Development Level

Tbio 31 | 10,625
Tchem 10 | 1,890
Tclin 5 | 602
Tdark 4 | 7,003

Collection

Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

abnormal bone structure 1 | 131
decreased bone mineral content 1 | 157
decreased circulating iron lev... 1 | 25
decreased grip strength 1 | 123
decreased lean body mass 1 | 195
decreased startle reflex 1 | 48
increased blood urea nitrogen ... 1 | 44
increased circulating iron lev... 1 | 25
increased fasted circulating g... 1 | 68
increased respiratory quotient 1 | 12

Disease

Rheumatoid Arthritis 23 | 1,170
lung carcinoma 21 | 2,844
osteosarcoma 18 | 7,933
sarcoidosis 18 | 368
Narcolepsy 17 | 69
lung cancer 17 | 4,473
psoriasis 16 | 6,685
Berylliosis 15 | 28
systemic lupus erythematosus 15 | 172
Multiple Sclerosis, Susceptibility to 14 | 15
Narcolepsy-cataplexy 14 | 21
diabetes mellitus 14 | 1,663
invasive ductal carcinoma 14 | 2,950
ovarian cancer 14 | 8,491
Diffuse cutaneous systemic sclerosis 13 | 17
Rheumatoid Arthritis, Systemic Juvenile 13 | 16
Sarcoidosis 1 13 | 14
cutaneous lupus erythematosus 13 | 1,056
follicular lymphoma 13 | 17
glioblastoma 13 | 5,572
interstitial cystitis 13 | 2,299
limited scleroderma 13 | 19
breast carcinoma 11 | 1,614
primary Sjogren syndrome 11 | 788
medulloblastoma, large-cell 9 | 6,234
non-small cell lung cancer 9 | 2,798
pilocytic astrocytoma 9 | 3,086
Hypersensitivity reaction type II disease 8 | 235
Multiple Sclerosis 8 | 498
adult high grade glioma 8 | 2,148
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,988
subependymal giant cell astrocytoma 8 | 2,287
ulcerative colitis 8 | 2,087
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,289
tuberculosis 7 | 1,563
Asthma 6 | 349
Juvenile rheumatoid arthritis 6 | 105
Type 1 diabetes mellitus 6 | 104
astrocytoma 6 | 1,493
pancreatic cancer 6 | 2,300
pediatric high grade glioma 6 | 2,712
Breast cancer 5 | 3,098
Cancer 5 | 2,346
Celiac disease 5 | 112
Hypersensitivity 5 | 63
IGA Glomerulonephritis 5 | 454
Proteinuria 5 | 63
Systemic scleroderma 5 | 66
Waldenstrons macroglobulinemia 5 | 764
active Crohn's disease 5 | 918
cystic fibrosis 5 | 1,670
dermatomyositis 5 | 966
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,956
juvenile dermatomyositis 5 | 1,189
Addison's disease 4 | 29
Atopic dermatitis 4 | 944
Autoimmune thyroiditis 4 | 24
Carcinoma 4 | 2,147
Diabetes Mellitus, Insulin-Dependent 4 | 77
Duchenne muscular dystrophy 4 | 602
Graves' disease 4 | 25
Hepatitis B, Chronic 4 | 15
Liver disease 4 | 219
Renal Cell Carcinoma 4 | 199
Severe Combined Immunodeficiency 4 | 46
atypical teratoid / rhabdoid tumor 4 | 4,369
chronic lymphocytic leukemia 4 | 244
ductal carcinoma in situ 4 | 1,745
head and neck cancer and chronic obstructive pulmonary disease 4 | 237
malignant mesothelioma 4 | 3,163
oligodendroglioma 4 | 2,849
posterior fossa group A ependymoma 4 | 1,511
primary pancreatic ductal adenocarcinoma 4 | 1,271
Angioedema 3 | 36
Leprosy 3 | 77
Lupus Erythematosus, Systemic 3 | 73
Pick disease 3 | 1,893
Polymyalgia rheumatica 3 | 10
Pre B-cell acute lymphoblastic leukemia 3 | 4
Psoriatic arthritis 3 | 85
Renal transplant rejection 3 | 13
Urticaria 3 | 53
Vasculitis 3 | 64
active ulcerative colitis 3 | 477
adrenocortical carcinoma 3 | 1,427
astrocytic glioma 3 | 2,241
ependymoma 3 | 2,514
esophageal adenocarcinoma 3 | 737
group 4 medulloblastoma 3 | 1,875
limb girdle muscular dystrophy 2I 3 | 56
membranous glomerulonephritis 3 | 12
pancreatic carcinoma 3 | 567
primitive neuroectodermal tumor 3 | 3,031
Down syndrome 2 | 548
colon cancer 2 | 1,475
lung adenocarcinoma 2 | 2,714
medulloblastoma 2 | 1,524
mucosa-associated lymphoid tissue lymphoma 2 | 480
nephrosclerosis 2 | 329
pituitary cancer 2 | 1,972

Tissue

Blood and immune system 35 | 17,994
Digestive Tract 35 | 18,472
Endocrine System 35 | 18,511
Female tissues 35 | 18,646
Liver and Pancreas 35 | 18,135
Male tissues 35 | 17,968
Nervous System 35 | 18,560
Respiratory system 35 | 17,483
Urinary Tract 35 | 18,443
Cardiovascular System 34 | 17,957
Skin and soft tissues 30 | 18,114

Target Family

Non-IDG 43 | 11,969
Kinase 6 | 634
Enzyme 1 | 4,146

Reactome Pathway

Generation of second messenger... 50 | 50
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

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