Development Level

Tdark 439 | 6,588
Tbio 374 | 11,445
Tchem 208 | 1,598
Tclin 136 | 613

Collection

GPCR: IDG Consortium (Targets) 59 | 126
RFA-RM-18-021 36 | 328
GPCR: IDG Consortium (Complete... 11 | 25
Kinase: IDG Consortium (Target... 3 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 24 | 979
preweaning lethality, incomple... 23 | 499
decreased vertical activity 18 | 208
abnormal behavior 17 | 298
enlarged heart 15 | 210
decreased bone mineral content 13 | 151
decreased total body fat amoun... 12 | 207
hyperactivity 12 | 148
increased total body fat amoun... 12 | 134
abnormal bone structure 11 | 187
increased lean body mass 11 | 172
abnormal heart morphology 10 | 162
hypoactivity 10 | 132
decreased body weight 9 | 161
decreased lean body mass 9 | 135
improved glucose tolerance 9 | 79
increased startle reflex 9 | 112
increased circulating alkaline... 8 | 122
male infertility 8 | 123
prolonged QT interval 8 | 38
prolonged ST segment 8 | 36
decreased grip strength 7 | 116
increased bone mineral content 7 | 108
increased circulating sodium l... 7 | 71
small superior vagus ganglion 7 | 74
abnormal kidney morphology 6 | 65
abnormal retina morphology 6 | 71
abnormal sleep behavior 5 | 70
decreased bone mineral density 5 | 126
decreased circulating insulin ... 5 | 76
decreased circulating serum al... 5 | 82
decreased circulating triglyce... 5 | 79
decreased fasted circulating g... 5 | 65
decreased neutrophil cell numb... 5 | 42
decreased prepulse inhibition 5 | 82
embryonic lethality prior to t... 5 | 278
increased circulating choleste... 5 | 66
increased circulating triglyce... 5 | 42
increased heart weight 5 | 62
abnormal seminal vesicle morph... 4 | 114
decreased circulating alanine ... 4 | 47
decreased circulating amylase ... 4 | 28
decreased lymphocyte cell numb... 4 | 83
female infertility 4 | 60
impaired righting response 4 | 26
increased blood urea nitrogen ... 4 | 48
increased circulating calcium ... 4 | 34
increased fasted circulating g... 4 | 76
increased hemoglobin content 4 | 45
increased mean corpuscular vol... 4 | 92
increased mean platelet volume 4 | 45
increased neutrophil cell numb... 4 | 46
thrombocytopenia 4 | 56
abnormal behavioral response t... 3 | 66
abnormal coat-hair pigmentatio... 3 | 64
abnormal gait 3 | 69
abnormal testis morphology 3 | 43
cardiovascular system phenotyp... 3 | 36
cataract 3 | 92
decreased body length 3 | 101
decreased circulating LDL chol... 3 | 38
decreased circulating creatini... 3 | 39
decreased circulating glucose ... 3 | 126
decreased exploration in new e... 3 | 11
decreased heart weight 3 | 27
decreased hematocrit 3 | 46
decreased hemoglobin content 3 | 68
decreased red blood cell distr... 3 | 41
decreased startle reflex 3 | 75
embryonic lethality prior to o... 3 | 239
hydrometra 3 | 53
impaired pupillary reflex 3 | 26
increased bone mineral density 3 | 72
increased circulating HDL chol... 3 | 80
increased circulating creatini... 3 | 38
increased circulating potassiu... 3 | 29
increased circulating total pr... 3 | 28
increased lymphocyte cell numb... 3 | 32
increased monocyte cell number 3 | 63
limb grasping 3 | 41
short tibia 3 | 97
small kidney 3 | 16
small testis 3 | 58
abnormal cranium morphology 2 | 36
abnormal epididymis morphology 2 | 42
abnormal lens morphology 2 | 81
abnormal skin coloration 2 | 25
abnormal spleen morphology 2 | 55
abnormal vibrissa morphology 2 | 25
abnormal whole-body plethysmog... 2 | 4
decreased IgE level 2 | 6
decreased T cell number 2 | 15
decreased caudal vertebrae num... 2 | 53
decreased circulating calcium ... 2 | 36
impaired glucose tolerance 2 | 75
increased blood uric acid leve... 2 | 5
increased circulating iron lev... 2 | 30
increased circulating phosphat... 2 | 26
small thymus 2 | 16
tremors 2 | 39

Disease

Carcinoma 797 | 11,493
psoriasis 330 | 6,694
osteosarcoma 324 | 7,950
medulloblastoma, large-cell 299 | 6,241
ovarian cancer 293 | 8,520
glioblastoma 261 | 5,792
atypical teratoid / rhabdoid tumor 228 | 5,112
lung cancer 220 | 4,740
ependymoma 217 | 4,679
adult high grade glioma 207 | 3,801
Cancer 190 | 2,499
diabetes mellitus 185 | 1,728
Astrocytoma, Pilocytic 175 | 3,081
lung carcinoma 171 | 2,843
group 3 medulloblastoma 160 | 4,104
malignant mesothelioma 154 | 3,232
primitive neuroectodermal tumor 153 | 3,035
invasive ductal carcinoma 150 | 2,951
Schizophrenia 147 | 1,160
lung adenocarcinoma 145 | 2,716
Breast cancer 144 | 3,578
oligodendroglioma 142 | 2,850
interstitial cystitis 140 | 2,312
non-small cell lung cancer 139 | 2,890
astrocytic glioma 136 | 2,597
Kidney cancer 128 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 124 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 120 | 2,955
Obesity 119 | 678
ulcerative colitis 114 | 1,819
subependymal giant cell astrocytoma 112 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 110 | 3,291
tuberculosis 105 | 2,010
pancreatic cancer 104 | 2,398
pituitary cancer 99 | 1,972
ductal carcinoma in situ 98 | 1,745
Bipolar Disorder 96 | 666
Depressive disorder 95 | 409
group 4 medulloblastoma 88 | 1,855
breast carcinoma 87 | 1,638
cystic fibrosis 85 | 1,696
Autosomal recessive predisposition 83 | 1,442
colon cancer 83 | 1,478
Hypertension 80 | 396
Pick disease 79 | 1,894
Rheumatoid arthritis 75 | 1,191
Alcoholic Intoxication, Chronic 72 | 289
Mental Depression 71 | 333
cutaneous lupus erythematosus 71 | 1,057
Asthma 70 | 385
Major Depressive Disorder 62 | 301
Epilepsy 57 | 792
Intellectual disability 56 | 1,016
Liver Cirrhosis, Experimental 54 | 769
Multiple Sclerosis 54 | 540
adrenocortical carcinoma 54 | 1,428
astrocytoma 54 | 1,146
Mood Disorders 53 | 184
Hypertensive disease 52 | 292
Parkinson's disease 51 | 392
pancreatic ductal adenocarcinoma liver metastasis 51 | 1,962
Kidney disease 50 | 430
Melanoma 50 | 711
primary Sjogren syndrome 50 | 735
Seizures 49 | 596
Unipolar Depression 49 | 250
active ulcerative colitis 44 | 764
Atherosclerosis 43 | 291
active Crohn's disease 43 | 922
Atopic dermatitis 42 | 952
primary pancreatic ductal adenocarcinoma 41 | 1,109
Alzheimer's disease 40 | 658
Dull intelligence 40 | 645
Low intelligence 40 | 645
Mental Retardation 40 | 645
Mental deficiency 40 | 645
Poor school performance 40 | 645
fibroadenoma 40 | 559
juvenile dermatomyositis 40 | 1,187
pediatric high grade glioma 40 | 1,064
Pain 39 | 103
Autistic Disorder 38 | 364
Vascular disease 38 | 319
Cerebrovascular disease 37 | 238
Coronary artery disease 37 | 268
Pain agnosia 37 | 104
nasopharyngeal carcinoma 37 | 1,058
Hypogonadism 36 | 173
Migraine 36 | 83
non primary Sjogren syndrome sicca 36 | 891
Adenoma 35 | 167
Endometriosis 35 | 540
Liver cancer 35 | 604
spina bifida 35 | 1,074
Down syndrome 34 | 499
Heart disease 34 | 306
aldosterone-producing adenoma 34 | 665
hepatocellular carcinoma 34 | 547
Prostatic Neoplasms 33 | 495
mucosa-associated lymphoid tissue lymphoma 33 | 484

Tissue

Endocrine System 811 | 18,159
Female tissues 700 | 17,400
Digestive Tract 690 | 17,369
Male tissues 680 | 17,142
Blood and immune system 670 | 16,909
Nervous System 670 | 16,725
Skin and soft tissues 669 | 17,230
Urinary Tract 641 | 16,678
Liver and Pancreas 635 | 16,750
Respiratory system 613 | 16,393
Cardiovascular System 534 | 15,192

Target Family

oGPCR 415 | 421
Non-IDG 289 | 12,091
GPCR 279 | 408
Enzyme 116 | 4,145
Kinase 48 | 634
Ion Channel 8 | 344
Transcription Factor 1 | 1,400
Transporter 1 | 473

Reactome Pathway

GPCR downstream signalling 1,157 | 1,157
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Metabotropic glutamate receptor 5 GRM5 Tchem GPCR -3.12353 1370.3 396
Olfactory receptor 51B2 OR51B2 Tdark oGPCR 0.12 0.65 26
Olfactory receptor 51B4 OR51B4 Tdark oGPCR 0.05 1.19 4
5-hydroxytryptamine receptor 1F HTR1F Tchem GPCR -2.39159 244.1 131
5-hydroxytryptamine receptor 2B HTR2B Tclin GPCR -2.66641 486.3 265
Metabotropic glutamate receptor 3 GRM3 Tchem GPCR -2.30964 186.9 274
Metabotropic glutamate receptor 7 GRM7 Tchem GPCR -2.25415 190.8 304
Metabotropic glutamate receptor 4 GRM4 Tchem GPCR -2.34335 217.2 150
Olfactory receptor 5B2 OR5B2 Tdark oGPCR 0.00000 1
Methionine aminopeptidase 1 METAP1 Tchem Enzyme -1.64901 44.4 149