Development Level

Tbio 215 | 10,625
Tchem 131 | 1,890
Tclin 75 | 602
Tdark 15 | 7,003

Collection

Eligible non-olfactory GPCR Proteins 9 | 143
Eligible Kinase Proteins 2 | 134
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 17 | 633
decreased body weight 11 | 174
abnormal behavior 8 | 226
decreased bone mineral content 7 | 157
decreased lean body mass 7 | 195
abnormal bone structure 6 | 131
decreased total body fat amoun... 6 | 186
enlarged heart 6 | 111
embryonic lethality prior to t... 5 | 187
male infertility 5 | 62
abnormal embryo size 4 | 112
abnormal seminal vesicle morph... 4 | 47
decreased bone mineral density 4 | 126
decreased circulating HDL chol... 4 | 77
decreased circulating alanine ... 4 | 53
decreased circulating choleste... 4 | 85
decreased circulating triglyce... 4 | 83
decreased grip strength 4 | 123
hypoactivity 4 | 89
increased total body fat amoun... 4 | 57
preweaning lethality, incomple... 4 | 260
abnormal retinal pigmentation 3 | 61
decreased body length 3 | 108
decreased circulating glucose ... 3 | 121
decreased circulating total pr... 3 | 41
decreased heart weight 3 | 44
decreased kidney weight 3 | 7
decreased lumbar vertebrae num... 3 | 62
decreased prepulse inhibition 3 | 52
increased circulating HDL chol... 3 | 63
increased startle reflex 3 | 38
thrombocytopenia 3 | 46
abnormal bone mineralization 2 | 55
abnormal coat/hair pigmentatio... 2 | 54
abnormal epididymis morphology 2 | 31
abnormal forebrain development 2 | 18
abnormal gait 2 | 51
abnormal hindbrain development 2 | 24
abnormal kidney morphology 2 | 30
abnormal midbrain development 2 | 22
abnormal neural tube closure 2 | 37
abnormal retina morphology 2 | 100
abnormal testis morphology 2 | 30
cataract 2 | 26
decreased caudal vertebrae num... 2 | 49
decreased circulating LDL chol... 2 | 37
decreased circulating amylase ... 2 | 24
decreased circulating bilirubi... 2 | 14
decreased circulating insulin ... 2 | 75
decreased circulating serum al... 2 | 79
decreased circulating sodium l... 2 | 18
decreased lactate dehydrogenas... 2 | 14
decreased neutrophil cell numb... 2 | 37
decreased rib number 2 | 59
decreased spleen weight 2 | 13
decreased thoracic vertebrae n... 2 | 7
female infertility 2 | 34
impaired pupillary reflex 2 | 14
impaired righting response 2 | 19
increased blood urea nitrogen ... 2 | 44
increased body length 2 | 20
increased circulating phosphat... 2 | 24
increased lean body mass 2 | 107
increased mean corpuscular hem... 2 | 93
increased neutrophil cell numb... 2 | 15
limb grasping 2 | 35
small kidney 2 | 10
small superior vagus ganglion 2 | 20
tremors 2 | 34
vertebral fusion 2 | 23
abnormal body wall morphology 1 | 7
abnormal coping response 1 | 12
abnormal heart morphology 1 | 51
abnormal locomotor activation 1 | 26
abnormal rib morphology 1 | 28
abnormal skin morphology 1 | 23
abnormal spleen morphology 1 | 36
abnormal vocalization 1 | 21
absent pinna reflex 1 | 21
corneal opacity 1 | 25
decreased circulating chloride... 1 | 32
decreased circulating phosphat... 1 | 15
decreased circulating potassiu... 1 | 17
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased exploration in new e... 1 | 9
decreased hematocrit 1 | 25
decreased mean corpuscular vol... 1 | 50
decreased vertical activity 1 | 22
dilated heart left ventricle 1 | 10
enlarged spleen 1 | 26
increased bone mineral density 1 | 52
increased circulating triglyce... 1 | 24
increased grip strength 1 | 83
increased mean corpuscular vol... 1 | 91
increased sacral vertebrae num... 1 | 62
oligodactyly 1 | 14
premature death 1 | 5
prenatal lethality prior to he... 1 | 64
small thymus 1 | 11

Disease

osteosarcoma 206 | 7,933
ovarian cancer 195 | 8,484
psoriasis 183 | 6,685
medulloblastoma, large-cell 169 | 6,234
glioblastoma 159 | 5,572
Cancer 143 | 2,346
lung cancer 135 | 4,466
atypical teratoid / rhabdoid tumor 114 | 4,369
pilocytic astrocytoma 102 | 3,086
malignant mesothelioma 99 | 3,162
Breast cancer 95 | 3,094
oligodendroglioma 90 | 2,849
lung carcinoma 88 | 2,844
ependymoma 87 | 2,514
invasive ductal carcinoma 87 | 2,950
lung adenocarcinoma 85 | 2,713
pediatric high grade glioma 83 | 2,712
Carcinoma 80 | 2,147
intraductal papillary-mucinous neoplasm (IPMN) 80 | 3,289
interstitial cystitis 79 | 2,299
primitive neuroectodermal tumor 78 | 3,031
non-small cell lung cancer 76 | 2,798
subependymal giant cell astrocytoma 73 | 2,287
ulcerative colitis 73 | 2,087
astrocytic glioma 71 | 2,241
intraductal papillary-mucinous adenoma (IPMA) 70 | 2,956
pancreatic cancer 68 | 2,300
intraductal papillary-mucinous carcinoma (IPMC) 67 | 2,988
diabetes mellitus 57 | 1,663
group 4 medulloblastoma 55 | 1,875
Pick disease 54 | 1,893
pituitary cancer 53 | 1,972
cystic fibrosis 51 | 1,665
Multiple myeloma 49 | 1,327
astrocytoma 48 | 1,493
Obesity 47 | 616
ductal carcinoma in situ 47 | 1,745
group 3 medulloblastoma 47 | 2,254
breast carcinoma 46 | 1,614
tuberculosis 46 | 1,557
Rheumatoid Arthritis 45 | 1,160
medulloblastoma 45 | 1,524
Schizophrenia 44 | 501
colon cancer 44 | 1,475
adult high grade glioma 41 | 2,148
primary pancreatic ductal adenocarcinoma 39 | 1,271
pancreatic ductal adenocarcinoma liver metastasis 38 | 1,795
posterior fossa group B ependymoma 37 | 1,530
Asthma 32 | 349
Parkinson's disease 32 | 364
juvenile dermatomyositis 32 | 1,189
atypical teratoid/rhabdoid tumor 31 | 1,095
adrenocortical carcinoma 30 | 1,427
Hypertension 28 | 287
cutaneous lupus erythematosus 28 | 1,056
Mammary Neoplasms 27 | 410
gastric carcinoma 27 | 832
posterior fossa group A ependymoma 27 | 1,511
sonic hedgehog group medulloblastoma 27 | 1,482
esophageal adenocarcinoma 26 | 737
spina bifida 26 | 1,064
Kidney disease 24 | 396
Atherosclerosis 23 | 275
Hyperalgesia 23 | 71
dermatomyositis 23 | 933
Alzheimer's disease 22 | 644
Autistic Disorder 22 | 320
Cerebrovascular disease 22 | 231
Hypertensive disease 22 | 193
Intellectual disability 22 | 573
non-small cell lung carcinoma 22 | 413
Waldenstrons macroglobulinemia 21 | 765
non primary Sjogren syndrome sicca 21 | 840
primary Sjogren syndrome 21 | 789
Down syndrome 20 | 548
Heart disease 20 | 279
Prostatic Neoplasms 20 | 471
Stomach Neoplasms 20 | 282
fibroadenoma 20 | 557
active Crohn's disease 19 | 918
hepatocellular carcinoma 19 | 532
Diarrhea 18 | 155
Liver carcinoma 18 | 217
Lung Neoplasms 18 | 171
Neoplasm Invasiveness 18 | 127
Pain 18 | 70
Vascular disease 18 | 281
nasopharyngeal carcinoma 18 | 1,056
pancreatic carcinoma 18 | 567
Animal Mammary Neoplasms 17 | 136
Cocaine-Related Disorders 17 | 88
HIV Infections 17 | 100
Mammary Neoplasms, Experimental 17 | 150
Melanoma 17 | 261
Osteoporosis 17 | 257
Pain agnosia 17 | 99
Polycystic Ovary Syndrome 17 | 332
autosomal dominant Emery-Dreifuss muscular dystrophy 17 | 499
Crohn's disease 16 | 304
mucosa-associated lymphoid tissue lymphoma 16 | 480

Tissue

Endocrine System 431 | 18,512
Female tissues 430 | 18,647
Nervous System 430 | 18,561
Digestive Tract 428 | 18,473
Urinary Tract 428 | 18,444
Skin and soft tissues 426 | 18,115
Liver and Pancreas 421 | 18,136
Blood and immune system 416 | 17,995
Cardiovascular System 416 | 17,958
Male tissues 412 | 17,969
Respiratory system 409 | 17,484

Target Family

Non-IDG 186 | 11,971
Enzyme 98 | 4,146
GPCR 86 | 406
Kinase 54 | 634
Ion Channel 11 | 341
Transcription Factor 1 | 1,400

Reactome Pathway

Gastrin-CREB signalling pathwa... 436 | 436
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
Fibroblast growth factor 5 FGF5 Tbio Non-IDG -2.00731 99.9 143
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Fibrinogen alpha chain FGA Tbio Non-IDG -2.84597 716.2 457
Beta-arrestin-1 ARRB1 Tchem Non-IDG -2.54226 366.3 416
Interleukin-2 receptor subunit beta IL2RB Tclin Non-IDG -2.08442 120.9 537
Beta-klotho KLB Tbio Enzyme -1.89423 69.9 47
Fibronectin FN1 Tchem Non-IDG -3.04098 1121.3 1253