Development Level

Tdark 439 | 6,588
Tbio 374 | 11,445
Tchem 208 | 1,598
Tclin 136 | 613

Collection

GPCR: IDG Consortium (Targets) 59 | 126
GPCR: IDG Consortium (Complete... 11 | 25
Kinase: IDG Consortium (Target... 3 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 24 | 979
preweaning lethality, incomple... 23 | 499
decreased vertical activity 18 | 208
abnormal behavior 17 | 298
enlarged heart 15 | 210
decreased bone mineral content 13 | 151
decreased total body fat amoun... 12 | 207
hyperactivity 12 | 148
increased total body fat amoun... 12 | 134
abnormal bone structure 11 | 187
increased lean body mass 11 | 172
abnormal heart morphology 10 | 162
hypoactivity 10 | 132
decreased body weight 9 | 161
decreased lean body mass 9 | 135
improved glucose tolerance 9 | 79
increased startle reflex 9 | 112
increased circulating alkaline... 8 | 122
male infertility 8 | 123
prolonged QT interval 8 | 38
prolonged ST segment 8 | 36
decreased grip strength 7 | 116
increased bone mineral content 7 | 108
increased circulating sodium l... 7 | 71
small superior vagus ganglion 7 | 74
abnormal kidney morphology 6 | 65
abnormal retina morphology 6 | 71
abnormal sleep behavior 5 | 70
decreased bone mineral density 5 | 126
decreased circulating insulin ... 5 | 76
decreased circulating serum al... 5 | 82
decreased circulating triglyce... 5 | 79
decreased fasted circulating g... 5 | 65
decreased neutrophil cell numb... 5 | 42
decreased prepulse inhibition 5 | 82
embryonic lethality prior to t... 5 | 278
increased circulating choleste... 5 | 66
increased circulating triglyce... 5 | 42
increased heart weight 5 | 62
abnormal seminal vesicle morph... 4 | 114
decreased circulating alanine ... 4 | 47
decreased circulating amylase ... 4 | 28
decreased lymphocyte cell numb... 4 | 83
female infertility 4 | 60
impaired righting response 4 | 26
increased blood urea nitrogen ... 4 | 48
increased circulating calcium ... 4 | 34
increased fasted circulating g... 4 | 76
increased hemoglobin content 4 | 45
increased mean corpuscular vol... 4 | 92
increased mean platelet volume 4 | 45
increased neutrophil cell numb... 4 | 46
thrombocytopenia 4 | 56
abnormal behavioral response t... 3 | 66
abnormal coat-hair pigmentatio... 3 | 64
abnormal gait 3 | 69
abnormal testis morphology 3 | 43
cardiovascular system phenotyp... 3 | 36
cataract 3 | 92
decreased body length 3 | 101
decreased circulating LDL chol... 3 | 38
decreased circulating creatini... 3 | 39
decreased circulating glucose ... 3 | 126
decreased exploration in new e... 3 | 11
decreased heart weight 3 | 27
decreased hematocrit 3 | 46
decreased hemoglobin content 3 | 68
decreased red blood cell distr... 3 | 41
decreased startle reflex 3 | 75
embryonic lethality prior to o... 3 | 239
hydrometra 3 | 53
impaired pupillary reflex 3 | 26
increased bone mineral density 3 | 72
increased circulating HDL chol... 3 | 80
increased circulating creatini... 3 | 38
increased circulating potassiu... 3 | 29
increased circulating total pr... 3 | 28
increased lymphocyte cell numb... 3 | 32
increased monocyte cell number 3 | 63
limb grasping 3 | 41
short tibia 3 | 97
small kidney 3 | 16
small testis 3 | 58
abnormal cranium morphology 2 | 36
abnormal epididymis morphology 2 | 42
abnormal lens morphology 2 | 81
abnormal skin coloration 2 | 25
abnormal spleen morphology 2 | 55
abnormal vibrissa morphology 2 | 25
abnormal whole-body plethysmog... 2 | 4
decreased IgE level 2 | 6
decreased T cell number 2 | 15
decreased caudal vertebrae num... 2 | 53
decreased circulating calcium ... 2 | 36
impaired glucose tolerance 2 | 75
increased blood uric acid leve... 2 | 5
increased circulating iron lev... 2 | 30
increased circulating phosphat... 2 | 26
small thymus 2 | 16
tremors 2 | 39

Disease

Carcinoma 797 | 11,493
psoriasis 330 | 6,694
osteosarcoma 324 | 7,950
medulloblastoma, large-cell 299 | 6,241
ovarian cancer 293 | 8,520
glioblastoma 261 | 5,792
atypical teratoid / rhabdoid tumor 228 | 5,112
lung cancer 220 | 4,740
ependymoma 217 | 4,679
adult high grade glioma 207 | 3,801
Cancer 190 | 2,499
diabetes mellitus 185 | 1,728
Astrocytoma, Pilocytic 175 | 3,081
lung carcinoma 171 | 2,843
group 3 medulloblastoma 160 | 4,104
malignant mesothelioma 154 | 3,232
primitive neuroectodermal tumor 153 | 3,035
invasive ductal carcinoma 150 | 2,951
Schizophrenia 147 | 1,160
lung adenocarcinoma 145 | 2,716
Breast cancer 144 | 3,578
oligodendroglioma 142 | 2,850
interstitial cystitis 140 | 2,312
non-small cell lung cancer 139 | 2,890
astrocytic glioma 136 | 2,597
Kidney cancer 128 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 124 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 120 | 2,955
Obesity 119 | 678
ulcerative colitis 114 | 1,819
subependymal giant cell astrocytoma 112 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 110 | 3,291
tuberculosis 105 | 2,010
pancreatic cancer 104 | 2,398
pituitary cancer 99 | 1,972
ductal carcinoma in situ 98 | 1,745
Bipolar Disorder 96 | 666
Depressive disorder 95 | 409
group 4 medulloblastoma 88 | 1,855
breast carcinoma 87 | 1,638
cystic fibrosis 85 | 1,696
Autosomal recessive predisposition 83 | 1,442
colon cancer 83 | 1,478
Hypertension 80 | 396
Pick disease 79 | 1,894
Rheumatoid arthritis 75 | 1,191
Alcoholic Intoxication, Chronic 72 | 289
Mental Depression 71 | 333
cutaneous lupus erythematosus 71 | 1,057
Asthma 70 | 385
Major Depressive Disorder 62 | 301
Epilepsy 57 | 792
Intellectual disability 56 | 1,016
Liver Cirrhosis, Experimental 54 | 769
Multiple Sclerosis 54 | 540
adrenocortical carcinoma 54 | 1,428
astrocytoma 54 | 1,146
Mood Disorders 53 | 184
Hypertensive disease 52 | 292
Parkinson's disease 51 | 392
pancreatic ductal adenocarcinoma liver metastasis 51 | 1,962
Kidney disease 50 | 430
Melanoma 50 | 711
primary Sjogren syndrome 50 | 735
Seizures 49 | 596
Unipolar Depression 49 | 250
active ulcerative colitis 44 | 764
Atherosclerosis 43 | 291
active Crohn's disease 43 | 922
Atopic dermatitis 42 | 952
primary pancreatic ductal adenocarcinoma 41 | 1,109
Alzheimer's disease 40 | 658
Dull intelligence 40 | 645
Low intelligence 40 | 645
Mental Retardation 40 | 645
Mental deficiency 40 | 645
Poor school performance 40 | 645
fibroadenoma 40 | 559
juvenile dermatomyositis 40 | 1,187
pediatric high grade glioma 40 | 1,064
Pain 39 | 103
Autistic Disorder 38 | 364
Vascular disease 38 | 319
Cerebrovascular disease 37 | 238
Coronary artery disease 37 | 268
Pain agnosia 37 | 104
nasopharyngeal carcinoma 37 | 1,058
Hypogonadism 36 | 173
Migraine 36 | 83
non primary Sjogren syndrome sicca 36 | 891
Adenoma 35 | 167
Endometriosis 35 | 540
Liver cancer 35 | 604
spina bifida 35 | 1,074
Down syndrome 34 | 499
Heart disease 34 | 306
aldosterone-producing adenoma 34 | 665
hepatocellular carcinoma 34 | 547
Prostatic Neoplasms 33 | 495
mucosa-associated lymphoid tissue lymphoma 33 | 484

Tissue

Endocrine System 811 | 18,159
Female tissues 700 | 17,400
Digestive Tract 690 | 17,369
Male tissues 680 | 17,142
Blood and immune system 670 | 16,909
Nervous System 670 | 16,725
Skin and soft tissues 669 | 17,230
Urinary Tract 641 | 16,678
Liver and Pancreas 635 | 16,750
Respiratory system 613 | 16,393
Cardiovascular System 534 | 15,192

Target Family

oGPCR 415 | 421
Non-IDG 289 | 12,091
GPCR 279 | 408
Enzyme 116 | 4,145
Kinase 48 | 634
Ion Channel 8 | 344
Transcription Factor 1 | 1,400
Transporter 1 | 473

Reactome Pathway

GPCR downstream signalling 1,157 | 1,157
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Urotensin-2 receptor UTS2R Tchem GPCR -1.95094 62.5 182
Relaxin-3 RLN3 Tbio Non-IDG -1.88808 92.6 93
Olfactory receptor 5H15 OR5H15 Tdark oGPCR 0.00000 35
Olfactory receptor 4F4 OR4F4 Tdark oGPCR 0.00000 45
Olfactory receptor 4C12 OR4C12 Tdark oGPCR 0.31 0.30 74
Olfactory receptor 4K3 OR4K3 Tdark oGPCR 0.00000 0
Adrenocorticotropic hormone receptor MC2R Tclin GPCR -2.22640 172.4 223
Olfactory receptor 6C68 OR6C68 Tdark oGPCR 0.00000 49
Olfactory receptor 2M4 OR2M4 Tdark oGPCR 0.95 0.18 19
Olfactory receptor 2M2 OR2M2 Tdark oGPCR 0.00000 61