Development Level

Tbio 232 | 11,651
Tchem 95 | 1,388
Tclin 51 | 612
Tdark 16 | 6,593

Collection

GPCR: IDG Consortium (Targets) 40 | 126
RFA-RM-18-021 17 | 328
GPCR: IDG Consortium (Complete... 5 | 25
Kinase: IDG Consortium (Target... 3 | 125

IMPC Phenotype

preweaning lethality, incomple... 13 | 499
preweaning lethality, complete... 11 | 979
abnormal behavior 9 | 298
decreased vertical activity 9 | 208
enlarged heart 9 | 210
hyperactivity 9 | 148
increased lean body mass 7 | 172
abnormal bone structure 6 | 187
abnormal heart morphology 6 | 162
decreased total body fat amoun... 6 | 207
small superior vagus ganglion 6 | 74
decreased bone mineral content 5 | 151
improved glucose tolerance 5 | 79
increased circulating triglyce... 5 | 42
increased heart weight 5 | 62
increased total body fat amoun... 5 | 134
decreased circulating insulin ... 4 | 76
embryonic lethality prior to t... 4 | 278
hypoactivity 4 | 132
increased bone mineral content 4 | 108
increased circulating sodium l... 4 | 71
increased mean corpuscular vol... 4 | 92
increased mean platelet volume 4 | 45
increased startle reflex 4 | 112
male infertility 4 | 123
abnormal retina morphology 3 | 71
cataract 3 | 92
decreased circulating serum al... 3 | 82
decreased exploration in new e... 3 | 11
decreased fasted circulating g... 3 | 65
decreased lean body mass 3 | 135
decreased lymphocyte cell numb... 3 | 83
decreased neutrophil cell numb... 3 | 42
hydrometra 3 | 53
impaired righting response 3 | 26
increased blood urea nitrogen ... 3 | 48
increased circulating alkaline... 3 | 122
increased circulating choleste... 3 | 66
increased circulating creatini... 3 | 38
increased circulating potassiu... 3 | 29
increased neutrophil cell numb... 3 | 46
prolonged QT interval 3 | 38
prolonged ST segment 3 | 36
abnormal behavioral response t... 2 | 66
abnormal coat-hair pigmentatio... 2 | 64
abnormal embryo size 2 | 220
abnormal gait 2 | 69
abnormal kidney morphology 2 | 65
abnormal lens morphology 2 | 81
abnormal seminal vesicle morph... 2 | 114
abnormal sleep behavior 2 | 70
abnormal whole-body plethysmog... 2 | 4
cardiovascular system phenotyp... 2 | 36
decreased body weight 2 | 161
decreased circulating amylase ... 2 | 28
decreased circulating chloride... 2 | 30
decreased circulating glucose ... 2 | 126
decreased grip strength 2 | 116
decreased red blood cell distr... 2 | 41
decreased startle reflex 2 | 75
embryonic lethality prior to o... 2 | 239
enlarged uterus 2 | 11
impaired pupillary reflex 2 | 26
increased blood uric acid leve... 2 | 5
increased circulating HDL chol... 2 | 80
increased circulating iron lev... 2 | 30
increased fasted circulating g... 2 | 76
increased mean corpuscular hem... 2 | 36
increased monocyte cell number 2 | 63
increased or absent threshold ... 2 | 101
limb grasping 2 | 41
mydriasis 2 | 6
small kidney 2 | 16
abnormal cornea morphology 1 | 31
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal vibrissa morphology 1 | 25
abnormal vocalization 1 | 21
absent pinna reflex 1 | 23
decreased T cell number 1 | 15
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased pulmonary respirator... 1 | 5
decreased total retina thickne... 1 | 17
enlarged spleen 1 | 41
increased bone mineral density 1 | 72
increased circulating bilirubi... 1 | 16
increased circulating magnesiu... 1 | 10
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased hemoglobin content 1 | 45
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
stereotypic behavior 1 | 3
trunk curl 1 | 16

Disease

Carcinoma 243 | 11,493
psoriasis 190 | 6,694
medulloblastoma, large-cell 149 | 6,241
osteosarcoma 149 | 7,950
glioblastoma 147 | 5,792
ovarian cancer 146 | 8,520
atypical teratoid / rhabdoid tumor 122 | 5,112
ependymoma 117 | 4,679
lung cancer 117 | 4,740
adult high grade glioma 107 | 3,801
Astrocytoma, Pilocytic 105 | 3,081
lung carcinoma 94 | 2,843
group 3 medulloblastoma 89 | 4,104
Breast cancer 85 | 3,578
Cancer 85 | 2,499
invasive ductal carcinoma 84 | 2,951
malignant mesothelioma 84 | 3,232
primitive neuroectodermal tumor 84 | 3,035
interstitial cystitis 79 | 2,312
oligodendroglioma 78 | 2,850
Schizophrenia 77 | 1,160
lung adenocarcinoma 77 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 73 | 2,989
non-small cell lung cancer 73 | 2,890
astrocytic glioma 71 | 2,597
Obesity 67 | 678
intraductal papillary-mucinous adenoma (IPMA) 67 | 2,955
ulcerative colitis 65 | 1,819
intraductal papillary-mucinous neoplasm (IPMN) 63 | 3,291
pancreatic cancer 63 | 2,398
diabetes mellitus 61 | 1,728
subependymal giant cell astrocytoma 61 | 2,287
tuberculosis 58 | 2,010
ductal carcinoma in situ 55 | 1,745
Kidney cancer 53 | 2,613
pituitary cancer 53 | 1,972
Bipolar Disorder 50 | 666
Depressive disorder 48 | 409
breast carcinoma 47 | 1,638
cystic fibrosis 47 | 1,696
group 4 medulloblastoma 47 | 1,855
Autosomal recessive predisposition 46 | 1,442
Alcoholic Intoxication, Chronic 45 | 289
colon cancer 44 | 1,478
Pick disease 43 | 1,894
cutaneous lupus erythematosus 42 | 1,057
Mental Depression 39 | 333
Rheumatoid arthritis 38 | 1,191
Epilepsy 35 | 792
Hypertension 35 | 396
Multiple Sclerosis 35 | 540
astrocytoma 34 | 1,146
Asthma 33 | 385
pancreatic ductal adenocarcinoma liver metastasis 33 | 1,962
Intellectual disability 32 | 1,016
Liver Cirrhosis, Experimental 31 | 769
Major Depressive Disorder 31 | 301
adrenocortical carcinoma 31 | 1,428
primary Sjogren syndrome 31 | 735
Atherosclerosis 30 | 291
Atopic dermatitis 30 | 952
Kidney disease 30 | 430
Mood Disorders 27 | 184
pediatric high grade glioma 27 | 1,064
Dull intelligence 26 | 645
Low intelligence 26 | 645
Mental Retardation 26 | 645
Mental deficiency 26 | 645
Poor school performance 26 | 645
Seizures 26 | 596
active Crohn's disease 26 | 922
Hypertensive disease 25 | 292
Parkinson's disease 25 | 392
active ulcerative colitis 25 | 764
Coronary artery disease 24 | 268
Night Blindness 24 | 101
nasopharyngeal carcinoma 24 | 1,058
non primary Sjogren syndrome sicca 24 | 891
Cerebrovascular disease 23 | 238
hepatocellular carcinoma 23 | 547
mucosa-associated lymphoid tissue lymphoma 23 | 484
Alzheimer's disease 22 | 658
Melanoma 22 | 711
Retinitis Pigmentosa 22 | 226
Unipolar Depression 22 | 250
aldosterone-producing adenoma 22 | 665
fibroadenoma 22 | 559
juvenile dermatomyositis 22 | 1,187
Difficulties with night vision 21 | 87
Pain 21 | 103
Vascular disease 21 | 319
sarcoidosis 21 | 370
Alcohol dependence 20 | 107
Nystagmus 20 | 317
Photodysphoria 20 | 121
Photophobia 20 | 121
Substance Withdrawal Syndrome 20 | 55
primary pancreatic ductal adenocarcinoma 20 | 1,109
Arthritis 19 | 290
gastric carcinoma 19 | 807

Tissue

Endocrine System 368 | 18,159
Digestive Tract 349 | 17,369
Female tissues 348 | 17,400
Skin and soft tissues 344 | 17,230
Male tissues 340 | 17,142
Blood and immune system 339 | 16,909
Nervous System 336 | 16,725
Liver and Pancreas 325 | 16,750
Urinary Tract 321 | 16,678
Respiratory system 310 | 16,393
Cardiovascular System 269 | 15,192

Target Family

Non-IDG 147 | 12,091
GPCR 146 | 408
Enzyme 78 | 4,145
Kinase 16 | 634
Ion Channel 5 | 344
Transcription Factor 1 | 1,400
Transporter 1 | 473

Reactome Pathway

G alpha (i) signalling events 394 | 394
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Relaxin-3 RLN3 Tbio Non-IDG -1.88808 92.6 93
Neuroendocrine secretory protein 55 GNAS Tbio Non-IDG -2.63356 1389.7 509
Regulator of G-protein signaling 21 RGS21 Tdark Non-IDG -0.64910 3.57 54
Long-wave-sensitive opsin 1 OPN1LW Tbio GPCR -2.37983 238.7 47
Medium-wave-sensitive opsin 1 OPN1MW Tbio GPCR -0.97721 8.41 18
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 PLCB1 Tbio Enzyme -2.50444 332.8 190
Syndecan-4 SDC4 Tbio Non-IDG -2.39649 274.8 297
Opsin-5 OPN5 Tbio GPCR -1.19753 14.2 151
Metabotropic glutamate receptor 2 GRM2 Tchem GPCR -2.77035 612.3 315
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform PPP2R1B Tbio Enzyme -1.20793 16.9 203