Development Level

Tclin 12 | 612

Collection

Ion Channel: IDG Consortium (T... 1 | 99

Disease

Anxiety 12 | 136
Carcinoma 12 | 11,493
Epilepsy 12 | 792
General anesthesia 12 | 53
Insomnia 12 | 20
Tonic-clonic epilepsy 12 | 47
Sedation as Adjunct to Anesthesia 11 | 15
ependymoma 10 | 4,679
medulloblastoma, large-cell 10 | 6,241
Alcoholic Intoxication, Chronic 9 | 289
Kidney cancer 9 | 2,613
atypical teratoid / rhabdoid tumor 9 | 5,112
glioblastoma 9 | 5,792
Alcohol withdrawal delirium 8 | 11
Alcohol withdrawal syndrome 8 | 20
Astrocytoma, Pilocytic 8 | 3,081
Autistic Disorder 8 | 364
Benzodiazepine Induced Sedation 8 | 8
Benzodiazepine Maintained Anesthesia 8 | 8
Benzodiazepine Toxicity 8 | 8
Induce Anterograde Amnesia 8 | 9
Local anesthesia 8 | 40
Preoperative Anxiety 8 | 9
Schizophrenia 8 | 1,160
Sedation 8 | 11
Sedation in Intubated Patients 8 | 8
Spasticity 8 | 26
Status Epilepticus 8 | 98
Tetanus 8 | 68
adult high grade glioma 8 | 3,801
oligodendroglioma 8 | 2,850
primitive neuroectodermal tumor 8 | 3,035
Alcohol dependence 7 | 107
Anxiety associated with Menopause 7 | 7
Conscious sedation 7 | 10
Feeling agitated 7 | 7
Generalized anxiety disorder 7 | 29
Irritable bowel syndrome 7 | 60
Mixed anxiety and depressive disorder 7 | 12
Panic disorder 7 | 61
Partial Epilepsy Treatment Adjunct 7 | 16
Peptic Ulcer 7 | 27
Pre-Op Apprehension 7 | 10
Severe Insomnia 7 | 7
Severe anxiety (panic) 7 | 7
astrocytic glioma 7 | 2,597
Bipolar Disorder 6 | 666
Initial insomnia 6 | 8
Pain with Tension and Anxiety 6 | 6
group 3 medulloblastoma 6 | 4,104
Disorders of initiating and maintaining sleep 5 | 8
Absence seizure 4 | 12
Alcoholism 4 | 45
Atonic seizure 4 | 4
Cerebral Ischemia 4 | 37
Lennox-Gastaut syndrome 4 | 34
Mood Disorders 4 | 184
Myoclonic seizure 4 | 4
Pick disease 4 | 1,894
Schizoaffective Disorder 4 | 55
Seizure disorder 4 | 4
Tetanus Adjunct Treatment 4 | 8
lung carcinoma 4 | 2,843
pituitary cancer 4 | 1,972
subependymal giant cell astrocytoma 4 | 2,287
Absence Epilepsy 3 | 22
Angelman syndrome 3 | 34
Benign intracranial hypertension 3 | 3
Bipolar disorder in remission 3 | 19
Depressive disorder 3 | 409
Dysuria 3 | 26
EPILEPSY, CHILDHOOD ABSENCE, 1 3 | 6
Epilepsy characterized by intractable complex partial seizures 3 | 28
Epileptic drop attack 3 | 11
Hepatic encephalopathy 3 | 27
Heroin dependence 3 | 30
Hypotonic seizures 3 | 11
Isodicentric Chromosome 15 Syndrome 3 | 3
Localization-related epilepsy 3 | 13
Mental Depression 3 | 333
Migraine Prevention 3 | 23
Narcoanalysis 3 | 3
Prader-Willi syndrome 3 | 48
Simple partial seizure 3 | 26
Tension-type headache 3 | 10
Tonic-clonic seizure 3 | 11
Tremor 3 | 113
Urinary Tract Irritation 3 | 24
psoriasis 3 | 6,694
Abnormal behavior 2 | 52
Ataxia 2 | 15
Autism spectrum disorder 2 | 101
Cocaine-Related Disorders 2 | 92
Electroencephalogram abnormal 2 | 101
Epilepsies, Myoclonic 2 | 32
Generalized myoclonic seizures 2 | 30
Liver cancer 2 | 604
Myoclonic Epilepsies, Progressive 2 | 44
Parkinson's disease 2 | 392
ovarian cancer 2 | 8,520

Tissue

Nervous System 12 | 16,725
Digestive Tract 11 | 17,369
Endocrine System 11 | 18,159
Male tissues 10 | 17,142
Blood and immune system 9 | 16,909
Female tissues 9 | 17,400
Skin and soft tissues 9 | 17,230
Urinary Tract 8 | 16,678
Liver and Pancreas 6 | 16,750
Cardiovascular System 5 | 15,192
Respiratory system 5 | 16,393

Target Family

Ion Channel 12 | 344

Reactome Pathway

GABA A receptor activation 12 | 12
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Gamma-aminobutyric acid receptor subunit alpha-6 GABRA6 Tclin Ion Channel -1.30795 19.3 145
Gamma-aminobutyric acid receptor subunit alpha-3 GABRA3 Tclin Ion Channel -1.53765 32.9 135
Gamma-aminobutyric acid receptor subunit beta-2 GABRB2 Tclin Ion Channel -1.49466 30.4 257
Gamma-aminobutyric acid receptor subunit alpha-2 GABRA2 Tclin Ion Channel -1.94775 88.5 201
Gamma-aminobutyric acid receptor subunit beta-3 GABRB3 Tclin Ion Channel -2.13205 136.0 202
Gamma-aminobutyric acid receptor subunit theta GABRQ Tclin Ion Channel -0.83091 6.58 66
Gamma-aminobutyric acid receptor subunit alpha-4 GABRA4 Tclin Ion Channel -1.28622 17.7 291
Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 Tclin Ion Channel -0.98683 8.48 87
Gamma-aminobutyric acid receptor subunit alpha-1 GABRA1 Tclin Ion Channel -1.79984 58.4 301
Gamma-aminobutyric acid receptor subunit beta-1 GABRB1 Tclin Ion Channel -1.35520 21.7 309