Development Level

Tbio 9 | 11,445
Tchem 4 | 1,598
Tclin 1 | 613

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

decreased total body fat amoun... 1 | 207
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 12 | 11,493
Glycogen storage disease 10 | 39
osteosarcoma 10 | 7,950
ovarian cancer 8 | 8,520
Autosomal recessive predisposition 6 | 1,442
ductal carcinoma in situ 6 | 1,745
glioblastoma 6 | 5,792
group 3 medulloblastoma 6 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
invasive ductal carcinoma 6 | 2,951
Astrocytoma, Pilocytic 5 | 3,081
Hepatomegaly 5 | 285
adult high grade glioma 5 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
malignant mesothelioma 5 | 3,232
medulloblastoma, large-cell 5 | 6,241
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
psoriasis 5 | 6,694
Kidney cancer 4 | 2,613
Muscle Weakness 4 | 170
breast carcinoma 4 | 1,638
ependymoma 4 | 4,679
oligodendroglioma 4 | 2,850
pituitary cancer 4 | 1,972
tuberculosis 4 | 2,010
Creatine phosphokinase serum increased 3 | 110
Duchenne muscular dystrophy 3 | 601
Elevated creatine kinase 3 | 110
Muscle hypotonia 3 | 571
Myocardial Ischemia 3 | 169
Myopathy 3 | 185
atypical teratoid / rhabdoid tumor 3 | 5,112
colon cancer 3 | 1,478
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
subependymal giant cell astrocytoma 3 | 2,287
Breast cancer 2 | 3,578
Elevated hepatic transaminases 2 | 81
Exercise-induced myalgia 2 | 8
Gastrointestinal stromal tumor 2 | 62
Glycogen Storage Disease IXC 2 | 2
Glycogen Storage Disease, Type IXD 2 | 2
Glycogen storage disease V 2 | 9
Glycogen storage disease VI 2 | 3
Growth delay 2 | 114
Growth failure 2 | 114
Growth retardation 2 | 115
Hepatic enzyme increased 2 | 81
Hypertriglyceridemia result 2 | 37
Hypoglycemia 2 | 152
Increased liver glycogen content 2 | 3
Ketonemia 2 | 11
Ketosis 2 | 11
Liver Dysfunction 2 | 99
Liver enzymes abnormal 2 | 81
Liver function test increased 2 | 81
Liver function tests abnormal finding 2 | 81
Motor delay 2 | 147
Multiple myeloma 2 | 1,332
Myoglobinuria 2 | 15
Neurogenic Muscular Atrophy 2 | 139
Neurogenic muscle atrophy, especially in the lower limbs 2 | 139
No development of motor milestones 2 | 147
Pancreatic Neuroendocrine Tumor 2 | 45
Pick disease 2 | 1,894
Poor growth 2 | 114
Renal Cell Carcinoma 2 | 214
Short stature 2 | 531
Skeletal muscle atrophy 2 | 139
Splenomegaly 2 | 190
Subclinical abnormal liver function tests 2 | 81
Transaminases increased 2 | 81
Very poor growth 2 | 114
Waldenstrons macroglobulinemia 2 | 765
X- linked recessive 2 | 110
adrenocortical carcinoma 2 | 1,428
astrocytic glioma 2 | 2,597
astrocytoma 2 | 1,146
cystic fibrosis 2 | 1,696
fibroadenoma 2 | 559
group 4 medulloblastoma 2 | 1,855
lung adenocarcinoma 2 | 2,716
lung cancer 2 | 4,740
lung carcinoma 2 | 2,843
muscle degeneration 2 | 139
non-small cell lung cancer 2 | 2,890
Adult onset 1 | 82
Cardiac Arrhythmia 1 | 103
Cardiomyopathy 1 | 116
Congenital deafness 1 | 185
Congenital disorder of glycosylation 1 | 54
Deafness 1 | 198
Fever 1 | 138
Gout 1 | 106
Hearing Loss, Partial 1 | 185
Hypertrophic Cardiomyopathy 1 | 117
Recurrent respiratory infections 1 | 141
Respiratory Failure 1 | 104
Ventricular arrhythmia 1 | 27
X-linked cerebral adrenoleukodystrophy 1 | 116
hearing impairment 1 | 199

Tissue

Blood and immune system 14 | 16,909
Cardiovascular System 14 | 15,192
Digestive Tract 14 | 17,369
Endocrine System 14 | 18,159
Female tissues 14 | 17,400
Liver and Pancreas 14 | 16,750
Male tissues 14 | 17,142
Nervous System 14 | 16,725
Respiratory system 14 | 16,393
Skin and soft tissues 14 | 17,230
Urinary Tract 14 | 16,678

Target Family

Enzyme 10 | 4,145
Kinase 4 | 634

Reactome Pathway

Glycogen breakdown (glycogenol... 14 | 14
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Phosphorylase b kinase regulatory subunit beta PHKB Tbio Enzyme -1.13261 11.6 113
Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform PHKA1 Tbio Kinase -1.17814 14.3 71
Phosphorylase b kinase regulatory subunit alpha, liver isoform PHKA2 Tbio Kinase -2.21111 153.2 59
Glycogen phosphorylase, muscle form PYGM Tchem Enzyme -2.24324 158.2 208
Glycogen phosphorylase, brain form PYGB Tbio Enzyme -1.98823 97.5 415
Phosphoglucomutase-1 PGM1 Tbio Enzyme -2.68870 491.5 141
Glucose 1,6-bisphosphate synthase PGM2L1 Tbio Enzyme -0.50191 2.73 91
Phosphoglucomutase-2 PGM2 Tbio Enzyme -1.88423 73.6 74
Glycogen phosphorylase, liver form PYGL Tchem Enzyme -2.00371 98.2 170
Glycogenin-2 GYG2 Tbio Enzyme -1.96980 92.0 145