Development Level

Tbio 20 | 11,445
Tchem 6 | 1,598
Tclin 5 | 613
Tdark 4 | 6,588

IMPC Phenotype

abnormal bone structure 6 | 187
increased heart weight 4 | 62
increased startle reflex 4 | 112
preweaning lethality, incomple... 4 | 499
decreased lean body mass 3 | 135
decreased body length 2 | 101
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
increased total body fat amoun... 2 | 134
abnormal behavioral response t... 1 | 66
abnormal sleep behavior 1 | 70
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased vertical activity 1 | 208
enlarged heart 1 | 210
enlarged spleen 1 | 41
impaired glucose tolerance 1 | 75
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small kidney 1 | 16
small superior vagus ganglion 1 | 74
thrombocytopenia 1 | 56

Disease

ovarian cancer 16 | 8,520
Carcinoma 15 | 11,493
osteosarcoma 14 | 7,950
ependymoma 13 | 4,679
glioblastoma 13 | 5,792
medulloblastoma, large-cell 13 | 6,241
Obesity 11 | 678
diabetes mellitus 10 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
Astrocytoma, Pilocytic 9 | 3,081
atypical teratoid / rhabdoid tumor 9 | 5,112
lung carcinoma 9 | 2,843
primitive neuroectodermal tumor 9 | 3,035
Cancer 8 | 2,499
adult high grade glioma 8 | 3,801
group 3 medulloblastoma 8 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
lung cancer 8 | 4,740
pituitary cancer 8 | 1,972
psoriasis 8 | 6,694
subependymal giant cell astrocytoma 8 | 2,287
Acromegaly 7 | 51
Adenoma 7 | 167
Breast cancer 7 | 3,578
Cushing's syndrome 7 | 48
invasive ductal carcinoma 7 | 2,951
non-small cell lung cancer 7 | 2,890
oligodendroglioma 7 | 2,850
pancreatic cancer 7 | 2,398
Hypoglycemia 6 | 152
Hypothyroidism 6 | 122
Multiple Endocrine Neoplasia Type 1 6 | 29
Pick disease 6 | 1,894
active Crohn's disease 6 | 922
astrocytic glioma 6 | 2,597
Hypertension 5 | 396
Hyperthyroidism 5 | 53
Kidney disease 5 | 430
Pituitary adenoma 5 | 38
Polycystic ovary syndrome 5 | 360
Pseudohypoparathyroidism 5 | 18
Schizophrenia 5 | 1,160
cystic fibrosis 5 | 1,696
ductal carcinoma in situ 5 | 1,745
interstitial cystitis 5 | 2,312
ACTH-secreting pituitary adenoma 4 | 9
Acrodysostosis 4 | 12
Adrenal gland cancer 4 | 12
Beckwith-Wiedemann syndrome 4 | 44
Biliary tract cancer 4 | 19
Bipolar Disorder 4 | 666
Bone cancer 4 | 16
Brachydactyly 4 | 156
Carney complex 4 | 25
Cervix carcinoma 4 | 10
Cushing syndrome due to macronodular adrenal hyperplasia 4 | 5
DOID:3297 4 | 4
Depressive disorder 4 | 409
Diarrhea 4 | 253
Fibrodysplasia ossificans progressiva 4 | 17
Fibrous dysplasia 4 | 15
Hyperglycemia 4 | 137
Hyperphosphatemia 4 | 32
Hypertensive disease 4 | 292
Hypoparathyroidism 4 | 41
Intellectual disability 4 | 1,016
Kidney cancer 4 | 2,613
Liver cancer 4 | 604
McCune Albright syndrome 4 | 19
Mccune-Albright Syndrome 4 | 4
Monostotic fibrous dysplasia 4 | 4
Ossifying fibroma 4 | 15
Pituitary Adenoma, Growth Hormone-Secreting, 1 4 | 5
Plummer's disease 4 | 11
Primary pigmented nodular adrenocortical disease 4 | 13
Progressive osseous heteroplasia 4 | 4
Pseudohypoparathyroidism type 1C 4 | 4
Pseudohypoparathyroidism, Type 1A 4 | 4
Pseudohypoparathyroidism, Type 1B 4 | 5
Pseudopseudohypoparathyroidism 4 | 6
Small intestine cancer 4 | 12
Stomach cancer 4 | 30
Substance Withdrawal Syndrome 4 | 55
Tachycardia 4 | 43
Thyroid cancer 4 | 36
breast carcinoma 4 | 1,638
group 4 medulloblastoma 4 | 1,855
lung adenocarcinoma 4 | 2,716
malignant mesothelioma 4 | 3,232
substance-related disorder 4 | 162
Asthma 3 | 385
Diabetes Mellitus, Non-Insulin-Dependent 3 | 145
Diabetes Mellitus, Type 2 3 | 142
Duchenne muscular dystrophy 3 | 601
Pancreatitis 3 | 123
astrocytoma 3 | 1,146
colon cancer 3 | 1,478
juvenile dermatomyositis 3 | 1,187
ulcerative colitis 3 | 1,819

Tissue

Endocrine System 32 | 18,159
Digestive Tract 31 | 17,369
Blood and immune system 30 | 16,909
Female tissues 29 | 17,400
Liver and Pancreas 28 | 16,750
Nervous System 28 | 16,725
Respiratory system 28 | 16,393
Skin and soft tissues 28 | 17,230
Urinary Tract 28 | 16,678
Cardiovascular System 27 | 15,192
Male tissues 26 | 17,142

Target Family

Non-IDG 26 | 12,091
GPCR 9 | 408

Reactome Pathway

Glucagon-type ligand receptors 35 | 35
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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