Development Level

Tbio 52 | 11,445
Tchem 14 | 1,598
Tdark 4 | 6,588

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 11 | 979
abnormal QT variability 2 | 10
decreased bone mineral density 2 | 126
decreased neutrophil cell numb... 2 | 42
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
increased lean body mass 2 | 172
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal vocalization 1 | 21
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
female infertility 1 | 60
impaired glucose tolerance 1 | 75
increased body temperature 1 | 9
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased heart rate 1 | 23
increased lymphocyte cell numb... 1 | 32
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
male infertility 1 | 123
shortened RR interval 1 | 17
small kidney 1 | 16
small superior vagus ganglion 1 | 74
thick ventricular wall 1 | 7
thin ventricular wall 1 | 24

Disease

Carcinoma 56 | 11,493
ovarian cancer 42 | 8,520
lung cancer 33 | 4,740
osteosarcoma 33 | 7,950
medulloblastoma, large-cell 28 | 6,241
group 3 medulloblastoma 27 | 4,104
glioblastoma 26 | 5,792
atypical teratoid / rhabdoid tumor 25 | 5,112
psoriasis 23 | 6,694
non-small cell lung cancer 18 | 2,890
pancreatic cancer 18 | 2,398
astrocytic glioma 17 | 2,597
ependymoma 17 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,291
adult high grade glioma 15 | 3,801
dermatomyositis 15 | 966
malignant mesothelioma 15 | 3,232
Autosomal recessive predisposition 14 | 1,442
Cancer 14 | 2,499
Kidney cancer 13 | 2,613
Multiple myeloma 13 | 1,332
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
lung adenocarcinoma 13 | 2,716
primitive neuroectodermal tumor 13 | 3,035
Breast cancer 12 | 3,578
acute quadriplegic myopathy 12 | 1,158
invasive ductal carcinoma 12 | 2,951
oligodendroglioma 12 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
Waldenstrons macroglobulinemia 11 | 765
Pick disease 10 | 1,894
adrenocortical carcinoma 10 | 1,428
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
ductal carcinoma in situ 9 | 1,745
subependymal giant cell astrocytoma 9 | 2,287
Astrocytoma, Pilocytic 8 | 3,081
Icterus 8 | 82
breast carcinoma 8 | 1,638
lung carcinoma 8 | 2,843
tuberculosis 8 | 2,010
Dull intelligence 7 | 645
Intellectual disability 7 | 1,016
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
Rheumatoid arthritis 7 | 1,191
colon cancer 7 | 1,478
diabetes mellitus 7 | 1,728
primary pancreatic ductal adenocarcinoma 7 | 1,109
Adenocarcinoma of lung 6 | 142
Cholecystitis 6 | 18
Cholelithiasis 6 | 33
Congenital hemolytic anemia 6 | 32
Glycogen storage disease 6 | 39
Myocardial Ischemia 6 | 169
Osteoporosis 6 | 363
Splenomegaly 6 | 190
astrocytoma 6 | 1,146
group 4 medulloblastoma 6 | 1,855
Disease Models, Animal 5 | 155
Epilepsy 5 | 792
Obesity 5 | 678
Seizures 5 | 596
pituitary cancer 5 | 1,972
ulcerative colitis 5 | 1,819
Alzheimer's disease 4 | 658
Amyotrophic lateral sclerosis 4 | 451
Anemia 4 | 365
Bipolar Disorder 4 | 666
Carcinoma, Hepatocellular 4 | 228
Carcinoma, Squamous Cell 4 | 110
Cognitive delay 4 | 608
Diabetes Mellitus, Experimental 4 | 108
Global developmental delay 4 | 608
Impaired exercise tolerance 4 | 42
Liver Cirrhosis, Experimental 4 | 769
Liver carcinoma 4 | 240
Mental and motor retardation 4 | 608
Mouth Neoplasms 4 | 55
Muscle Weakness 4 | 170
Nonspherocytic hemolytic anemia 4 | 6
Normochromic anemia 4 | 6
Normocytic anemia 4 | 6
Reticulocytosis 4 | 20
Schizophrenia 4 | 1,160
Squamous cell carcinoma 4 | 129
Stomach Neoplasms 4 | 300
active ulcerative colitis 4 | 764
acute myeloid leukemia 4 | 783
aldosterone-producing adenoma 4 | 665
spina bifida 4 | 1,074
Atopic dermatitis 3 | 952
Diabetes Mellitus, Non-Insulin-Dependent 3 | 145
Duchenne muscular dystrophy 3 | 601
Male infertility 3 | 206
Type 2 diabetes mellitus 3 | 272
fibroadenoma 3 | 559
mucosa-associated lymphoid tissue lymphoma 3 | 484
sonic hedgehog group medulloblastoma 3 | 467

Tissue

Endocrine System 69 | 18,159
Male tissues 69 | 17,142
Blood and immune system 67 | 16,909
Digestive Tract 67 | 17,369
Female tissues 67 | 17,400
Liver and Pancreas 67 | 16,750
Nervous System 67 | 16,725
Skin and soft tissues 67 | 17,230
Urinary Tract 67 | 16,678
Cardiovascular System 66 | 15,192
Respiratory system 66 | 16,393

Target Family

Enzyme 26 | 4,145
Non-IDG 26 | 12,091
Kinase 18 | 634

Reactome Pathway

Glycolysis 70 | 70
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nucleoporin NDC1 NDC1 Tbio Non-IDG -0.66901 4.57 46
Glycerol-3-phosphate phosphatase PGP Tbio Enzyme -1.48294 30.0 90
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform PPP2R5D Tbio Enzyme -0.70843 3.59 261
Nucleoprotein TPR TPR Tbio Non-IDG -2.11491 135.6 161
Nuclear pore complex protein Nup160 NUP160 Tbio Non-IDG -1.13177 13.6 169
Hexokinase-2 HK2 Tchem Kinase -2.64934 432.5 446
Nuclear pore complex protein Nup85 NUP85 Tbio Non-IDG -1.23703 17.9 139
Pyruvate kinase PKLR PKLR Tbio Kinase -2.37549 231.1 391
Nucleoporin-like protein 2 NUPL2 Tbio Non-IDG -1.04073 10.5 78
Phosphoglycerate kinase 1 PGK1 Tchem Kinase -2.79738 602.5 340