Development Level

Tbio 99 | 11,178
Tchem 39 | 1,885
Tclin 5 | 612
Tdark 5 | 6,569

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 19 | 979
embryonic lethality prior to o... 11 | 239
embryonic lethality prior to t... 10 | 278
abnormal embryo size 5 | 220
preweaning lethality, incomple... 3 | 499
abnormal blood vessel morpholo... 2 | 5
abnormal embryo turning 2 | 31
abnormal heart morphology 2 | 162
abnormal skin morphology 2 | 50
decreased caudal vertebrae num... 2 | 53
decreased circulating glucose ... 2 | 126
decreased vertical activity 2 | 208
embryonic growth retardation 2 | 106
increased circulating sodium l... 2 | 71
increased mean corpuscular vol... 2 | 92
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal chorioallantoic fusio... 1 | 8
abnormal embryo development 1 | 7
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal kidney morphology 1 | 65
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal somite shape 1 | 5
abnormal spinal cord morpholog... 1 | 9
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
decreased circulating alanine ... 1 | 47
decreased circulating choleste... 1 | 93
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased heart rate variabili... 1 | 13
decreased mean corpuscular hem... 1 | 50
decreased red blood cell distr... 1 | 41
edema 1 | 59
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
increased erythrocyte cell num... 1 | 39
increased grip strength 1 | 41
increased heart weight 1 | 62
increased mean corpuscular hem... 1 | 96
increased mean platelet volume 1 | 45
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
thrombocytosis 1 | 27
urinary bladder obstruction 1 | 4

Disease

ovarian cancer 85 | 8,297
Carcinoma 77 | 11,192
lung cancer 66 | 4,607
psoriasis 58 | 6,514
osteosarcoma 57 | 7,766
glioblastoma 51 | 5,635
Breast cancer 50 | 3,469
malignant mesothelioma 48 | 3,135
non-small cell lung cancer 48 | 2,799
group 3 medulloblastoma 47 | 4,002
medulloblastoma, large-cell 47 | 6,086
Cancer 46 | 2,388
atypical teratoid / rhabdoid tumor 45 | 4,971
intraductal papillary-mucinous neoplasm (IPMN) 36 | 3,204
primitive neuroectodermal tumor 36 | 2,957
lung adenocarcinoma 35 | 2,627
invasive ductal carcinoma 32 | 2,867
adult high grade glioma 31 | 3,701
adrenocortical carcinoma 30 | 1,385
ependymoma 30 | 4,559
ductal carcinoma in situ 29 | 1,686
intraductal papillary-mucinous carcinoma (IPMC) 29 | 2,902
Multiple myeloma 25 | 1,296
colon cancer 23 | 1,428
nasopharyngeal carcinoma 23 | 1,024
breast carcinoma 20 | 1,589
oligodendroglioma 18 | 2,768
Autosomal recessive predisposition 16 | 1,407
pancreatic cancer 15 | 2,322
Ataxia telangiectasia 14 | 33
Endometriosis 14 | 521
astrocytic glioma 14 | 2,530
Astrocytoma, Pilocytic 13 | 3,006
Small head 13 | 366
Waldenstrons macroglobulinemia 13 | 742
dermatomyositis 13 | 941
astrocytoma 12 | 1,113
Atopic dermatitis 11 | 915
Hypoplastic mandible condyle 11 | 273
Kidney cancer 11 | 2,548
Mandibular hypoplasia 11 | 273
Micrognathism 11 | 273
Nijmegen breakage syndrome 11 | 23
Pick disease 11 | 1,856
Seckel syndrome 11 | 34
ulcerative colitis 11 | 1,765
Breast Neoplasms 10 | 423
Fanconi anemia 10 | 56
Fetal Growth Retardation 10 | 186
HIV Infections 10 | 94
Infant, Small for Gestational Age 10 | 174
Intellectual disability 10 | 998
Intrauterine retardation 10 | 174
Mammary Neoplasms 10 | 403
Short stature 10 | 514
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,911
pituitary cancer 10 | 1,915
subependymal giant cell astrocytoma 10 | 2,230
Bloom syndrome 9 | 29
diabetes mellitus 9 | 1,683
interstitial cystitis 9 | 2,237
Delayed bone age 8 | 132
Dull intelligence 8 | 634
Low intelligence 8 | 634
Mental Retardation 8 | 634
Mental deficiency 8 | 634
Poor school performance 8 | 634
Schizophrenia 8 | 1,136
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,872
lung carcinoma 8 | 2,755
pediatric high grade glioma 8 | 1,035
Cleft Palate 7 | 265
Hereditary Breast and Ovarian Cancer Syndrome 7 | 13
Meier-Gorlin syndrome 7 | 10
Microcephaly 7 | 166
cutaneous lupus erythematosus 7 | 1,016
cystic fibrosis 7 | 1,629
tuberculosis 7 | 1,963
Convex nasal ridge 6 | 36
Cryptorchidism 6 | 287
Rothmund-Thomson syndrome 6 | 19
group 4 medulloblastoma 6 | 1,806
non primary Sjogren syndrome sicca 6 | 861
Bilateral fifth finger clinodactyly 5 | 109
Bipolar Disorder 5 | 646
Cognitive delay 5 | 596
Curvature of little finger 5 | 109
Epilepsy 5 | 775
Failure to gain weight 5 | 359
Global developmental delay 5 | 596
Mental and motor retardation 5 | 596
Pediatric failure to thrive 5 | 359
Seizures 5 | 584
Strabismus 5 | 265
Uranostaphyloschisis 5 | 162
acute quadriplegic myopathy 5 | 1,133
esophageal adenocarcinoma 5 | 696
gastric carcinoma 5 | 781
juvenile dermatomyositis 5 | 1,147
progressive supranuclear palsy 5 | 656

Tissue

Endocrine System 147 | 18,159
Blood and immune system 145 | 16,909
Digestive Tract 145 | 17,369
Female tissues 145 | 17,400
Male tissues 145 | 17,142
Nervous System 145 | 16,725
Respiratory system 145 | 16,393
Urinary Tract 145 | 16,678
Liver and Pancreas 144 | 16,750
Skin and soft tissues 144 | 17,230
Cardiovascular System 142 | 15,192

Target Family

Non-IDG 82 | 12,091
Enzyme 53 | 4,145
Kinase 8 | 634
Epigenetic 2 | 242
Transcription Factor 2 | 1,400
TF/Epigenetic 1 | 38

Reactome Pathway

G2/M Checkpoints 148 | 148
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2B type 2-E HIST2H2BE Tbio Non-IDG -3.48425 2920.0 135
Histone H3.1t HIST3H3 Tbio Non-IDG -1.05426 10.9 1265
Histone H2B type 3-B HIST3H2BB Tbio Non-IDG -0.72238 5.02 53
Histone H2B type 1-K HIST1H2BK Tbio Non-IDG -0.50219 4.04 29
Proteasome subunit beta type-11 PSMB11 Tchem Enzyme -1.40386 27.2 74
26S proteasome non-ATPase regulatory subunit 2 PSMD2 Tbio Enzyme -1.60281 36.3 389
Origin recognition complex subunit 3 ORC3 Tbio Non-IDG -1.25409 17.4 192
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.17 0.33 21
Histone H2B type 1-N HIST1H2BN Tbio Non-IDG -1.51422 30.2 60