Development Level

Tbio 64 | 10,625
Tchem 10 | 1,890
Tdark 6 | 7,003
Tclin 4 | 602

IMPC Term

preweaning lethality, complete... 10 | 633
embryonic lethality prior to o... 8 | 148
embryonic lethality prior to t... 4 | 187
preweaning lethality, incomple... 3 | 260
abnormal behavior 2 | 226
abnormal embryo size 2 | 112
hypoactivity 2 | 89
increased body weight 2 | 42
increased heart weight 2 | 37
abnormal QRS complex 1 | 25
abnormal embryo turning 1 | 15
abnormal liver size 1 | 4
abnormal locomotor activation 1 | 26
abnormal pericardium morpholog... 1 | 11
abnormal pharyngeal arch morph... 1 | 2
abnormal retina morphology 1 | 100
abnormal retinal inner nuclear... 1 | 5
abnormal seminal vesicle morph... 1 | 47
abnormal vocalization 1 | 21
decreased body weight 1 | 174
decreased circulating serum al... 1 | 79
decreased grip strength 1 | 123
decreased hematocrit 1 | 25
decreased total retina thickne... 1 | 20
embryonic growth retardation 1 | 28
increased body length 1 | 20
increased circulating HDL chol... 1 | 63
increased circulating potassiu... 1 | 31
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 93
increased mean corpuscular hem... 1 | 25
increased mean corpuscular vol... 1 | 91
pale yolk sac 1 | 12
polydactyly 1 | 22
prenatal lethality prior to he... 1 | 64
straub tail 1 | 26

Disease

ovarian cancer 56 | 8,484
osteosarcoma 38 | 7,933
lung cancer 32 | 4,466
Cancer 29 | 2,346
medulloblastoma, large-cell 27 | 6,234
psoriasis 25 | 6,685
malignant mesothelioma 22 | 3,162
Xeroderma pigmentosum 20 | 41
glioblastoma 20 | 5,572
group 3 medulloblastoma 18 | 2,254
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,289
Cockayne syndrome 16 | 54
atypical teratoid / rhabdoid tumor 16 | 4,369
non-small cell lung cancer 14 | 2,798
primitive neuroectodermal tumor 14 | 3,031
Multiple myeloma 13 | 1,327
Waldenstrons macroglobulinemia 13 | 765
Breast cancer 12 | 3,094
Photosensitive trichothiodystrophy 12 | 24
ependymoma 11 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,988
oligodendroglioma 11 | 2,849
Pick disease 9 | 1,893
acute myeloid leukemia 9 | 780
pediatric high grade glioma 9 | 2,712
Carcinoma 8 | 2,147
Peripheral Neuropathy 8 | 303
adult high grade glioma 8 | 2,148
astrocytic glioma 8 | 2,241
atypical teratoid/rhabdoid tumor 8 | 1,095
diabetes mellitus 8 | 1,663
lung adenocarcinoma 8 | 2,713
astrocytoma 7 | 1,493
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,956
nasopharyngeal carcinoma 7 | 1,056
Alzheimer's disease 6 | 644
Stomach Neoplasms 6 | 282
invasive ductal carcinoma 6 | 2,950
pituitary cancer 6 | 1,972
sonic hedgehog group medulloblastoma 6 | 1,482
tuberculosis and treatment for 6 months 6 | 686
Intellectual disability 5 | 573
Rheumatoid Arthritis 5 | 1,160
dermatomyositis 5 | 933
pancreatic cancer 5 | 2,300
pilocytic astrocytoma 5 | 3,086
spina bifida 5 | 1,064
Arsenic Poisoning 4 | 59
Colorectal Neoplasms 4 | 217
Disease Progression 4 | 125
Malignant tumor of ovary 4 | 25
Micronuclei, Chromosome-Defective 4 | 19
Prostatic Neoplasms 4 | 471
Stevens-Johnson syndrome 4 | 78
acute quadriplegic myopathy 4 | 1,157
adrenocortical carcinoma 4 | 1,427
hepatocellular carcinoma 4 | 532
juvenile dermatomyositis 4 | 1,189
lung carcinoma 4 | 2,844
non primary Sjogren syndrome sicca 4 | 840
posterior fossa group B ependymoma 4 | 1,530
primary pancreatic ductal adenocarcinoma 4 | 1,271
subependymal giant cell astrocytoma 4 | 2,287
Animal Mammary Neoplasms 3 | 136
Bladder Neoplasm 3 | 109
CAMFAK syndrome 3 | 4
Cerebrooculofacioskeletal Syndrome 1 3 | 4
Fanconi's anemia 3 | 50
IGA Glomerulonephritis 3 | 454
Lung Neoplasms 3 | 171
Mammary Neoplasms, Experimental 3 | 150
Neurodegenerative disease 3 | 383
Pena Shokeir syndrome Type 2 3 | 4
Progeria 3 | 22
Trichothiodystrophy Syndromes 3 | 5
Uterine Cervical Neoplasm 3 | 21
colon cancer 3 | 1,475
ductal carcinoma in situ 3 | 1,745
gastric cancer 3 | 430
group 4 medulloblastoma 3 | 1,875
medulloblastoma 3 | 1,524
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,795
posterior fossa group A ependymoma 3 | 1,511
progressive supranuclear palsy 3 | 674
Brain Ischemia 2 | 87
Cataract 2 | 104
Cerebrovascular disease 2 | 231
Chronic Lymphocytic Leukemia 2 | 242
Colonic Neoplasms 2 | 126
Craniofacial Abnormalities 2 | 147
Dermatologic disorders 2 | 65
Down syndrome 2 | 548
Endometriosis 2 | 535
Liver carcinoma 2 | 217
Neoplasm Metastasis 2 | 138
cystic fibrosis and chronic rhinosinusitis 2 | 213
glioblastoma multiforme 2 | 347
hereditary spastic paraplegia 2 | 313
pancreatic carcinoma 2 | 567
tuberculosis 2 | 1,557

Tissue

Blood and immune system 84 | 17,995
Cardiovascular System 84 | 17,958
Digestive Tract 84 | 18,473
Endocrine System 84 | 18,512
Female tissues 84 | 18,647
Liver and Pancreas 84 | 18,136
Male tissues 84 | 17,969
Nervous System 84 | 18,561
Respiratory system 84 | 17,484
Skin and soft tissues 84 | 18,115
Urinary Tract 84 | 18,444

Target Family

Non-IDG 57 | 11,971
Enzyme 23 | 4,146
Transcription Factor 3 | 1,400
Kinase 1 | 634

Reactome Pathway

Global Genome Nucleotide Excis... 84 | 84
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.76828 59.7 468
Replication factor C subunit 3 RFC3 Tbio Non-IDG -1.28299 19.5 161
Replication factor C subunit 5 RFC5 Tbio Non-IDG -1.02728 11.1 64
Transcriptional repressor protein YY1 YY1 Tbio Transcription Factor -2.75991 594.0 437
General transcription factor IIH subunit 3 GTF2H3 Tbio Non-IDG -0.79392 6.02 65
General transcription factor IIH subunit 2 GTF2H2 Tbio Non-IDG -0.87357 6.84 120
Small ubiquitin-related modifier 1 SUMO1 Tbio Non-IDG -2.69547 474.2 685
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
Replication factor C subunit 2 RFC2 Tbio Non-IDG -1.34287 19.7 194