Development Level

Tbio 595 | 11,651
Tdark 314 | 6,593
Tchem 151 | 1,388
Tclin 48 | 612

Collection

Kinase: IDG Consortium (Target... 5 | 125
RFA-RM-18-021 5 | 328
Kinase: IDG Consortium (Comple... 3 | 37

IMPC Phenotype

preweaning lethality, complete... 83 | 979
preweaning lethality, incomple... 35 | 499
embryonic lethality prior to t... 27 | 278
embryonic lethality prior to o... 26 | 239
abnormal embryo size 21 | 220
abnormal behavior 18 | 298
enlarged heart 16 | 210
abnormal heart morphology 15 | 162
decreased vertical activity 15 | 208
increased bone mineral content 11 | 108
abnormal bone structure 10 | 187
increased lean body mass 10 | 172
decreased mean corpuscular vol... 9 | 79
decreased total body fat amoun... 9 | 207
increased startle reflex 9 | 112
decreased bone mineral content 8 | 151
decreased lean body mass 8 | 135
embryonic growth retardation 8 | 106
hyperactivity 8 | 148
increased mean corpuscular hem... 8 | 96
male infertility 8 | 123
abnormal seminal vesicle morph... 7 | 114
decreased body weight 7 | 161
decreased bone mineral density 7 | 126
decreased circulating glucose ... 7 | 126
hypoactivity 7 | 132
increased mean corpuscular vol... 7 | 92
increased total body fat amoun... 7 | 134
prenatal lethality prior to he... 7 | 87
small testis 7 | 58
abnormal embryo turning 6 | 31
cataract 6 | 92
decreased circulating choleste... 6 | 93
decreased leukocyte cell numbe... 6 | 73
decreased prepulse inhibition 6 | 82
increased monocyte cell number 6 | 63
increased neutrophil cell numb... 6 | 46
abnormal eye morphology 5 | 68
abnormal lens morphology 5 | 81
abnormal lung morphology 5 | 26
abnormal neural tube closure 5 | 46
abnormal testis morphology 5 | 43
abnormal tooth morphology 5 | 24
decreased caudal vertebrae num... 5 | 53
decreased circulating LDL chol... 5 | 38
decreased circulating alkaline... 5 | 46
decreased lymphocyte cell numb... 5 | 83
decreased startle reflex 5 | 75
edema 5 | 59
enlarged spleen 5 | 41
increased bone mineral density 5 | 72
increased circulating HDL chol... 5 | 80
increased circulating alkaline... 5 | 122
increased circulating choleste... 5 | 66
increased circulating sodium l... 5 | 71
increased circulating triglyce... 5 | 42
increased hemoglobin content 5 | 45
increased or absent threshold ... 5 | 101
pallor 5 | 34
abnormal bone mineralization 4 | 38
abnormal gait 4 | 69
abnormal placenta size 4 | 20
abnormal retina morphology 4 | 71
abnormal retinal blood vessel ... 4 | 26
abnormal retinal vasculature m... 4 | 27
abnormal spleen morphology 4 | 55
corneal opacity 4 | 32
decreased body length 4 | 101
decreased circulating HDL chol... 4 | 68
decreased circulating insulin ... 4 | 76
decreased circulating serum al... 4 | 82
decreased erythrocyte cell num... 4 | 62
decreased fasted circulating g... 4 | 65
decreased neutrophil cell numb... 4 | 42
enlarged lymph nodes 4 | 37
female infertility 4 | 60
impaired glucose tolerance 4 | 75
increased circulating LDL chol... 4 | 13
increased circulating creatini... 4 | 38
increased heart weight 4 | 62
increased mean platelet volume 4 | 45
pale yolk sac 4 | 25
short tibia 4 | 97
small superior vagus ganglion 4 | 74
tremors 4 | 39
abnormal craniofacial morpholo... 3 | 33
abnormal epididymis morphology 3 | 42
abnormal kidney morphology 3 | 65
abnormal skin coloration 3 | 25
abnormal skin morphology 3 | 50
abnormal vertebrae morphology 3 | 18
anophthalmia 3 | 33
decreased T cell number 3 | 15
decreased blood urea nitrogen ... 3 | 51
decreased hemoglobin content 3 | 68
improved glucose tolerance 3 | 79
increased circulating phosphat... 3 | 26
increased fasted circulating g... 3 | 76
microphthalmia 3 | 26
persistence of hyaloid vascula... 3 | 33

Disease

Carcinoma 759 | 11,493
ovarian cancer 575 | 8,520
osteosarcoma 552 | 7,950
psoriasis 395 | 6,694
glioblastoma 371 | 5,792
lung cancer 368 | 4,740
medulloblastoma, large-cell 366 | 6,241
Cancer 348 | 2,499
atypical teratoid / rhabdoid tumor 315 | 5,112
group 3 medulloblastoma 306 | 4,104
Breast cancer 275 | 3,578
ependymoma 250 | 4,679
malignant mesothelioma 229 | 3,232
primitive neuroectodermal tumor 222 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 200 | 3,291
adult high grade glioma 197 | 3,801
Kidney cancer 193 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 175 | 2,989
oligodendroglioma 172 | 2,850
invasive ductal carcinoma 169 | 2,951
non-small cell lung cancer 169 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 156 | 2,955
group 4 medulloblastoma 152 | 1,855
pancreatic cancer 152 | 2,398
astrocytic glioma 150 | 2,597
tuberculosis 145 | 2,010
Astrocytoma, Pilocytic 139 | 3,081
lung adenocarcinoma 138 | 2,716
lung carcinoma 126 | 2,843
Pick disease 124 | 1,894
interstitial cystitis 119 | 2,312
diabetes mellitus 118 | 1,728
subependymal giant cell astrocytoma 118 | 2,287
Multiple myeloma 115 | 1,332
pituitary cancer 115 | 1,972
ductal carcinoma in situ 111 | 1,745
adrenocortical carcinoma 108 | 1,428
colon cancer 107 | 1,478
pancreatic ductal adenocarcinoma liver metastasis 107 | 1,962
breast carcinoma 101 | 1,638
Rheumatoid arthritis 99 | 1,191
ulcerative colitis 96 | 1,819
Intellectual disability 86 | 1,016
Schizophrenia 86 | 1,160
astrocytoma 86 | 1,146
acute quadriplegic myopathy 85 | 1,158
Breast Neoplasms 84 | 445
juvenile dermatomyositis 82 | 1,187
Autosomal recessive predisposition 79 | 1,442
Mammary Neoplasms 79 | 425
cystic fibrosis 79 | 1,696
spina bifida 76 | 1,074
pediatric high grade glioma 73 | 1,064
primary pancreatic ductal adenocarcinoma 73 | 1,109
dermatomyositis 71 | 966
Waldenstrons macroglobulinemia 69 | 765
acute myeloid leukemia 69 | 783
nasopharyngeal carcinoma 69 | 1,058
Short stature 68 | 531
cutaneous lupus erythematosus 67 | 1,057
Dull intelligence 63 | 645
Low intelligence 63 | 645
Mental Retardation 63 | 645
Mental deficiency 63 | 645
Poor school performance 63 | 645
non primary Sjogren syndrome sicca 61 | 891
Endometriosis 60 | 540
Stomach Neoplasms 59 | 300
Epilepsy 57 | 792
Obesity 56 | 678
Prostatic Neoplasms 55 | 495
Atopic dermatitis 54 | 952
medulloblastoma 54 | 720
Cognitive delay 53 | 608
Global developmental delay 53 | 608
Mental and motor retardation 53 | 608
Seizures 53 | 596
gastric cancer 53 | 459
gastric carcinoma 50 | 807
hepatocellular carcinoma 50 | 547
Carcinoma, Hepatocellular 49 | 228
esophageal adenocarcinoma 49 | 737
Liver carcinoma 48 | 240
Alzheimer's disease 47 | 658
Bipolar Disorder 47 | 666
Lung Neoplasms 47 | 232
Melanoma 47 | 711
Muscle hypotonia 47 | 571
pancreatic carcinoma 47 | 562
Kidney disease 46 | 430
Small head 42 | 374
Cryptorchidism 41 | 296
Liver cancer 41 | 604
active Crohn's disease 41 | 922
Amyotrophic lateral sclerosis 40 | 451
primary Sjogren syndrome 40 | 735
progressive supranuclear palsy 40 | 676
Strabismus 39 | 270
Vascular disease 39 | 319
tuberculosis and treatment for 6 months 39 | 409

Tissue

Endocrine System 1,085 | 18,159
Female tissues 1,071 | 17,400
Male tissues 1,069 | 17,142
Digestive Tract 1,067 | 17,369
Skin and soft tissues 1,067 | 17,230
Blood and immune system 1,065 | 16,909
Nervous System 1,060 | 16,725
Urinary Tract 1,059 | 16,678
Liver and Pancreas 1,057 | 16,750
Respiratory system 1,053 | 16,393
Cardiovascular System 1,040 | 15,192

Target Family

Transcription Factor 413 | 1,400
Non-IDG 351 | 12,091
Enzyme 178 | 4,145
Kinase 58 | 634
Epigenetic 53 | 242
Nuclear Receptor 47 | 48
TF/Epigenetic 6 | 38
Transporter 2 | 473

Reactome Pathway

Generic Transcription Pathway 1,108 | 1,108
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Transcription factor HES-1 HES1 Tbio Transcription Factor -1.77409 55.5 444
ETS-related transcription factor Elf-2 ELF2 Tbio Transcription Factor -2.04794 106.4 92
Zinc finger protein 561 ZNF561 Tdark Transcription Factor 0.00000 36
Thrombospondin-1 THBS1 Tbio Non-IDG -3.06622 1281.6 504
General transcription factor IIH subunit 1 GTF2H1 Tbio Non-IDG -1.65323 46.0 231
Chromobox protein homolog 3 CBX3 Tbio Epigenetic -2.00023 90.5 366
Zinc finger protein 154 ZNF154 Tdark Transcription Factor -0.59081 4.13 76
Zinc finger protein 678 ZNF678 Tdark Transcription Factor 0.00000 70
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform PPP2R1B Tbio Enzyme -1.20793 16.9 203