Development Level

Tbio 25 | 11,445
Tchem 7 | 1,598
Tclin 3 | 613
Tdark 3 | 6,588

IMPC Phenotype

preweaning lethality, complete... 4 | 979
decreased bone mineral content 2 | 151
enlarged heart 2 | 210
preweaning lethality, incomple... 2 | 499
abnormal coat-hair pigmentatio... 1 | 64
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal seminal vesicle morph... 1 | 114
abnormal snout morphology 1 | 23
abnormal vibrissa morphology 1 | 25
brachydactyly 1 | 19
decreased circulating creatini... 1 | 39
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mean corpuscular vol... 1 | 79
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
increased caudal vertebrae num... 1 | 7
increased circulating alkaline... 1 | 122
increased total body fat amoun... 1 | 134
thrombocytosis 1 | 27
tremors 1 | 39
vertebral transformation 1 | 12

Disease

Carcinoma 26 | 11,493
psoriasis 15 | 6,694
ovarian cancer 14 | 8,520
glioblastoma 13 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
osteosarcoma 12 | 7,950
Cancer 10 | 2,499
atypical teratoid / rhabdoid tumor 10 | 5,112
ependymoma 10 | 4,679
lung cancer 9 | 4,740
Diphtheria 8 | 40
medulloblastoma, large-cell 8 | 6,241
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
Autosomal recessive predisposition 7 | 1,442
Vitamin K deficiency hemorrhagic disease 7 | 11
adult high grade glioma 7 | 3,801
lung carcinoma 7 | 2,843
malignant mesothelioma 7 | 3,232
tuberculosis 7 | 2,010
Astrocytoma, Pilocytic 6 | 3,081
Chondrodysplasia punctata 6 | 41
Thrombosis 6 | 46
group 3 medulloblastoma 6 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
invasive ductal carcinoma 6 | 2,951
lung adenocarcinoma 6 | 2,716
pancreatic cancer 6 | 2,398
primitive neuroectodermal tumor 6 | 3,035
Factor X Deficiency 5 | 6
Hemarthrosis 5 | 12
Pulmonary embolism 5 | 55
Thromboembolism 5 | 15
Thrombophilia 5 | 38
cystic fibrosis 5 | 1,696
diabetes mellitus 5 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
non-small cell lung cancer 5 | 2,890
Alzheimer's disease 4 | 658
Atherosclerosis 4 | 291
Breast cancer 4 | 3,578
Deep Vein Thrombosis 4 | 8
Disseminated intravascular coagulation 4 | 38
Epistaxis 4 | 43
Factor VII Deficiency 4 | 7
Hemophilia B 4 | 11
Highly variable severity 4 | 157
Ichthyosis 4 | 56
Mucopolysaccharidosis 4 | 26
Partial thromboplastin time increased (finding) 4 | 11
Pick disease 4 | 1,894
Protein C deficiency 4 | 19
Variable expressivity 4 | 157
Vascular disease 4 | 319
oligodendroglioma 4 | 2,850
subependymal giant cell astrocytoma 4 | 2,287
Asthma 3 | 385
Blood Coagulation Disorders 3 | 42
Cerebrovascular disease 3 | 238
Cognitive delay 3 | 608
Coronary artery disease 3 | 268
Factor VIII deficiency 3 | 10
Factor XI Deficiency 3 | 12
Global developmental delay 3 | 608
Heart valve disease 3 | 39
Hypertension 3 | 396
Hypogonadism 3 | 173
Intellectual disability 3 | 1,016
Liver disease 3 | 237
Menorrhagia 3 | 25
Mental and motor retardation 3 | 608
Metachromatic leukodystrophy 3 | 14
Mucosulfatidosis 3 | 5
Multiple myeloma 3 | 1,332
Obesity 3 | 678
Purpura 3 | 43
Thrombophlebitis 3 | 19
Thrombosis of cerebral veins 3 | 6
Venous Thrombosis 3 | 47
Von Willebrand's disease 3 | 19
X- linked recessive 3 | 110
X-linked ichthyosis 3 | 18
active Crohn's disease 3 | 922
active ulcerative colitis 3 | 764
acute myeloid leukemia 3 | 783
adrenocortical carcinoma 3 | 1,428
gastric cancer 3 | 459
group 4 medulloblastoma 3 | 1,855
non primary Sjogren syndrome sicca 3 | 891
pancreatic carcinoma 3 | 562
pediatric high grade glioma 3 | 1,064
Atrial Fibrillation 2 | 124
Concave bridge of nose 2 | 195
Depressed nasal root/bridge 2 | 195
Diarrhea 2 | 253
Heart disease 2 | 306
Hepatitis B 2 | 108
Kidney disease 2 | 430
Malaria 2 | 160
Ocular albinism 2 | 26
Osteomyelitis 2 | 42

Tissue

Liver and Pancreas 38 | 16,750
Urinary Tract 38 | 16,678
Digestive Tract 37 | 17,369
Male tissues 37 | 17,142
Skin and soft tissues 37 | 17,230
Endocrine System 36 | 18,159
Female tissues 36 | 17,400
Nervous System 35 | 16,725
Blood and immune system 34 | 16,909
Respiratory system 34 | 16,393
Cardiovascular System 32 | 15,192

Target Family

Enzyme 26 | 4,145
Non-IDG 10 | 12,091
Kinase 2 | 634

Reactome Pathway

Gamma carboxylation, hypusine ... 38 | 38
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Vitamin K-dependent gamma-carboxylase GGCX Tclin Enzyme -1.90296 79.3 192
Eukaryotic translation initiation factor 5A-1 EIF5A Tbio Non-IDG -2.10288 142.0 231
Arylsulfatase F ARSF Tbio Enzyme -0.44326 2.74 138
Arylsulfatase J ARSJ Tdark Enzyme -0.22432 1.18 25
Arylsulfatase H ARSH Tbio Enzyme -2.14770 118.6 81
Elongation factor 2 EEF2 Tchem Non-IDG -2.95619 938.4 363
Arylsulfatase D ARSD Tbio Enzyme -2.09545 123.1 132
Arylsulfatase B ARSB Tbio Enzyme -2.51626 314.5 216
Sulfatase-modifying factor 1 SUMF1 Tbio Enzyme -2.21118 157.7 145
DnaJ homolog subfamily C member 24 DNAJC24 Tbio Non-IDG -0.60608 4.38 0