Development Level

Tdark 419 | 6,593
Tbio 86 | 11,651
Tclin 45 | 612
Tchem 24 | 1,388

Collection

GPCR: IDG Consortium (Targets) 11 | 126
RFA-RM-18-021 11 | 328
GPCR: IDG Consortium (Complete... 3 | 25

IMPC Phenotype

preweaning lethality, incomple... 9 | 499
abnormal bone structure 7 | 187
decreased vertical activity 7 | 208
decreased bone mineral content 5 | 151
decreased lean body mass 5 | 135
increased startle reflex 5 | 112
decreased total body fat amoun... 4 | 207
increased heart weight 4 | 62
increased total body fat amoun... 4 | 134
preweaning lethality, complete... 4 | 979
decreased grip strength 3 | 116
enlarged heart 3 | 210
thrombocytopenia 3 | 56
abnormal behavior 2 | 298
abnormal coat-hair pigmentatio... 2 | 64
abnormal heart morphology 2 | 162
abnormal kidney morphology 2 | 65
decreased body length 2 | 101
decreased bone mineral density 2 | 126
decreased fasted circulating g... 2 | 65
decreased neutrophil cell numb... 2 | 42
impaired glucose tolerance 2 | 75
increased circulating alkaline... 2 | 122
increased circulating sodium l... 2 | 71
increased lymphocyte cell numb... 2 | 32
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
small testis 2 | 58
abnormal behavioral response t... 1 | 66
abnormal cranium morphology 1 | 36
abnormal head morphology 1 | 10
abnormal liver morphology 1 | 17
abnormal lymph node morphology 1 | 3
abnormal male genitalia morpho... 1 | 3
abnormal ovary morphology 1 | 7
abnormal skin coloration 1 | 25
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
absent startle reflex 1 | 24
cardiovascular system phenotyp... 1 | 36
convulsive seizures 1 | 13
decreased IgE level 1 | 6
decreased basophil cell number 1 | 16
decreased body weight 1 | 161
decreased brain size 1 | 4
decreased circulating alanine ... 1 | 47
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
fusion of vertebral arches 1 | 7
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating lipase l... 1 | 3
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
polycystic kidney 1 | 15
polysyndactyly 1 | 2
small heart 1 | 10
small kidney 1 | 16
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 19
small stomach 1 | 3
small superior vagus ganglion 1 | 74
small thymus 1 | 16
urinary bladder obstruction 1 | 4
vertebral transformation 1 | 12

Disease

Carcinoma 410 | 11,493
diabetes mellitus 107 | 1,728
osteosarcoma 83 | 7,950
ovarian cancer 75 | 8,520
medulloblastoma, large-cell 73 | 6,241
psoriasis 63 | 6,694
glioblastoma 55 | 5,792
lung cancer 51 | 4,740
adult high grade glioma 49 | 3,801
atypical teratoid / rhabdoid tumor 47 | 5,112
ependymoma 44 | 4,679
lung carcinoma 40 | 2,843
Astrocytoma, Pilocytic 35 | 3,081
group 3 medulloblastoma 35 | 4,104
Schizophrenia 34 | 1,160
primitive neuroectodermal tumor 34 | 3,035
Bipolar Disorder 33 | 666
astrocytic glioma 33 | 2,597
Depressive disorder 32 | 409
Breast cancer 31 | 3,578
invasive ductal carcinoma 31 | 2,951
lung adenocarcinoma 29 | 2,716
oligodendroglioma 29 | 2,850
Kidney cancer 28 | 2,613
Obesity 28 | 678
intraductal papillary-mucinous adenoma (IPMA) 28 | 2,955
non-small cell lung cancer 28 | 2,890
interstitial cystitis 27 | 2,312
Hypertension 26 | 396
Mental Depression 26 | 333
malignant mesothelioma 26 | 3,232
pituitary cancer 26 | 1,972
Cancer 25 | 2,499
intraductal papillary-mucinous carcinoma (IPMC) 25 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,291
breast carcinoma 22 | 1,638
ductal carcinoma in situ 21 | 1,745
colon cancer 20 | 1,478
pancreatic cancer 20 | 2,398
tuberculosis 19 | 2,010
ulcerative colitis 19 | 1,819
Major Depressive Disorder 18 | 301
Pick disease 18 | 1,894
subependymal giant cell astrocytoma 18 | 2,287
Asthma 17 | 385
Hypertensive disease 17 | 292
group 4 medulloblastoma 17 | 1,855
Adenoma 16 | 167
Cushing's syndrome 16 | 48
Alcoholic Intoxication, Chronic 15 | 289
Atrial Fibrillation 15 | 124
Hypothyroidism 15 | 122
Mood Disorders 15 | 184
Rheumatoid arthritis 15 | 1,191
Autistic Disorder 14 | 364
Chronic heart failure 14 | 46
Migraine 14 | 83
Myocardial Perfusion Imaging Adjunct 14 | 25
Autosomal recessive predisposition 13 | 1,442
Osteoporosis 13 | 363
cystic fibrosis 13 | 1,696
Hemolytic anemia 12 | 77
Hypogonadism 12 | 173
Kidney disease 12 | 430
Platelet Aggregation Inhibition 12 | 22
Polycystic ovary syndrome 12 | 360
Prevention of Cerebral Thrombosis 12 | 29
Unipolar Depression 12 | 250
adrenocortical carcinoma 12 | 1,428
Acquired metabolic disease 11 | 336
Acromegaly 11 | 51
Diarrhea 11 | 253
Hyperthyroidism 11 | 53
Liver Cirrhosis, Experimental 11 | 769
Parkinson's disease 11 | 392
Substance Withdrawal Syndrome 11 | 55
active Crohn's disease 11 | 922
Constipation 10 | 181
Hypoglycemia 10 | 152
Infertility 10 | 188
Melanoma 10 | 711
Short stature 10 | 531
astrocytoma 10 | 1,146
fibroadenoma 10 | 559
non primary Sjogren syndrome sicca 10 | 891
pediatric high grade glioma 10 | 1,064
Alzheimer's disease 9 | 658
Anorexia nervosa 9 | 80
Cardiomyopathies 9 | 110
Chronic obstructive pulmonary disease 9 | 184
Epilepsy 9 | 792
Heart disease 9 | 306
Hyperactive behavior 9 | 91
Hypoparathyroidism 9 | 41
Liver cancer 9 | 604
Pituitary adenoma 9 | 38
Pseudohypoparathyroidism 9 | 18
Seizures 9 | 596
cutaneous lupus erythematosus 9 | 1,057
juvenile dermatomyositis 9 | 1,187

Tissue

Endocrine System 256 | 18,159
Female tissues 175 | 17,400
Blood and immune system 164 | 16,909
Male tissues 162 | 17,142
Digestive Tract 161 | 17,369
Nervous System 155 | 16,725
Skin and soft tissues 150 | 17,230
Urinary Tract 150 | 16,678
Liver and Pancreas 142 | 16,750
Respiratory system 136 | 16,393
Cardiovascular System 120 | 15,192

Target Family

oGPCR 415 | 421
Non-IDG 70 | 12,091
GPCR 61 | 408
Enzyme 24 | 4,145
Kinase 4 | 634

Reactome Pathway

G alpha (s) signalling events 574 | 574
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Relaxin-3 RLN3 Tbio Non-IDG -1.88808 92.6 93
Olfactory receptor 5H15 OR5H15 Tdark oGPCR 0.00000 35
Olfactory receptor 7D2 OR7D2 Tdark oGPCR 0.00000 2
Neuroendocrine secretory protein 55 GNAS Tbio Non-IDG -2.63356 1389.7 509
Olfactory receptor 5B21 OR5B21 Tdark oGPCR 0.00000 4
cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A Tclin Enzyme -2.09039 125.7 168
G-protein coupled receptor 176 GPR176 Tbio GPCR -2.38327 235.4 133
Olfactory receptor 1A2 OR1A2 Tdark oGPCR -0.35218 1.89 21
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 GNB3 Tbio Non-IDG -2.34836 235.8 161
Olfactory receptor 2A25 OR2A25 Tdark oGPCR 0.00000 44