Development Level

Tbio 73 | 10,625
Tchem 30 | 1,890
Tdark 19 | 7,003
Tclin 3 | 602

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 4 | 633
decreased total body fat amoun... 3 | 186
preweaning lethality, incomple... 3 | 260
abnormal bone structure 2 | 131
abnormal lens morphology 2 | 73
decreased bone mineral content 2 | 157
decreased circulating alanine ... 2 | 53
decreased circulating calcium ... 2 | 33
decreased circulating glucose ... 2 | 121
decreased lean body mass 2 | 195
embryonic lethality prior to o... 2 | 148
increased lean body mass 2 | 107
increased mean corpuscular hem... 2 | 93
increased red blood cell distr... 2 | 21
abnormal QRS complex 1 | 25
abnormal coat appearance 1 | 25
abnormal embryo size 1 | 112
abnormal spleen morphology 1 | 36
abnormal tibia morphology 1 | 14
abnormal vocalization 1 | 21
decreased B cell number 1 | 30
decreased Ly6C low monocyte nu... 1 | 23
decreased NK T cell number 1 | 28
decreased body length 1 | 108
decreased body weight 1 | 174
decreased circulating aspartat... 1 | 27
decreased circulating iron lev... 1 | 25
decreased circulating lactate ... 1 | 1
decreased circulating potassiu... 1 | 17
decreased circulating thyroxin... 1 | 5
decreased eosinophil cell numb... 1 | 41
decreased lactate dehydrogenas... 1 | 14
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased prepulse inhibition 1 | 52
decreased rib number 1 | 59
enlarged lymph nodes 1 | 27
hydrometra 1 | 13
hyperactivity 1 | 108
hypoactivity 1 | 89
increased B cell number 1 | 23
increased body weight 1 | 42
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating calcium ... 1 | 32
increased circulating iron lev... 1 | 25
increased circulating phosphat... 1 | 24
increased circulating sodium l... 1 | 71
increased effector memory CD4-... 1 | 15
increased exploration in new e... 1 | 56
increased fasted circulating g... 1 | 68
increased gamma-delta T cell n... 1 | 16
increased heart rate variabili... 1 | 4
increased mature B cell number 1 | 12
increased mean corpuscular hem... 1 | 25
increased mean corpuscular vol... 1 | 91
increased mean platelet volume 1 | 19
increased monocyte cell number 1 | 27
increased prepulse inhibition 1 | 21
increased total body fat amoun... 1 | 57
male infertility 1 | 62
oligodactyly 1 | 14
small seminal vesicle 1 | 6
thrombocytopenia 1 | 46
thrombocytosis 1 | 23

Disease

ovarian cancer 65 | 8,484
osteosarcoma 60 | 7,933
psoriasis 51 | 6,685
medulloblastoma, large-cell 44 | 6,234
intraductal papillary-mucinous neoplasm (IPMN) 38 | 3,289
glioblastoma 35 | 5,572
lung cancer 32 | 4,466
atypical teratoid / rhabdoid tumor 31 | 4,369
invasive ductal carcinoma 31 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 28 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,988
pancreatic ductal adenocarcinoma liver metastasis 26 | 1,795
pilocytic astrocytoma 26 | 3,086
non-small cell lung cancer 25 | 2,798
oligodendroglioma 25 | 2,849
lung carcinoma 24 | 2,844
interstitial cystitis 22 | 2,299
ulcerative colitis 22 | 2,087
ependymoma 21 | 2,514
pancreatic cancer 21 | 2,300
malignant mesothelioma 20 | 3,162
primitive neuroectodermal tumor 20 | 3,031
Breast cancer 19 | 3,094
group 4 medulloblastoma 19 | 1,875
lung adenocarcinoma 19 | 2,713
adult high grade glioma 18 | 2,148
ductal carcinoma in situ 18 | 1,745
subependymal giant cell astrocytoma 18 | 2,287
astrocytic glioma 17 | 2,241
pediatric high grade glioma 16 | 2,712
pituitary cancer 16 | 1,972
Pick disease 15 | 1,893
breast carcinoma 15 | 1,614
group 3 medulloblastoma 14 | 2,254
diabetes mellitus 13 | 1,663
Rheumatoid Arthritis 12 | 1,160
active Crohn's disease 12 | 918
sonic hedgehog group medulloblastoma 12 | 1,482
cystic fibrosis 11 | 1,665
posterior fossa group A ependymoma 11 | 1,511
primary pancreatic ductal adenocarcinoma 11 | 1,271
spina bifida 11 | 1,064
acute quadriplegic myopathy 10 | 1,157
colon cancer 10 | 1,475
esophageal adenocarcinoma 10 | 737
juvenile dermatomyositis 10 | 1,189
nasopharyngeal carcinoma 10 | 1,056
non primary Sjogren syndrome sicca 10 | 840
tuberculosis 10 | 1,557
adrenocortical carcinoma 9 | 1,427
cutaneous lupus erythematosus 9 | 1,056
dermatomyositis 9 | 933
Multiple myeloma 8 | 1,327
fibroadenoma 8 | 557
Alzheimer's disease 7 | 644
Sengers syndrome 7 | 17
Toxic encephalopathy 7 | 131
astrocytoma 7 | 1,493
progressive supranuclear palsy 7 | 674
Atopic dermatitis 6 | 944
Barth syndrome 6 | 23
Cancer 6 | 2,346
Fatty liver disease 6 | 84
Obesity 6 | 616
Waldenstrons macroglobulinemia 6 | 765
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 499
gastric carcinoma 6 | 832
medulloblastoma 6 | 1,524
pancreatic carcinoma 6 | 567
Amyotrophic Lateral Sclerosis 5 | 431
Intellectual disability 5 | 573
Lipodystrophy 5 | 32
Neutral lipid storage disease 5 | 14
aldosterone-producing adenoma 5 | 664
inflammatory breast cancer 5 | 404
nephrosclerosis 5 | 329
posterior fossa group B ependymoma 5 | 1,530
primary Sjogren syndrome 5 | 789
Carcinoma 4 | 2,147
Down syndrome 4 | 548
Duchenne muscular dystrophy 4 | 602
Lipid metabolism disorder 4 | 102
Liver disease 4 | 219
Mammary Neoplasms 4 | 410
Newborn respiratory distress syndrome 4 | 8
Parkinson's disease 4 | 364
Poland syndrome 4 | 7
atypical teratoid/rhabdoid tumor 4 | 1,095
tuberculosis and treatment for 6 months 4 | 686
Arthritis 3 | 248
Atherosclerosis 3 | 275
Coronary artery disease 3 | 240
Dementia 3 | 129
Neurodegenerative disease 3 | 383
Polycystic Ovary Syndrome 3 | 332
Prostatic Neoplasms 3 | 471
Schizophrenia 3 | 501
Seizures 3 | 95
gastric cancer 3 | 430
hepatocellular carcinoma 3 | 532

Tissue

Digestive Tract 124 | 18,473
Endocrine System 124 | 18,512
Female tissues 124 | 18,647
Nervous System 124 | 18,561
Skin and soft tissues 124 | 18,115
Urinary Tract 124 | 18,444
Cardiovascular System 122 | 17,958
Liver and Pancreas 122 | 18,136
Blood and immune system 121 | 17,995
Male tissues 120 | 17,969
Respiratory system 120 | 17,484

Target Family

Enzyme 92 | 4,146
Non-IDG 21 | 11,971
Kinase 7 | 634
Transporter 5 | 473

Reactome Pathway

Glycerophospholipid biosynthes... 125 | 125
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial PGS1 Tdark Enzyme -0.35218 2.20 100
Trifunctional enzyme subunit alpha, mitochondrial HADHA Tbio Non-IDG -2.96515 948.2 132
Phosphatidylserine synthase 2 PTDSS2 Tbio Enzyme -0.74689 6.34 68
Choline dehydrogenase, mitochondrial CHDH Tbio Enzyme -1.38953 24.8 68
Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 Tbio Enzyme -3.11277 1238.0 122
Phospholipase A1 member A PLA1A Tbio Enzyme -1.76413 56.8 115
Choline transporter-like protein 2 SLC44A2 Tbio Transporter -1.57202 38.4 77
Group 10 secretory phospholipase A2 PLA2G10 Tchem Enzyme -2.39398 288.4 31
Lysophospholipid acyltransferase 2 MBOAT2 Tbio Enzyme -1.34198 18.9 57
Phosphatidylserine synthase 1 PTDSS1 Tbio Enzyme -1.84361 76.0 90