Development Level

Tdark 441 | 7,003
Tbio 271 | 10,625
Tchem 177 | 1,890
Tclin 126 | 602

Collection

Eligible non-olfactory GPCR Proteins 61 | 143
Eligible Kinase Proteins 2 | 134
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 11 | 633
preweaning lethality, incomple... 11 | 260
decreased lean body mass 10 | 195
abnormal behavior 9 | 226
abnormal bone structure 9 | 131
decreased body weight 8 | 174
decreased bone mineral content 8 | 157
decreased bone mineral density 7 | 126
decreased grip strength 7 | 123
abnormal bone mineralization 6 | 55
improved glucose tolerance 6 | 56
increased circulating alkaline... 6 | 119
decreased circulating triglyce... 5 | 83
increased circulating HDL chol... 5 | 63
increased heart weight 5 | 37
increased total body fat amoun... 5 | 57
male infertility 5 | 62
decreased circulating alanine ... 4 | 53
decreased circulating glucose ... 4 | 121
decreased circulating insulin ... 4 | 75
decreased prepulse inhibition 4 | 52
decreased total body fat amoun... 4 | 186
hypoactivity 4 | 89
increased circulating calcium ... 4 | 32
increased grip strength 4 | 83
abnormal behavioral response t... 3 | 52
abnormal kidney morphology 3 | 30
decreased CD8-positive, alpha-... 3 | 26
decreased NK T cell number 3 | 28
decreased T cell number 3 | 31
decreased body length 3 | 108
decreased circulating LDL chol... 3 | 37
decreased circulating choleste... 3 | 85
decreased circulating creatini... 3 | 31
decreased fasted circulating g... 3 | 49
decreased heart weight 3 | 44
decreased hemoglobin content 3 | 53
decreased vertical activity 3 | 22
enlarged heart 3 | 111
increased circulating sodium l... 3 | 71
increased circulating total pr... 3 | 20
increased fasted circulating g... 3 | 68
increased mean corpuscular hem... 3 | 93
increased mean corpuscular vol... 3 | 91
increased monocyte cell number 3 | 27
thrombocytopenia 3 | 46
abnormal coat/hair pigmentatio... 2 | 54
abnormal epididymis morphology 2 | 31
abnormal lens morphology 2 | 73
abnormal retina morphology 2 | 100
abnormal retinal pigmentation 2 | 61
abnormal seminal vesicle morph... 2 | 47
abnormal sleep behavior 2 | 63
abnormal spleen morphology 2 | 36
abnormal testis morphology 2 | 30
abnormal vibrissa morphology 2 | 17
absent testes 2 | 2
cardiovascular system phenotyp... 2 | 35
decreased IgE level 2 | 3
decreased brain size 2 | 4
decreased caudal vertebrae num... 2 | 49
decreased circulating HDL chol... 2 | 77
decreased circulating amylase ... 2 | 24
decreased circulating bilirubi... 2 | 14
decreased circulating calcium ... 2 | 33
decreased circulating chloride... 2 | 32
decreased circulating phosphat... 2 | 15
decreased dendritic cell numbe... 2 | 3
decreased hematocrit 2 | 25
decreased lumbar vertebrae num... 2 | 62
decreased monocyte cell number 2 | 28
hyperactivity 2 | 108
increased blood urea nitrogen ... 2 | 44
increased bone mineral density 2 | 52
increased circulating choleste... 2 | 53
increased circulating phosphat... 2 | 24
increased effector memory CD8-... 2 | 14
increased hemoglobin content 2 | 45
no abnormal phenotype detected 2 | 3
small heart 2 | 8
small kidney 2 | 10
small liver 2 | 8
small lung 2 | 5
small spleen 2 | 11
small stomach 2 | 3
small superior vagus ganglion 2 | 20
small testis 2 | 37
small thymus 2 | 11
tremors 2 | 34
abnormal embryo size 1 | 112
abnormal heart morphology 1 | 51
abnormal locomotor activation 1 | 26
abnormal neural tube closure 1 | 37
decreased circulating sodium l... 1 | 18
decreased eosinophil cell numb... 1 | 41
decreased mean corpuscular hem... 1 | 34
female infertility 1 | 34
impaired righting response 1 | 19
increased NK cell number 1 | 19
increased sacral vertebrae num... 1 | 62

Disease

osteosarcoma 262 | 7,933
psoriasis 255 | 6,685
medulloblastoma, large-cell 244 | 6,234
ovarian cancer 229 | 8,484
glioblastoma 191 | 5,572
atypical teratoid / rhabdoid tumor 152 | 4,369
diabetes mellitus 150 | 1,663
lung cancer 146 | 4,466
pilocytic astrocytoma 145 | 3,086
Cancer 142 | 2,346
lung carcinoma 139 | 2,844
primitive neuroectodermal tumor 120 | 3,031
invasive ductal carcinoma 117 | 2,950
interstitial cystitis 116 | 2,299
lung adenocarcinoma 116 | 2,713
malignant mesothelioma 114 | 3,162
oligodendroglioma 114 | 2,849
ulcerative colitis 109 | 2,087
adult high grade glioma 105 | 2,148
Carcinoma 101 | 2,147
non-small cell lung cancer 101 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 98 | 2,988
ependymoma 97 | 2,514
pediatric high grade glioma 94 | 2,712
Breast cancer 93 | 3,094
intraductal papillary-mucinous adenoma (IPMA) 93 | 2,956
astrocytic glioma 89 | 2,241
subependymal giant cell astrocytoma 85 | 2,287
Obesity 84 | 616
intraductal papillary-mucinous neoplasm (IPMN) 82 | 3,289
pancreatic cancer 81 | 2,300
pituitary cancer 76 | 1,972
Schizophrenia 74 | 501
colon cancer 70 | 1,475
ductal carcinoma in situ 70 | 1,745
tuberculosis 69 | 1,557
breast carcinoma 68 | 1,614
medulloblastoma 67 | 1,524
Asthma 65 | 349
Pick disease 65 | 1,893
group 4 medulloblastoma 64 | 1,875
Rheumatoid Arthritis 63 | 1,160
cystic fibrosis 61 | 1,665
posterior fossa group A ependymoma 59 | 1,511
astrocytoma 57 | 1,493
cutaneous lupus erythematosus 57 | 1,056
group 3 medulloblastoma 55 | 2,254
Hypertension 49 | 287
primary Sjogren syndrome 49 | 789
posterior fossa group B ependymoma 47 | 1,530
Multiple Sclerosis 43 | 498
adrenocortical carcinoma 42 | 1,427
atypical teratoid/rhabdoid tumor 40 | 1,095
Hypertensive disease 39 | 193
Parkinson's disease 39 | 364
sonic hedgehog group medulloblastoma 39 | 1,482
Kidney disease 36 | 396
Pain 36 | 70
Epilepsy 34 | 346
Pain agnosia 34 | 99
primary pancreatic ductal adenocarcinoma 34 | 1,271
Autistic Disorder 33 | 320
Migraine 33 | 79
juvenile dermatomyositis 32 | 1,189
Alzheimer's disease 31 | 644
active Crohn's disease 31 | 918
gastric carcinoma 31 | 832
Adenoma 30 | 165
Alcohol dependence 30 | 107
Allergic rhinitis 30 | 91
Atopic dermatitis 30 | 944
Bipolar Disorder 30 | 266
Down syndrome 29 | 548
Cerebrovascular disease 28 | 231
Hyperalgesia 28 | 71
Major Depressive Disorder 28 | 106
Vascular disease 28 | 281
mucosa-associated lymphoid tissue lymphoma 28 | 480
Arthritis 27 | 248
Atherosclerosis 27 | 275
fibroadenoma 27 | 557
hepatocellular carcinoma 27 | 532
Cocaine-Related Disorders 26 | 88
Hypotension 26 | 53
Heart disease 25 | 279
Substance Withdrawal Syndrome 25 | 52
esophageal adenocarcinoma 25 | 737
non primary Sjogren syndrome sicca 25 | 840
non-small cell lung carcinoma 25 | 413
Endometriosis 24 | 535
Seizures 24 | 95
aldosterone-producing adenoma 24 | 664
spina bifida 24 | 1,064
Acromegaly 23 | 40
Common cold 23 | 63
Crohn's disease 23 | 304
Prostatic Neoplasms 23 | 471
nasopharyngeal carcinoma 23 | 1,056
pancreatic carcinoma 23 | 567
pancreatic ductal adenocarcinoma liver metastasis 23 | 1,795

Tissue

Female tissues 895 | 18,647
Urinary Tract 868 | 18,444
Nervous System 814 | 18,561
Endocrine System 812 | 18,512
Digestive Tract 785 | 18,473
Skin and soft tissues 743 | 18,115
Liver and Pancreas 677 | 18,136
Blood and immune system 659 | 17,995
Cardiovascular System 651 | 17,958
Male tissues 613 | 17,969
Respiratory system 590 | 17,484

Target Family

oGPCR 416 | 421
GPCR 268 | 406
Non-IDG 240 | 11,971
Enzyme 54 | 4,146
Kinase 31 | 634
Ion Channel 6 | 341

Reactome Pathway

GPCR downstream signaling 1,015 | 1,015
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Pro-neuropeptide Y NPY Tbio Non-IDG -3.81741 7285.3 401
Short-wave-sensitive opsin 1 OPN1SW Tbio GPCR -1.90084 81.3 15
Olfactory receptor 2T1 OR2T1 Tdark oGPCR 0.00000 38
Regulator of G-protein signaling 22 RGS22 Tbio Non-IDG -0.31702 2.73 99
Rho guanine nucleotide exchange factor 11 ARHGEF11 Tbio Non-IDG -1.54485 39.7 163
5-hydroxytryptamine receptor 6 HTR6 Tchem GPCR -2.29395 203.8 55
Neuropeptides B/W receptor type 1 NPBWR1 Tchem GPCR -1.34565 19.5 151
Neuropeptides B/W receptor type 2 NPBWR2 Tbio GPCR -1.14202 8.84 57