Development Level

Tbio 31 | 10,625
Tchem 10 | 1,890
Tclin 5 | 602
Tdark 4 | 7,003

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

abnormal bone structure 1 | 131
decreased bone mineral content 1 | 157
decreased circulating iron lev... 1 | 25
decreased grip strength 1 | 123
decreased lean body mass 1 | 195
decreased startle reflex 1 | 48
increased blood urea nitrogen ... 1 | 44
increased circulating iron lev... 1 | 25
increased fasted circulating g... 1 | 68
increased respiratory quotient 1 | 12

Disease

lung carcinoma 21 | 2,844
osteosarcoma 18 | 7,933
lung cancer 17 | 4,466
psoriasis 16 | 6,685
diabetes mellitus 14 | 1,663
invasive ductal carcinoma 14 | 2,950
ovarian cancer 14 | 8,484
Rheumatoid Arthritis 13 | 1,160
cutaneous lupus erythematosus 13 | 1,056
glioblastoma 13 | 5,572
interstitial cystitis 13 | 2,299
breast carcinoma 11 | 1,614
primary Sjogren syndrome 11 | 789
medulloblastoma, large-cell 9 | 6,234
non-small cell lung cancer 9 | 2,798
pilocytic astrocytoma 9 | 3,086
Hypersensitivity reaction type II disease 8 | 235
Multiple Sclerosis 8 | 498
adult high grade glioma 8 | 2,148
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,988
sarcoidosis 8 | 358
subependymal giant cell astrocytoma 8 | 2,287
ulcerative colitis 8 | 2,087
Narcolepsy 7 | 58
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,289
tuberculosis 7 | 1,557
Asthma 6 | 349
Juvenile rheumatoid arthritis 6 | 104
Type 1 diabetes mellitus 6 | 101
astrocytoma 6 | 1,493
pancreatic cancer 6 | 2,300
pediatric high grade glioma 6 | 2,712
Breast cancer 5 | 3,094
Cancer 5 | 2,346
Celiac disease 5 | 112
Hypersensitivity 5 | 63
IGA Glomerulonephritis 5 | 454
Proteinuria 5 | 63
Systemic scleroderma 5 | 66
Waldenstrons macroglobulinemia 5 | 765
active Crohn's disease 5 | 918
cystic fibrosis 5 | 1,665
dermatomyositis 5 | 933
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,956
juvenile dermatomyositis 5 | 1,189
Addison's disease 4 | 29
Atopic dermatitis 4 | 944
Autoimmune thyroiditis 4 | 24
Carcinoma 4 | 2,147
Chronic Lymphocytic Leukemia 4 | 242
Diabetes Mellitus, Insulin-Dependent 4 | 76
Duchenne muscular dystrophy 4 | 602
Graves' disease 4 | 25
Hepatitis B, Chronic 4 | 15
Liver disease 4 | 219
Renal Cell Carcinoma 4 | 199
Severe Combined Immunodeficiency 4 | 46
atypical teratoid / rhabdoid tumor 4 | 4,369
ductal carcinoma in situ 4 | 1,745
head and neck cancer and chronic obstructive pulmonary disease 4 | 237
malignant mesothelioma 4 | 3,162
oligodendroglioma 4 | 2,849
posterior fossa group A ependymoma 4 | 1,511
primary pancreatic ductal adenocarcinoma 4 | 1,271
Angioedema 3 | 36
Berylliosis 3 | 16
Leprosy 3 | 77
Lupus Erythematosus, Systemic 3 | 73
Membranous glomerulonephritis 3 | 11
Pick disease 3 | 1,893
Polymyalgia rheumatica 3 | 10
Pre B-cell acute lymphoblastic leukemia 3 | 4
Psoriatic arthritis 3 | 83
Renal transplant rejection 3 | 13
Urticaria 3 | 53
Vasculitis 3 | 64
active ulcerative colitis 3 | 477
adrenocortical carcinoma 3 | 1,427
astrocytic glioma 3 | 2,241
ependymoma 3 | 2,514
esophageal adenocarcinoma 3 | 737
group 4 medulloblastoma 3 | 1,875
limb girdle muscular dystrophy 2I 3 | 56
pancreatic carcinoma 3 | 567
primitive neuroectodermal tumor 3 | 3,031
Becker muscular dystrophy 2 | 187
Collagen disease 2 | 25
Dermatitis 2 | 107
Dermatitis, Allergic Contact 2 | 66
Down syndrome 2 | 548
Drug Eruptions 2 | 18
Hepatitis B 2 | 103
atypical teratoid/rhabdoid tumor 2 | 1,095
colon cancer 2 | 1,475
lung adenocarcinoma 2 | 2,713
medulloblastoma 2 | 1,524
mucosa-associated lymphoid tissue lymphoma 2 | 480
nephrosclerosis 2 | 329
pituitary cancer 2 | 1,972
systemic lupus erythematosus 2 | 156

Tissue

Blood and immune system 35 | 17,995
Digestive Tract 35 | 18,473
Endocrine System 35 | 18,512
Female tissues 35 | 18,647
Liver and Pancreas 35 | 18,136
Male tissues 35 | 17,969
Nervous System 35 | 18,561
Respiratory system 35 | 17,484
Urinary Tract 35 | 18,444
Cardiovascular System 34 | 17,958
Skin and soft tissues 30 | 18,115

Target Family

Non-IDG 43 | 11,971
Kinase 6 | 634
Enzyme 1 | 4,146

Reactome Pathway

Generation of second messenger... 50 | 50
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

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