Development Level

Tbio 27 | 11,445
Tchem 12 | 1,598
Tclin 4 | 613

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 3 | 979
decreased total body fat amoun... 2 | 207
increased bone mineral content 2 | 108
increased lean body mass 2 | 172
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal gait 1 | 69
abnormal gallbladder morpholog... 1 | 1
abnormal locomotor behavior 1 | 24
abnormal retina morphology 1 | 71
abnormal spleen morphology 1 | 55
abnormal vocalization 1 | 21
decreased bone mineral content 1 | 151
decreased circulating chloride... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased fasted circulating g... 1 | 65
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged gallbladder 1 | 2
hydrometra 1 | 53
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired righting response 1 | 26
increased circulating creatini... 1 | 38
increased circulating triglyce... 1 | 42
increased mean platelet volume 1 | 45
increased or absent threshold ... 1 | 101
male infertility 1 | 123
small epididymis 1 | 3
small superior vagus ganglion 1 | 74

Disease

Carcinoma 39 | 11,493
medulloblastoma, large-cell 27 | 6,241
atypical teratoid / rhabdoid tumor 25 | 5,112
glioblastoma 25 | 5,792
ovarian cancer 24 | 8,520
osteosarcoma 22 | 7,950
psoriasis 22 | 6,694
group 3 medulloblastoma 21 | 4,104
ependymoma 19 | 4,679
adult high grade glioma 18 | 3,801
Breast cancer 17 | 3,578
primitive neuroectodermal tumor 17 | 3,035
Astrocytoma, Pilocytic 16 | 3,081
astrocytic glioma 14 | 2,597
lung cancer 14 | 4,740
oligodendroglioma 14 | 2,850
subependymal giant cell astrocytoma 13 | 2,287
Kidney cancer 12 | 2,613
lung carcinoma 12 | 2,843
malignant mesothelioma 12 | 3,232
Pick disease 11 | 1,894
colon cancer 11 | 1,478
invasive ductal carcinoma 11 | 2,951
lung adenocarcinoma 11 | 2,716
Autosomal recessive predisposition 10 | 1,442
Bipolar Disorder 9 | 666
Depressive disorder 9 | 409
Schizophrenia 9 | 1,160
interstitial cystitis 9 | 2,312
ulcerative colitis 9 | 1,819
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
Mental Depression 7 | 333
breast carcinoma 7 | 1,638
cystic fibrosis 7 | 1,696
group 4 medulloblastoma 7 | 1,855
pancreatic cancer 7 | 2,398
Carney complex 6 | 25
Obesity 6 | 678
diabetes mellitus 6 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
Acquired metabolic disease 5 | 336
Epilepsy 5 | 792
Hypertensive disease 5 | 292
Liver cancer 5 | 604
Major Depressive Disorder 5 | 301
Substance Withdrawal Syndrome 5 | 55
astrocytoma 5 | 1,146
cutaneous lupus erythematosus 5 | 1,057
ductal carcinoma in situ 5 | 1,745
non-small cell lung cancer 5 | 2,890
tuberculosis 5 | 2,010
Alcoholic Intoxication, Chronic 4 | 289
Cancer 4 | 2,499
Cognitive delay 4 | 608
Global developmental delay 4 | 608
Intellectual disability 4 | 1,016
Melanoma 4 | 711
Mental and motor retardation 4 | 608
Mood Disorders 4 | 184
Osteoporosis 4 | 363
Primary pigmented nodular adrenocortical disease 4 | 13
Unipolar Depression 4 | 250
Waldenstrons macroglobulinemia 4 | 765
acute quadriplegic myopathy 4 | 1,158
juvenile dermatomyositis 4 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
pediatric high grade glioma 4 | 1,064
pituitary cancer 4 | 1,972
Amyotrophic lateral sclerosis 3 | 451
Angle class 3 malocclusion 3 | 57
Atrial Fibrillation 3 | 124
Autistic Disorder 3 | 364
Cardiomegaly 3 | 116
Cardiomyopathies 3 | 110
Chronic heart failure 3 | 46
Cocaine-Related Disorders 3 | 92
Common variable immunodeficiency 3 | 101
Duchenne muscular dystrophy 3 | 601
Dull intelligence 3 | 645
Heart failure 3 | 162
Hypertension 3 | 396
Liver Cirrhosis, Experimental 3 | 769
Low intelligence 3 | 645
Malocclusion 3 | 57
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Neurodegenerative disease 3 | 414
Parkinson's disease 3 | 392
Poor school performance 3 | 645
Rheumatoid arthritis 3 | 1,191
Round face 3 | 45
Round, full face 3 | 45
Short stature 3 | 531
Skin cancer 3 | 469
active Crohn's disease 3 | 922
nasopharyngeal carcinoma 3 | 1,058
pancreatic carcinoma 3 | 562
sarcoidosis 3 | 370
spina bifida 3 | 1,074

Tissue

Endocrine System 43 | 18,159
Digestive Tract 42 | 17,369
Male tissues 41 | 17,142
Nervous System 41 | 16,725
Skin and soft tissues 41 | 17,230
Blood and immune system 40 | 16,909
Female tissues 40 | 17,400
Liver and Pancreas 40 | 16,750
Respiratory system 39 | 16,393
Cardiovascular System 38 | 15,192
Urinary Tract 38 | 16,678

Target Family

Enzyme 21 | 4,145
Kinase 9 | 634
Non-IDG 9 | 12,091
Ion Channel 3 | 344
Transcription Factor 1 | 1,400

Reactome Pathway

G-protein mediated events 43 | 43
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adenylate cyclase type 8 ADCY8 Tbio Enzyme -2.04645 112.4 147
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A Tclin Enzyme -1.27429 21.3 169
Adenylate cyclase type 7 ADCY7 Tbio Enzyme -1.68806 49.1 114
Guanine nucleotide-binding protein G(t) subunit alpha-3 GNAT3 Tbio Non-IDG -2.28370 189.3 111
Adenylate cyclase type 6 ADCY6 Tchem Enzyme -2.05332 113.7 111
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 PLCB2 Tbio Enzyme -2.14048 137.8 104
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 PLCB3 Tbio Enzyme -1.88444 66.2 265
Protein kinase C gamma type PRKCG Tchem Kinase -2.04120 103.9 435
Cytosolic phospholipase A2 PLA2G4A Tchem Enzyme -2.68316 506.7 274
Guanine nucleotide-binding protein G(o) subunit alpha GNAO1 Tbio Non-IDG -2.24331 158.7 195