Development Level

Tbio 53 | 11,445
Tchem 6 | 1,598
Tdark 3 | 6,588
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 8 | 979
embryonic lethality prior to o... 6 | 239
embryonic lethality prior to t... 3 | 278
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal pharyngeal arch morph... 1 | 8
abnormal retina morphology 1 | 71
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased circulating glucose ... 1 | 126
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
embryonic growth retardation 1 | 106
increased anti-nuclear antigen... 1 | 19
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating potassiu... 1 | 29
increased heart weight 1 | 62
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
prenatal lethality prior to he... 1 | 87

Disease

ovarian cancer 36 | 8,520
Carcinoma 33 | 11,493
osteosarcoma 27 | 7,950
lung cancer 25 | 4,740
Cockayne syndrome 24 | 60
group 3 medulloblastoma 19 | 4,104
malignant mesothelioma 17 | 3,232
psoriasis 17 | 6,694
Cancer 14 | 2,499
primitive neuroectodermal tumor 13 | 3,035
Photosensitive trichothiodystrophy 12 | 30
medulloblastoma, large-cell 12 | 6,241
Xeroderma pigmentosum 11 | 43
atypical teratoid / rhabdoid tumor 11 | 5,112
glioblastoma 11 | 5,792
Kidney cancer 10 | 2,613
non-small cell lung cancer 10 | 2,890
acute myeloid leukemia 9 | 783
diabetes mellitus 9 | 1,728
ependymoma 9 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
Breast cancer 8 | 3,578
Intellectual disability 8 | 1,016
Short stature 8 | 531
Xeroderma pigmentosum group B 8 | 20
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
Cryptorchidism 7 | 296
Dull intelligence 7 | 645
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Multiple myeloma 7 | 1,332
Poor school performance 7 | 645
UV-sensitive syndrome 7 | 10
Waldenstrons macroglobulinemia 7 | 765
Xeroderma pigmentosum group D 7 | 33
adult high grade glioma 7 | 3,801
Autosomal recessive predisposition 6 | 1,442
Cataract 6 | 297
Epilepsy 6 | 792
Hypogonadism 6 | 173
Hypoplastic mandible condyle 6 | 275
Mandibular hypoplasia 6 | 275
Micrognathism 6 | 275
Seizures 6 | 596
Sensorineural Hearing Loss (disorder) 6 | 284
Small head 6 | 374
Strabismus 6 | 270
Xeroderma pigmentosum group G 6 | 16
astrocytoma 6 | 1,146
oligodendroglioma 6 | 2,850
pituitary cancer 6 | 1,972
Cerebellar Ataxia 5 | 304
Colorectal Neoplasms 5 | 243
Hyperkyphosis 5 | 111
Kyphosis deformity of spine 5 | 114
Lens Opacities 5 | 231
Muscle hypotonia 5 | 571
Photosensitivity of skin 5 | 51
Pick disease 5 | 1,894
Rheumatoid arthritis 5 | 1,191
Stomach Neoplasms 5 | 300
astrocytic glioma 5 | 2,597
nasopharyngeal carcinoma 5 | 1,058
Angle class 2 malocclusion 4 | 57
Angle class 3 malocclusion 4 | 57
Atrophic condition of skin 4 | 25
Bladder Neoplasm 4 | 112
Broad flat nasal bridge 4 | 236
Congenital hypoplasia of penis 4 | 176
Deafness 4 | 198
Dry skin 4 | 75
Failure to gain weight 4 | 365
Freckles 4 | 33
Hereditary spherocytosis type 5 4 | 12
Malocclusion 4 | 57
Muscle Spasticity 4 | 195
Nasal bridge wide 4 | 236
Optic Atrophy 4 | 242
Pediatric failure to thrive 4 | 365
Tremor 4 | 113
Urinary Bladder Neoplasms 4 | 114
Xerosis 4 | 75
adrenocortical carcinoma 4 | 1,428
ductal carcinoma in situ 4 | 1,745
hearing impairment 4 | 199
Acquired scoliosis 3 | 281
Atrophy of cerebellum 3 | 103
Bilateral fifth finger clinodactyly 3 | 110
Cerebellar degeneration 3 | 103
Cerebral atrophy 3 | 178
Curvature of little finger 3 | 110
Curvature of spine 3 | 282
Electroencephalogram abnormal 3 | 101
Hyperreflexia 3 | 209
Kidney Failure 3 | 111
Melanoma 3 | 711
Neurodegenerative disease 3 | 414
Renal Insufficiency 3 | 90
Renal failure in adulthood 3 | 76

Tissue

Blood and immune system 63 | 16,909
Cardiovascular System 63 | 15,192
Digestive Tract 63 | 17,369
Endocrine System 63 | 18,159
Female tissues 63 | 17,400
Liver and Pancreas 63 | 16,750
Male tissues 63 | 17,142
Nervous System 63 | 16,725
Respiratory system 63 | 16,393
Skin and soft tissues 63 | 17,230
Urinary Tract 63 | 16,678

Target Family

Non-IDG 33 | 12,091
Enzyme 29 | 4,145
Epigenetic 1 | 242
Kinase 1 | 634

Reactome Pathway

Gap-filling DNA repair synthes... 64 | 64
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.49730 299.8 149
DNA polymerase delta subunit 4 POLD4 Tbio Enzyme -0.84887 7.32 24
Pre-mRNA-splicing factor SYF1 XAB2 Tbio Non-IDG -1.02890 12.5 247
DNA-directed RNA polymerases I, II, and III subunit RPABC2 POLR2F Tbio Enzyme -1.13403 13.9 68
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
General transcription factor IIH subunit 2 GTF2H2 Tbio Non-IDG -1.32757 20.2 148
DNA-directed RNA polymerases I, II, and III subunit RPABC4 POLR2K Tbio Enzyme -0.90716 7.36 65
Pre-mRNA-splicing factor ISY1 homolog ISY1 Tdark Non-IDG 0.70 0.00000 26
DNA-directed RNA polymerases I, II, and III subunit RPABC3 POLR2H Tbio Enzyme -1.13403 13.5 180