Development Level

Tbio 8 | 11,445
Tchem 4 | 1,598
Tclin 3 | 613

IMPC Phenotype

preweaning lethality, complete... 2 | 979
decreased leukocyte cell numbe... 1 | 73
increased circulating glucose ... 1 | 24
prenatal lethality 1 | 28
short tibia 1 | 97

Disease

Cancer 12 | 2,499
Carcinoma 11 | 11,493
lung cancer 11 | 4,740
Breast cancer 10 | 3,578
glioblastoma 9 | 5,792
osteosarcoma 9 | 7,950
Kidney cancer 8 | 2,613
medulloblastoma, large-cell 8 | 6,241
ovarian cancer 8 | 8,520
atypical teratoid / rhabdoid tumor 7 | 5,112
interstitial cystitis 7 | 2,312
psoriasis 7 | 6,694
Breast Neoplasms 6 | 445
Mammary Neoplasms 6 | 425
Melanoma 6 | 711
Rheumatoid arthritis 6 | 1,191
Schizophrenia 6 | 1,160
Stomach Neoplasms 6 | 300
pancreatic cancer 6 | 2,398
Lung Neoplasms 5 | 232
ependymoma 5 | 4,679
group 3 medulloblastoma 5 | 4,104
lung adenocarcinoma 5 | 2,716
ulcerative colitis 5 | 1,819
Abnormal dermatoglyphic pattern 4 | 24
Adenocarcinoma 4 | 122
Adenocarcinoma of lung 4 | 142
Adenocarcinoma of lung (disorder) 4 | 60
Adenoma 4 | 167
Alopecia 4 | 115
Arthritis, Juvenile 4 | 126
Autosomal recessive predisposition 4 | 1,442
Basal cell carcinoma 4 | 54
Blepharoptosis 4 | 231
Byzanthine arch palate 4 | 194
Carcinoma, Hepatocellular 4 | 228
Cardiac Arrhythmia 4 | 103
Cardiac conduction abnormalities 4 | 78
Cell Transformation, Neoplastic 4 | 97
Conduction disorder of the heart 4 | 79
Congenital pectus carinatum 4 | 52
Cryptorchidism 4 | 296
Curly hair (finding) 4 | 14
Delayed bone age 4 | 136
Diarrhea 4 | 253
Disease Progression 4 | 136
Downward slant of palpebral fissure 4 | 158
EKG abnormalities 4 | 78
Electrocardiogram abnormal 4 | 81
Electrocardiogram change 4 | 78
Endometriosis 4 | 540
Exanthem 4 | 37
Excess nuchal skin 4 | 30
Familial adenomatous polyposis 4 | 32
Full lower lip 4 | 64
Gallbladder Neoplasms 4 | 10
Hypoplastic mandible condyle 4 | 275
Joint hyperflexibility 4 | 78
Juvenile arthritis 4 | 126
Liver carcinoma 4 | 240
Mandibular hypoplasia 4 | 275
Micrognathism 4 | 275
Muscle hypotonia 4 | 571
Neck webbing 4 | 35
Neoplasm Invasiveness 4 | 161
Neoplasm Metastasis 4 | 168
Neoplasms, Experimental 4 | 40
Neoplastic Cell Transformation 4 | 89
Neuroblastoma 4 | 80
Neutropenia 4 | 72
Noonan syndrome 4 | 34
Orbital separation excessive 4 | 244
Ovarian Neoplasms 4 | 102
Prominent lower lip 4 | 64
Short stature 4 | 531
Skin cancer 4 | 469
Strabismus 4 | 270
Thyroid cancer 4 | 36
Upper respiratory tract disease 4 | 15
adult high grade glioma 4 | 3,801
astrocytic glioma 4 | 2,597
gallbladder neoplasm 4 | 10
gastric cancer 4 | 459
hepatocellular carcinoma 4 | 547
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
malignant mesothelioma 4 | 3,232
oligodendroglioma 4 | 2,850
ovarian neoplasm 4 | 99
Coarse hair 3 | 31
Generalized osteopenia 3 | 99
Hemangioma 3 | 69
Hemangioma, Cavernous 3 | 20
Horseshoe Kidney 3 | 16
Hypogonadism, Isolated Hypogonadotropic 3 | 71
Hypogonadotropic hypogonadism 3 | 89
Low posterior hairline 3 | 52
Lymphoid leukemia 3 | 160
Osteopenia 3 | 99
Pulmonary artery stenosis 3 | 22
Rough hair texture 3 | 31

Tissue

Blood and immune system 15 | 16,909
Digestive Tract 15 | 17,369
Endocrine System 15 | 18,159
Female tissues 15 | 17,400
Liver and Pancreas 15 | 16,750
Male tissues 15 | 17,142
Nervous System 15 | 16,725
Respiratory system 15 | 16,393
Skin and soft tissues 15 | 17,230
Urinary Tract 15 | 16,678
Cardiovascular System 14 | 15,192

Target Family

Non-IDG 9 | 12,091
Enzyme 3 | 4,145
Kinase 3 | 634

Reactome Pathway

GRB2 events in ERBB2 signaling 15 | 15
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pro-neuregulin-4, membrane-bound isoform NRG4 Tbio Non-IDG -1.33564 24.6 137
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Pro-neuregulin-2, membrane-bound isoform NRG2 Tbio Non-IDG -1.46980 32.0 141
Receptor tyrosine-protein kinase erbB-4 ERBB4 Tclin Kinase -2.78704 558.2 1072
Pro-neuregulin-3, membrane-bound isoform NRG3 Tbio Non-IDG -1.56404 39.4 165
Pro-epidermal growth factor EGF Tbio Non-IDG -3.75933 4903.2 978
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -3.02404 981.4 501
Son of sevenless homolog 1 SOS1 Tbio Non-IDG -2.69482 466.2 147