Development Level

Tbio 22 | 11,445
Tdark 4 | 6,588
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, incomple... 3 | 499
preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
decreased bone mineral content 1 | 151
decreased circulating iron lev... 1 | 32
decreased fasted circulating g... 1 | 65
decreased lean body mass 1 | 135
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
enlarged heart 1 | 210
enlarged spleen 1 | 41
hyperactivity 1 | 148
impaired righting response 1 | 26
increased circulating creatini... 1 | 38
increased circulating triglyce... 1 | 42
increased total body fat amoun... 1 | 134
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
shortened QRS complex duration 1 | 1
small kidney 1 | 16
small superior vagus ganglion 1 | 74

Disease

glioblastoma 16 | 5,792
medulloblastoma, large-cell 14 | 6,241
osteosarcoma 13 | 7,950
ependymoma 11 | 4,679
ovarian cancer 11 | 8,520
Astrocytoma, Pilocytic 10 | 3,081
Carcinoma 10 | 11,493
atypical teratoid / rhabdoid tumor 10 | 5,112
group 3 medulloblastoma 9 | 4,104
primitive neuroectodermal tumor 9 | 3,035
psoriasis 9 | 6,694
adult high grade glioma 8 | 3,801
lung carcinoma 8 | 2,843
subependymal giant cell astrocytoma 8 | 2,287
Breast cancer 7 | 3,578
oligodendroglioma 6 | 2,850
Depressive disorder 5 | 409
Mental Depression 5 | 333
Pick disease 5 | 1,894
Schizophrenia 5 | 1,160
astrocytic glioma 5 | 2,597
breast carcinoma 5 | 1,638
invasive ductal carcinoma 5 | 2,951
lung cancer 5 | 4,740
non-small cell lung cancer 5 | 2,890
Alcoholic Intoxication, Chronic 4 | 289
Duchenne muscular dystrophy 4 | 601
Epilepsy 4 | 792
Seizures 4 | 596
active Crohn's disease 4 | 922
astrocytoma 4 | 1,146
diabetes mellitus 4 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
juvenile dermatomyositis 4 | 1,187
lung adenocarcinoma 4 | 2,716
malignant mesothelioma 4 | 3,232
pituitary cancer 4 | 1,972
Alcohol dependence 3 | 107
Amnesia 3 | 17
Autosomal recessive predisposition 3 | 1,442
Bipolar Disorder 3 | 666
Bradycardia 3 | 36
Cancer 3 | 2,499
Cocaine-Related Disorders 3 | 92
Liver Cirrhosis, Experimental 3 | 769
Major Depressive Disorder 3 | 301
Multiple myeloma 3 | 1,332
Obesity 3 | 678
Pain 3 | 103
Pain agnosia 3 | 104
Rheumatoid arthritis 3 | 1,191
Substance abuse 3 | 59
Withdrawal disorder 3 | 19
ductal carcinoma in situ 3 | 1,745
group 4 medulloblastoma 3 | 1,855
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
pancreatic cancer 3 | 2,398
pediatric high grade glioma 3 | 1,064
ulcerative colitis 3 | 1,819
Alcoholism 2 | 45
Amnestic disorder 2 | 35
Amphetamine-Related Disorders 2 | 74
Asthma 2 | 385
Cardiovascular system disease 2 | 246
Cholestasis 2 | 155
Cocaine Dependence 2 | 51
Colorectal Neoplasms 2 | 243
Cone dystrophy 2 | 71
Congenital stationary night blindness 2 | 29
Constipation 2 | 181
Fever 2 | 138
Heroin dependence 2 | 30
Hyperalgesia 2 | 83
Hypertension 2 | 396
Hypertensive disease 2 | 292
Hypotension 2 | 82
Hypoxia 2 | 33
Intellectual disability 2 | 1,016
Mood Disorders 2 | 184
Movement Disorders 2 | 55
Nausea 2 | 20
Neurodegenerative disease 2 | 414
Neuropathy 2 | 261
Night blindness, congenital stationary 2 | 16
Respiratory Insufficiency 2 | 132
Substance Withdrawal Syndrome 2 | 55
Unipolar Depression 2 | 250
Weight Gain 2 | 100
active ulcerative colitis 2 | 764
acute quadriplegic myopathy 2 | 1,158
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
colon cancer 2 | 1,478
cystic fibrosis 2 | 1,696
non primary Sjogren syndrome sicca 2 | 891
primary Sjogren syndrome 2 | 735
primary pancreatic ductal adenocarcinoma 2 | 1,109
sarcoidosis 2 | 370
tuberculosis 2 | 2,010

Tissue

Digestive Tract 27 | 17,369
Endocrine System 27 | 18,159
Blood and immune system 25 | 16,909
Nervous System 25 | 16,725
Skin and soft tissues 25 | 17,230
Female tissues 24 | 17,400
Male tissues 24 | 17,142
Liver and Pancreas 23 | 16,750
Respiratory system 23 | 16,393
Urinary Tract 22 | 16,678
Cardiovascular System 21 | 15,192

Target Family

Non-IDG 26 | 12,091
GPCR 1 | 408

Reactome Pathway

G-protein activation 27 | 27
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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