Development Level

Tbio 77 | 11,445
Tdark 15 | 6,588
Tchem 11 | 1,598

IMPC Phenotype

preweaning lethality, complete... 12 | 979
decreased body weight 5 | 161
abnormal behavior 4 | 298
decreased circulating glucose ... 4 | 126
abnormal cornea morphology 3 | 31
embryonic lethality prior to o... 3 | 239
increased lean body mass 3 | 172
preweaning lethality, incomple... 3 | 499
abnormal eye morphology 2 | 68
abnormal maxilla morphology 2 | 17
abnormal tooth morphology 2 | 24
corneal opacity 2 | 32
decreased lean body mass 2 | 135
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
embryonic lethality prior to t... 2 | 278
increased mean corpuscular vol... 2 | 92
increased total body fat amoun... 2 | 134
abnormal bone mineralization 1 | 38
abnormal coat-hair pigmentatio... 1 | 64
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal eye pigmentation 1 | 3
abnormal eye size 1 | 7
abnormal eyelid aperture 1 | 2
abnormal gait 1 | 69
abnormal hair texture 1 | 4
abnormal iris morphology 1 | 13
abnormal lens morphology 1 | 81
abnormal retinal outer nuclear... 1 | 3
cataract 1 | 92
corneal vascularization 1 | 6
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating potassiu... 1 | 20
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased leukocyte cell numbe... 1 | 73
decreased mean platelet volume 1 | 25
decreased startle reflex 1 | 75
decreased total retina thickne... 1 | 17
eyelids fail to open 1 | 3
female infertility 1 | 60
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating creatine... 1 | 5
increased circulating magnesiu... 1 | 10
increased circulating sodium l... 1 | 71
increased lactate dehydrogenas... 1 | 3
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
irregularly shaped pupil 1 | 7
male infertility 1 | 123
mammalian phenotype 1 | 17
mydriasis 1 | 6
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
tremors 1 | 39

Disease

Carcinoma 70 | 11,493
ovarian cancer 55 | 8,520
osteosarcoma 48 | 7,950
psoriasis 35 | 6,694
Breast cancer 31 | 3,578
lung cancer 31 | 4,740
glioblastoma 25 | 5,792
group 3 medulloblastoma 25 | 4,104
atypical teratoid / rhabdoid tumor 24 | 5,112
medulloblastoma, large-cell 22 | 6,241
Cancer 21 | 2,499
Kidney cancer 20 | 2,613
lung adenocarcinoma 19 | 2,716
malignant mesothelioma 19 | 3,232
invasive ductal carcinoma 14 | 2,951
Multiple myeloma 13 | 1,332
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
non-small cell lung cancer 13 | 2,890
oligodendroglioma 13 | 2,850
Intellectual disability 12 | 1,016
ependymoma 12 | 4,679
subependymal giant cell astrocytoma 11 | 2,287
adult high grade glioma 10 | 3,801
pancreatic cancer 10 | 2,398
primitive neuroectodermal tumor 10 | 3,035
colon cancer 9 | 1,478
Rheumatoid arthritis 8 | 1,191
Schizophrenia 8 | 1,160
acute myeloid leukemia 8 | 783
astrocytoma 8 | 1,146
breast carcinoma 8 | 1,638
ductal carcinoma in situ 8 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
spina bifida 8 | 1,074
tuberculosis 8 | 2,010
Pick disease 7 | 1,894
Spinocerebellar ataxia type 7 7 | 13
cystic fibrosis 7 | 1,696
diabetes mellitus 7 | 1,728
Adenoid Cystic Carcinoma 6 | 99
Breast Neoplasms 6 | 445
Carcinoma, Adenoid Cystic 6 | 99
Dull intelligence 6 | 645
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Muscle hypotonia 6 | 571
Poor school performance 6 | 645
Small head 6 | 374
dermatomyositis 6 | 966
gastric cancer 6 | 459
juvenile dermatomyositis 6 | 1,187
non-small cell lung carcinoma 6 | 317
pediatric high grade glioma 6 | 1,064
Astrocytoma, Pilocytic 5 | 3,081
Bipolar Disorder 5 | 666
Mammary Neoplasms 5 | 425
Waldenstrons macroglobulinemia 5 | 765
acute quadriplegic myopathy 5 | 1,158
astrocytic glioma 5 | 2,597
hepatocellular carcinoma 5 | 547
medulloblastoma 5 | 720
pituitary cancer 5 | 1,972
Atrial Septal Defects 4 | 85
Blepharoptosis 4 | 231
Cataract 4 | 297
Congenital deafness 4 | 185
Deafness 4 | 198
Downward slant of palpebral fissure 4 | 158
Endometrial cancer 4 | 311
Hearing Loss, Partial 4 | 185
Low set ears 4 | 181
Riley-Day syndrome 4 | 11
Short stature 4 | 531
Strabismus 4 | 270
Ventricular Septal Defects 4 | 119
aldosterone-producing adenoma 4 | 665
cutaneous lupus erythematosus 4 | 1,057
group 4 medulloblastoma 4 | 1,855
hearing impairment 4 | 199
lung carcinoma 4 | 2,843
non primary Sjogren syndrome sicca 4 | 891
pancreatic carcinoma 4 | 562
Acquired scoliosis 3 | 281
Broad flat nasal bridge 3 | 236
Byzanthine arch palate 3 | 194
Congenital Epicanthus 3 | 177
Curvature of spine 3 | 282
Delayed bone age 3 | 136
Epilepsy 3 | 792
Failure to gain weight 3 | 365
Glaucoma 3 | 239
Nasal bridge wide 3 | 236
Pectus excavatum 3 | 100
Seizures 3 | 596
primary pancreatic ductal adenocarcinoma 3 | 1,109
progressive supranuclear palsy 3 | 676
sonic hedgehog group medulloblastoma 3 | 467

Tissue

Endocrine System 102 | 18,159
Blood and immune system 101 | 16,909
Cardiovascular System 101 | 15,192
Digestive Tract 101 | 17,369
Female tissues 101 | 17,400
Liver and Pancreas 101 | 16,750
Male tissues 101 | 17,142
Nervous System 101 | 16,725
Respiratory system 101 | 16,393
Skin and soft tissues 101 | 17,230
Urinary Tract 101 | 16,678

Target Family

Non-IDG 64 | 12,091
Epigenetic 25 | 242
Enzyme 7 | 4,145
Transcription Factor 5 | 1,400
TF/Epigenetic 2 | 38

Reactome Pathway

HATs acetylate histones 103 | 103
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 1-A HIST1H2AA Tbio Non-IDG -0.84480 8.19 69
Bromodomain and PHD finger-containing protein 3 BRPF3 Tchem Epigenetic -0.46982 2.70 64
Inhibitor of growth protein 3 ING3 Tbio Epigenetic -2.33680 199.4 175
Histone H2B type 1-N HIST1H2BN Tbio Non-IDG -1.51422 30.2 60
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 48
Histone H2A type 1-B/E HIST1H2AB Tbio Non-IDG -1.27041 18.5 133
YEATS domain-containing protein 2 YEATS2 Tbio Non-IDG -0.51547 3.19 61
Inhibitor of growth protein 4 ING4 Tbio Epigenetic -1.76632 69.3 193
STAGA complex 65 subunit gamma SUPT7L Tdark Non-IDG -0.46246 2.75 76
Histone H2A type 1-J HIST1H2AJ Tdark Non-IDG -0.13212 1.19 16