Development Level

Tbio 802 | 11,445
Tdark 344 | 6,588
Tchem 172 | 1,598
Tclin 51 | 613

Collection

Kinase: IDG Consortium (Target... 5 | 125
RFA-RM-18-021 5 | 328
Kinase: IDG Consortium (Comple... 3 | 37

IMPC Phenotype

preweaning lethality, complete... 127 | 979
preweaning lethality, incomple... 42 | 499
embryonic lethality prior to o... 39 | 239
embryonic lethality prior to t... 39 | 278
abnormal embryo size 28 | 220
abnormal behavior 21 | 298
abnormal heart morphology 17 | 162
decreased vertical activity 17 | 208
enlarged heart 17 | 210
increased bone mineral content 14 | 108
embryonic growth retardation 13 | 106
decreased bone mineral density 11 | 126
decreased mean corpuscular vol... 11 | 79
abnormal bone structure 10 | 187
decreased bone mineral content 10 | 151
decreased lean body mass 10 | 135
decreased total body fat amoun... 10 | 207
increased lean body mass 10 | 172
increased total body fat amoun... 10 | 134
male infertility 10 | 123
decreased body weight 9 | 161
hypoactivity 9 | 132
increased mean corpuscular hem... 9 | 96
increased startle reflex 9 | 112
prenatal lethality prior to he... 9 | 87
abnormal seminal vesicle morph... 8 | 114
cataract 8 | 92
decreased circulating choleste... 8 | 93
hyperactivity 8 | 148
increased bone mineral density 8 | 72
abnormal embryo turning 7 | 31
abnormal lens morphology 7 | 81
decreased caudal vertebrae num... 7 | 53
decreased circulating HDL chol... 7 | 68
decreased circulating glucose ... 7 | 126
decreased leukocyte cell numbe... 7 | 73
edema 7 | 59
increased circulating alkaline... 7 | 122
increased circulating creatini... 7 | 38
increased mean corpuscular vol... 7 | 92
small testis 7 | 58
abnormal neural tube closure 6 | 46
abnormal retina morphology 6 | 71
decreased circulating LDL chol... 6 | 38
decreased lymphocyte cell numb... 6 | 83
decreased prepulse inhibition 6 | 82
increased circulating HDL chol... 6 | 80
increased circulating triglyce... 6 | 42
increased grip strength 6 | 41
increased monocyte cell number 6 | 63
increased neutrophil cell numb... 6 | 46
abnormal bone mineralization 5 | 38
abnormal eye morphology 5 | 68
abnormal gait 5 | 69
abnormal lung morphology 5 | 26
abnormal pericardium morpholog... 5 | 26
abnormal testis morphology 5 | 43
abnormal tooth morphology 5 | 24
decreased circulating alkaline... 5 | 46
decreased erythrocyte cell num... 5 | 62
decreased fasted circulating g... 5 | 65
decreased neutrophil cell numb... 5 | 42
decreased startle reflex 5 | 75
enlarged lymph nodes 5 | 37
enlarged spleen 5 | 41
impaired glucose tolerance 5 | 75
increased circulating choleste... 5 | 66
increased circulating sodium l... 5 | 71
increased hemoglobin content 5 | 45
increased or absent threshold ... 5 | 101
pallor 5 | 34
short tibia 5 | 97
small superior vagus ganglion 5 | 74
thrombocytopenia 5 | 56
abnormal craniofacial morpholo... 4 | 33
abnormal epididymis morphology 4 | 42
abnormal placenta size 4 | 20
abnormal retinal blood vessel ... 4 | 26
abnormal retinal vasculature m... 4 | 27
abnormal spleen morphology 4 | 55
corneal opacity 4 | 32
decreased body length 4 | 101
decreased circulating insulin ... 4 | 76
decreased circulating serum al... 4 | 82
decreased hemoglobin content 4 | 68
female infertility 4 | 60
increased circulating LDL chol... 4 | 13
increased fasted circulating g... 4 | 76
increased heart weight 4 | 62
increased mean corpuscular hem... 4 | 36
increased mean platelet volume 4 | 45
pale yolk sac 4 | 25
tremors 4 | 39
abnormal kidney morphology 3 | 65
abnormal skin coloration 3 | 25
anophthalmia 3 | 33
improved glucose tolerance 3 | 79
increased circulating chloride... 3 | 41
increased circulating potassiu... 3 | 29
microphthalmia 3 | 26

Disease

Carcinoma 946 | 11,493
ovarian cancer 729 | 8,520
osteosarcoma 681 | 7,950
psoriasis 473 | 6,694
lung cancer 467 | 4,740
medulloblastoma, large-cell 460 | 6,241
glioblastoma 438 | 5,792
group 3 medulloblastoma 396 | 4,104
Cancer 383 | 2,499
atypical teratoid / rhabdoid tumor 377 | 5,112
Breast cancer 320 | 3,578
ependymoma 302 | 4,679
malignant mesothelioma 281 | 3,232
primitive neuroectodermal tumor 269 | 3,035
Kidney cancer 252 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 244 | 3,291
adult high grade glioma 222 | 3,801
oligodendroglioma 211 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 209 | 2,989
non-small cell lung cancer 205 | 2,890
invasive ductal carcinoma 204 | 2,951
astrocytic glioma 189 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 188 | 2,955
group 4 medulloblastoma 174 | 1,855
pancreatic cancer 172 | 2,398
tuberculosis 166 | 2,010
lung adenocarcinoma 163 | 2,716
Multiple myeloma 158 | 1,332
Astrocytoma, Pilocytic 151 | 3,081
Pick disease 151 | 1,894
lung carcinoma 137 | 2,843
subependymal giant cell astrocytoma 135 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 133 | 1,962
diabetes mellitus 132 | 1,728
pituitary cancer 129 | 1,972
interstitial cystitis 128 | 2,312
adrenocortical carcinoma 122 | 1,428
colon cancer 122 | 1,478
ductal carcinoma in situ 122 | 1,745
acute quadriplegic myopathy 119 | 1,158
breast carcinoma 116 | 1,638
Rheumatoid arthritis 115 | 1,191
ulcerative colitis 111 | 1,819
astrocytoma 109 | 1,146
Intellectual disability 107 | 1,016
juvenile dermatomyositis 104 | 1,187
Schizophrenia 101 | 1,160
Waldenstrons macroglobulinemia 100 | 765
dermatomyositis 99 | 966
Autosomal recessive predisposition 94 | 1,442
pediatric high grade glioma 94 | 1,064
Breast Neoplasms 91 | 445
spina bifida 90 | 1,074
Mammary Neoplasms 86 | 425
cystic fibrosis 85 | 1,696
acute myeloid leukemia 84 | 783
nasopharyngeal carcinoma 81 | 1,058
Short stature 80 | 531
primary pancreatic ductal adenocarcinoma 80 | 1,109
non primary Sjogren syndrome sicca 78 | 891
Dull intelligence 76 | 645
Low intelligence 76 | 645
Mental Retardation 76 | 645
Mental deficiency 76 | 645
Poor school performance 76 | 645
cutaneous lupus erythematosus 73 | 1,057
Prostatic Neoplasms 66 | 495
Stomach Neoplasms 66 | 300
hepatocellular carcinoma 65 | 547
Cognitive delay 63 | 608
Endometriosis 63 | 540
Epilepsy 63 | 792
Global developmental delay 63 | 608
Mental and motor retardation 63 | 608
Atopic dermatitis 61 | 952
Obesity 61 | 678
gastric cancer 61 | 459
Bipolar Disorder 59 | 666
medulloblastoma 59 | 720
pancreatic carcinoma 59 | 562
Seizures 57 | 596
Alzheimer's disease 56 | 658
gastric carcinoma 55 | 807
progressive supranuclear palsy 54 | 676
Muscle hypotonia 52 | 571
Carcinoma, Hepatocellular 51 | 228
Lung Neoplasms 51 | 232
Small head 51 | 374
Kidney disease 50 | 430
Liver carcinoma 50 | 240
Melanoma 50 | 711
esophageal adenocarcinoma 49 | 737
Amyotrophic lateral sclerosis 48 | 451
Liver cancer 48 | 604
tuberculosis and treatment for 6 months 48 | 409
Cryptorchidism 47 | 296
active Crohn's disease 47 | 922
primary Sjogren syndrome 47 | 735
Strabismus 43 | 270
aldosterone-producing adenoma 43 | 665

Tissue

Endocrine System 1,343 | 18,159
Female tissues 1,327 | 17,400
Digestive Tract 1,323 | 17,369
Male tissues 1,322 | 17,142
Blood and immune system 1,320 | 16,909
Skin and soft tissues 1,320 | 17,230
Nervous System 1,315 | 16,725
Urinary Tract 1,312 | 16,678
Liver and Pancreas 1,310 | 16,750
Respiratory system 1,306 | 16,393
Cardiovascular System 1,291 | 15,192

Target Family

Non-IDG 508 | 12,091
Transcription Factor 431 | 1,400
Enzyme 243 | 4,145
Epigenetic 69 | 242
Kinase 60 | 634
Nuclear Receptor 47 | 48
TF/Epigenetic 9 | 38
Transporter 2 | 473

Reactome Pathway

Gene expression (Transcription... 1,369 | 1,369
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
Zinc finger protein 160 ZNF160 Tdark Transcription Factor -0.67261 4.33 63
Zinc finger protein 99 ZNF99 Tdark Transcription Factor 1.38 0.03 50
Metastasis-associated protein MTA3 MTA3 Tbio Transcription Factor -1.36174 24.5 204
RNA polymerase II subunit A C-terminal domain phosphatase CTDP1 Tbio Enzyme -1.88697 80.7 113
Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 ASZ1 Tbio Non-IDG -2.81661 644.9 107
Rapamycin-insensitive companion of mTOR RICTOR Tbio Non-IDG -2.79454 597.0 440
Zinc finger protein 792 ZNF792 Tdark Transcription Factor 0.00000 24
DNA damage-inducible transcript 4 protein DDIT4 Tbio Non-IDG -2.11497 150.3 231
Histone-arginine methyltransferase CARM1 CARM1 Tchem Epigenetic -2.04034 130.8 476