Development Level

Tbio 105 | 11,445
Tdark 9 | 6,588
Tchem 7 | 1,598

Collection

Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, incomple... 6 | 499
preweaning lethality, complete... 4 | 979
abnormal bone structure 2 | 187
abnormal eye morphology 2 | 68
decreased circulating serum al... 2 | 82
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
hypoactivity 2 | 132
short tibia 2 | 97
abnormal QT variability 1 | 10
abnormal behavior 1 | 298
abnormal coat appearance 1 | 31
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo size 1 | 220
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal tail morphology 1 | 25
absent startle reflex 1 | 24
cataract 1 | 92
decreased body length 1 | 101
decreased circulating alanine ... 1 | 47
decreased circulating glucose ... 1 | 126
decreased eosinophil cell numb... 1 | 24
decreased exploration in new e... 1 | 11
decreased red blood cell distr... 1 | 41
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
enlarged kidney 1 | 14
enlarged spleen 1 | 41
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating creatini... 1 | 38
increased circulating potassiu... 1 | 29
increased circulating triglyce... 1 | 42
increased lean body mass 1 | 172
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased startle reflex 1 | 112
mydriasis 1 | 6
small adrenal glands 1 | 16
small kidney 1 | 16
thick skin 1 | 4
thrombocytosis 1 | 27

Disease

Carcinoma 97 | 11,493
ovarian cancer 74 | 8,520
glioblastoma 59 | 5,792
psoriasis 58 | 6,694
osteosarcoma 55 | 7,950
ependymoma 46 | 4,679
atypical teratoid / rhabdoid tumor 45 | 5,112
medulloblastoma, large-cell 45 | 6,241
Astrocytoma, Pilocytic 39 | 3,081
lung cancer 37 | 4,740
Breast cancer 36 | 3,578
adult high grade glioma 34 | 3,801
malignant mesothelioma 34 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 33 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 33 | 3,291
group 3 medulloblastoma 31 | 4,104
invasive ductal carcinoma 31 | 2,951
lung carcinoma 31 | 2,843
pancreatic cancer 30 | 2,398
pituitary cancer 30 | 1,972
interstitial cystitis 29 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 28 | 2,955
primitive neuroectodermal tumor 27 | 3,035
Autosomal recessive predisposition 26 | 1,442
lung adenocarcinoma 25 | 2,716
non-small cell lung cancer 24 | 2,890
oligodendroglioma 23 | 2,850
Cancer 22 | 2,499
astrocytic glioma 22 | 2,597
adrenocortical carcinoma 21 | 1,428
ductal carcinoma in situ 21 | 1,745
ulcerative colitis 21 | 1,819
cystic fibrosis 20 | 1,696
group 4 medulloblastoma 20 | 1,855
tuberculosis 19 | 2,010
Kidney cancer 18 | 2,613
subependymal giant cell astrocytoma 18 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
breast carcinoma 15 | 1,638
diabetes mellitus 15 | 1,728
pediatric high grade glioma 15 | 1,064
Atopic dermatitis 14 | 952
Pick disease 14 | 1,894
Short stature 14 | 531
colon cancer 14 | 1,478
gastric carcinoma 14 | 807
juvenile dermatomyositis 14 | 1,187
primary pancreatic ductal adenocarcinoma 14 | 1,109
Coarse facial features 12 | 108
Congenital deafness 12 | 185
Deafness 12 | 198
Hearing Loss, Partial 12 | 185
Intellectual disability 12 | 1,016
Mucopolysaccharidosis 12 | 26
Multiple myeloma 12 | 1,332
Short neck 12 | 140
Thickened facial skin with coarse facial features 12 | 108
active Crohn's disease 12 | 922
aldosterone-producing adenoma 12 | 665
astrocytoma 12 | 1,146
hearing impairment 12 | 199
nasopharyngeal carcinoma 12 | 1,058
Big calvaria 11 | 147
Duchenne muscular dystrophy 11 | 601
Increased head circumference 11 | 147
Increased size of cranium 11 | 147
Increased size of skull 11 | 147
Muscle hypotonia 11 | 571
cutaneous lupus erythematosus 11 | 1,057
primary Sjogren syndrome 11 | 735
Acquired scoliosis 10 | 281
Concave bridge of nose 10 | 195
Curvature of spine 10 | 282
Depressed nasal bridge 10 | 195
Depressed nasal root/bridge 10 | 195
Hepatomegaly 10 | 285
Hernia, Inguinal 10 | 89
Hydrocephalus 10 | 152
Splenomegaly 10 | 190
non primary Sjogren syndrome sicca 10 | 891
sonic hedgehog group medulloblastoma 10 | 467
Dull intelligence 9 | 645
Joint stiffness 9 | 84
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Poor school performance 9 | 645
Umbilical hernia 9 | 93
Congenital clubfoot 8 | 109
Craniofacial Abnormalities 8 | 151
Ehlers-Danlos syndrome 8 | 43
Epilepsy 8 | 792
Frontal bossing 8 | 157
Knee joint valgus deformity 8 | 56
Osteoarthritis 8 | 184
Rheumatoid arthritis 8 | 1,191
Schizophrenia 8 | 1,160
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 510
esophageal adenocarcinoma 8 | 737
medulloblastoma 8 | 720

Tissue

Digestive Tract 119 | 17,369
Endocrine System 119 | 18,159
Female tissues 119 | 17,400
Nervous System 119 | 16,725
Urinary Tract 119 | 16,678
Male tissues 118 | 17,142
Skin and soft tissues 117 | 17,230
Blood and immune system 116 | 16,909
Liver and Pancreas 116 | 16,750
Respiratory system 116 | 16,393
Cardiovascular System 107 | 15,192

Target Family

Enzyme 84 | 4,145
Non-IDG 31 | 12,091
Transporter 5 | 473
Ion Channel 1 | 344

Reactome Pathway

Glycosaminoglycan metabolism 121 | 121
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Beta-1,4-galactosyltransferase 1 B4GALT1 Tbio Enzyme -2.34454 211.1 130
Dermatan-sulfate epimerase DSE Tbio Enzyme -2.57112 360.0 44
Xylosyltransferase 1 XYLT1 Tbio Enzyme -2.10436 129.4 88
Heparan sulfate glucosamine 3-O-sulfotransferase 4 HS3ST4 Tdark Enzyme -0.45852 2.98 18
Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 Tbio Enzyme -0.79764 6.35 32
Glypican-6 GPC6 Tbio Non-IDG -1.33560 21.9 125
Alpha-N-acetylglucosaminidase NAGLU Tbio Enzyme -2.18649 159.9 64
Heparan sulfate glucosamine 3-O-sulfotransferase 6 HS3ST6 Tdark Enzyme -0.31878 2.19 19
Chondroitin sulfate synthase 1 CHSY1 Tbio Enzyme -1.69082 48.5 101
Carbohydrate sulfotransferase 2 CHST2 Tbio Enzyme -1.29443 20.9 188