Development Level

Tbio 73 | 10,625
Tchem 30 | 1,890
Tdark 19 | 7,003
Tclin 3 | 602

Collection

Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

preweaning lethality, complete... 4 | 633
decreased total body fat amoun... 3 | 186
preweaning lethality, incomple... 3 | 260
abnormal bone structure 2 | 131
abnormal lens morphology 2 | 73
decreased bone mineral content 2 | 157
decreased circulating alanine ... 2 | 53
decreased circulating calcium ... 2 | 33
decreased circulating glucose ... 2 | 121
decreased lean body mass 2 | 195
embryonic lethality prior to o... 2 | 148
increased lean body mass 2 | 107
increased mean corpuscular hem... 2 | 93
increased red blood cell distr... 2 | 21
abnormal QRS complex 1 | 25
abnormal coat appearance 1 | 25
abnormal embryo size 1 | 112
abnormal spleen morphology 1 | 36
abnormal tibia morphology 1 | 14
abnormal vocalization 1 | 21
decreased B cell number 1 | 30
decreased Ly6C low monocyte nu... 1 | 23
decreased NK T cell number 1 | 28
decreased body length 1 | 108
decreased body weight 1 | 174
decreased circulating aspartat... 1 | 27
decreased circulating iron lev... 1 | 25
decreased circulating lactate ... 1 | 1
decreased circulating potassiu... 1 | 17
decreased circulating thyroxin... 1 | 5
decreased eosinophil cell numb... 1 | 41
decreased lactate dehydrogenas... 1 | 14
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased prepulse inhibition 1 | 52
decreased rib number 1 | 59
enlarged lymph nodes 1 | 27
hydrometra 1 | 13
hyperactivity 1 | 108
hypoactivity 1 | 89
increased B cell number 1 | 23
increased body weight 1 | 42
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating calcium ... 1 | 32
increased circulating iron lev... 1 | 25
increased circulating phosphat... 1 | 24
increased circulating sodium l... 1 | 71
increased effector memory CD4-... 1 | 15
increased exploration in new e... 1 | 56
increased fasted circulating g... 1 | 68
increased gamma-delta T cell n... 1 | 16
increased heart rate variabili... 1 | 4
increased mature B cell number 1 | 12
increased mean corpuscular hem... 1 | 25
increased mean corpuscular vol... 1 | 91
increased mean platelet volume 1 | 19
increased monocyte cell number 1 | 27
increased prepulse inhibition 1 | 21
increased total body fat amoun... 1 | 57
male infertility 1 | 62
oligodactyly 1 | 14
small seminal vesicle 1 | 6
thrombocytopenia 1 | 46
thrombocytosis 1 | 23

Disease

ovarian cancer 65 | 8,491
osteosarcoma 60 | 7,933
psoriasis 51 | 6,685
medulloblastoma, large-cell 44 | 6,234
intraductal papillary-mucinous neoplasm (IPMN) 38 | 3,289
glioblastoma 35 | 5,572
lung cancer 32 | 4,473
atypical teratoid / rhabdoid tumor 31 | 4,369
invasive ductal carcinoma 31 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 28 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,988
pancreatic ductal adenocarcinoma liver metastasis 26 | 1,795
pilocytic astrocytoma 26 | 3,086
non-small cell lung cancer 25 | 2,798
oligodendroglioma 25 | 2,849
lung carcinoma 24 | 2,844
interstitial cystitis 22 | 2,299
ulcerative colitis 22 | 2,087
ependymoma 21 | 2,514
pancreatic cancer 21 | 2,300
malignant mesothelioma 20 | 3,163
primitive neuroectodermal tumor 20 | 3,031
Breast cancer 19 | 3,098
group 4 medulloblastoma 19 | 1,875
lung adenocarcinoma 19 | 2,714
adult high grade glioma 18 | 2,148
ductal carcinoma in situ 18 | 1,745
subependymal giant cell astrocytoma 18 | 2,287
astrocytic glioma 17 | 2,241
pediatric high grade glioma 16 | 2,712
pituitary cancer 16 | 1,972
Pick disease 15 | 1,893
breast carcinoma 15 | 1,614
group 3 medulloblastoma 14 | 2,254
diabetes mellitus 13 | 1,663
Rheumatoid Arthritis 12 | 1,170
active Crohn's disease 12 | 918
sonic hedgehog group medulloblastoma 12 | 1,482
cystic fibrosis 11 | 1,670
posterior fossa group A ependymoma 11 | 1,511
primary pancreatic ductal adenocarcinoma 11 | 1,271
spina bifida 11 | 1,064
acute quadriplegic myopathy 10 | 1,157
colon cancer 10 | 1,475
esophageal adenocarcinoma 10 | 737
juvenile dermatomyositis 10 | 1,189
nasopharyngeal carcinoma 10 | 1,056
non primary Sjogren syndrome sicca 10 | 840
tuberculosis 10 | 1,563
adrenocortical carcinoma 9 | 1,427
cutaneous lupus erythematosus 9 | 1,056
dermatomyositis 9 | 966
Multiple myeloma 8 | 1,327
fibroadenoma 8 | 557
Alzheimer's disease 7 | 644
Sengers syndrome 7 | 17
Toxic encephalopathy 7 | 131
astrocytoma 7 | 1,493
progressive supranuclear palsy 7 | 674
Atopic dermatitis 6 | 944
Barth syndrome 6 | 23
Cancer 6 | 2,346
Fatty liver disease 6 | 86
Obesity 6 | 616
Waldenstrons macroglobulinemia 6 | 764
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 499
gastric carcinoma 6 | 832
medulloblastoma 6 | 1,524
pancreatic carcinoma 6 | 567
Amyotrophic Lateral Sclerosis 5 | 432
Intellectual disability 5 | 573
Lipodystrophy 5 | 32
Neutral lipid storage disease 5 | 14
aldosterone-producing adenoma 5 | 664
inflammatory breast cancer 5 | 404
nephrosclerosis 5 | 329
posterior fossa group B ependymoma 5 | 1,530
primary Sjogren syndrome 5 | 788
Carcinoma 4 | 2,147
Down syndrome 4 | 548
Duchenne muscular dystrophy 4 | 602
Lipid metabolism disorder 4 | 102
Liver disease 4 | 219
Mammary Neoplasms 4 | 410
Newborn respiratory distress syndrome 4 | 11
Parkinson's disease 4 | 364
Poland syndrome 4 | 7
atypical teratoid/rhabdoid tumor 4 | 1,095
tuberculosis and treatment for 6 months 4 | 686
Arthritis 3 | 248
Atherosclerosis 3 | 275
Coronary artery disease 3 | 240
Neurodegenerative disease 3 | 383
Polycystic Ovary Syndrome 3 | 334
Prostatic Neoplasms 3 | 471
Schizophrenia 3 | 503
Seizures 3 | 95
chronic lymphocytic leukemia 3 | 244
gastric cancer 3 | 436
hepatocellular carcinoma 3 | 550

Tissue

Digestive Tract 124 | 18,472
Endocrine System 124 | 18,511
Female tissues 124 | 18,646
Nervous System 124 | 18,560
Skin and soft tissues 124 | 18,114
Urinary Tract 124 | 18,443
Cardiovascular System 122 | 17,957
Liver and Pancreas 122 | 18,135
Blood and immune system 121 | 17,994
Male tissues 120 | 17,968
Respiratory system 120 | 17,483

Target Family

Enzyme 92 | 4,146
Non-IDG 21 | 11,969
Kinase 7 | 634
Transporter 5 | 473

Reactome Pathway

Glycerophospholipid biosynthes... 125 | 125
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Phospholipid-metabolizing enzyme A-C1 HRASLS Tdark Non-IDG -0.86185 7.79 0
Membrane-associated phosphatidylinositol transfer protein 2 PITPNM2 Tdark Non-IDG -0.73640 4.35 57
Membrane-associated phosphatidylinositol transfer protein 3 PITPNM3 Tbio Non-IDG -1.33078 20.4 103
Phosphatidylserine synthase 2 PTDSS2 Tbio Enzyme -0.81845 6.34 68
HRAS-like suppressor 3 PLA2G16 Tbio Non-IDG -1.93878 90.2 128
Group IIE secretory phospholipase A2 PLA2G2E Tchem Enzyme -0.44734 2.09 26
Group IID secretory phospholipase A2 PLA2G2D Tchem Enzyme -2.11153 121.4 103
Phospholipase DDHD2 DDHD2 Tbio Enzyme -1.21059 15.3 39
Lysophospholipid acyltransferase 1 MBOAT1 Tdark Enzyme -0.90322 7.90 19
Group 3 secretory phospholipase A2 PLA2G3 Tchem Enzyme -0.82035 7.31 117