Development Level

Tbio 49 | 11,445
Tchem 11 | 1,598
Tclin 5 | 613
Tdark 3 | 6,588

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal lens morphology 2 | 81
cataract 2 | 92
preweaning lethality, incomple... 2 | 499
abnormal behavioral response t... 1 | 66
abnormal epididymis morphology 1 | 42
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal lung morphology 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
decreased caudal vertebrae num... 1 | 53
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating total pr... 1 | 49
decreased vertical activity 1 | 208
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
increased circulating sodium l... 1 | 71
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small seminal vesicle 1 | 10
small testis 1 | 58

Disease

ovarian cancer 50 | 8,520
lung cancer 36 | 4,740
psoriasis 33 | 6,694
Carcinoma 32 | 11,493
osteosarcoma 29 | 7,950
Multiple myeloma 28 | 1,332
glioblastoma 27 | 5,792
Cancer 22 | 2,499
medulloblastoma, large-cell 19 | 6,241
Breast cancer 18 | 3,578
malignant mesothelioma 18 | 3,232
HIV Infections 17 | 102
group 3 medulloblastoma 16 | 4,104
atypical teratoid / rhabdoid tumor 15 | 5,112
non-small cell lung cancer 14 | 2,890
adult high grade glioma 12 | 3,801
ependymoma 12 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
dermatomyositis 11 | 966
primitive neuroectodermal tumor 11 | 3,035
pancreatic cancer 10 | 2,398
subependymal giant cell astrocytoma 10 | 2,287
Waldenstrons macroglobulinemia 9 | 765
diabetes mellitus 9 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
invasive ductal carcinoma 9 | 2,951
Breast Neoplasms 8 | 445
Mammary Neoplasms 8 | 425
adrenocortical carcinoma 8 | 1,428
astrocytoma 8 | 1,146
lung adenocarcinoma 8 | 2,716
oligodendroglioma 8 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
Astrocytoma, Pilocytic 7 | 3,081
tuberculosis 7 | 2,010
Liver Cirrhosis, Experimental 6 | 769
Pick disease 6 | 1,894
active Crohn's disease 6 | 922
astrocytic glioma 6 | 2,597
breast carcinoma 6 | 1,638
colon cancer 6 | 1,478
ductal carcinoma in situ 6 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
juvenile dermatomyositis 6 | 1,187
Adenoma 5 | 167
Bladder Neoplasm 5 | 112
Carcinoma, Hepatocellular 5 | 228
Esophageal Squamous Cell Carcinoma 5 | 77
Li-Fraumeni syndrome 5 | 13
Liver carcinoma 5 | 240
Lung Neoplasms 5 | 232
Lymphoma 5 | 81
Mantle cell lymphoma 5 | 23
Melanoma 5 | 711
Prostatic Neoplasms 5 | 495
Squamous cell carcinoma of esophagus 5 | 77
Stomach Neoplasms 5 | 300
Urinary Bladder Neoplasms 5 | 114
nasopharyngeal carcinoma 5 | 1,058
non primary Sjogren syndrome sicca 5 | 891
primary Sjogren syndrome 5 | 735
ulcerative colitis 5 | 1,819
Anemia 4 | 365
Ataxia telangiectasia 4 | 34
Barrett's esophagus 4 | 182
Colonic Neoplasms 4 | 142
DOID:2627 4 | 94
Endometriosis 4 | 540
Liver neoplasms 4 | 130
Mesothelioma, Malignant 4 | 105
Osteoporosis 4 | 363
Pancreatic Neoplasm 4 | 85
Papilloma 4 | 44
Stomach cancer 4 | 30
Vascular disease 4 | 319
acute quadriplegic myopathy 4 | 1,158
cutaneous lupus erythematosus 4 | 1,057
hepatocellular carcinoma 4 | 547
lung carcinoma 4 | 2,843
progressive supranuclear palsy 4 | 676
Amyotrophic lateral sclerosis 3 | 451
Atopic dermatitis 3 | 952
Diarrhea 3 | 253
Esophageal carcinoma 3 | 16
Glaucoma 3 | 239
Head and neck squamous cell carcinoma 3 | 11
Liver cancer 3 | 604
Lymphoid leukemia 3 | 160
Major Depressive Disorder 3 | 301
Mouth Neoplasms 3 | 55
Polycystic ovary syndrome 3 | 360
Prostate cancer 3 | 175
Schizophrenia 3 | 1,160
Skin cancer 3 | 469
Unipolar Depression 3 | 250
acute myeloid leukemia 3 | 783
cystic fibrosis 3 | 1,696
non-small cell lung carcinoma 3 | 317
pituitary cancer 3 | 1,972
primary pancreatic ductal adenocarcinoma 3 | 1,109

Tissue

Endocrine System 66 | 18,159
Blood and immune system 65 | 16,909
Digestive Tract 65 | 17,369
Female tissues 65 | 17,400
Male tissues 65 | 17,142
Nervous System 65 | 16,725
Respiratory system 65 | 16,393
Urinary Tract 65 | 16,678
Liver and Pancreas 64 | 16,750
Skin and soft tissues 64 | 17,230
Cardiovascular System 63 | 15,192

Target Family

Enzyme 44 | 4,145
Non-IDG 19 | 12,091
Kinase 3 | 634
Epigenetic 1 | 242
Transcription Factor 1 | 1,400

Reactome Pathway

G1/S DNA Damage Checkpoints 68 | 68
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
Zinc finger protein 385A ZNF385A Tbio Non-IDG -0.03141 1.24 99
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Proteasome activator complex subunit 4 PSME4 Tdark Non-IDG -1.60128 39.3 43
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG -1.66231 61.9 139
Putative protein SEM1, isoform 2 SEM1 Tbio Non-IDG 0.30 0.49 109
26S proteasome regulatory subunit 10B PSMC6 Tbio Enzyme -2.65165 339.0 214