Development Level

Tbio 56 | 10,625
Tchem 22 | 1,890
Tclin 1 | 602

Collection

Eligible Kinase Proteins 5 | 134

IMPC Term

preweaning lethality, incomple... 4 | 260
abnormal retinal pigmentation 2 | 61
decreased body weight 2 | 174
decreased neutrophil cell numb... 2 | 37
decreased total body fat amoun... 2 | 186
increased or absent threshold ... 2 | 128
abnormal embryo size 1 | 112
abnormal heart left ventricle ... 1 | 20
abnormal kidney morphology 1 | 30
abnormal lens morphology 1 | 73
abnormal vibrissa morphology 1 | 17
abnormal vocalization 1 | 21
cataract 1 | 26
decreased NK T cell number 1 | 28
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating glucose ... 1 | 121
decreased circulating glycerol... 1 | 19
decreased circulating serum al... 1 | 79
decreased lean body mass 1 | 195
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
female infertility 1 | 34
increased NK T cell number 1 | 11
increased circulating alkaline... 1 | 119
increased circulating calcium ... 1 | 32
increased circulating chloride... 1 | 43
increased circulating fructosa... 1 | 11
increased circulating serum al... 1 | 25
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 20
increased erythrocyte cell num... 1 | 26
increased exploration in new e... 1 | 56
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased lymphocyte cell numb... 1 | 9
increased marginal zone B cell... 1 | 3
increased neutrophil cell numb... 1 | 15
long tibia 1 | 13
male infertility 1 | 62
preweaning lethality, complete... 1 | 633
small kidney 1 | 10
small superior vagus ganglion 1 | 20
thick ventricular wall 1 | 7
thin ventricular wall 1 | 5

Disease

ovarian cancer 44 | 8,492
psoriasis 35 | 6,685
osteosarcoma 33 | 7,933
glioblastoma 32 | 5,572
lung cancer 25 | 4,473
medulloblastoma, large-cell 25 | 6,234
pancreatic ductal adenocarcinoma liver metastasis 23 | 1,795
Glycogen storage disease 20 | 37
malignant mesothelioma 20 | 3,163
invasive ductal carcinoma 19 | 2,950
atypical teratoid / rhabdoid tumor 17 | 4,369
ductal carcinoma in situ 17 | 1,745
pancreatic cancer 17 | 2,300
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,988
non-small cell lung cancer 16 | 2,798
Multiple myeloma 15 | 1,328
astrocytic glioma 15 | 2,241
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,289
lung adenocarcinoma 15 | 2,714
Cancer 14 | 2,346
subependymal giant cell astrocytoma 14 | 2,287
adrenocortical carcinoma 13 | 1,427
astrocytoma 13 | 1,493
breast carcinoma 13 | 1,614
lung carcinoma 13 | 2,844
primitive neuroectodermal tumor 13 | 3,031
oligodendroglioma 12 | 2,849
Waldenstrons macroglobulinemia 11 | 765
pilocytic astrocytoma 11 | 3,086
Breast cancer 10 | 3,099
Pick disease 10 | 1,893
colon cancer 10 | 1,475
pediatric high grade glioma 10 | 2,712
posterior fossa group A ependymoma 10 | 1,511
primary pancreatic ductal adenocarcinoma 10 | 1,271
Myocardial Ischemia 9 | 169
atypical teratoid/rhabdoid tumor 9 | 1,095
ependymoma 9 | 2,514
group 3 medulloblastoma 9 | 2,254
group 4 medulloblastoma 9 | 1,875
medulloblastoma 9 | 1,524
Obesity 8 | 616
acute quadriplegic myopathy 8 | 1,157
adult high grade glioma 8 | 2,148
diabetes mellitus 8 | 1,663
pituitary cancer 8 | 1,972
ulcerative colitis 8 | 2,087
Duchenne muscular dystrophy 7 | 602
Liver carcinoma 7 | 217
Myopathy 7 | 128
Rheumatoid Arthritis 7 | 1,171
dermatomyositis 7 | 967
fibroadenoma 7 | 557
Alzheimer's disease 6 | 644
Carcinoma 6 | 2,147
Congenital hemolytic anemia 6 | 31
Hypoglycemia 6 | 81
Animal Mammary Neoplasms 5 | 136
Diabetes Mellitus, Experimental 5 | 106
Mammary Neoplasms, Experimental 5 | 150
Neurodegenerative disease 5 | 383
Osteoporosis 5 | 259
Stomach Neoplasms 5 | 282
acute myeloid leukemia 5 | 785
esophageal adenocarcinoma 5 | 737
sonic hedgehog group medulloblastoma 5 | 1,482
tuberculosis 5 | 1,563
Lafora disease 4 | 9
Liver Cirrhosis, Experimental 4 | 108
Mouth Neoplasms 4 | 44
Myoglobinuria 4 | 11
Squamous cell carcinoma 4 | 96
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 499
cystic fibrosis 4 | 1,670
fructose-1,6-bisphosphatase deficiency 4 | 8
gastric carcinoma 4 | 832
juvenile dermatomyositis 4 | 1,189
nephrosclerosis 4 | 329
tuberculosis and treatment for 3 months 4 | 327
Anoxia 3 | 33
Atopic dermatitis 3 | 944
Bilirubin metabolic disorder 3 | 39
Degenerative polyarthritis 3 | 93
Down syndrome 3 | 548
Drug-Induced Liver Injury 3 | 118
Endometrial cancer 3 | 32
Epilepsy 3 | 346
Hemolytic anemia 3 | 70
Mammary Neoplasms 3 | 410
Neoplasm Invasiveness 3 | 127
Neuropathy 3 | 210
Parkinson's disease 3 | 364
Renal Cell Carcinoma 3 | 199
aldosterone-producing adenoma 3 | 664
hereditary spastic paraplegia 3 | 313
interstitial cystitis 3 | 2,299
mucosa-associated lymphoid tissue lymphoma 3 | 480
non-small cell lung carcinoma 3 | 413
progressive supranuclear palsy 3 | 674

Tissue

Blood and immune system 79 | 17,995
Cardiovascular System 79 | 17,958
Digestive Tract 79 | 18,473
Endocrine System 79 | 18,512
Female tissues 79 | 18,647
Liver and Pancreas 79 | 18,136
Male tissues 79 | 17,969
Nervous System 79 | 18,561
Urinary Tract 79 | 18,444
Respiratory system 78 | 17,484
Skin and soft tissues 78 | 18,115

Target Family

Enzyme 44 | 4,146
Kinase 24 | 634
Non-IDG 6 | 11,969
Transporter 5 | 473

Reactome Pathway

Glucose metabolism 79 | 79
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
ADP-dependent glucokinase ADPGK Tbio Kinase -0.76066 6.95 123
Glyceraldehyde-3-phosphate dehydrogenase GAPDH Tchem Enzyme -3.66772 4499.1 1649
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform PPP2R5D Tbio Enzyme -0.64445 3.33 246
Hexokinase-2 HK2 Tchem Kinase -2.60415 391.1 373
Polyubiquitin-C UBC Tbio Non-IDG -2.87696 56.7 130
Hexokinase-3 HK3 Tbio Kinase -1.70703 47.9 299
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform PHKG2 Tchem Kinase -0.90687 8.65 202
Polyubiquitin-B UBB Tbio Non-IDG -1.96206 92.3 370
Mitochondrial 2-oxoglutarate/malate carrier protein SLC25A11 Tbio Transporter -1.36706 24.8 148