Development Level

Tbio 70 | 10,625
Tchem 35 | 1,890
Tclin 11 | 602
Tdark 1 | 7,003

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 14 | 633
embryonic lethality prior to o... 6 | 148
embryonic lethality prior to t... 4 | 187
decreased body length 2 | 108
male infertility 2 | 62
abnormal bone mineralization 1 | 55
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal eye morphology 1 | 38
abnormal glucose homeostasis 1 | 5
abnormal heart morphology 1 | 51
abnormal respiratory quotient 1 | 9
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
decreased body weight 1 | 174
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating choleste... 1 | 85
decreased circulating insulin ... 1 | 75
decreased circulating serum al... 1 | 79
decreased circulating triglyce... 1 | 83
decreased grip strength 1 | 123
decreased lean body mass 1 | 195
decreased neutrophil cell numb... 1 | 37
enlarged epididymis 1 | 27
enlarged heart 1 | 111
enlarged spleen 1 | 26
female infertility 1 | 34
hydrops fetalis 1 | 22
increased bone mineral content 1 | 92
increased circulating LDL chol... 1 | 15
increased circulating alkaline... 1 | 119
increased circulating choleste... 1 | 53
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased grip strength 1 | 83
increased heart weight 1 | 37
increased mean corpuscular vol... 1 | 91
increased neutrophil cell numb... 1 | 15
microphthalmia 1 | 15
prenatal lethality prior to he... 1 | 64
preweaning lethality, incomple... 1 | 260
small testis 1 | 37
thrombocytosis 1 | 23
urinary bladder obstruction 1 | 2

Disease

ovarian cancer 88 | 8,484
lung cancer 63 | 4,466
psoriasis 62 | 6,685
glioblastoma 55 | 5,572
medulloblastoma, large-cell 52 | 6,234
osteosarcoma 52 | 7,933
Cancer 49 | 2,346
malignant mesothelioma 43 | 3,162
non-small cell lung cancer 41 | 2,798
Breast cancer 37 | 3,094
Multiple myeloma 37 | 1,327
primitive neuroectodermal tumor 37 | 3,031
pediatric high grade glioma 34 | 2,712
adrenocortical carcinoma 33 | 1,427
atypical teratoid / rhabdoid tumor 32 | 4,369
group 3 medulloblastoma 32 | 2,254
intraductal papillary-mucinous neoplasm (IPMN) 30 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 29 | 2,988
lung adenocarcinoma 29 | 2,713
invasive ductal carcinoma 28 | 2,950
nasopharyngeal carcinoma 24 | 1,056
colon cancer 22 | 1,475
ductal carcinoma in situ 22 | 1,745
oligodendroglioma 21 | 2,849
Waldenstrons macroglobulinemia 20 | 765
astrocytoma 20 | 1,493
posterior fossa group A ependymoma 20 | 1,511
Endometriosis 16 | 535
dermatomyositis 16 | 933
pilocytic astrocytoma 16 | 3,086
HIV Infections 15 | 100
primary Sjogren syndrome 15 | 789
Atopic dermatitis 14 | 944
pancreatic cancer 14 | 2,300
subependymal giant cell astrocytoma 14 | 2,287
breast carcinoma 13 | 1,614
atypical teratoid/rhabdoid tumor 12 | 1,095
medulloblastoma 11 | 1,524
sonic hedgehog group medulloblastoma 11 | 1,482
Liver carcinoma 10 | 217
diabetes mellitus 10 | 1,663
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,956
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,795
tuberculosis 10 | 1,557
ulcerative colitis 10 | 2,087
IGA Glomerulonephritis 9 | 454
Mammary Neoplasms 9 | 410
interstitial cystitis 9 | 2,299
non primary Sjogren syndrome sicca 9 | 840
pituitary cancer 9 | 1,972
Lung Neoplasms 8 | 171
Pick disease 8 | 1,893
astrocytic glioma 8 | 2,241
ependymoma 8 | 2,514
esophageal adenocarcinoma 8 | 737
juvenile dermatomyositis 8 | 1,189
lung carcinoma 8 | 2,844
Meier-Gorlin syndrome 7 | 12
Stomach Neoplasms 7 | 282
acute myeloid leukemia 7 | 780
Adenoma 6 | 165
Animal Mammary Neoplasms 6 | 136
Colonic Neoplasms 6 | 126
Colorectal Neoplasms 6 | 217
Mammary Neoplasms, Experimental 6 | 150
Prostatic Neoplasms 6 | 471
Seckel syndrome 6 | 34
active Crohn's disease 6 | 918
acute quadriplegic myopathy 6 | 1,157
adult high grade glioma 6 | 2,148
cystic fibrosis 6 | 1,665
ovarian neoplasm 6 | 97
tuberculosis and treatment for 6 months 6 | 686
Bladder Neoplasm 5 | 109
EAR, PATELLA, SHORT STATURE SYNDROME 5 | 6
Mantle cell lymphoma 5 | 18
Peripheral Neuropathy 5 | 303
Polycystic Ovary Syndrome 5 | 332
Rheumatoid Arthritis 5 | 1,160
Squamous cell carcinoma of esophagus 5 | 82
cutaneous lupus erythematosus 5 | 1,056
inflammatory breast cancer 5 | 404
primary pancreatic ductal adenocarcinoma 5 | 1,271
Acute lymphoid leukemia 4 | 25
Adenocarcinoma of pancreas 4 | 12
Carcinoma 4 | 2,147
Metastatic Breast Carcinoma 4 | 21
Microcephaly 4 | 149
gastric cancer 4 | 430
group 4 medulloblastoma 4 | 1,875
progressive supranuclear palsy 4 | 674
Alzheimer's disease 3 | 644
Myocardial Ischemia 3 | 169
Pancreatic Neoplasm 3 | 79
Vascular disease 3 | 281
chronic rhinosinusitis 3 | 512
glioblastoma multiforme 3 | 347
hepatocellular carcinoma 3 | 532
non-small cell lung carcinoma 3 | 413
pancreatic carcinoma 3 | 567

Tissue

Blood and immune system 117 | 17,995
Cardiovascular System 117 | 17,958
Digestive Tract 117 | 18,473
Endocrine System 117 | 18,512
Female tissues 117 | 18,647
Liver and Pancreas 117 | 18,136
Male tissues 117 | 17,969
Nervous System 117 | 18,561
Respiratory system 117 | 17,484
Urinary Tract 117 | 18,444
Skin and soft tissues 116 | 18,115

Target Family

Enzyme 61 | 4,146
Non-IDG 40 | 11,971
Kinase 11 | 634
Transcription Factor 5 | 1,400

Reactome Pathway

G1/S Transition 117 | 117
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.76828 59.7 468
Protein-tyrosine kinase 6 PTK6 Tchem Kinase -2.14303 167.1 320
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
26S proteasome non-ATPase regulatory subunit 8 PSMD8 Tbio Enzyme -1.35900 20.6 94
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
G1/S-specific cyclin-D1 CCND1 Tchem Non-IDG -3.77851 5447.1 1111
Cyclin-dependent kinase 7 CDK7 Tchem Kinase -2.28652 191.1 505
Cyclin-H CCNH Tbio Non-IDG -1.98840 89.8 354