Development Level

Tbio 114 | 11,445
Tchem 22 | 1,598
Tdark 7 | 6,588
Tclin 5 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 19 | 979
embryonic lethality prior to o... 11 | 239
embryonic lethality prior to t... 10 | 278
abnormal embryo size 5 | 220
preweaning lethality, incomple... 3 | 499
abnormal blood vessel morpholo... 2 | 5
abnormal embryo turning 2 | 31
abnormal heart morphology 2 | 162
abnormal skin morphology 2 | 50
decreased caudal vertebrae num... 2 | 53
decreased circulating glucose ... 2 | 126
decreased vertical activity 2 | 208
embryonic growth retardation 2 | 106
increased circulating sodium l... 2 | 71
increased mean corpuscular vol... 2 | 92
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal chorioallantoic fusio... 1 | 8
abnormal embryo development 1 | 7
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal kidney morphology 1 | 65
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal somite shape 1 | 5
abnormal spinal cord morpholog... 1 | 9
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
decreased circulating alanine ... 1 | 47
decreased circulating choleste... 1 | 93
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased heart rate variabili... 1 | 13
decreased mean corpuscular hem... 1 | 50
decreased red blood cell distr... 1 | 41
edema 1 | 59
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
increased erythrocyte cell num... 1 | 39
increased grip strength 1 | 41
increased heart weight 1 | 62
increased mean corpuscular hem... 1 | 96
increased mean platelet volume 1 | 45
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
thrombocytosis 1 | 27
urinary bladder obstruction 1 | 4

Disease

ovarian cancer 101 | 8,520
Carcinoma 82 | 11,493
lung cancer 75 | 4,740
psoriasis 69 | 6,694
osteosarcoma 63 | 7,950
glioblastoma 59 | 5,792
Breast cancer 55 | 3,578
malignant mesothelioma 52 | 3,232
Cancer 51 | 2,499
group 3 medulloblastoma 51 | 4,104
medulloblastoma, large-cell 51 | 6,241
non-small cell lung cancer 50 | 2,890
atypical teratoid / rhabdoid tumor 47 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 40 | 3,291
Multiple myeloma 38 | 1,332
primitive neuroectodermal tumor 38 | 3,035
lung adenocarcinoma 36 | 2,716
adult high grade glioma 34 | 3,801
ependymoma 34 | 4,679
invasive ductal carcinoma 34 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 33 | 2,989
adrenocortical carcinoma 30 | 1,428
ductal carcinoma in situ 30 | 1,745
colon cancer 25 | 1,478
nasopharyngeal carcinoma 24 | 1,058
oligodendroglioma 22 | 2,850
Waldenstrons macroglobulinemia 21 | 765
breast carcinoma 21 | 1,638
dermatomyositis 18 | 966
Autosomal recessive predisposition 17 | 1,442
pancreatic cancer 17 | 2,398
Astrocytoma, Pilocytic 16 | 3,081
astrocytic glioma 16 | 2,597
Ataxia telangiectasia 15 | 34
HIV Infections 15 | 102
Endometriosis 14 | 540
astrocytoma 14 | 1,146
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
Pick disease 13 | 1,894
Small head 13 | 374
diabetes mellitus 13 | 1,728
Kidney cancer 12 | 2,613
Nijmegen breakage syndrome 12 | 24
subependymal giant cell astrocytoma 12 | 2,287
Atopic dermatitis 11 | 952
Breast Neoplasms 11 | 445
Hypoplastic mandible condyle 11 | 275
Mammary Neoplasms 11 | 425
Mandibular hypoplasia 11 | 275
Micrognathism 11 | 275
Seckel syndrome 11 | 34
interstitial cystitis 11 | 2,312
lung carcinoma 11 | 2,843
pituitary cancer 11 | 1,972
ulcerative colitis 11 | 1,819
Fanconi anemia 10 | 56
Fetal Growth Retardation 10 | 189
Infant, Small for Gestational Age 10 | 176
Intellectual disability 10 | 1,016
Intrauterine retardation 10 | 176
Short stature 10 | 531
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
non primary Sjogren syndrome sicca 10 | 891
Bloom syndrome 9 | 29
Schizophrenia 9 | 1,160
tuberculosis 9 | 2,010
Delayed bone age 8 | 136
Dull intelligence 8 | 645
Hereditary Breast and Ovarian Cancer Syndrome 8 | 14
Liver Cirrhosis, Experimental 8 | 769
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Poor school performance 8 | 645
cutaneous lupus erythematosus 8 | 1,057
cystic fibrosis 8 | 1,696
pediatric high grade glioma 8 | 1,064
primary Sjogren syndrome 8 | 735
Cleft Palate 7 | 271
Meier-Gorlin syndrome 7 | 10
Microcephaly 7 | 166
esophageal adenocarcinoma 7 | 737
juvenile dermatomyositis 7 | 1,187
Anemia 6 | 365
Convex nasal ridge 6 | 37
Cryptorchidism 6 | 296
Failure to gain weight 6 | 365
Mantle cell lymphoma 6 | 23
Pediatric failure to thrive 6 | 365
Rothmund-Thomson syndrome 6 | 19
Xeroderma pigmentosum 6 | 43
group 4 medulloblastoma 6 | 1,855
Bipolar Disorder 5 | 666
Cognitive delay 5 | 608
Mental and motor retardation 5 | 608
Prostatic Neoplasms 5 | 495
Rheumatoid arthritis 5 | 1,191
Uranostaphyloschisis 5 | 167
gastric carcinoma 5 | 807
primary pancreatic ductal adenocarcinoma 5 | 1,109

Tissue

Endocrine System 147 | 18,159
Blood and immune system 145 | 16,909
Digestive Tract 145 | 17,369
Female tissues 145 | 17,400
Male tissues 145 | 17,142
Nervous System 145 | 16,725
Respiratory system 145 | 16,393
Urinary Tract 145 | 16,678
Liver and Pancreas 144 | 16,750
Skin and soft tissues 144 | 17,230
Cardiovascular System 142 | 15,192

Target Family

Non-IDG 82 | 12,091
Enzyme 53 | 4,145
Kinase 8 | 634
Epigenetic 2 | 242
Transcription Factor 2 | 1,400
TF/Epigenetic 1 | 38

Reactome Pathway

G2/M Checkpoints 148 | 148
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cellular tumor antigen p53 TP53 Tchem Transcription Factor -4.74112 54026.3 6298
Breast cancer type 1 susceptibility protein BRCA1 Tchem Non-IDG -3.76784 6081.3 1542
Histone H2B type 2-E HIST2H2BE Tbio Non-IDG -3.48425 2920.0 135
Cyclin-dependent kinase 2 CDK2 Tchem Kinase -3.44266 2522.8 1114