Development Level

Tbio 30 | 10,625
Tchem 8 | 1,890
Tclin 2 | 602

IMPC Phenotype

abnormal lens morphology 2 | 73
cataract 2 | 26
male infertility 2 | 62
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal eye morphology 1 | 38
abnormal heart morphology 1 | 51
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
decreased circulating insulin ... 1 | 75
decreased neutrophil cell numb... 1 | 37
enlarged epididymis 1 | 27
enlarged heart 1 | 111
enlarged spleen 1 | 26
female infertility 1 | 34
hydrops fetalis 1 | 22
increased circulating triglyce... 1 | 24
increased neutrophil cell numb... 1 | 15
microphthalmia 1 | 15
preweaning lethality, complete... 1 | 633
preweaning lethality, incomple... 1 | 260
small testis 1 | 37

Disease

Cancer 30 | 2,346
ovarian cancer 26 | 8,491
glioblastoma 24 | 5,572
medulloblastoma, large-cell 21 | 6,234
osteosarcoma 21 | 7,933
lung cancer 20 | 4,473
atypical teratoid / rhabdoid tumor 15 | 4,369
psoriasis 15 | 6,685
malignant mesothelioma 14 | 3,163
Breast cancer 13 | 3,098
ependymoma 11 | 2,514
pilocytic astrocytoma 11 | 3,086
primitive neuroectodermal tumor 11 | 3,031
lung adenocarcinoma 10 | 2,714
oligodendroglioma 10 | 2,849
subependymal giant cell astrocytoma 10 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,956
astrocytic glioma 8 | 2,241
ductal carcinoma in situ 8 | 1,745
invasive ductal carcinoma 8 | 2,950
pancreatic cancer 8 | 2,300
pediatric high grade glioma 8 | 2,712
Multiple myeloma 7 | 1,327
Stomach Neoplasms 7 | 282
adult high grade glioma 7 | 2,148
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,988
nasopharyngeal carcinoma 7 | 1,056
non-small cell lung cancer 7 | 2,798
pituitary cancer 7 | 1,972
Atopic dermatitis 6 | 944
Carcinoma 6 | 2,147
Liver carcinoma 6 | 217
Lung Neoplasms 6 | 171
adrenocortical carcinoma 6 | 1,427
astrocytoma 6 | 1,493
colon cancer 6 | 1,475
medulloblastoma 6 | 1,524
sonic hedgehog group medulloblastoma 6 | 1,482
Adenoma 5 | 165
Mammary Neoplasms 5 | 410
Mammary Neoplasms, Experimental 5 | 149
Rheumatoid Arthritis 5 | 1,170
acute myeloid leukemia 5 | 785
breast carcinoma 5 | 1,614
group 3 medulloblastoma 5 | 2,254
group 4 medulloblastoma 5 | 1,875
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,289
lung carcinoma 5 | 2,844
primary pancreatic ductal adenocarcinoma 5 | 1,271
tuberculosis and treatment for 6 months 5 | 686
Animal Mammary Neoplasms 4 | 135
Melanoma 4 | 261
Multiple Endocrine Neoplasia Type 1 4 | 30
Papilloma 4 | 27
Prostatic Neoplasms 4 | 471
Squamous cell carcinoma of esophagus 4 | 82
Stomach cancer 4 | 18
atypical teratoid/rhabdoid tumor 4 | 1,095
cystic fibrosis 4 | 1,670
ovarian neoplasm 4 | 97
ulcerative colitis 4 | 2,087
Bladder Neoplasm 3 | 109
Brain Neoplasms 3 | 23
Brain Stem Neoplasms 3 | 4
Colonic Neoplasms 3 | 126
Diffuse large B-cell lymphoma 3 | 42
Glaucoma 3 | 135
Hormone receptor positive malignant neoplasm of breast 3 | 10
Human epidermal growth factor 2 negative carcinoma of breast 3 | 3
Kidney cancer 3 | 121
Lymphoma 3 | 57
Myeloma, Multiple 3 | 6
Myocardial Ischemia 3 | 169
Precursor Cell Lymphoblastic Leukemia Lymphoma 3 | 42
Sezary Syndrome 3 | 26
Vascular disease 3 | 281
Waldenstrons macroglobulinemia 3 | 764
acute quadriplegic myopathy 3 | 1,157
cutaneous lupus erythematosus 3 | 1,056
dermatomyositis 3 | 966
diabetes mellitus 3 | 1,663
familial melanoma 3 | 10
fibroadenoma 3 | 557
gastric cancer 3 | 436
tuberculosis 3 | 1,563
Acquired metabolic disease 2 | 267
Carcinoma, Transitional Cell 2 | 31
Esophageal carcinoma 2 | 5
Mesothelioma 2 | 40
Pancreatic Neoplasm 2 | 79
Peripheral Neuropathy 2 | 303
Peripheral vascular disease 2 | 90
Primary cutaneous T-cell lymphoma 2 | 29
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
hepatocellular carcinoma 2 | 550
inflammatory breast cancer 2 | 404
non-small cell lung carcinoma 2 | 413
pancreatic carcinoma 2 | 567
progressive supranuclear palsy 2 | 674
tuberculosis and treatment for 3 months 2 | 327

Tissue

Endocrine System 40 | 18,511
Blood and immune system 39 | 17,994
Cardiovascular System 39 | 17,957
Digestive Tract 39 | 18,472
Female tissues 39 | 18,646
Liver and Pancreas 39 | 18,135
Male tissues 39 | 17,968
Nervous System 39 | 18,560
Respiratory system 39 | 17,483
Skin and soft tissues 39 | 18,114
Urinary Tract 39 | 18,443

Target Family

Enzyme 17 | 4,146
Non-IDG 13 | 11,969
Transcription Factor 7 | 1,400
Kinase 3 | 634

Reactome Pathway

G1 Phase 40 | 40
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cyclin-dependent kinase inhibitor 2A CDKN2A Tbio Enzyme -3.70375 8561.3 896
Cyclin-dependent kinase 6 CDK6 Tclin Kinase -2.67376 362.2 617
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform PPP2R2A Tchem Enzyme -1.27308 14.5 115
S-phase kinase-associated protein 1 SKP1 Tbio Enzyme -2.54884 305.8 337
Retinoblastoma-like protein 1 RBL1 Tbio Non-IDG -2.61943 376.7 290
Transcription factor E2F1 E2F1 Tchem Transcription Factor -2.27364 187.2 928
G1/S-specific cyclin-D2 CCND2 Tchem Non-IDG -2.64611 381.1 418
G1/S-specific cyclin-D3 CCND3 Tchem Non-IDG -2.52581 299.6 513
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform PPP2R1A Tbio Enzyme -1.40388 25.3 259
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform PPP2R1B Tbio Enzyme -1.20793 17.1 179