Development Level

Tbio 32 | 11,445
Tchem 7 | 1,598
Tclin 5 | 613

IMPC Phenotype

preweaning lethality, incomple... 5 | 499
male infertility 3 | 123
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
abnormal heart morphology 2 | 162
abnormal lens morphology 2 | 81
cataract 2 | 92
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
edema 2 | 59
female infertility 2 | 60
increased neutrophil cell numb... 2 | 46
abnormal bone structure 1 | 187
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal lung morphology 1 | 26
abnormal maxilla morphology 1 | 17
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal urinary bladder morph... 1 | 11
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased cardiac muscle contr... 1 | 11
decreased circulating insulin ... 1 | 76
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased blood urea nitrogen ... 1 | 48
increased cardiac muscle contr... 1 | 8
increased fasted circulating g... 1 | 76
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased monocyte cell number 1 | 63
increased spleen weight 1 | 10
microphthalmia 1 | 26
preweaning lethality, complete... 1 | 979
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
small testis 1 | 58
thrombocytopenia 1 | 56

Disease

Cancer 34 | 2,499
ovarian cancer 31 | 8,520
glioblastoma 25 | 5,792
osteosarcoma 25 | 7,950
Carcinoma 23 | 11,493
lung cancer 23 | 4,740
medulloblastoma, large-cell 23 | 6,241
atypical teratoid / rhabdoid tumor 18 | 5,112
Breast cancer 17 | 3,578
malignant mesothelioma 17 | 3,232
psoriasis 17 | 6,694
group 3 medulloblastoma 14 | 4,104
adult high grade glioma 13 | 3,801
Astrocytoma, Pilocytic 11 | 3,081
ependymoma 11 | 4,679
lung adenocarcinoma 11 | 2,716
primitive neuroectodermal tumor 11 | 3,035
subependymal giant cell astrocytoma 11 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
oligodendroglioma 10 | 2,850
pancreatic cancer 10 | 2,398
Kidney cancer 9 | 2,613
astrocytic glioma 9 | 2,597
ductal carcinoma in situ 9 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
invasive ductal carcinoma 9 | 2,951
Multiple myeloma 8 | 1,332
Stomach Neoplasms 8 | 300
nasopharyngeal carcinoma 8 | 1,058
tuberculosis 8 | 2,010
Carcinoma, Hepatocellular 7 | 228
Liver carcinoma 7 | 240
Lung Neoplasms 7 | 232
Melanoma 7 | 711
astrocytoma 7 | 1,146
colon cancer 7 | 1,478
cystic fibrosis 7 | 1,696
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
non-small cell lung cancer 7 | 2,890
pituitary cancer 7 | 1,972
Anemia 6 | 365
Atopic dermatitis 6 | 952
Breast Neoplasms 6 | 445
Mammary Neoplasms 6 | 425
Rheumatoid arthritis 6 | 1,191
adrenocortical carcinoma 6 | 1,428
group 4 medulloblastoma 6 | 1,855
lung carcinoma 6 | 2,843
Adenoma 5 | 167
Hypercalcemia 5 | 59
Hyperparathyroidism 5 | 48
Immune system cancer 5 | 140
Lymphoid leukemia 5 | 160
Mammary Neoplasms, Experimental 5 | 154
Parathyroid Adenoma 5 | 19
Prostatic Neoplasms 5 | 495
acute myeloid leukemia 5 | 783
breast carcinoma 5 | 1,638
diabetes mellitus 5 | 1,728
primary pancreatic ductal adenocarcinoma 5 | 1,109
Abdominal pain, episodic 4 | 9
Abnormality of the lymphatic system 4 | 14
Acromegaly 4 | 51
Adrenal cortical adenoma 4 | 19
Animal Mammary Neoplasms 4 | 136
Bladder Neoplasm 4 | 112
Colonic Neoplasms 4 | 142
Diarrhea 4 | 253
Dry skin 4 | 75
Esophageal Squamous Cell Carcinoma 4 | 77
Esophagitis 4 | 35
Freckles 4 | 33
Hair shaft abnormalities 4 | 30
Hereditary Melanoma 4 | 12
Insulinoma 4 | 24
Lymphatic Diseases 4 | 14
Lymphoma 4 | 81
MELANOMA, CUTANEOUS MALIGNANT, 1 4 | 13
Mammary Neoplasms, Animal 4 | 136
Melanocytic nevus 4 | 43
Mesothelioma, Malignant 4 | 105
Myocardial Ischemia 4 | 169
Nevus 4 | 19
Ovarian Neoplasms 4 | 102
Papilloma 4 | 44
Squamous cell carcinoma of esophagus 4 | 77
Stomach cancer 4 | 30
Urinary Bladder Neoplasms 4 | 114
Vascular disease 4 | 319
Waldenstrons macroglobulinemia 4 | 765
Xerosis 4 | 75
active ulcerative colitis 4 | 764
cutaneous lupus erythematosus 4 | 1,057
dermatomyositis 4 | 966
hair abnormalities (non-specific) 4 | 30
intermittent abdominal pain 4 | 9
medulloblastoma 4 | 720
ovarian neoplasm 4 | 99
primary Sjogren syndrome 4 | 735
ulcerative colitis 4 | 1,819

Tissue

Blood and immune system 43 | 16,909
Digestive Tract 43 | 17,369
Endocrine System 43 | 18,159
Female tissues 43 | 17,400
Liver and Pancreas 43 | 16,750
Male tissues 43 | 17,142
Nervous System 43 | 16,725
Respiratory system 43 | 16,393
Skin and soft tissues 43 | 17,230
Urinary Tract 43 | 16,678
Cardiovascular System 41 | 15,192

Target Family

Enzyme 17 | 4,145
Non-IDG 13 | 12,091
Kinase 7 | 634
Transcription Factor 7 | 1,400

Reactome Pathway

G1 Phase 44 | 44
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Retinoblastoma-associated protein RB1 Tchem Non-IDG -3.07052 1137.4 2150
Transcription factor E2F2 E2F2 Tbio Transcription Factor -2.10245 108.0 267
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG -1.66231 61.9 139
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181
Cyclin-dependent kinase inhibitor 1C CDKN1C Tbio Enzyme -2.81199 631.0 665
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform PPP2R1B Tbio Enzyme -1.20793 16.9 203
Cullin-1 CUL1 Tbio Non-IDG -2.37931 182.6 416
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta PPP2R3B Tbio Enzyme -1.28190 19.5 142