Development Level

Tchem 11 | 1,885
Tbio 5 | 11,178
Tclin 1 | 612

IMPC Phenotype

preweaning lethality, complete... 3 | 979
decreased leukocyte cell numbe... 1 | 73
increased circulating glucose ... 1 | 24
prenatal lethality 1 | 28
short tibia 1 | 97

Disease

Cancer 16 | 2,388
Carcinoma 11 | 11,192
ovarian cancer 11 | 8,297
medulloblastoma, large-cell 10 | 6,086
osteosarcoma 10 | 7,766
Breast cancer 8 | 3,469
Stomach Neoplasms 8 | 287
atypical teratoid / rhabdoid tumor 8 | 4,971
group 3 medulloblastoma 8 | 4,002
lung cancer 8 | 4,607
psoriasis 8 | 6,514
glioblastoma 7 | 5,635
Kidney cancer 6 | 2,548
Lung Neoplasms 6 | 217
Schizophrenia 6 | 1,136
Short stature 6 | 514
Byzanthine arch palate 5 | 194
Carcinoma, Squamous Cell 5 | 107
Congenital pectus carinatum 5 | 51
Delayed bone age 5 | 132
Downward slant of palpebral fissure 5 | 158
Dull intelligence 5 | 634
Epilepsy 5 | 775
Full lower lip 5 | 61
Intellectual disability 5 | 998
Joint hyperflexibility 5 | 76
Low intelligence 5 | 634
Mental Retardation 5 | 634
Mental deficiency 5 | 634
Muscle hypotonia 5 | 562
Neoplasm Invasiveness 5 | 151
Neoplasm Metastasis 5 | 160
Orbital separation excessive 5 | 240
Poor school performance 5 | 634
Prominent lower lip 5 | 61
Squamous cell carcinoma 5 | 125
juvenile dermatomyositis 5 | 1,147
Abnormal dermatoglyphic pattern 4 | 24
Acquired scoliosis 4 | 274
Adenocarcinoma of lung 4 | 140
Adenocarcinoma of lung (disorder) 4 | 59
Adenoma 4 | 159
Blepharoptosis 4 | 229
Carcinoma, Hepatocellular 4 | 217
Cardiac Arrhythmia 4 | 101
Cardiac conduction abnormalities 4 | 78
Coarse hair 4 | 31
Concave bridge of nose 4 | 191
Conduction disorder of the heart 4 | 79
Congenital Epicanthus 4 | 175
Cryptorchidism 4 | 287
Curly hair (finding) 4 | 14
Curvature of spine 4 | 275
Dental abnormalities 4 | 57
Depressed nasal bridge 4 | 191
Depressed nasal root/bridge 4 | 191
Diarrhea 4 | 245
Disease Models, Animal 4 | 148
EKG abnormalities 4 | 78
Electrocardiogram abnormal 4 | 81
Electrocardiogram change 4 | 78
Excess nuchal skin 4 | 30
Familial adenomatous polyposis 4 | 32
Feeding difficulties in infancy 4 | 174
Frontal bossing 4 | 154
Hypoplastic mandible condyle 4 | 273
Isolated cases 4 | 70
Kyphoscoliosis deformity of spine 4 | 59
Liver Neoplasms, Experimental 4 | 58
Liver carcinoma 4 | 229
Mandibular hypoplasia 4 | 273
Melanoma 4 | 689
Micrognathism 4 | 273
Neck webbing 4 | 35
Noonan syndrome 4 | 34
Ovarian Neoplasms 4 | 96
Pectus excavatum 4 | 100
Pick disease 4 | 1,856
Rough hair texture 4 | 31
Seizures 4 | 584
Strabismus 4 | 265
Telecanthus 4 | 62
Tooth Abnormalities 4 | 66
Upper respiratory tract disease 4 | 15
Vascular disease 4 | 294
astrocytic glioma 4 | 2,530
diabetes mellitus 4 | 1,683
invasive ductal carcinoma 4 | 2,867
lung carcinoma 4 | 2,755
ovarian neoplasm 4 | 93
primitive neuroectodermal tumor 4 | 2,957
Basal cell carcinoma 3 | 54
Generalized osteopenia 3 | 94
Hemangioma 3 | 69
Hemangioma, Cavernous 3 | 20
Hypopigmentation disorder 3 | 24
Low posterior hairline 3 | 52
Lymphoid leukemia 3 | 156
Osteopenia 3 | 94
Pulmonary artery stenosis 3 | 26

Tissue

Blood and immune system 17 | 16,909
Digestive Tract 17 | 17,369
Endocrine System 17 | 18,159
Female tissues 17 | 17,400
Nervous System 17 | 16,725
Respiratory system 17 | 16,393
Liver and Pancreas 16 | 16,750
Male tissues 16 | 17,142
Skin and soft tissues 16 | 17,230
Urinary Tract 16 | 16,678
Cardiovascular System 15 | 15,192

Target Family

Kinase 8 | 634
Non-IDG 5 | 12,091
Enzyme 3 | 4,145
Transcription Factor 1 | 1,400

Reactome Pathway

Gastrin-CREB signalling pathwa... 17 | 17
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ribosomal protein S6 kinase alpha-2 RPS6KA2 Tchem Kinase -2.17609 136.7 406
Ribosomal protein S6 kinase alpha-1 RPS6KA1 Tchem Kinase -2.57872 338.0 1158
GTPase KRas KRAS Tbio Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Ribosomal protein S6 kinase alpha-3 RPS6KA3 Tchem Kinase -2.50143 325.4 425
Gastrin GAST Tbio Non-IDG -3.90567 8162.7 320
Mitogen-activated protein kinase 7 MAPK7 Tbio Kinase -2.48754 340.0 422
Mitogen-activated protein kinase 3 MAPK3 Tchem Kinase -3.66226 3484.0 1440
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248