decreased mean platelet volume 1 | 12
embryonic lethality prior to o... 1 | 148
hypoactivity 1 | 89
increased body weight 1 | 42
increased circulating creatini... 1 | 29
increased circulating glycerol... 1 | 11
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased sacral vertebrae num... 1 | 62
increased startle reflex 1 | 38
long tibia 1 | 13
oligodactyly 1 | 14
preweaning lethality, incomple... 1 | 260
small heart 1 | 8
small kidney 1 | 10
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 11
thrombocytopenia 1 | 46
trunk curl 1 | 15

Disease

ovarian cancer 28 | 8,484
psoriasis 22 | 6,685
osteosarcoma 20 | 7,933
glioblastoma 17 | 5,572
lung cancer 16 | 4,466
Breast cancer 14 | 3,094
atypical teratoid / rhabdoid tumor 14 | 4,369
lung adenocarcinoma 14 | 2,713
Cancer 13 | 2,346
Multiple myeloma 12 | 1,327
medulloblastoma, large-cell 12 | 6,234
invasive ductal carcinoma 11 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,988
breast carcinoma 9 | 1,614
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,289
non-small cell lung cancer 9 | 2,798
astrocytoma 8 | 1,493
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,956
non-small cell lung carcinoma 8 | 413
sonic hedgehog group medulloblastoma 8 | 1,482
subependymal giant cell astrocytoma 8 | 2,287
Carcinoma 7 | 2,147
Peripheral T-cell lymphoma 7 | 24
Primary cutaneous T-cell lymphoma 7 | 24
ductal carcinoma in situ 7 | 1,745
pancreatic cancer 7 | 2,300
primitive neuroectodermal tumor 7 | 3,031
adult high grade glioma 6 | 2,148
group 4 medulloblastoma 6 | 1,875
pediatric high grade glioma 6 | 2,712
Endometriosis 5 | 535
Intellectual disability 5 | 573
Rheumatoid Arthritis 5 | 1,160
cutaneous lupus erythematosus 5 | 1,056
cystic fibrosis 5 | 1,665
gastric cancer 5 | 430
malignant mesothelioma 5 | 3,162
pituitary cancer 5 | 1,972
Pick disease 4 | 1,893
acute myeloid leukemia 4 | 780
colon cancer 4 | 1,475
ependymoma 4 | 2,514
juvenile dermatomyositis 4 | 1,189
Cleft palate 3 | 125
Connective tissue disease 3 | 59
Down syndrome 3 | 548
Leishmaniasis 3 | 49
Lupus erythematosus 3 | 80
Mammary Neoplasms 3 | 410
Retinoblastoma 3 | 14
acute quadriplegic myopathy 3 | 1,157
dermatomyositis 3 | 933
diabetes mellitus 3 | 1,663
gastric carcinoma 3 | 832
group 3 medulloblastoma 3 | 2,254
hepatocellular carcinoma 3 | 532
lung carcinoma 3 | 2,844
medulloblastoma 3 | 1,524
pancreatic carcinoma 3 | 567
pilocytic astrocytoma 3 | 3,086
posterior fossa group B ependymoma 3 | 1,530
primary pancreatic ductal adenocarcinoma 3 | 1,271
Heart Diseases 2 | 42
IGA Glomerulonephritis 2 | 454
Nephroblastoma 2 | 45
Primary ciliary dyskinesia 2 | 73
Schizophrenia 2 | 501
Squamous cell carcinoma 2 | 94
Thyroiditis 2 | 25
Waldenstrons macroglobulinemia 2 | 765
atypical teratoid/rhabdoid tumor 2 | 1,095
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
inflammatory breast cancer 2 | 404
interstitial cystitis 2 | 2,299
non primary Sjogren syndrome sicca 2 | 840
oligodendroglioma 2 | 2,849
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
spina bifida 2 | 1,064
Adenoid Cystic Carcinoma 1 | 99
Allergic hypersensitivity disease 1 | 123
Alzheimer's disease 1 | 644
Aniridia 1 | 26
Autistic Disorder 1 | 320
Bladder Neoplasm 1 | 109
Carcinoma, Transitional Cell 1 | 31
Cardiovascular system disease 1 | 194
Chronic obstructive pulmonary disease 1 | 146
Disease Progression 1 | 125
Epilepsy 1 | 346
Huntington's disease 1 | 72
Hyperplasia 1 | 26
Malaria 1 | 140
Myeloid Leukemia 1 | 19
Ocular albinism 1 | 29
Polycystic Ovary Syndrome 1 | 332
Seizures 1 | 95
active Crohn's disease 1 | 918
glioblastoma multiforme 1 | 347
tuberculosis 1 | 1,557
tuberculosis and treatment for 3 months 1 | 327

Tissue

Blood and immune system 57 | 17,995
Cardiovascular System 57 | 17,958
Digestive Tract 57 | 18,473
Endocrine System 57 | 18,512
Female tissues 57 | 18,647
Liver and Pancreas 57 | 18,136
Male tissues 57 | 17,969
Nervous System 57 | 18,561
Respiratory system 57 | 17,484
Urinary Tract 57 | 18,444
Skin and soft tissues 47 | 18,115

Target Family

Non-IDG 32 | 11,971
Transcription Factor 10 | 1,400
Epigenetic 9 | 242
Enzyme 4 | 4,146
TF/Epigenetic 2 | 38

Reactome Pathway

HDACs deacetylate histones 57 | 57
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transcriptional repressor p66-alpha GATAD2A Tbio Non-IDG -0.79314 7.11 142
Histone H2B type 1-C/E/F/G/I HIST1H2BC Tbio Non-IDG -1.35785 22.1 103
Transcriptional repressor p66-beta GATAD2B Tbio Transcription Factor -0.86137 7.48 174
Methyl-CpG-binding domain protein 3 MBD3 Tbio Transcription Factor -0.80239 7.92 283
Histone H2A type 2-B HIST2H2AB Tdark Non-IDG -0.51977 3.28 43
F-box-like/WD repeat-containing protein TBL1XR1 TBL1XR1 Tbio Non-IDG -1.85375 68.0 209
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.36 0.40 42
Histone H2B type 1-N HIST1H2BN Tdark Non-IDG -1.48218 30.2 48
Histone H2A type 1-J HIST1H2AJ Tdark Non-IDG -0.12825 1.19 10
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.16 0.33 20