Development Level

Tbio 88 | 11,651
Tchem 22 | 1,388
Tdark 14 | 6,593
Tclin 3 | 612

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, incomple... 7 | 499
preweaning lethality, complete... 6 | 979
cataract 4 | 92
abnormal lens morphology 3 | 81
decreased bone mineral content 3 | 151
decreased total body fat amoun... 3 | 207
hyperactivity 3 | 148
abnormal behavior 2 | 298
decreased circulating aspartat... 2 | 34
decreased circulating calcium ... 2 | 36
decreased circulating glucose ... 2 | 126
decreased lactate dehydrogenas... 2 | 16
decreased vertical activity 2 | 208
embryonic lethality prior to o... 2 | 239
increased lean body mass 2 | 172
increased mean platelet volume 2 | 45
increased red blood cell distr... 2 | 34
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal heart morphology 1 | 162
abnormal joint morphology 1 | 23
abnormal maxilla morphology 1 | 17
abnormal snout morphology 1 | 23
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
anophthalmia 1 | 33
brachydactyly 1 | 19
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating choleste... 1 | 93
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 50
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
enlarged testis 1 | 6
hydrometra 1 | 53
hypoactivity 1 | 132
increased anti-nuclear antigen... 1 | 19
increased body length 1 | 32
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating creatini... 1 | 38
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased circulating sodium l... 1 | 71
increased grip strength 1 | 41
increased heart rate 1 | 23
increased heart rate variabili... 1 | 7
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased prepulse inhibition 1 | 32
increased total body fat amoun... 1 | 134
male infertility 1 | 123
small seminal vesicle 1 | 10
syndactyly 1 | 23
thrombocytopenia 1 | 56

Disease

Carcinoma 83 | 11,493
ovarian cancer 67 | 8,520
osteosarcoma 61 | 7,950
psoriasis 50 | 6,694
medulloblastoma, large-cell 48 | 6,241
intraductal papillary-mucinous neoplasm (IPMN) 41 | 3,291
glioblastoma 38 | 5,792
atypical teratoid / rhabdoid tumor 36 | 5,112
ependymoma 34 | 4,679
invasive ductal carcinoma 33 | 2,951
lung cancer 32 | 4,740
group 3 medulloblastoma 30 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 29 | 2,955
adult high grade glioma 28 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,989
non-small cell lung cancer 27 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 27 | 1,962
oligodendroglioma 26 | 2,850
Astrocytoma, Pilocytic 25 | 3,081
lung carcinoma 25 | 2,843
Breast cancer 22 | 3,578
interstitial cystitis 22 | 2,312
pancreatic cancer 22 | 2,398
primitive neuroectodermal tumor 21 | 3,035
lung adenocarcinoma 20 | 2,716
astrocytic glioma 19 | 2,597
ductal carcinoma in situ 19 | 1,745
group 4 medulloblastoma 19 | 1,855
subependymal giant cell astrocytoma 19 | 2,287
malignant mesothelioma 18 | 3,232
ulcerative colitis 17 | 1,819
Pick disease 16 | 1,894
pituitary cancer 16 | 1,972
breast carcinoma 14 | 1,638
diabetes mellitus 14 | 1,728
tuberculosis 14 | 2,010
Autosomal recessive predisposition 13 | 1,442
Kidney cancer 13 | 2,613
active Crohn's disease 13 | 922
Rheumatoid arthritis 12 | 1,191
Schizophrenia 11 | 1,160
nasopharyngeal carcinoma 11 | 1,058
non primary Sjogren syndrome sicca 11 | 891
spina bifida 11 | 1,074
acute quadriplegic myopathy 10 | 1,158
colon cancer 10 | 1,478
cystic fibrosis 10 | 1,696
esophageal adenocarcinoma 10 | 737
primary pancreatic ductal adenocarcinoma 10 | 1,109
Intellectual disability 9 | 1,016
Obesity 9 | 678
active ulcerative colitis 9 | 764
adrenocortical carcinoma 9 | 1,428
cutaneous lupus erythematosus 9 | 1,057
juvenile dermatomyositis 9 | 1,187
Multiple myeloma 8 | 1,332
Sengers syndrome 8 | 18
dermatomyositis 8 | 966
pediatric high grade glioma 8 | 1,064
Alzheimer's disease 7 | 658
Barth syndrome 7 | 23
Toxic encephalopathy 7 | 141
progressive supranuclear palsy 7 | 676
Amyotrophic lateral sclerosis 6 | 451
Atopic dermatitis 6 | 952
Cancer 6 | 2,499
Dull intelligence 6 | 645
Failure to gain weight 6 | 365
Fatty liver disease 6 | 103
Liver Cirrhosis, Experimental 6 | 769
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Muscle hypotonia 6 | 571
Pediatric failure to thrive 6 | 365
Poor school performance 6 | 645
Waldenstrons macroglobulinemia 6 | 765
aldosterone-producing adenoma 6 | 665
astrocytoma 6 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 510
fibroadenoma 6 | 559
pancreatic carcinoma 6 | 562
Bipolar Disorder 5 | 666
Cardiomyopathy 5 | 116
Hepatomegaly 5 | 285
Lipodystrophy 5 | 40
Melanoma 5 | 711
Seizures 5 | 596
gastric carcinoma 5 | 807
primary Sjogren syndrome 5 | 735
Cognitive delay 4 | 608
Down syndrome 4 | 499
Duchenne muscular dystrophy 4 | 601
Global developmental delay 4 | 608
Mental and motor retardation 4 | 608
Neuropathy 4 | 261
Parkinson's disease 4 | 392
Polycystic ovary syndrome 4 | 360
Type 2 diabetes mellitus 4 | 272
nephrosclerosis 4 | 333

Tissue

Digestive Tract 125 | 17,369
Female tissues 125 | 17,400
Skin and soft tissues 125 | 17,230
Blood and immune system 123 | 16,909
Endocrine System 123 | 18,159
Male tissues 122 | 17,142
Urinary Tract 121 | 16,678
Liver and Pancreas 120 | 16,750
Nervous System 119 | 16,725
Respiratory system 118 | 16,393
Cardiovascular System 115 | 15,192

Target Family

Enzyme 92 | 4,145
Non-IDG 23 | 12,091
Kinase 7 | 634
Transporter 5 | 473

Reactome Pathway

Glycerophospholipid biosynthes... 127 | 127
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ethanolaminephosphotransferase 1 SELENOI Tbio Enzyme -2.01142 98.3 12
Choline/ethanolaminephosphotransferase 1 CEPT1 Tbio Enzyme -1.65915 46.8 82
Phosphatidylcholine transfer protein PCTP Tbio Non-IDG -1.72354 56.3 156
Lipase member H LIPH Tbio Enzyme -1.36582 22.3 43
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha AGPAT1 Tbio Enzyme -1.04175 10.1 88
Ethanolamine kinase 2 ETNK2 Tdark Kinase -0.68956 4.93 132
Phospholipase DDHD2 DDHD2 Tbio Enzyme -1.23833 16.6 49
Group IID secretory phospholipase A2 PLA2G2D Tchem Enzyme -2.16892 139.3 119
Phospholipase DDHD1 DDHD1 Tbio Enzyme -1.23443 15.3 31
Phospholipase B1, membrane-associated PLB1 Tdark Enzyme -1.65839 46.0 43