Development Level

Tbio 70 | 10,625
Tdark 21 | 7,003
Tchem 14 | 1,890

IMPC Term

preweaning lethality, complete... 6 | 633
decreased body weight 4 | 174
abnormal behavior 2 | 226
decreased T cell number 2 | 31
decreased circulating glucose ... 2 | 121
decreased leukocyte cell numbe... 2 | 54
embryonic lethality prior to o... 2 | 148
increased mean corpuscular vol... 2 | 91
abnormal bone mineralization 1 | 55
abnormal coping response 1 | 12
abnormal cornea morphology 1 | 24
abnormal gait 1 | 51
abnormal hair texture 1 | 4
abnormal maxilla morphology 1 | 16
abnormal tooth morphology 1 | 24
decreased B cell number 1 | 30
decreased CD4-positive, alpha ... 1 | 19
decreased CD8-positive, alpha-... 1 | 26
decreased Ly6C high monocyte n... 1 | 18
decreased Ly6C low monocyte nu... 1 | 23
decreased NK cell number 1 | 16
decreased alpha-beta T cell nu... 1 | 12
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 41
decreased circulating choleste... 1 | 85
decreased circulating insulin ... 1 | 75
decreased circulating potassiu... 1 | 17
decreased eosinophil cell numb... 1 | 41
decreased fasted circulating g... 1 | 49
decreased lumbar vertebrae num... 1 | 62
decreased mature B cell number 1 | 25
decreased respiratory quotient 1 | 12
decreased total body fat amoun... 1 | 186
embryonic lethality prior to t... 1 | 187
increased CD4-positive, CD25-p... 1 | 18
increased Ly6C low monocyte nu... 1 | 8
increased circulating creatine... 1 | 2
increased circulating magnesiu... 1 | 10
increased effector memory CD4-... 1 | 15
increased granulocyte number 1 | 8
increased lactate dehydrogenas... 1 | 3
increased monocyte cell number 1 | 27
increased plasma cell number 1 | 5
increased sacral vertebrae num... 1 | 62
prenatal lethality prior to he... 1 | 64
short tibia 1 | 82
tremors 1 | 34

Disease

ovarian cancer 57 | 8,484
osteosarcoma 50 | 7,933
psoriasis 35 | 6,685
lung cancer 28 | 4,466
Breast cancer 26 | 3,094
glioblastoma 26 | 5,572
atypical teratoid / rhabdoid tumor 24 | 4,369
medulloblastoma, large-cell 24 | 6,234
Cancer 23 | 2,346
lung adenocarcinoma 20 | 2,713
malignant mesothelioma 19 | 3,162
Carcinoma 16 | 2,147
group 3 medulloblastoma 16 | 2,254
Multiple myeloma 15 | 1,327
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,289
invasive ductal carcinoma 14 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,988
oligodendroglioma 13 | 2,849
non-small cell lung cancer 12 | 2,798
pediatric high grade glioma 12 | 2,712
pancreatic cancer 11 | 2,300
primitive neuroectodermal tumor 11 | 3,031
subependymal giant cell astrocytoma 11 | 2,287
Rheumatoid Arthritis 9 | 1,160
astrocytoma 9 | 1,493
colon cancer 9 | 1,475
group 4 medulloblastoma 9 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,956
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,795
Intellectual disability 8 | 573
Pick disease 8 | 1,893
acute myeloid leukemia 8 | 780
breast carcinoma 8 | 1,614
dermatomyositis 8 | 933
ductal carcinoma in situ 8 | 1,745
ependymoma 8 | 2,514
spina bifida 8 | 1,064
tuberculosis 8 | 1,557
Spinocerebellar ataxia type 7 7 | 13
cystic fibrosis 7 | 1,665
diabetes mellitus 7 | 1,663
non-small cell lung carcinoma 7 | 413
sonic hedgehog group medulloblastoma 7 | 1,482
Adenoid Cystic Carcinoma 6 | 99
gastric cancer 6 | 430
juvenile dermatomyositis 6 | 1,189
medulloblastoma 6 | 1,524
pilocytic astrocytoma 6 | 3,086
Kidney cancer 5 | 118
Mammary Neoplasms 5 | 410
Waldenstrons macroglobulinemia 5 | 765
acute quadriplegic myopathy 5 | 1,157
adult high grade glioma 5 | 2,148
astrocytic glioma 5 | 2,241
hepatocellular carcinoma 5 | 532
pituitary cancer 5 | 1,972
Bipolar Disorder 4 | 266
Neurodegenerative disease 4 | 383
Riley-Day syndrome 4 | 8
Schizophrenia 4 | 501
aldosterone-producing adenoma 4 | 664
cutaneous lupus erythematosus 4 | 1,056
lung carcinoma 4 | 2,844
pancreatic carcinoma 4 | 567
posterior fossa group A ependymoma 4 | 1,511
posterior fossa group B ependymoma 4 | 1,530
primary pancreatic ductal adenocarcinoma 4 | 1,271
tuberculosis and treatment for 6 months 4 | 686
Aicardi syndrome 3 | 15
Alzheimer's disease 3 | 644
Cleft palate 3 | 125
Connective tissue disease 3 | 59
Craniofacial Abnormalities 3 | 147
Down syndrome 3 | 548
Gaucher disease type 1 3 | 171
Leishmaniasis 3 | 49
Lupus erythematosus 3 | 80
Melanoma 3 | 261
Obesity 3 | 616
Prostatic Neoplasms 3 | 471
Squamous cell carcinoma of esophagus 3 | 82
atypical teratoid/rhabdoid tumor 3 | 1,095
non primary Sjogren syndrome sicca 3 | 840
progressive supranuclear palsy 3 | 674
ulcerative colitis 3 | 2,087
Acquired metabolic disease 2 | 267
Amyotrophic Lateral Sclerosis 2 | 431
Bladder Neoplasm 2 | 109
Carcinoma, Transitional Cell 2 | 31
Crohn's disease 2 | 304
Degenerative polyarthritis 2 | 93
Endometriosis 2 | 535
Major Depressive Disorder 2 | 106
Mammary Neoplasms, Experimental 2 | 150
Rubinstein-Taybi syndrome 2 | 11
active Crohn's disease 2 | 918
adrenocortical carcinoma 2 | 1,427
hereditary spastic paraplegia 2 | 313
inflammatory breast cancer 2 | 404
interstitial cystitis 2 | 2,299

Tissue

Cardiovascular System 105 | 17,958
Female tissues 105 | 18,647
Nervous System 105 | 18,561
Blood and immune system 104 | 17,995
Digestive Tract 104 | 18,473
Endocrine System 104 | 18,512
Liver and Pancreas 104 | 18,136
Male tissues 104 | 17,969
Respiratory system 103 | 17,484
Urinary Tract 103 | 18,444
Skin and soft tissues 93 | 18,115

Target Family

Non-IDG 66 | 11,971
Epigenetic 25 | 242
Enzyme 7 | 4,146
Transcription Factor 5 | 1,400
TF/Epigenetic 2 | 38

Reactome Pathway

HATs acetylate histones 105 | 105
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ubiquitin carboxyl-terminal hydrolase 22 USP22 Tbio Enzyme -1.59877 51.0 199
Host cell factor 1 HCFC1 Tbio Non-IDG -2.50024 341.6 160
PHD finger protein 20 PHF20 Tbio Epigenetic -2.79926 660.7 91
Protein Jade-1 JADE1 Tbio Epigenetic -0.97841 12.2 121
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OGT Tchem Enzyme -2.92944 916.6 217
ZZ-type zinc finger-containing protein 3 ZZZ3 Tdark Transcription Factor -0.52288 2.55 48
Ataxin-7 ATXN7 Tbio Non-IDG -2.31354 225.6 109
Histone H2B type 1-C/E/F/G/I HIST1H2BC Tbio Non-IDG -1.35785 22.1 103
Bromodomain-containing protein 8 BRD8 Tbio Epigenetic -0.58943 5.02 106
Histone deacetylase complex subunit SAP130 SAP130 Tdark Enzyme 0.00000 112