Development Level

Tbio 17 | 11,445
Tchem 10 | 1,598
Tclin 4 | 613

IMPC Phenotype

preweaning lethality, complete... 3 | 979
preweaning lethality, incomple... 3 | 499
decreased body weight 2 | 161
decreased circulating creatini... 2 | 39
decreased hemoglobin content 2 | 68
increased total body fat amoun... 2 | 134
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal digit morphology 1 | 10
abnormal eye anterior chamber ... 1 | 9
abnormal gait 1 | 69
abnormal lens morphology 1 | 81
abnormal maxilla morphology 1 | 17
absent vibrissae 1 | 12
cataract 1 | 92
decreased IgG3 level 1 | 1
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased blood urea nitrogen ... 1 | 48
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating calcium ... 1 | 34
increased circulating iron lev... 1 | 30
increased erythrocyte cell num... 1 | 39
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56

Disease

osteosarcoma 24 | 7,950
Cancer 22 | 2,499
Carcinoma 22 | 11,493
ovarian cancer 21 | 8,520
psoriasis 15 | 6,694
glioblastoma 14 | 5,792
lung cancer 14 | 4,740
interstitial cystitis 13 | 2,312
subependymal giant cell astrocytoma 13 | 2,287
invasive ductal carcinoma 12 | 2,951
medulloblastoma, large-cell 12 | 6,241
pancreatic cancer 12 | 2,398
lung carcinoma 11 | 2,843
Astrocytoma, Pilocytic 10 | 3,081
malignant mesothelioma 10 | 3,232
primary Sjogren syndrome 10 | 735
adult high grade glioma 9 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
non-small cell lung cancer 9 | 2,890
Breast cancer 8 | 3,578
Kidney cancer 8 | 2,613
Waldenstrons macroglobulinemia 8 | 765
ependymoma 8 | 4,679
ulcerative colitis 8 | 1,819
astrocytoma 7 | 1,146
atypical teratoid / rhabdoid tumor 7 | 5,112
cutaneous lupus erythematosus 7 | 1,057
ductal carcinoma in situ 7 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
oligodendroglioma 7 | 2,850
Multiple myeloma 6 | 1,332
cystic fibrosis 6 | 1,696
group 4 medulloblastoma 6 | 1,855
juvenile dermatomyositis 6 | 1,187
pancreatic carcinoma 6 | 562
Autosomal recessive predisposition 5 | 1,442
Liver Cirrhosis, Experimental 5 | 769
Schizophrenia 5 | 1,160
active ulcerative colitis 5 | 764
astrocytic glioma 5 | 2,597
breast carcinoma 5 | 1,638
colon cancer 5 | 1,478
dermatomyositis 5 | 966
diabetes mellitus 5 | 1,728
group 3 medulloblastoma 5 | 4,104
primary pancreatic ductal adenocarcinoma 5 | 1,109
primitive neuroectodermal tumor 5 | 3,035
spina bifida 5 | 1,074
Diffuse large B-cell lymphoma 4 | 39
Down syndrome 4 | 499
Infantile onset 4 | 238
Lymphoma, Large B-Cell, Diffuse 4 | 34
Melanoma 4 | 711
lung adenocarcinoma 4 | 2,716
pituitary cancer 4 | 1,972
tuberculosis 4 | 2,010
Blastic phase chronic myeloid leukemia 3 | 58
Cherubism 3 | 13
Chronic Lymphocytic Leukemia 3 | 262
Chronic Myelocytic Leukemia Accelerated Phase 3 | 59
DOID:2627 3 | 94
Failure to gain weight 3 | 365
Frontal bossing 3 | 157
Gaucher disease type 1 3 | 180
Heart failure 3 | 162
High forehead 3 | 102
Hypoplastic mandible condyle 3 | 275
Immunologic Deficiency Syndromes 3 | 113
Leukemia 3 | 104
Mandibular hypoplasia 3 | 275
Micrognathism 3 | 275
Myopia 3 | 176
Orbital separation excessive 3 | 244
Pediatric failure to thrive 3 | 365
Pick disease 3 | 1,894
Prostatic Neoplasms 3 | 495
Rheumatoid arthritis 3 | 1,191
Stomach Neoplasms 3 | 300
Tall forehead 3 | 102
Ventricular Septal Defects 3 | 119
acute quadriplegic myopathy 3 | 1,158
esophageal adenocarcinoma 3 | 737
follicular lymphoma 3 | 20
gastric carcinoma 3 | 807
mucosa-associated lymphoid tissue lymphoma 3 | 484
pediatric high grade glioma 3 | 1,064
periodontitis 3 | 293
posterior fossa group A ependymoma 3 | 468
Broad flat nasal bridge 2 | 236
Cerebrovascular disease 2 | 238
Concave bridge of nose 2 | 195
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Endometrial cancer 2 | 311
Hypertension 2 | 396
Multiple Sclerosis 2 | 540
Nasal bridge wide 2 | 236
Pectus excavatum 2 | 100
active Crohn's disease 2 | 922

Tissue

Blood and immune system 31 | 16,909
Digestive Tract 31 | 17,369
Endocrine System 31 | 18,159
Female tissues 31 | 17,400
Liver and Pancreas 31 | 16,750
Male tissues 31 | 17,142
Respiratory system 31 | 16,393
Skin and soft tissues 31 | 17,230
Urinary Tract 31 | 16,678
Cardiovascular System 30 | 15,192
Nervous System 30 | 16,725

Target Family

Enzyme 12 | 4,145
Kinase 10 | 634
Non-IDG 9 | 12,091

Reactome Pathway

GPVI-mediated activation casca... 31 | 31
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Linker for activation of T-cells family member 1 LAT Tbio Non-IDG -2.16291 169.4 667
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.41628 245.1 733
Rho-related GTP-binding protein RhoB RHOB Tbio Enzyme -2.41406 272.2 151
Rho-related GTP-binding protein RhoG RHOG Tbio Enzyme -2.04297 108.1 142
C-type lectin domain family 1 member B CLEC1B Tbio Non-IDG -1.92806 93.6 224
Phosphoinositide 3-kinase regulatory subunit 6 PIK3R6 Tbio Enzyme 0.00000 69
Proto-oncogene vav VAV1 Tchem Non-IDG -2.66356 489.1 548
Guanine nucleotide exchange factor VAV2 VAV2 Tbio Non-IDG -1.81793 64.6 227
Ras-related C3 botulinum toxin substrate 2 RAC2 Tbio Enzyme -2.89402 669.8 273
Guanine nucleotide exchange factor VAV3 VAV3 Tbio Non-IDG -1.82116 74.0 249