Development Level

Tbio 31 | 11,651
Tchem 8 | 1,388
Tclin 5 | 612
Tdark 4 | 6,593

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal skin morphology 1 | 50
anophthalmia 1 | 33
cataract 1 | 92
decreased bone mineral content 1 | 151
decreased circulating iron lev... 1 | 32
decreased neutrophil cell numb... 1 | 42
decreased startle reflex 1 | 75
enlarged heart 1 | 210
increased blood urea nitrogen ... 1 | 48
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
preweaning lethality, complete... 1 | 979

Disease

Rheumatoid arthritis 22 | 1,191
lung carcinoma 19 | 2,843
Narcolepsy 17 | 72
lung cancer 17 | 4,740
sarcoidosis 17 | 370
osteosarcoma 16 | 7,950
psoriasis 16 | 6,694
Berylliosis 15 | 28
Carcinoma 14 | 11,493
Multiple Sclerosis, Susceptibility to 14 | 15
Narcolepsy-cataplexy 14 | 21
Systemic lupus erythematosus 14 | 194
diabetes mellitus 14 | 1,728
Diffuse cutaneous systemic sclerosis 13 | 17
Rheumatoid Arthritis, Systemic Juvenile 13 | 16
Sarcoidosis 1 13 | 14
follicular lymphoma 13 | 20
glioblastoma 13 | 5,792
invasive ductal carcinoma 13 | 2,951
limited scleroderma 13 | 19
ovarian cancer 13 | 8,520
cutaneous lupus erythematosus 12 | 1,057
interstitial cystitis 12 | 2,312
breast carcinoma 10 | 1,638
Hypersensitivity reaction type II disease 9 | 253
Multiple Sclerosis 9 | 540
adult high grade glioma 9 | 3,801
non-small cell lung cancer 9 | 2,890
primary Sjogren syndrome 9 | 735
Astrocytoma, Pilocytic 8 | 3,081
Autosomal recessive predisposition 8 | 1,442
Cancer 8 | 2,499
Juvenile rheumatoid arthritis 8 | 111
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
medulloblastoma, large-cell 8 | 6,241
Autoimmune Diseases 7 | 67
Immunologic Deficiency Syndromes 7 | 113
Proteinuria 7 | 144
ependymoma 7 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
subependymal giant cell astrocytoma 7 | 2,287
ulcerative colitis 7 | 1,819
Recurrent respiratory infections 6 | 141
Type 1 diabetes mellitus 6 | 109
astrocytoma 6 | 1,146
pancreatic cancer 6 | 2,398
tuberculosis 6 | 2,010
Asthma 5 | 385
Celiac disease 5 | 116
Eczema 5 | 45
Hepatitis B 5 | 108
Hypersensitivity 5 | 63
Schizophrenia 5 | 1,160
Waldenstrons macroglobulinemia 5 | 765
active Crohn's disease 5 | 922
atypical teratoid / rhabdoid tumor 5 | 5,112
cystic fibrosis 5 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
juvenile dermatomyositis 5 | 1,187
Addison's disease 4 | 31
Arthritis, Rheumatoid 4 | 174
Atopic dermatitis 4 | 952
Autoimmune thyroiditis 4 | 27
Breast cancer 4 | 3,578
Duchenne muscular dystrophy 4 | 601
ESR raised 4 | 20
Failure to gain weight 4 | 365
Graves' disease 4 | 24
Infantile onset 4 | 238
Liver disease 4 | 237
Lymphopenia 4 | 67
Pediatric failure to thrive 4 | 365
Recurrent infections 4 | 48
Renal Cell Carcinoma 4 | 214
Severe combined immunodeficiency 4 | 51
Vasculitis 4 | 80
ductal carcinoma in situ 4 | 1,745
group 3 medulloblastoma 4 | 4,104
malignant mesothelioma 4 | 3,232
oligodendroglioma 4 | 2,850
Bipolar Disorder 3 | 666
Collagen disease 3 | 27
Diarrhea 3 | 253
Fever 3 | 138
Highly variable severity 3 | 157
Kidney cancer 3 | 2,613
Lymphoma 3 | 81
Pick disease 3 | 1,894
Thrombocytopenia 3 | 197
Urticaria 3 | 67
Variable expressivity 3 | 157
Weight decreased 3 | 103
active ulcerative colitis 3 | 764
adrenocortical carcinoma 3 | 1,428
astrocytic glioma 3 | 2,597
esophageal adenocarcinoma 3 | 737
head and neck cancer and chronic obstructive pulmonary disease 3 | 239
pancreatic carcinoma 3 | 562
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pediatric high grade glioma 3 | 1,064

Tissue

Blood and immune system 28 | 16,909
Liver and Pancreas 28 | 16,750
Respiratory system 28 | 16,393
Skin and soft tissues 28 | 17,230
Digestive Tract 27 | 17,369
Endocrine System 27 | 18,159
Female tissues 27 | 17,400
Male tissues 27 | 17,142
Urinary Tract 27 | 16,678
Cardiovascular System 26 | 15,192
Nervous System 25 | 16,725

Target Family

Non-IDG 41 | 12,091
Kinase 6 | 634
Enzyme 1 | 4,145

Reactome Pathway

Generation of second messenger... 48 | 48
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein kinase ZAP-70 ZAP70 Tchem Kinase -2.91589 798.2 1515
T-cell surface glycoprotein CD3 zeta chain CD247 Tbio Non-IDG -2.61157 386.3 882
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Cytoplasmic protein NCK1 NCK1 Tbio Non-IDG -2.25032 186.5 398
T-cell receptor alpha chain V region CTL-L17 TCRA Tdark Non-IDG 0.00000 0
Ena/VASP-like protein EVL Tbio Non-IDG -2.21334 170.1 137
HLA class II histocompatibility antigen, DP beta 1 chain HLA-DPB1 Tbio Non-IDG -2.69219 594.4 321
Wiskott-Aldrich syndrome protein WAS Tbio Non-IDG -3.10496 1242.1 320
T-cell receptor alpha chain C region TRAC Tbio Non-IDG 0.00000 0
Vasodilator-stimulated phosphoprotein VASP Tbio Non-IDG -2.98534 952.6 796