Development Level

Tbio 95 | 10,625
Tchem 39 | 1,890
Tdark 8 | 7,003
Tclin 5 | 602

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 16 | 633
embryonic lethality prior to o... 6 | 148
embryonic lethality prior to t... 4 | 187
increased circulating sodium l... 2 | 71
abnormal behavioral response t... 1 | 52
abnormal blood vessel morpholo... 1 | 2
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal gait 1 | 51
abnormal retina morphology 1 | 100
abnormal skin morphology 1 | 23
cardiovascular system phenotyp... 1 | 35
decreased body length 1 | 108
decreased caudal vertebrae num... 1 | 49
decreased circulating alanine ... 1 | 53
decreased circulating glucose ... 1 | 121
decreased circulating serum al... 1 | 79
decreased fasted circulating g... 1 | 49
decreased heart rate variabili... 1 | 11
enlarged lymph nodes 1 | 27
hydrops fetalis 1 | 22
increased bone mineral density 1 | 52
increased exploration in new e... 1 | 56
increased grip strength 1 | 83
increased heart weight 1 | 37
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular vol... 1 | 91
prenatal lethality prior to he... 1 | 64
preweaning lethality, incomple... 1 | 260
urinary bladder obstruction 1 | 2

Disease

ovarian cancer 101 | 8,484
lung cancer 72 | 4,466
psoriasis 69 | 6,685
osteosarcoma 64 | 7,933
glioblastoma 55 | 5,572
Cancer 52 | 2,346
malignant mesothelioma 52 | 3,162
Breast cancer 51 | 3,094
medulloblastoma, large-cell 51 | 6,234
non-small cell lung cancer 47 | 2,798
intraductal papillary-mucinous neoplasm (IPMN) 39 | 3,289
primitive neuroectodermal tumor 38 | 3,031
Multiple myeloma 37 | 1,327
group 3 medulloblastoma 37 | 2,254
lung adenocarcinoma 35 | 2,713
invasive ductal carcinoma 33 | 2,950
atypical teratoid / rhabdoid tumor 32 | 4,369
intraductal papillary-mucinous carcinoma (IPMC) 32 | 2,988
adrenocortical carcinoma 30 | 1,427
ductal carcinoma in situ 29 | 1,745
pediatric high grade glioma 29 | 2,712
colon cancer 24 | 1,475
nasopharyngeal carcinoma 24 | 1,056
oligodendroglioma 23 | 2,849
Waldenstrons macroglobulinemia 21 | 765
posterior fossa group A ependymoma 21 | 1,511
atypical teratoid/rhabdoid tumor 18 | 1,095
dermatomyositis 18 | 933
breast carcinoma 17 | 1,614
pancreatic cancer 17 | 2,300
astrocytoma 16 | 1,493
ependymoma 16 | 2,514
HIV Infections 15 | 100
astrocytic glioma 15 | 2,241
diabetes mellitus 15 | 1,663
Endometriosis 14 | 535
Pick disease 14 | 1,893
pilocytic astrocytoma 14 | 3,086
sonic hedgehog group medulloblastoma 14 | 1,482
ulcerative colitis 14 | 2,087
Ataxia telangiectasia 13 | 31
Nijmegen breakage syndrome 13 | 23
Seckel syndrome 13 | 34
adult high grade glioma 12 | 2,148
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,795
Fanconi's anemia 11 | 50
Mammary Neoplasms 11 | 410
interstitial cystitis 11 | 2,299
lung carcinoma 11 | 2,844
non primary Sjogren syndrome sicca 11 | 840
pituitary cancer 11 | 1,972
Atopic dermatitis 10 | 944
Bloom syndrome 10 | 30
Carcinoma 10 | 2,147
Neoplastic Syndromes, Hereditary 10 | 48
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,956
subependymal giant cell astrocytoma 10 | 2,287
Peripheral Neuropathy 9 | 303
IGA Glomerulonephritis 8 | 454
cutaneous lupus erythematosus 8 | 1,056
cystic fibrosis 8 | 1,665
primary Sjogren syndrome 8 | 789
Hereditary Breast and Ovarian Cancer Syndrome 7 | 14
Meier-Gorlin syndrome 7 | 12
Microcephaly 7 | 149
esophageal adenocarcinoma 7 | 737
juvenile dermatomyositis 7 | 1,189
tuberculosis 7 | 1,557
Malignant neoplasm of breast 6 | 63
Mantle cell lymphoma 6 | 18
Rothmund-Thomson syndrome 6 | 22
Werner syndrome 6 | 29
acute quadriplegic myopathy 6 | 1,157
inflammatory breast cancer 6 | 404
primary pancreatic ductal adenocarcinoma 6 | 1,271
progressive supranuclear palsy 6 | 674
tuberculosis and treatment for 6 months 6 | 686
Alzheimer's disease 5 | 644
Breast Cancer, Familial 5 | 12
Chronic Lymphocytic Leukemia 5 | 242
Intellectual disability 5 | 573
Prostatic Neoplasms 5 | 471
Rheumatoid Arthritis 5 | 1,160
Squamous cell carcinoma of esophagus 5 | 82
acute myeloid leukemia 5 | 780
group 4 medulloblastoma 5 | 1,875
Anemia 4 | 252
Animal Mammary Neoplasms 4 | 136
Cockayne syndrome 4 | 54
Mammary Neoplasms, Experimental 4 | 150
Parkinson's disease 4 | 364
Polycystic Ovary Syndrome 4 | 332
Prostate cancer 4 | 172
active Crohn's disease 4 | 918
gastric carcinoma 4 | 832
glioblastoma multiforme 4 | 347
hepatocellular carcinoma 4 | 532
medulloblastoma 4 | 1,524
non-small cell lung carcinoma 4 | 413
pancreatic carcinoma 4 | 567

Tissue

Blood and immune system 147 | 17,995
Digestive Tract 147 | 18,473
Endocrine System 147 | 18,512
Female tissues 147 | 18,647
Male tissues 147 | 17,969
Nervous System 147 | 18,561
Urinary Tract 147 | 18,444
Cardiovascular System 146 | 17,958
Liver and Pancreas 146 | 18,136
Respiratory system 145 | 17,484
Skin and soft tissues 142 | 18,115

Target Family

Non-IDG 81 | 11,971
Enzyme 53 | 4,146
Kinase 9 | 634
Epigenetic 2 | 242
Transcription Factor 2 | 1,400

Reactome Pathway

G2/M Checkpoints 147 | 147
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.76828 59.7 468
Replication factor C subunit 3 RFC3 Tbio Non-IDG -1.28299 19.5 161
Replication factor C subunit 5 RFC5 Tbio Non-IDG -1.02728 11.1 64
Small ubiquitin-related modifier 1 SUMO1 Tbio Non-IDG -2.69547 474.2 685
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
Replication factor C subunit 2 RFC2 Tbio Non-IDG -1.34287 19.7 194
26S proteasome non-ATPase regulatory subunit 8 PSMD8 Tbio Enzyme -1.35900 20.6 94
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
E3 ubiquitin-protein ligase RNF168 RNF168 Tbio Enzyme -1.46566 28.7 150