Development Level

Tbio 42 | 10,625
Tchem 8 | 1,890
Tdark 6 | 7,003

IMPC Phenotype

preweaning lethality, complete... 5 | 633
decreased total body fat amoun... 4 | 186
increased or absent threshold ... 4 | 128
abnormal behavior 3 | 226
abnormal lens morphology 3 | 73
decreased circulating triglyce... 3 | 83
embryonic lethality prior to t... 3 | 187
abnormal bone structure 2 | 131
abnormal heart morphology 2 | 51
cardiovascular system phenotyp... 2 | 35
decreased bone mineral content 2 | 157
decreased caudal vertebrae num... 2 | 49
decreased circulating HDL chol... 2 | 77
decreased grip strength 2 | 123
decreased lean body mass 2 | 195
decreased mean corpuscular hem... 2 | 34
decreased mean corpuscular vol... 2 | 50
decreased vertical activity 2 | 22
enlarged heart 2 | 111
enlarged lymph nodes 2 | 27
increased circulating alkaline... 2 | 119
increased startle reflex 2 | 38
abnormal behavioral response t... 1 | 52
abnormal coat-hair pigmentatio... 1 | 54
abnormal embryo size 1 | 112
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal iris pigmentation 1 | 3
abnormal kidney morphology 1 | 30
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal retinal inner nuclear... 1 | 5
abnormal retinal pigmentation 1 | 61
abnormal seminal vesicle morph... 1 | 47
abnormal sensory capabilities-... 1 | 3
abnormal sleep behavior 1 | 63
abnormal spinal cord morpholog... 1 | 8
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
abnormal vertebrae morphology 1 | 14
abnormal vitreous body morphol... 1 | 7
absent heartbeat 1 | 6
decreased Ly6C low monocyte nu... 1 | 23
decreased alpha-beta T cell nu... 1 | 12
decreased body length 1 | 108
decreased bone mineral density 1 | 126
decreased cardiac output 1 | 2
decreased cardiac stroke volum... 1 | 3
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating choleste... 1 | 85
decreased circulating glucose ... 1 | 121
decreased circulating insulin ... 1 | 75
decreased circulating potassiu... 1 | 17
decreased heart rate 1 | 10
decreased heart rate variabili... 1 | 11
decreased heart weight 1 | 44
decreased hemoglobin content 1 | 53
decreased monocyte cell number 1 | 28
decreased prepulse inhibition 1 | 52
decreased respiratory quotient 1 | 12
decreased total retina thickne... 1 | 20
embryonic lethality prior to o... 1 | 148
enlarged spleen 1 | 26
enlarged urinary bladder 1 | 4
hemorrhage 1 | 12
hyperactivity 1 | 108
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
increased body weight 1 | 42
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased cardiac muscle contr... 1 | 5
increased circulating choleste... 1 | 53
increased circulating fructosa... 1 | 11
increased circulating total pr... 1 | 20
increased erythrocyte cell num... 1 | 26
increased fasted circulating g... 1 | 68
increased gamma-delta T cell n... 1 | 16
increased heart rate 1 | 17
increased heart weight 1 | 37
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased kidney weight 1 | 4
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
increased mean corpuscular hem... 1 | 25
increased mean corpuscular vol... 1 | 91
increased neutrophil cell numb... 1 | 15
increased prepulse inhibition 1 | 21
increased sacral vertebrae num... 1 | 62
limb grasping 1 | 35
polydactyly 1 | 22
preweaning lethality, incomple... 1 | 260
short tibia 1 | 82
small seminal vesicle 1 | 6
small superior vagus ganglion 1 | 20
small testis 1 | 37
thrombocytopenia 1 | 46

Disease

ovarian cancer 35 | 8,491
osteosarcoma 29 | 7,933
medulloblastoma, large-cell 26 | 6,234
psoriasis 22 | 6,685
glioblastoma 21 | 5,572
atypical teratoid / rhabdoid tumor 19 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,956
lung cancer 15 | 4,473
Breast cancer 14 | 3,098
Multiple myeloma 14 | 1,327
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,988
ependymoma 13 | 2,514
lung carcinoma 13 | 2,844
pilocytic astrocytoma 12 | 3,086
malignant mesothelioma 11 | 3,163
non-small cell lung cancer 11 | 2,798
astrocytic glioma 10 | 2,241
cystic fibrosis 10 | 1,670
group 4 medulloblastoma 10 | 1,875
invasive ductal carcinoma 10 | 2,950
pediatric high grade glioma 10 | 2,712
tuberculosis 10 | 1,563
adrenocortical carcinoma 9 | 1,427
ductal carcinoma in situ 9 | 1,745
Pick disease 8 | 1,893
astrocytoma 8 | 1,493
lung adenocarcinoma 8 | 2,714
oligodendroglioma 8 | 2,849
pancreatic cancer 8 | 2,300
subependymal giant cell astrocytoma 8 | 2,287
Hermansky-Pudlak syndrome 7 | 43
acute quadriplegic myopathy 7 | 1,157
adult high grade glioma 7 | 2,148
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
Cancer 6 | 2,346
Carcinoma 6 | 2,147
Neurodegenerative disease 6 | 383
Waldenstrons macroglobulinemia 6 | 764
medulloblastoma 6 | 1,524
pituitary cancer 6 | 1,972
primitive neuroectodermal tumor 6 | 3,031
ulcerative colitis 6 | 2,087
Alzheimer's disease 5 | 644
Intellectual disability 5 | 573
Parkinson's disease 5 | 364
Platelet storage pool deficiency 5 | 21
Rheumatoid Arthritis 5 | 1,170
acute myeloid leukemia 5 | 785
diabetes mellitus 5 | 1,663
juvenile dermatomyositis 5 | 1,189
progressive supranuclear palsy 5 | 674
Down syndrome 4 | 548
Gaucher disease type 1 4 | 171
active Crohn's disease 4 | 918
atypical teratoid/rhabdoid tumor 4 | 1,095
breast carcinoma 4 | 1,614
esophageal adenocarcinoma 4 | 737
gastric carcinoma 4 | 832
group 3 medulloblastoma 4 | 2,254
interstitial cystitis 4 | 2,299
mucosa-associated lymphoid tissue lymphoma 4 | 480
primary pancreatic ductal adenocarcinoma 4 | 1,271
spina bifida 4 | 1,064
Oculocutaneous albinism 3 | 28
Parkinson Disease 3 | 105
Prostatic Neoplasms 3 | 471
Schizophrenia 3 | 503
Tetanus 3 | 66
chronic lymphocytic leukemia 3 | 244
colon cancer 3 | 1,475
dermatomyositis 3 | 966
posterior fossa group B ependymoma 3 | 1,530
Atopic dermatitis 2 | 944
Cataract 2 | 104
Cerebral palsy 2 | 28
Depressive disorder 2 | 48
Duchenne muscular dystrophy 2 | 602
Hereditary spherocytosis 2 | 20
IGA Glomerulonephritis 2 | 454
Kidney disease 2 | 397
Microcephaly 2 | 149
Myopathy 2 | 128
Neoplasm Metastasis 2 | 138
Neuropathy 2 | 210
Pain agnosia 2 | 99
Paraplegia 2 | 71
Polycystic Ovary Syndrome 2 | 334
Quadriplegia 2 | 14
Stomach Neoplasms 2 | 282
Vascular disease 2 | 281
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
fibroadenoma 2 | 557
hepatocellular carcinoma 2 | 550
hereditary spastic paraplegia 2 | 313
inflammatory breast cancer 2 | 404
posterior fossa group A ependymoma 2 | 1,511
primary Sjogren syndrome 2 | 788
sonic hedgehog group medulloblastoma 2 | 1,482
urothelial carcinoma 2 | 318

Tissue

Blood and immune system 56 | 17,994
Cardiovascular System 56 | 17,957
Digestive Tract 56 | 18,472
Endocrine System 56 | 18,511
Female tissues 56 | 18,646
Liver and Pancreas 56 | 18,135
Male tissues 56 | 17,968
Nervous System 56 | 18,560
Respiratory system 56 | 17,483
Skin and soft tissues 56 | 18,114
Urinary Tract 56 | 18,443

Target Family

Non-IDG 49 | 11,969
Enzyme 5 | 4,146
Kinase 2 | 634

Reactome Pathway

Golgi Associated Vesicle Bioge... 56 | 56
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Alpha-soluble NSF attachment protein NAPA Tbio Non-IDG -1.91708 86.7 133
AP-1 complex subunit mu-1 AP1M1 Tbio Non-IDG -1.18893 12.9 104
Ras-related protein Rab-5C RAB5C Tbio Enzyme -1.13690 11.1 135
Clathrin heavy chain 1 CLTC Tbio Non-IDG -1.63705 36.3 159
Vesicle-associated membrane protein 2 VAMP2 Tbio Non-IDG -2.50812 310.3 171
Inositol polyphosphate 5-phosphatase OCRL-1 OCRL Tbio Enzyme -2.17795 160.1 198
Sorting nexin-2 SNX2 Tbio Non-IDG -1.21476 15.2 127
Protein YIPF6 YIPF6 Tdark Non-IDG -1.08743 9.41 22
AP-1 complex subunit sigma-1A AP1S1 Tbio Non-IDG -1.57544 34.7 73
AP-3 complex subunit sigma-1 AP3S1 Tbio Non-IDG -0.63515 4.24 102