Development Level

Tbio 12 | 11,445
Tchem 4 | 1,598
Tclin 2 | 613

IMPC Phenotype

decreased heart left ventricle... 1 | 28
increased circulating chloride... 1 | 41
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased total body fat amoun... 1 | 134
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499
thin ventricular wall 1 | 24

Disease

adult high grade glioma 16 | 3,801
glioblastoma 16 | 5,792
atypical teratoid / rhabdoid tumor 15 | 5,112
medulloblastoma, large-cell 15 | 6,241
ependymoma 14 | 4,679
group 3 medulloblastoma 14 | 4,104
oligodendroglioma 13 | 2,850
Astrocytoma, Pilocytic 12 | 3,081
Carcinoma 12 | 11,493
Schizophrenia 12 | 1,160
astrocytic glioma 12 | 2,597
primitive neuroectodermal tumor 11 | 3,035
Epilepsy 10 | 792
Pick disease 8 | 1,894
ovarian cancer 7 | 8,520
Bipolar Disorder 6 | 666
osteosarcoma 6 | 7,950
psoriasis 6 | 6,694
subependymal giant cell astrocytoma 6 | 2,287
Autistic Disorder 5 | 364
Cognitive delay 5 | 608
Global developmental delay 5 | 608
Mental and motor retardation 5 | 608
lung carcinoma 5 | 2,843
Alzheimer's disease 4 | 658
Cerebellar Ataxia 4 | 304
Depressive disorder 4 | 409
Glaucoma 4 | 239
Intellectual disability 4 | 1,016
Major Depressive Disorder 4 | 301
Mental Depression 4 | 333
Parkinson's disease 4 | 392
Seizures 4 | 596
cystic fibrosis 4 | 1,696
interstitial cystitis 4 | 2,312
lung cancer 4 | 4,740
Alcoholic Intoxication, Chronic 3 | 289
Attention deficit hyperactivity disorder 3 | 278
Botulism 3 | 24
Neurodevelopmental Disorders 3 | 70
Psychotic Disorders 3 | 151
Status Epilepticus 3 | 98
Succinic semialdehyde dehydrogenase deficiency 3 | 16
Unipolar Depression 3 | 250
active ulcerative colitis 3 | 764
adrenocortical carcinoma 3 | 1,428
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
malignant mesothelioma 3 | 3,232
medulloblastoma 3 | 720
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
Abnormal behavior 2 | 52
Acquired scoliosis 2 | 281
Amyotrophic lateral sclerosis 2 | 451
Autosomal recessive predisposition 2 | 1,442
Blepharoptosis 2 | 231
Brain disease 2 | 96
Cleft Palate 2 | 271
Cocaine-Related Disorders 2 | 92
Contracture 2 | 96
Contracture of joint 2 | 93
Curvature of spine 2 | 282
Developmental regression 2 | 95
Dull intelligence 2 | 645
Dysarthria 2 | 192
Electroencephalogram abnormal 2 | 101
Epilepsies, Myoclonic 2 | 32
Epilepsy characterized by intractable complex partial seizures 2 | 28
Flexion contracture 2 | 93
Flexion contractures of joints 2 | 93
Generalized myoclonic seizures 2 | 30
Infantile onset 2 | 238
Kidney cancer 2 | 2,613
Loss of developmental milestones 2 | 95
Low intelligence 2 | 645
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Mental deterioration in childhood 2 | 95
Mood Disorders 2 | 184
Muscle hypotonia 2 | 571
Myoclonic Epilepsies, Progressive 2 | 44
Neurodegenerative disease 2 | 414
Neurodevelopmental regression 2 | 95
Poor school performance 2 | 645
Psychomotor regression 2 | 95
Psychomotor regression beginning in infancy 2 | 95
Psychomotor regression in infants 2 | 95
Psychomotor regression, progressive 2 | 95
Reduced fetal movement 2 | 51
Rheumatoid arthritis 2 | 1,191
Severe mental retardation (I.Q. 20-34) 2 | 99
Small head 2 | 374
Spastic Quadriplegia 2 | 42
astrocytoma 2 | 1,146
colon cancer 2 | 1,478
diabetes mellitus 2 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
nasopharyngeal carcinoma 2 | 1,058
non-small cell lung cancer 2 | 2,890
pituitary cancer 2 | 1,972

Tissue

Endocrine System 18 | 18,159
Nervous System 18 | 16,725
Digestive Tract 17 | 17,369
Male tissues 17 | 17,142
Skin and soft tissues 17 | 17,230
Blood and immune system 16 | 16,909
Female tissues 16 | 17,400
Liver and Pancreas 16 | 16,750
Urinary Tract 16 | 16,678
Respiratory system 15 | 16,393
Cardiovascular System 12 | 15,192

Target Family

Non-IDG 9 | 12,091
Transporter 5 | 473
Enzyme 4 | 4,145

Reactome Pathway

GABA synthesis, release, reupt... 18 | 18
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Succinate-semialdehyde dehydrogenase, mitochondrial ALDH5A1 Tclin Enzyme -2.23586 168.4 347
Sodium- and chloride-dependent GABA transporter 3 SLC6A11 Tbio Transporter -2.26927 175.1 75
Sodium- and chloride-dependent betaine transporter SLC6A12 Tchem Transporter -2.34582 212.0 104
DnaJ homolog subfamily C member 5 DNAJC5 Tbio Non-IDG -1.98508 92.5 193
Sodium- and chloride-dependent GABA transporter 2 SLC6A13 Tchem Transporter -2.43015 259.2 51
Regulating synaptic membrane exocytosis protein 1 RIMS1 Tbio Non-IDG -1.95711 85.7 11
Vesicle-associated membrane protein 2 VAMP2 Tbio Non-IDG -2.53335 323.7 203
Vesicular inhibitory amino acid transporter SLC32A1 Tchem Transporter -2.58494 352.6 151
Heat shock cognate 71 kDa protein HSPA8 Tchem Non-IDG -2.95379 881.0 741
Glutamate decarboxylase 2 GAD2 Tbio Enzyme -3.03047 1065.4 459