Development Level

Tbio 22 | 11,445
Tclin 12 | 613
Tchem 9 | 1,598
Tdark 4 | 6,588

IMPC Phenotype

preweaning lethality, incomple... 3 | 499
decreased body weight 2 | 161
decreased circulating creatini... 2 | 39
female infertility 2 | 60
male infertility 2 | 123
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal colon morphology 1 | 3
abnormal duodenum morphology 1 | 4
abnormal eye anterior chamber ... 1 | 9
abnormal glucose homeostasis 1 | 4
abnormal spleen morphology 1 | 55
abnormal vertebrae morphology 1 | 18
decreased bone mineral content 1 | 151
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating choleste... 1 | 93
decreased circulating triglyce... 1 | 79
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased heart rate 1 | 23
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased total body fat amoun... 1 | 134
preweaning lethality, complete... 1 | 979
small kidney 1 | 16
small superior vagus ganglion 1 | 74
thrombocytosis 1 | 27

Disease

osteosarcoma 27 | 7,950
Carcinoma 26 | 11,493
ovarian cancer 26 | 8,520
Cancer 25 | 2,499
medulloblastoma, large-cell 23 | 6,241
glioblastoma 21 | 5,792
psoriasis 18 | 6,694
invasive ductal carcinoma 15 | 2,951
lung cancer 15 | 4,740
lung carcinoma 15 | 2,843
malignant mesothelioma 15 | 3,232
interstitial cystitis 14 | 2,312
Rheumatoid arthritis 13 | 1,191
Schizophrenia 13 | 1,160
ependymoma 13 | 4,679
subependymal giant cell astrocytoma 13 | 2,287
atypical teratoid / rhabdoid tumor 12 | 5,112
Astrocytoma, Pilocytic 11 | 3,081
Breast cancer 11 | 3,578
lung adenocarcinoma 11 | 2,716
non-small cell lung cancer 11 | 2,890
adult high grade glioma 10 | 3,801
primitive neuroectodermal tumor 10 | 3,035
juvenile dermatomyositis 9 | 1,187
tuberculosis 9 | 2,010
ulcerative colitis 9 | 1,819
Asthma 8 | 385
group 3 medulloblastoma 8 | 4,104
pancreatic cancer 8 | 2,398
primary Sjogren syndrome 8 | 735
Autosomal recessive predisposition 7 | 1,442
Kidney cancer 7 | 2,613
Multiple myeloma 7 | 1,332
cystic fibrosis 7 | 1,696
diabetes mellitus 7 | 1,728
ductal carcinoma in situ 7 | 1,745
group 4 medulloblastoma 7 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
pituitary cancer 7 | 1,972
Hypereosinophilic syndrome 6 | 71
Pick disease 6 | 1,894
active Crohn's disease 6 | 922
breast carcinoma 6 | 1,638
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
Anemia 5 | 365
Crohn's disease 5 | 321
Diffuse large B-cell lymphoma 5 | 39
Hypersensitivity reaction type II disease 5 | 253
Lymphoma, Large B-Cell, Diffuse 5 | 34
Pneumonia 5 | 174
Prostatic Neoplasms 5 | 495
Seizures 5 | 596
Severe combined immunodeficiency 5 | 51
Splenomegaly 5 | 190
Thrombocytopenia 5 | 197
cutaneous lupus erythematosus 5 | 1,057
oligodendroglioma 5 | 2,850
pancreatic carcinoma 5 | 562
periodontitis 5 | 293
Allergic hypersensitivity disease 4 | 126
Allergic rhinitis 4 | 94
Breast Neoplasms 4 | 445
Colorectal Neoplasms 4 | 243
Epilepsy 4 | 792
Failure to gain weight 4 | 365
Fever 4 | 138
Hepatomegaly 4 | 285
Influenza 4 | 142
Intellectual disability 4 | 1,016
Liver Cirrhosis, Experimental 4 | 769
Lung disease 4 | 142
Major Depressive Disorder 4 | 301
Mammary Neoplasms 4 | 425
Multiple Sclerosis 4 | 540
Pediatric failure to thrive 4 | 365
Waldenstrons macroglobulinemia 4 | 765
astrocytic glioma 4 | 2,597
astrocytoma 4 | 1,146
dermatomyositis 4 | 966
follicular lymphoma 4 | 20
primary pancreatic ductal adenocarcinoma 4 | 1,109
Arthritis 3 | 290
Bipolar Disorder 3 | 666
Concave bridge of nose 3 | 195
Depressed nasal bridge 3 | 195
Depressed nasal root/bridge 3 | 195
Depressive disorder 3 | 409
Dermatitis 3 | 157
Dermatitis, Allergic Contact 3 | 67
Inflammatory bowel disease 3 | 151
Leishmaniasis 3 | 47
Leukemia 3 | 104
Unipolar Depression 3 | 250
Vascular disease 3 | 319
Ventricular Septal Defects 3 | 119
active ulcerative colitis 3 | 764
mucosa-associated lymphoid tissue lymphoma 3 | 484
nasopharyngeal carcinoma 3 | 1,058
posterior fossa group B ependymoma 3 | 416

Tissue

Blood and immune system 47 | 16,909
Digestive Tract 46 | 17,369
Endocrine System 46 | 18,159
Male tissues 46 | 17,142
Female tissues 45 | 17,400
Skin and soft tissues 45 | 17,230
Liver and Pancreas 44 | 16,750
Urinary Tract 44 | 16,678
Nervous System 43 | 16,725
Respiratory system 43 | 16,393
Cardiovascular System 42 | 15,192

Target Family

Non-IDG 31 | 12,091
Kinase 11 | 634
Enzyme 5 | 4,145

Reactome Pathway

G beta:gamma signalling throug... 47 | 47
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 GNG8 Tdark Non-IDG -2.17483 154.8 34
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 GNG10 Tdark Non-IDG 0.16 0.62 18
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 GNG5 Tbio Non-IDG -0.57807 4.05 87
GRB2-associated-binding protein 2 GAB2 Tbio Non-IDG -2.08460 139.8 494
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 GNG12 Tbio Non-IDG -0.39851 2.26 42
Interleukin-3 IL3 Tbio Non-IDG -3.35359 2101.5 583
Interleukin-5 IL5 Tclin Non-IDG -3.45852 2701.9 571
Interleukin-2 IL2 Tchem Non-IDG -4.37903 24027.6 1518
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 GNGT2 Tbio Non-IDG -1.16971 13.6 55
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 GNG7 Tbio Non-IDG -0.76260 5.38 63