Development Level

Tbio 42 | 10,625
Tchem 8 | 1,890
Tdark 6 | 7,003

IMPC Term

preweaning lethality, complete... 5 | 633
decreased total body fat amoun... 4 | 186
increased or absent threshold ... 4 | 128
abnormal behavior 3 | 226
abnormal lens morphology 3 | 73
decreased circulating triglyce... 3 | 83
embryonic lethality prior to t... 3 | 187
abnormal bone structure 2 | 131
abnormal heart morphology 2 | 51
cardiovascular system phenotyp... 2 | 35
decreased bone mineral content 2 | 157
decreased caudal vertebrae num... 2 | 49
decreased circulating HDL chol... 2 | 77
decreased grip strength 2 | 123
decreased lean body mass 2 | 195
decreased mean corpuscular hem... 2 | 34
decreased mean corpuscular vol... 2 | 50
decreased vertical activity 2 | 22
enlarged heart 2 | 111
enlarged lymph nodes 2 | 27
increased circulating alkaline... 2 | 119
increased startle reflex 2 | 38
abnormal behavioral response t... 1 | 52
abnormal coat/hair pigmentatio... 1 | 54
abnormal embryo size 1 | 112
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal iris pigmentation 1 | 3
abnormal kidney morphology 1 | 30
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal retinal inner nuclear... 1 | 5
abnormal retinal pigmentation 1 | 61
abnormal seminal vesicle morph... 1 | 47
abnormal sensory capabilities/... 1 | 3
abnormal sleep behavior 1 | 63
abnormal spinal cord morpholog... 1 | 8
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
abnormal vertebrae morphology 1 | 14
abnormal vitreous body morphol... 1 | 7
absent heartbeat 1 | 6
decreased Ly6C low monocyte nu... 1 | 23
decreased alpha-beta T cell nu... 1 | 12
decreased body length 1 | 108
decreased bone mineral density 1 | 126
decreased cardiac output 1 | 2
decreased cardiac stroke volum... 1 | 3
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating choleste... 1 | 85
decreased circulating glucose ... 1 | 121
decreased circulating insulin ... 1 | 75
decreased circulating potassiu... 1 | 17
decreased heart rate 1 | 10
decreased heart rate variabili... 1 | 11
decreased heart weight 1 | 44
decreased hemoglobin content 1 | 53
decreased monocyte cell number 1 | 28
decreased prepulse inhibition 1 | 52
decreased respiratory quotient 1 | 12
decreased total retina thickne... 1 | 20
embryonic lethality prior to o... 1 | 148
enlarged spleen 1 | 26
enlarged urinary bladder 1 | 4
hemorrhage 1 | 12
hyperactivity 1 | 108
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
increased body weight 1 | 42
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased cardiac muscle contr... 1 | 5
increased circulating choleste... 1 | 53
increased circulating fructosa... 1 | 11
increased circulating total pr... 1 | 20
increased erythrocyte cell num... 1 | 26
increased fasted circulating g... 1 | 68
increased gamma-delta T cell n... 1 | 16
increased heart rate 1 | 17
increased heart weight 1 | 37
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased kidney weight 1 | 4
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
increased mean corpuscular hem... 1 | 25
increased mean corpuscular vol... 1 | 91
increased neutrophil cell numb... 1 | 15
increased prepulse inhibition 1 | 21
increased sacral vertebrae num... 1 | 62
limb grasping 1 | 35
polydactyly 1 | 22
preweaning lethality, incomple... 1 | 260
short tibia 1 | 82
small seminal vesicle 1 | 6
small superior vagus ganglion 1 | 20
small testis 1 | 37
thrombocytopenia 1 | 46

Disease

ovarian cancer 35 | 8,484
osteosarcoma 29 | 7,933
medulloblastoma, large-cell 26 | 6,234
psoriasis 22 | 6,685
glioblastoma 21 | 5,572
atypical teratoid / rhabdoid tumor 19 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,956
lung cancer 15 | 4,466
Breast cancer 14 | 3,094
Multiple myeloma 14 | 1,327
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,988
ependymoma 13 | 2,514
lung carcinoma 13 | 2,844
pilocytic astrocytoma 12 | 3,086
malignant mesothelioma 11 | 3,162
non-small cell lung cancer 11 | 2,798
astrocytic glioma 10 | 2,241
cystic fibrosis 10 | 1,665
group 4 medulloblastoma 10 | 1,875
invasive ductal carcinoma 10 | 2,950
pediatric high grade glioma 10 | 2,712
tuberculosis 10 | 1,557
adrenocortical carcinoma 9 | 1,427
ductal carcinoma in situ 9 | 1,745
Pick disease 8 | 1,893
astrocytoma 8 | 1,493
lung adenocarcinoma 8 | 2,713
oligodendroglioma 8 | 2,849
pancreatic cancer 8 | 2,300
subependymal giant cell astrocytoma 8 | 2,287
Hermansky-Pudlak syndrome 7 | 43
acute quadriplegic myopathy 7 | 1,157
adult high grade glioma 7 | 2,148
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
Cancer 6 | 2,346
Carcinoma 6 | 2,147
Neurodegenerative disease 6 | 383
Waldenstrons macroglobulinemia 6 | 765
medulloblastoma 6 | 1,524
pituitary cancer 6 | 1,972
primitive neuroectodermal tumor 6 | 3,031
ulcerative colitis 6 | 2,087
Alzheimer's disease 5 | 644
Intellectual disability 5 | 573
Parkinson's disease 5 | 364
Platelet storage pool deficiency 5 | 21
Rheumatoid Arthritis 5 | 1,160
acute myeloid leukemia 5 | 780
diabetes mellitus 5 | 1,663
juvenile dermatomyositis 5 | 1,189
progressive supranuclear palsy 5 | 674
Down syndrome 4 | 548
Gaucher disease type 1 4 | 171
active Crohn's disease 4 | 918
atypical teratoid/rhabdoid tumor 4 | 1,095
breast carcinoma 4 | 1,614
esophageal adenocarcinoma 4 | 737
gastric carcinoma 4 | 832
group 3 medulloblastoma 4 | 2,254
interstitial cystitis 4 | 2,299
mucosa-associated lymphoid tissue lymphoma 4 | 480
primary pancreatic ductal adenocarcinoma 4 | 1,271
spina bifida 4 | 1,064
Chronic Lymphocytic Leukemia 3 | 242
Oculocutaneous albinism 3 | 27
Parkinson Disease 3 | 102
Prostatic Neoplasms 3 | 471
Schizophrenia 3 | 501
Tetanus 3 | 66
colon cancer 3 | 1,475
dermatomyositis 3 | 933
posterior fossa group B ependymoma 3 | 1,530
Atopic dermatitis 2 | 944
Cataract 2 | 104
Cerebral palsy 2 | 28
Depressive disorder 2 | 48
Duchenne muscular dystrophy 2 | 602
Hereditary spherocytosis 2 | 20
IGA Glomerulonephritis 2 | 454
Kidney disease 2 | 396
Microcephaly 2 | 149
Myopathy 2 | 128
Neoplasm Metastasis 2 | 138
Neuropathy 2 | 210
Obesity 2 | 616
Pain agnosia 2 | 99
Paraplegia 2 | 71
Polycystic Ovary Syndrome 2 | 332
Quadriplegia 2 | 14
Stomach Neoplasms 2 | 282
Vascular disease 2 | 281
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
fibroadenoma 2 | 557
hereditary spastic paraplegia 2 | 313
inflammatory breast cancer 2 | 404
posterior fossa group A ependymoma 2 | 1,511
primary Sjogren syndrome 2 | 789
sonic hedgehog group medulloblastoma 2 | 1,482
urothelial carcinoma 2 | 318

Tissue

Blood and immune system 56 | 17,995
Cardiovascular System 56 | 17,958
Digestive Tract 56 | 18,473
Endocrine System 56 | 18,512
Female tissues 56 | 18,647
Liver and Pancreas 56 | 18,136
Male tissues 56 | 17,969
Nervous System 56 | 18,561
Respiratory system 56 | 17,484
Skin and soft tissues 56 | 18,115
Urinary Tract 56 | 18,444

Target Family

Non-IDG 49 | 11,971
Enzyme 5 | 4,146
Kinase 2 | 634

Reactome Pathway

Golgi Associated Vesicle Bioge... 56 | 56
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Beta-arrestin-1 ARRB1 Tchem Non-IDG -2.54226 366.3 416
Ferritin heavy chain FTH1 Tbio Non-IDG -2.95630 924.5 435
Ras-related protein Rab-5C RAB5C Tbio Enzyme -1.13458 11.1 135
Transferrin receptor protein 1 TFRC Tbio Non-IDG -3.39868 2437.0 1167
Ferritin light chain FTL Tbio Non-IDG -2.37909 242.0 430
Huntingtin-interacting protein 1-related protein HIP1R Tbio Non-IDG -1.51948 37.8 178
TBC1 domain family member 8B TBC1D8B Tdark Non-IDG 0.00000 20
Putative tyrosine-protein phosphatase auxilin DNAJC6 Tbio Enzyme -1.67985 56.6 79
Vesicle-associated membrane protein 7 VAMP7 Tbio Non-IDG -1.83769 81.7 133
Dynamin-2 DNM2 Tchem Non-IDG -3.22299 1426.1 125