Development Level

Tchem 84 | 1,598
Tbio 83 | 11,445
Tclin 37 | 613
Tdark 7 | 6,588

Collection

GPCR: IDG Consortium (Targets) 10 | 126
GPCR: IDG Consortium (Complete... 4 | 25
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 10 | 979
enlarged heart 6 | 210
abnormal behavior 5 | 298
decreased vertical activity 5 | 208
preweaning lethality, incomple... 5 | 499
abnormal kidney morphology 4 | 65
decreased body weight 4 | 161
hypoactivity 4 | 132
prolonged QT interval 4 | 38
prolonged ST segment 4 | 36
small superior vagus ganglion 4 | 74
abnormal heart morphology 3 | 162
decreased bone mineral content 3 | 151
decreased lean body mass 3 | 135
decreased prepulse inhibition 3 | 82
decreased total body fat amoun... 3 | 207
increased bone mineral content 3 | 108
increased lean body mass 3 | 172
increased startle reflex 3 | 112
increased total body fat amoun... 3 | 134
male infertility 3 | 123
abnormal bone structure 2 | 187
abnormal epididymis morphology 2 | 42
abnormal gait 2 | 69
abnormal seminal vesicle morph... 2 | 114
abnormal sleep behavior 2 | 70
abnormal testis morphology 2 | 43
decreased bone mineral density 2 | 126
decreased circulating amylase ... 2 | 28
decreased circulating insulin ... 2 | 76
decreased circulating triglyce... 2 | 79
hyperactivity 2 | 148
short tibia 2 | 97
small kidney 2 | 16
abnormal embryo size 1 | 220
abnormal forelimb morphology 1 | 2
abnormal locomotor activation 1 | 16
abnormal locomotor behavior 1 | 24
abnormal ovary morphology 1 | 7
abnormal pancreas morphology 1 | 13
abnormal response to new envir... 1 | 10
abnormal skin morphology 1 | 50
abnormal vocalization 1 | 21
absent testes 1 | 6
corneal vascularization 1 | 6
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased brain size 1 | 4
decreased caudal vertebrae num... 1 | 53
decreased circulating bilirubi... 1 | 19
decreased circulating creatini... 1 | 39
decreased circulating glycerol... 1 | 16
decreased circulating phosphat... 1 | 27
decreased circulating total pr... 1 | 49
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart rate 1 | 18
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased neutrophil cell numb... 1 | 42
decreased startle reflex 1 | 75
decreased threshold for audito... 1 | 26
decreased urine magnesium leve... 1 | 3
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged spleen 1 | 41
enlarged uterus 1 | 11
female infertility 1 | 60
hydrometra 1 | 53
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased bone mineral density 1 | 72
increased circulating calcium ... 1 | 34
increased circulating glucose ... 1 | 24
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased lymphocyte cell numb... 1 | 32
increased or absent threshold ... 1 | 101
increased prepulse inhibition 1 | 32
limb grasping 1 | 41
mammalian phenotype 1 | 17
polycystic kidney 1 | 15
premature death 1 | 5
prenatal lethality 1 | 28
prolonged RR interval 1 | 8
small heart 1 | 10
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 19
small stomach 1 | 3
small testis 1 | 58
small thymus 1 | 16
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Carcinoma 135 | 11,493
psoriasis 91 | 6,694
osteosarcoma 89 | 7,950
medulloblastoma, large-cell 82 | 6,241
ovarian cancer 72 | 8,520
glioblastoma 66 | 5,792
ependymoma 63 | 4,679
atypical teratoid / rhabdoid tumor 60 | 5,112
Cancer 59 | 2,499
lung cancer 52 | 4,740
group 3 medulloblastoma 49 | 4,104
adult high grade glioma 48 | 3,801
lung carcinoma 47 | 2,843
Schizophrenia 46 | 1,160
malignant mesothelioma 46 | 3,232
Astrocytoma, Pilocytic 45 | 3,081
Breast cancer 45 | 3,578
Obesity 43 | 678
primitive neuroectodermal tumor 42 | 3,035
invasive ductal carcinoma 38 | 2,951
lung adenocarcinoma 38 | 2,716
non-small cell lung cancer 38 | 2,890
interstitial cystitis 37 | 2,312
oligodendroglioma 37 | 2,850
astrocytic glioma 36 | 2,597
Depressive disorder 35 | 409
ulcerative colitis 33 | 1,819
Kidney cancer 32 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 32 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 32 | 2,989
Bipolar Disorder 30 | 666
pancreatic cancer 30 | 2,398
subependymal giant cell astrocytoma 30 | 2,287
Hypertension 29 | 396
diabetes mellitus 29 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 29 | 3,291
Pick disease 28 | 1,894
Autosomal recessive predisposition 26 | 1,442
cystic fibrosis 25 | 1,696
pituitary cancer 25 | 1,972
Asthma 23 | 385
Mental Depression 23 | 333
Hypertensive disease 22 | 292
tuberculosis 22 | 2,010
Alcoholic Intoxication, Chronic 21 | 289
Major Depressive Disorder 21 | 301
Rheumatoid arthritis 21 | 1,191
Unipolar Depression 21 | 250
breast carcinoma 21 | 1,638
colon cancer 21 | 1,478
ductal carcinoma in situ 21 | 1,745
group 4 medulloblastoma 21 | 1,855
Hyperalgesia 18 | 83
Mood Disorders 18 | 184
Seizures 18 | 596
Epilepsy 17 | 792
Melanoma 17 | 711
Pain agnosia 17 | 104
Parkinson's disease 17 | 392
juvenile dermatomyositis 17 | 1,187
Kidney disease 16 | 430
Constipation 15 | 181
Hypotension 15 | 82
Intellectual disability 15 | 1,016
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
primary pancreatic ductal adenocarcinoma 15 | 1,109
Atherosclerosis 14 | 291
Cerebrovascular disease 14 | 238
Liver Cirrhosis, Experimental 14 | 769
adrenocortical carcinoma 14 | 1,428
cutaneous lupus erythematosus 14 | 1,057
Cryptorchidism 13 | 296
Delayed bone age 13 | 136
Diarrhea 13 | 253
Endometriosis 13 | 540
Pain 13 | 103
Pancreatitis 13 | 123
Stomach Neoplasms 13 | 300
active Crohn's disease 13 | 922
Bradycardia 12 | 36
Cocaine-Related Disorders 12 | 92
Heart disease 12 | 306
Skin cancer 12 | 469
active ulcerative colitis 12 | 764
astrocytoma 12 | 1,146
Alzheimer's disease 11 | 658
Cardiac Arrhythmia 11 | 103
Coronary artery disease 11 | 268
Dull intelligence 11 | 645
Hypoglycemia 11 | 152
Hypogonadotropic hypogonadism 11 | 89
Irritable bowel syndrome 11 | 60
Low intelligence 11 | 645
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Poor school performance 11 | 645
Substance Withdrawal Syndrome 11 | 55
esophageal adenocarcinoma 11 | 737
hepatocellular carcinoma 11 | 547
spina bifida 11 | 1,074

Tissue

Endocrine System 204 | 18,159
Digestive Tract 195 | 17,369
Nervous System 189 | 16,725
Female tissues 187 | 17,400
Skin and soft tissues 186 | 17,230
Male tissues 184 | 17,142
Urinary Tract 181 | 16,678
Blood and immune system 178 | 16,909
Liver and Pancreas 173 | 16,750
Respiratory system 173 | 16,393
Cardiovascular System 150 | 15,192

Target Family

GPCR 89 | 408
Non-IDG 73 | 12,091
Enzyme 21 | 4,145
Kinase 21 | 634
Ion Channel 6 | 344
Transcription Factor 1 | 1,400

Reactome Pathway

G alpha (q) signalling events 211 | 211
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Urotensin-2 receptor UTS2R Tchem GPCR -1.95094 62.5 182
Monoacylglycerol lipase ABHD6 ABHD6 Tchem Enzyme -1.37418 26.1 71
G-protein coupled receptor 39 GPR39 Tchem GPCR -1.77076 66.5 232
Guanine nucleotide-binding protein subunit alpha-11 GNA11 Tbio Non-IDG -2.80484 555.1 184
Diacylglycerol kinase eta DGKH Tbio Kinase -1.45863 29.5 92
Proteinase-activated receptor 4 F2RL3 Tchem GPCR -1.50044 34.1 276
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 GNG8 Tdark Non-IDG -2.17483 154.8 34
5-hydroxytryptamine receptor 2B HTR2B Tclin GPCR -2.66641 486.3 265
Short transient receptor potential channel 7 TRPC7 Tchem Ion Channel -2.43775 199.8 220
Guanine nucleotide-binding protein subunit alpha-14 GNA14 Tbio Non-IDG -0.78609 4.51 142