Development Level

Tbio 80 | 11,178
Tchem 35 | 1,885
Tclin 12 | 612
Tdark 3 | 6,569

IMPC Phenotype

preweaning lethality, complete... 17 | 979
embryonic lethality prior to o... 10 | 239
embryonic lethality prior to t... 8 | 278
abnormal embryo size 4 | 220
preweaning lethality, incomple... 4 | 499
male infertility 3 | 123
abnormal lens morphology 2 | 81
cataract 2 | 92
decreased caudal vertebrae num... 2 | 53
decreased circulating choleste... 2 | 93
female infertility 2 | 60
increased circulating choleste... 2 | 66
increased mean corpuscular vol... 2 | 92
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal epididymis morphology 1 | 42
abnormal glucose homeostasis 1 | 4
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal lung morphology 1 | 26
abnormal pericardium morpholog... 1 | 26
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal urinary bladder morph... 1 | 11
cardiovascular system phenotyp... 1 | 36
decreased body weight 1 | 161
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased vertical activity 1 | 208
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
hyperactivity 1 | 148
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased grip strength 1 | 41
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased neutrophil cell numb... 1 | 46
increased total body fat amoun... 1 | 134
microphthalmia 1 | 26
prenatal lethality prior to he... 1 | 87
small seminal vesicle 1 | 10
small testis 1 | 58
thrombocytosis 1 | 27
urinary bladder obstruction 1 | 4

Disease

ovarian cancer 78 | 8,297
Carcinoma 62 | 11,192
lung cancer 60 | 4,607
glioblastoma 55 | 5,635
osteosarcoma 54 | 7,766
psoriasis 54 | 6,514
medulloblastoma, large-cell 53 | 6,086
Cancer 52 | 2,388
group 3 medulloblastoma 50 | 4,002
atypical teratoid / rhabdoid tumor 45 | 4,971
malignant mesothelioma 43 | 3,135
non-small cell lung cancer 43 | 2,799
Breast cancer 39 | 3,469
primitive neuroectodermal tumor 38 | 2,957
adrenocortical carcinoma 36 | 1,385
lung adenocarcinoma 31 | 2,627
adult high grade glioma 30 | 3,701
intraductal papillary-mucinous neoplasm (IPMN) 30 | 3,204
intraductal papillary-mucinous carcinoma (IPMC) 28 | 2,902
invasive ductal carcinoma 27 | 2,867
Multiple myeloma 25 | 1,296
nasopharyngeal carcinoma 25 | 1,024
ductal carcinoma in situ 24 | 1,686
ependymoma 24 | 4,559
colon cancer 21 | 1,428
Endometriosis 19 | 521
astrocytoma 19 | 1,113
oligodendroglioma 19 | 2,768
Astrocytoma, Pilocytic 16 | 3,006
Atopic dermatitis 15 | 915
Waldenstrons macroglobulinemia 15 | 742
breast carcinoma 14 | 1,589
subependymal giant cell astrocytoma 14 | 2,230
pancreatic cancer 13 | 2,322
primary Sjogren syndrome 13 | 710
tuberculosis 13 | 1,963
Autosomal recessive predisposition 11 | 1,407
Carcinoma, Hepatocellular 11 | 217
Liver carcinoma 11 | 229
dermatomyositis 11 | 941
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,872
ulcerative colitis 11 | 1,765
HIV Infections 10 | 94
Kidney cancer 10 | 2,548
pediatric high grade glioma 10 | 1,035
interstitial cystitis 9 | 2,237
Breast Neoplasms 8 | 423
Lung Neoplasms 8 | 217
Mammary Neoplasms 8 | 403
Meier-Gorlin syndrome 8 | 10
astrocytic glioma 8 | 2,530
pituitary cancer 8 | 1,915
EAR, PATELLA, SHORT STATURE SYNDROME 7 | 7
Intellectual disability 7 | 998
Pick disease 7 | 1,856
Stomach Neoplasms 7 | 287
acute myeloid leukemia 7 | 760
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,911
Colonic Neoplasms 6 | 133
Colorectal Neoplasms 6 | 235
Fetal Growth Retardation 6 | 186
Infant, Small for Gestational Age 6 | 174
Intrauterine retardation 6 | 174
Liver Cirrhosis, Experimental 6 | 733
Ovarian Neoplasms 6 | 96
Polycystic ovary syndrome 6 | 348
Seckel syndrome 6 | 34
Small head 6 | 366
acute quadriplegic myopathy 6 | 1,133
esophageal adenocarcinoma 6 | 696
group 4 medulloblastoma 6 | 1,806
juvenile dermatomyositis 6 | 1,147
lung carcinoma 6 | 2,755
ovarian neoplasm 6 | 93
Animal Mammary Neoplasms 5 | 130
Cleft Palate 5 | 265
Cognitive delay 5 | 596
Dull intelligence 5 | 634
Epilepsy 5 | 775
Esophageal Squamous Cell Carcinoma 5 | 72
Global developmental delay 5 | 596
Hypoplastic mandible condyle 5 | 273
Low intelligence 5 | 634
Mammary Neoplasms, Animal 5 | 130
Mammary Neoplasms, Experimental 5 | 147
Mandibular hypoplasia 5 | 273
Mental Retardation 5 | 634
Mental and motor retardation 5 | 596
Mental deficiency 5 | 634
Micrognathism 5 | 273
Poor school performance 5 | 634
Prostatic Neoplasms 5 | 472
Rheumatoid arthritis 5 | 1,156
Seizures 5 | 584
Squamous cell carcinoma of esophagus 5 | 72
active Crohn's disease 5 | 882
cystic fibrosis 5 | 1,629
diabetes mellitus 5 | 1,683
medulloblastoma 5 | 702
non primary Sjogren syndrome sicca 5 | 861

Tissue

Blood and immune system 129 | 16,909
Digestive Tract 129 | 17,369
Endocrine System 129 | 18,159
Female tissues 129 | 17,400
Liver and Pancreas 129 | 16,750
Male tissues 129 | 17,142
Nervous System 129 | 16,725
Respiratory system 129 | 16,393
Skin and soft tissues 129 | 17,230
Urinary Tract 129 | 16,678
Cardiovascular System 128 | 15,192

Target Family

Enzyme 61 | 4,145
Non-IDG 50 | 12,091
Kinase 10 | 634
Transcription Factor 8 | 1,400
Epigenetic 1 | 242

Reactome Pathway

G1/S Transition 130 | 130
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cyclin-A1 CCNA1 Tchem Non-IDG -2.02564 107.2 314
Thymidine kinase, cytosolic TK1 Tchem Kinase -2.56213 363.6 281
26S proteasome non-ATPase regulatory subunit 2 PSMD2 Tbio Enzyme -1.60281 36.3 389
Retinoblastoma-associated protein RB1 Tchem Non-IDG -3.07052 1137.4 2150
Origin recognition complex subunit 3 ORC3 Tbio Non-IDG -1.25409 17.4 192
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
DNA replication licensing factor MCM6 MCM6 Tbio Non-IDG -1.99059 90.3 260
Proteasome subunit beta type-8 PSMB8 Tclin Enzyme -2.43601 278.6 295
Proteasome subunit beta type-6 PSMB6 Tbio Enzyme -1.08909 10.9 98
26S proteasome non-ATPase regulatory subunit 1 PSMD1 Tchem Enzyme -1.36924 21.2 105