Development Level

Tbio 374 | 10,625
Tdark 308 | 7,003
Tchem 141 | 1,890
Tclin 29 | 602

Collection

Eligible Kinase Proteins 6 | 134

IMPC Term

preweaning lethality, complete... 37 | 633
embryonic lethality prior to t... 16 | 187
preweaning lethality, incomple... 14 | 260
embryonic lethality prior to o... 13 | 148
abnormal behavior 11 | 226
abnormal embryo size 8 | 112
decreased lean body mass 8 | 195
enlarged heart 7 | 111
decreased body length 6 | 108
decreased total body fat amoun... 6 | 186
abnormal bone structure 5 | 131
abnormal lens morphology 5 | 73
decreased body weight 5 | 174
decreased circulating serum al... 5 | 79
hypoactivity 5 | 89
increased mean corpuscular hem... 5 | 93
increased or absent threshold ... 5 | 128
abnormal retina morphology 4 | 100
abnormal tooth morphology 4 | 24
cataract 4 | 26
decreased circulating LDL chol... 4 | 37
decreased circulating choleste... 4 | 85
decreased circulating glucose ... 4 | 121
decreased fasted circulating g... 4 | 49
decreased grip strength 4 | 123
decreased hemoglobin content 4 | 53
decreased startle reflex 4 | 48
increased circulating HDL chol... 4 | 63
increased circulating LDL chol... 4 | 15
increased circulating alkaline... 4 | 119
increased circulating choleste... 4 | 53
increased circulating sodium l... 4 | 71
increased circulating triglyce... 4 | 24
increased exploration in new e... 4 | 56
increased grip strength 4 | 83
increased mean corpuscular vol... 4 | 91
prenatal lethality prior to he... 4 | 64
abnormal heart morphology 3 | 51
abnormal skin coloration 3 | 18
corneal opacity 3 | 25
decreased Ly6C low monocyte nu... 3 | 23
decreased bone mineral content 3 | 157
decreased caudal vertebrae num... 3 | 49
decreased circulating HDL chol... 3 | 77
decreased mean corpuscular vol... 3 | 50
enlarged spleen 3 | 26
hyperactivity 3 | 108
increased heart weight 3 | 37
increased hemoglobin content 3 | 45
pallor 3 | 13
short tibia 3 | 82
small testis 3 | 37
abnormal bone mineralization 2 | 55
abnormal embryo turning 2 | 15
abnormal epididymis morphology 2 | 31
abnormal eye morphology 2 | 38
abnormal hindbrain development 2 | 24
abnormal limb bud morphology 2 | 15
abnormal locomotor activation 2 | 26
abnormal maxilla morphology 2 | 16
abnormal midbrain development 2 | 22
abnormal neural tube closure 2 | 37
abnormal placenta morphology 2 | 4
abnormal placenta size 2 | 10
abnormal respiratory quotient 2 | 9
abnormal skin morphology 2 | 23
abnormal spleen morphology 2 | 36
decreased CD4-positive, CD25-p... 2 | 24
decreased T cell number 2 | 31
decreased anxiety-related resp... 2 | 12
decreased blood urea nitrogen ... 2 | 31
decreased bone mineral density 2 | 126
decreased circulating alkaline... 2 | 41
decreased circulating calcium ... 2 | 33
decreased circulating sodium l... 2 | 18
decreased circulating triglyce... 2 | 83
decreased eosinophil cell numb... 2 | 41
decreased prepulse inhibition 2 | 52
decreased rib number 2 | 59
decreased total retina thickne... 2 | 20
embryonic growth retardation 2 | 28
enlarged epididymis 2 | 27
impaired glucose tolerance 2 | 52
increased Ly6C high monocyte n... 2 | 12
increased bone mineral content 2 | 92
increased bone mineral density 2 | 52
increased circulating bilirubi... 2 | 16
increased circulating creatini... 2 | 29
increased circulating free fat... 2 | 17
increased fasted circulating g... 2 | 68
increased lean body mass 2 | 107
increased leukocyte cell numbe... 2 | 37
increased mean platelet volume 2 | 19
irregularly shaped pupil 2 | 7
male infertility 2 | 62
pale liver 2 | 5
pale yolk sac 2 | 12
persistence of hyaloid vascula... 2 | 22
prenatal lethality 2 | 16
tremors 2 | 34

Disease

osteosarcoma 423 | 7,933
ovarian cancer 415 | 8,484
medulloblastoma, large-cell 282 | 6,234
psoriasis 274 | 6,685
glioblastoma 256 | 5,572
lung cancer 254 | 4,466
Cancer 221 | 2,346
atypical teratoid / rhabdoid tumor 191 | 4,369
primitive neuroectodermal tumor 171 | 3,031
malignant mesothelioma 162 | 3,162
Breast cancer 160 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 148 | 3,289
group 3 medulloblastoma 139 | 2,254
group 4 medulloblastoma 129 | 1,875
intraductal papillary-mucinous carcinoma (IPMC) 120 | 2,988
oligodendroglioma 119 | 2,849
ependymoma 116 | 2,514
pediatric high grade glioma 113 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 109 | 2,956
non-small cell lung cancer 109 | 2,798
Carcinoma 108 | 2,147
invasive ductal carcinoma 107 | 2,950
astrocytic glioma 98 | 2,241
pancreatic cancer 98 | 2,300
Pick disease 92 | 1,893
pilocytic astrocytoma 92 | 3,086
lung carcinoma 89 | 2,844
adult high grade glioma 88 | 2,148
adrenocortical carcinoma 87 | 1,427
pituitary cancer 87 | 1,972
lung adenocarcinoma 84 | 2,713
tuberculosis 82 | 1,557
subependymal giant cell astrocytoma 81 | 2,287
diabetes mellitus 76 | 1,663
medulloblastoma 76 | 1,524
ulcerative colitis 75 | 2,087
interstitial cystitis 74 | 2,299
colon cancer 73 | 1,475
ductal carcinoma in situ 73 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 72 | 1,795
astrocytoma 68 | 1,493
Multiple myeloma 65 | 1,327
acute quadriplegic myopathy 62 | 1,157
Rheumatoid Arthritis 61 | 1,160
sonic hedgehog group medulloblastoma 61 | 1,482
atypical teratoid/rhabdoid tumor 59 | 1,095
primary pancreatic ductal adenocarcinoma 58 | 1,271
juvenile dermatomyositis 56 | 1,189
spina bifida 56 | 1,064
breast carcinoma 55 | 1,614
Mammary Neoplasms 54 | 410
acute myeloid leukemia 52 | 780
posterior fossa group A ependymoma 52 | 1,511
Endometriosis 51 | 535
non primary Sjogren syndrome sicca 49 | 840
Waldenstrons macroglobulinemia 46 | 765
cystic fibrosis 46 | 1,665
nasopharyngeal carcinoma 45 | 1,056
tuberculosis and treatment for 6 months 45 | 686
gastric cancer 43 | 430
posterior fossa group B ependymoma 41 | 1,530
Prostatic Neoplasms 40 | 471
cutaneous lupus erythematosus 40 | 1,056
dermatomyositis 39 | 933
Obesity 37 | 616
pancreatic carcinoma 36 | 567
Stomach Neoplasms 35 | 282
Atopic dermatitis 34 | 944
Intellectual disability 34 | 573
Alzheimer's disease 33 | 644
hepatocellular carcinoma 32 | 532
active Crohn's disease 31 | 918
esophageal adenocarcinoma 30 | 737
gastric carcinoma 30 | 832
Amyotrophic Lateral Sclerosis 29 | 431
Liver carcinoma 29 | 217
Lung Neoplasms 29 | 171
Kidney disease 27 | 396
progressive supranuclear palsy 27 | 674
Peripheral Neuropathy 26 | 303
aldosterone-producing adenoma 26 | 664
Adenoma 24 | 165
Colorectal Neoplasms 23 | 217
Heart disease 23 | 279
Schizophrenia 23 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 23 | 499
IGA Glomerulonephritis 21 | 454
Melanoma 21 | 261
Neurodegenerative disease 21 | 383
Polycystic Ovary Syndrome 21 | 332
inflammatory breast cancer 21 | 404
Adenocarcinoma 20 | 115
Neoplastic Syndromes, Hereditary 20 | 48
Parkinson's disease 20 | 364
Asthma 19 | 349
Vascular disease 19 | 281
ovarian neoplasm 19 | 97
primary Sjogren syndrome 19 | 789
Down syndrome 18 | 548
Duchenne muscular dystrophy 18 | 602

Tissue

Nervous System 843 | 18,561
Female tissues 840 | 18,647
Urinary Tract 840 | 18,444
Digestive Tract 839 | 18,473
Endocrine System 839 | 18,512
Blood and immune system 838 | 17,995
Liver and Pancreas 838 | 18,136
Male tissues 838 | 17,969
Cardiovascular System 836 | 17,958
Respiratory system 831 | 17,484
Skin and soft tissues 825 | 18,115

Target Family

Transcription Factor 360 | 1,400
Non-IDG 243 | 11,971
Enzyme 119 | 4,146
Kinase 47 | 634
Nuclear Receptor 47 | 48
Epigenetic 32 | 242
TF/Epigenetic 3 | 38
Transporter 1 | 473

Reactome Pathway

Generic Transcription Pathway 852 | 852
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Zinc finger protein 485 ZNF485 Tdark Transcription Factor 0.00000 48
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
Cyclin-dependent kinase 8 CDK8 Tchem Kinase -1.96301 102.7 307
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.76828 59.7 468
Protein KRBA1 KRBA1 Tdark Non-IDG 0.78 0.17 7
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062