Development Level

Tdark 419 | 6,588
Tbio 80 | 11,445
Tclin 45 | 613
Tchem 30 | 1,598

Collection

GPCR: IDG Consortium (Targets) 11 | 126
GPCR: IDG Consortium (Complete... 3 | 25

IMPC Phenotype

preweaning lethality, incomple... 9 | 499
abnormal bone structure 7 | 187
decreased vertical activity 7 | 208
decreased bone mineral content 5 | 151
decreased lean body mass 5 | 135
increased startle reflex 5 | 112
decreased total body fat amoun... 4 | 207
increased heart weight 4 | 62
increased total body fat amoun... 4 | 134
preweaning lethality, complete... 4 | 979
decreased grip strength 3 | 116
enlarged heart 3 | 210
thrombocytopenia 3 | 56
abnormal behavior 2 | 298
abnormal coat-hair pigmentatio... 2 | 64
abnormal heart morphology 2 | 162
abnormal kidney morphology 2 | 65
decreased body length 2 | 101
decreased bone mineral density 2 | 126
decreased fasted circulating g... 2 | 65
decreased neutrophil cell numb... 2 | 42
impaired glucose tolerance 2 | 75
increased circulating alkaline... 2 | 122
increased circulating sodium l... 2 | 71
increased lymphocyte cell numb... 2 | 32
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
small testis 2 | 58
abnormal behavioral response t... 1 | 66
abnormal cranium morphology 1 | 36
abnormal head morphology 1 | 10
abnormal liver morphology 1 | 17
abnormal lymph node morphology 1 | 3
abnormal male genitalia morpho... 1 | 3
abnormal ovary morphology 1 | 7
abnormal skin coloration 1 | 25
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
absent startle reflex 1 | 24
cardiovascular system phenotyp... 1 | 36
convulsive seizures 1 | 13
decreased IgE level 1 | 6
decreased basophil cell number 1 | 16
decreased body weight 1 | 161
decreased brain size 1 | 4
decreased circulating alanine ... 1 | 47
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
fusion of vertebral arches 1 | 7
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating lipase l... 1 | 3
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
polycystic kidney 1 | 15
polysyndactyly 1 | 2
small heart 1 | 10
small kidney 1 | 16
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 19
small stomach 1 | 3
small superior vagus ganglion 1 | 74
small thymus 1 | 16
urinary bladder obstruction 1 | 4
vertebral transformation 1 | 12

Disease

Carcinoma 410 | 11,493
diabetes mellitus 107 | 1,728
osteosarcoma 83 | 7,950
ovarian cancer 75 | 8,520
medulloblastoma, large-cell 73 | 6,241
psoriasis 63 | 6,694
glioblastoma 55 | 5,792
lung cancer 51 | 4,740
adult high grade glioma 49 | 3,801
atypical teratoid / rhabdoid tumor 47 | 5,112
ependymoma 44 | 4,679
lung carcinoma 40 | 2,843
Astrocytoma, Pilocytic 35 | 3,081
group 3 medulloblastoma 35 | 4,104
Schizophrenia 34 | 1,160
primitive neuroectodermal tumor 34 | 3,035
Bipolar Disorder 33 | 666
astrocytic glioma 33 | 2,597
Depressive disorder 32 | 409
Breast cancer 31 | 3,578
invasive ductal carcinoma 31 | 2,951
lung adenocarcinoma 29 | 2,716
oligodendroglioma 29 | 2,850
Kidney cancer 28 | 2,613
Obesity 28 | 678
intraductal papillary-mucinous adenoma (IPMA) 28 | 2,955
non-small cell lung cancer 28 | 2,890
interstitial cystitis 27 | 2,312
Hypertension 26 | 396
Mental Depression 26 | 333
malignant mesothelioma 26 | 3,232
pituitary cancer 26 | 1,972
Cancer 25 | 2,499
intraductal papillary-mucinous carcinoma (IPMC) 25 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,291
breast carcinoma 22 | 1,638
ductal carcinoma in situ 21 | 1,745
colon cancer 20 | 1,478
pancreatic cancer 20 | 2,398
tuberculosis 19 | 2,010
ulcerative colitis 19 | 1,819
Major Depressive Disorder 18 | 301
Pick disease 18 | 1,894
subependymal giant cell astrocytoma 18 | 2,287
Asthma 17 | 385
Hypertensive disease 17 | 292
group 4 medulloblastoma 17 | 1,855
Adenoma 16 | 167
Cushing's syndrome 16 | 48
Alcoholic Intoxication, Chronic 15 | 289
Atrial Fibrillation 15 | 124
Hypothyroidism 15 | 122
Mood Disorders 15 | 184
Rheumatoid arthritis 15 | 1,191
Autistic Disorder 14 | 364
Chronic heart failure 14 | 46
Migraine 14 | 83
Myocardial Perfusion Imaging Adjunct 14 | 25
Autosomal recessive predisposition 13 | 1,442
Osteoporosis 13 | 363
cystic fibrosis 13 | 1,696
Hemolytic anemia 12 | 77
Hypogonadism 12 | 173
Kidney disease 12 | 430
Platelet Aggregation Inhibition 12 | 22
Polycystic ovary syndrome 12 | 360
Prevention of Cerebral Thrombosis 12 | 29
Unipolar Depression 12 | 250
adrenocortical carcinoma 12 | 1,428
Acquired metabolic disease 11 | 336
Acromegaly 11 | 51
Diarrhea 11 | 253
Hyperthyroidism 11 | 53
Liver Cirrhosis, Experimental 11 | 769
Parkinson's disease 11 | 392
Substance Withdrawal Syndrome 11 | 55
active Crohn's disease 11 | 922
Constipation 10 | 181
Hypoglycemia 10 | 152
Infertility 10 | 188
Melanoma 10 | 711
Short stature 10 | 531
astrocytoma 10 | 1,146
fibroadenoma 10 | 559
non primary Sjogren syndrome sicca 10 | 891
pediatric high grade glioma 10 | 1,064
Alzheimer's disease 9 | 658
Anorexia nervosa 9 | 80
Cardiomyopathies 9 | 110
Chronic obstructive pulmonary disease 9 | 184
Epilepsy 9 | 792
Heart disease 9 | 306
Hyperactive behavior 9 | 91
Hypoparathyroidism 9 | 41
Liver cancer 9 | 604
Pituitary adenoma 9 | 38
Pseudohypoparathyroidism 9 | 18
Seizures 9 | 596
cutaneous lupus erythematosus 9 | 1,057
juvenile dermatomyositis 9 | 1,187

Tissue

Endocrine System 256 | 18,159
Female tissues 175 | 17,400
Blood and immune system 164 | 16,909
Male tissues 162 | 17,142
Digestive Tract 161 | 17,369
Nervous System 155 | 16,725
Skin and soft tissues 150 | 17,230
Urinary Tract 150 | 16,678
Liver and Pancreas 142 | 16,750
Respiratory system 136 | 16,393
Cardiovascular System 120 | 15,192

Target Family

oGPCR 415 | 421
Non-IDG 70 | 12,091
GPCR 61 | 408
Enzyme 24 | 4,145
Kinase 4 | 634

Reactome Pathway

G alpha (s) signalling events 574 | 574
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Relaxin-3 RLN3 Tbio Non-IDG -1.88808 92.6 93
Olfactory receptor 5H15 OR5H15 Tdark oGPCR 0.00000 35
Olfactory receptor 4F4 OR4F4 Tdark oGPCR 0.00000 45
Olfactory receptor 4C12 OR4C12 Tdark oGPCR 0.31 0.30 74
Olfactory receptor 4K3 OR4K3 Tdark oGPCR 0.00000 0
Adrenocorticotropic hormone receptor MC2R Tclin GPCR -2.22640 172.4 223
Olfactory receptor 6C68 OR6C68 Tdark oGPCR 0.00000 49
Olfactory receptor 2M4 OR2M4 Tdark oGPCR 0.95 0.18 19
Olfactory receptor 2M2 OR2M2 Tdark oGPCR 0.00000 61
Olfactory receptor 2V2 OR2V2 Tdark oGPCR 0.00000 58