Development Level

Tbio 74 | 10,625
Tdark 20 | 7,003
Tchem 17 | 1,890

IMPC Term

preweaning lethality, complete... 17 | 633
embryonic lethality prior to t... 5 | 187
abnormal embryo size 4 | 112
decreased circulating alanine ... 3 | 53
decreased circulating glucose ... 3 | 121
embryonic lethality prior to o... 3 | 148
abnormal behavior 2 | 226
abnormal lens morphology 2 | 73
decreased bone mineral content 2 | 157
decreased circulating aspartat... 2 | 27
decreased circulating choleste... 2 | 85
decreased circulating free fat... 2 | 39
decreased grip strength 2 | 123
decreased startle reflex 2 | 48
hyperactivity 2 | 108
increased or absent threshold ... 2 | 128
abnormal behavioral response t... 1 | 52
abnormal bone structure 1 | 131
abnormal facial morphology 1 | 9
abnormal head shape 1 | 4
abnormal hindbrain development 1 | 24
abnormal limb morphology 1 | 7
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal outer ear morphology 1 | 1
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal sleep behavior 1 | 63
abnormal testis morphology 1 | 30
absent pinna reflex 1 | 21
cataract 1 | 26
cyanosis 1 | 6
decreased caudal vertebrae num... 1 | 49
decreased circulating HDL chol... 1 | 77
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased circulating total pr... 1 | 41
decreased effector memory CD4-... 1 | 6
decreased hematocrit 1 | 25
decreased lactate dehydrogenas... 1 | 14
decreased lean body mass 1 | 195
decreased lumbar vertebrae num... 1 | 62
decreased red blood cell distr... 1 | 11
decreased rib number 1 | 59
decreased total body fat amoun... 1 | 186
embryonic growth retardation 1 | 28
hemorrhage 1 | 12
immune system phenotype 1 | 17
impaired glucose tolerance 1 | 52
impaired pupillary reflex 1 | 14
increased bone mineral content 1 | 92
increased circulating HDL chol... 1 | 63
increased circulating alkaline... 1 | 119
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 43
increased circulating creatini... 1 | 29
increased circulating glucose ... 1 | 16
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 68
increased grip strength 1 | 83
increased hematocrit 1 | 36
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
increased mean corpuscular hem... 1 | 25
increased mean corpuscular vol... 1 | 91
increased sacral vertebrae num... 1 | 62
limb grasping 1 | 35
male infertility 1 | 62
prenatal lethality prior to he... 1 | 64
small testis 1 | 37
thrombocytosis 1 | 23

Disease

ovarian cancer 69 | 8,484
glioblastoma 57 | 5,572
osteosarcoma 57 | 7,933
medulloblastoma, large-cell 50 | 6,234
atypical teratoid / rhabdoid tumor 43 | 4,369
lung cancer 38 | 4,466
pediatric high grade glioma 35 | 2,712
psoriasis 35 | 6,685
Breast cancer 32 | 3,094
malignant mesothelioma 28 | 3,162
primitive neuroectodermal tumor 28 | 3,031
non-small cell lung cancer 27 | 2,798
pilocytic astrocytoma 26 | 3,086
lung adenocarcinoma 25 | 2,713
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,988
invasive ductal carcinoma 24 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,289
oligodendroglioma 21 | 2,849
group 3 medulloblastoma 20 | 2,254
Carcinoma 19 | 2,147
adrenocortical carcinoma 19 | 1,427
breast carcinoma 19 | 1,614
Multiple myeloma 18 | 1,327
posterior fossa group B ependymoma 18 | 1,530
astrocytoma 17 | 1,493
colon cancer 17 | 1,475
ependymoma 17 | 2,514
Pick disease 16 | 1,893
diabetes mellitus 15 | 1,663
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,795
ductal carcinoma in situ 14 | 1,745
group 4 medulloblastoma 14 | 1,875
lung carcinoma 14 | 2,844
pancreatic cancer 14 | 2,300
pituitary cancer 14 | 1,972
Atopic dermatitis 13 | 944
adult high grade glioma 13 | 2,148
posterior fossa group A ependymoma 13 | 1,511
acute quadriplegic myopathy 12 | 1,157
sonic hedgehog group medulloblastoma 12 | 1,482
astrocytic glioma 11 | 2,241
dermatomyositis 11 | 933
medulloblastoma 11 | 1,524
subependymal giant cell astrocytoma 11 | 2,287
IGA Glomerulonephritis 10 | 454
juvenile dermatomyositis 10 | 1,189
nasopharyngeal carcinoma 10 | 1,056
Endometriosis 9 | 535
Neurodegenerative disease 9 | 383
tuberculosis and treatment for 6 months 9 | 686
Microcephaly 8 | 149
Paraplegia 8 | 71
active Crohn's disease 8 | 918
interstitial cystitis 8 | 2,299
non primary Sjogren syndrome sicca 8 | 840
spina bifida 7 | 1,064
Amyotrophic Lateral Sclerosis 6 | 431
Cancer 6 | 2,346
Neuropathy 6 | 210
Rheumatoid Arthritis 6 | 1,160
atypical teratoid/rhabdoid tumor 6 | 1,095
cutaneous lupus erythematosus 6 | 1,056
inflammatory breast cancer 6 | 404
tuberculosis 6 | 1,557
Intellectual disability 5 | 573
acute myeloid leukemia 5 | 780
cystic fibrosis 5 | 1,665
esophageal adenocarcinoma 5 | 737
hereditary spastic paraplegia 5 | 313
pancreatic carcinoma 5 | 567
primary Sjogren syndrome 5 | 789
primary pancreatic ductal adenocarcinoma 5 | 1,271
ulcerative colitis 5 | 2,087
Alzheimer's disease 4 | 644
Duchenne muscular dystrophy 4 | 602
Parkinson's disease 4 | 364
Waldenstrons macroglobulinemia 4 | 765
Warburg micro syndrome 4 | 19
active ulcerative colitis 4 | 477
hepatocellular carcinoma 4 | 532
Charcot-Marie-Tooth disease 3 | 74
Gaucher disease type 1 3 | 171
Legionnaires' disease 3 | 20
Lissencephaly 3 | 61
Malformations of Cortical Development 3 | 11
Menkes disease 3 | 20
Polycystic kidney disease 3 | 54
Schizophrenia 3 | 501
Warburg Sjo Fledelius syndrome 3 | 4
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
cystic fibrosis and chronic rhinosinusitis 3 | 213
fibroadenoma 3 | 557
gastric cancer 3 | 430
gastric carcinoma 3 | 832
progressive supranuclear palsy 3 | 674
Attention deficit hyperactivity disorder 2 | 156
Down syndrome 2 | 548
Myocardial Ischemia 2 | 169
Prostatic Neoplasms 2 | 471

Tissue

Blood and immune system 110 | 17,995
Cardiovascular System 110 | 17,958
Digestive Tract 110 | 18,473
Endocrine System 110 | 18,512
Female tissues 110 | 18,647
Liver and Pancreas 110 | 18,136
Male tissues 110 | 17,969
Nervous System 110 | 18,561
Urinary Tract 110 | 18,444
Respiratory system 109 | 17,484
Skin and soft tissues 109 | 18,115

Target Family

Non-IDG 87 | 11,971
Enzyme 24 | 4,146

Reactome Pathway

Golgi-to-ER retrograde transpo... 111 | 111
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Rac GTPase-activating protein 1 RACGAP1 Tbio Enzyme -1.64660 53.0 346
Kinesin-like protein KIF11 KIF11 Tchem Non-IDG -2.55070 377.6 296
Kinesin-1 heavy chain KIF5B Tchem Non-IDG -2.29226 188.2 283
Transmembrane emp24 domain-containing protein 10 TMED10 Tbio Non-IDG -1.43300 31.4 277
Vesicle transport protein SEC20 BNIP1 Tbio Non-IDG -1.24979 18.7 257
Cytosolic phospholipase A2 PLA2G4A Tchem Enzyme -2.67329 492.3 251
Kinesin-like protein KIF2C KIF2C Tbio Non-IDG -2.10218 131.9 241
Dynactin subunit 2 DCTN2 Tbio Non-IDG -1.88984 67.3 222
Platelet-activating factor acetylhydrolase IB subunit alpha PAFAH1B1 Tbio Enzyme -2.44443 296.3 212
Dynactin subunit 1 DCTN1 Tbio Non-IDG -2.00825 101.5 206