Development Level

Tbio 18 | 10,625
Tchem 14 | 1,890
Tdark 5 | 7,003
Tclin 2 | 602

Collection

Eligible Ion Channel Proteins 1 | 117

IMPC Term

abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal epididymis morphology 1 | 31
abnormal response to tactile s... 1 | 16
abnormal spleen morphology 1 | 36
abnormal startle reflex 1 | 14
decreased body weight 1 | 174
decreased bone mineral density 1 | 126
decreased circulating chloride... 1 | 32
decreased circulating choleste... 1 | 85
decreased lean body mass 1 | 195
enlarged epididymis 1 | 27
hyperactivity 1 | 108
increased bone mineral content 1 | 92
increased circulating alkaline... 1 | 119
limb grasping 1 | 35
preweaning lethality, complete... 1 | 633
preweaning lethality, incomple... 1 | 260
tremors 1 | 34

Disease

medulloblastoma, large-cell 24 | 6,234
glioblastoma 19 | 5,572
primitive neuroectodermal tumor 19 | 3,031
osteosarcoma 17 | 7,933
pilocytic astrocytoma 17 | 3,086
psoriasis 17 | 6,685
atypical teratoid / rhabdoid tumor 16 | 4,369
ovarian cancer 16 | 8,484
ependymoma 15 | 2,514
oligodendroglioma 15 | 2,849
subependymal giant cell astrocytoma 15 | 2,287
group 3 medulloblastoma 12 | 2,254
astrocytic glioma 11 | 2,241
pediatric high grade glioma 11 | 2,712
pituitary cancer 11 | 1,972
Breast cancer 10 | 3,094
interstitial cystitis 10 | 2,299
invasive ductal carcinoma 10 | 2,950
lung carcinoma 10 | 2,844
Pick disease 9 | 1,893
adult high grade glioma 9 | 2,148
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,988
lung cancer 9 | 4,466
non-small cell lung cancer 8 | 2,798
breast carcinoma 7 | 1,614
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,289
malignant mesothelioma 7 | 3,162
medulloblastoma 7 | 1,524
pancreatic cancer 7 | 2,300
Carcinoma 6 | 2,147
astrocytoma 6 | 1,493
atypical teratoid/rhabdoid tumor 6 | 1,095
ductal carcinoma in situ 6 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,956
lung adenocarcinoma 6 | 2,713
Schnyder corneal dystrophy 5 | 23
posterior fossa group A ependymoma 5 | 1,511
ulcerative colitis 5 | 2,087
Acquired metabolic disease 4 | 267
Atrial Fibrillation 4 | 110
Duchenne muscular dystrophy 4 | 602
Rheumatoid Arthritis 4 | 1,160
gastric carcinoma 4 | 832
group 4 medulloblastoma 4 | 1,875
sonic hedgehog group medulloblastoma 4 | 1,482
Alcohol dependence 3 | 107
Down syndrome 3 | 548
Hyperactive behavior 3 | 31
Intellectual disability 3 | 573
Long QT syndrome 3 | 52
Multiple myeloma 3 | 1,327
Pain agnosia 3 | 99
Substance Withdrawal Syndrome 3 | 52
adrenocortical carcinoma 3 | 1,427
chronic rhinosinusitis 3 | 512
colon cancer 3 | 1,475
cystic fibrosis 3 | 1,665
diabetes mellitus 3 | 1,663
glioblastoma multiforme 3 | 347
head and neck cancer 3 | 270
juvenile dermatomyositis 3 | 1,189
mucosa-associated lymphoid tissue lymphoma 3 | 480
posterior fossa group B ependymoma 3 | 1,530
primary Sjogren syndrome 3 | 789
primary pancreatic ductal adenocarcinoma 3 | 1,271
Amnesia 2 | 17
Andersen Syndrome 2 | 2
Animal Mammary Neoplasms 2 | 136
Atopic dermatitis 2 | 944
Autistic Disorder 2 | 320
Cataplexy and narcolepsy 2 | 3
Diabetes Mellitus, Non-Insulin-Dependent 2 | 157
Dystonia 2 | 77
EAST syndrome 2 | 5
Epilepsy 2 | 346
Hypertension 2 | 287
Hypertensive disease 2 | 193
Hypokalemia 2 | 40
Hypokalemic periodic paralysis 2 | 13
Juvenile arthritis 2 | 124
Mammary Neoplasms, Experimental 2 | 150
Muscle Spasticity of Cerebral Origin 2 | 8
Muscle Weakness 2 | 92
Muscle spasticity of spinal origin 2 | 8
Narcolepsy 2 | 58
Nerve Degeneration 2 | 73
Obesity 2 | 616
Waldenstrons macroglobulinemia 2 | 765
active ulcerative colitis 2 | 477
acute quadriplegic myopathy 2 | 1,157
cutaneous lupus erythematosus 2 | 1,056
cystic fibrosis and chronic rhinosinusitis 2 | 213
dermatomyositis 2 | 933
nephrosclerosis 2 | 329
non primary Sjogren syndrome sicca 2 | 840
pancreatic carcinoma 2 | 567
sarcoidosis 2 | 358
tuberculosis 2 | 1,557
tuberculosis and treatment for 6 months 2 | 686
Dermatologic disorders 1 | 65

Tissue

Blood and immune system 39 | 17,995
Digestive Tract 39 | 18,473
Endocrine System 39 | 18,512
Female tissues 39 | 18,647
Liver and Pancreas 39 | 18,136
Male tissues 39 | 17,969
Nervous System 39 | 18,561
Skin and soft tissues 39 | 18,115
Urinary Tract 39 | 18,444
Cardiovascular System 38 | 17,958
Respiratory system 38 | 17,484

Target Family

Non-IDG 18 | 11,971
Ion Channel 10 | 341
Enzyme 9 | 4,146
GPCR 2 | 406

Reactome Pathway

GABA B receptor activation 39 | 39
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adenylate cyclase type 1 ADCY1 Tchem Enzyme -1.58202 42.2 123
G protein-activated inward rectifier potassium channel 4 KCNJ5 Tchem Ion Channel -2.24687 186.6 114
G protein-activated inward rectifier potassium channel 1 KCNJ3 Tchem Ion Channel -2.31340 205.5 237
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 GNB2 Tbio Non-IDG -0.43889 2.98 102
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 GNB1 Tbio Non-IDG -1.15715 18.1 144
Adenylate cyclase type 7 ADCY7 Tbio Enzyme -1.66594 47.2 113
Guanine nucleotide-binding protein G(i) subunit alpha-2 GNAI2 Tbio Non-IDG -1.23038 16.6 188
Adenylate cyclase type 8 ADCY8 Tchem Enzyme -2.01455 108.3 130
G protein-activated inward rectifier potassium channel 2 KCNJ6 Tchem Ion Channel -2.22618 178.1 188
Inward rectifier potassium channel 4 KCNJ4 Tchem Ion Channel -1.87814 80.2 193