Development Level

Tbio 113 | 10,625
Tchem 80 | 1,890
Tclin 38 | 602
Tdark 14 | 7,003

Collection

Eligible non-olfactory GPCR Proteins 42 | 143

IMPC Term

preweaning lethality, incomple... 6 | 260
abnormal bone structure 5 | 131
increased heart weight 5 | 37
abnormal bone mineralization 4 | 55
improved glucose tolerance 4 | 56
preweaning lethality, complete... 3 | 633
abnormal behavioral response t... 2 | 52
decreased CD8-positive, alpha-... 2 | 26
decreased NK T cell number 2 | 28
decreased bone mineral content 2 | 157
decreased circulating chloride... 2 | 32
decreased circulating glucose ... 2 | 121
decreased circulating insulin ... 2 | 75
decreased fasted circulating g... 2 | 49
decreased grip strength 2 | 123
decreased lean body mass 2 | 195
increased circulating HDL chol... 2 | 63
increased circulating sodium l... 2 | 71
increased circulating total pr... 2 | 20
increased mean corpuscular vol... 2 | 91
abnormal coat appearance 1 | 25
abnormal coat/hair pigmentatio... 1 | 54
abnormal colon morphology 1 | 1
abnormal coping response 1 | 12
abnormal ileum morphology 1 | 2
abnormal spleen morphology 1 | 36
abnormal vibrissa morphology 1 | 17
abnormal whole-body plethysmog... 1 | 4
absent testes 1 | 2
cardiovascular system phenotyp... 1 | 35
cataract 1 | 26
decreased T cell number 1 | 31
decreased alpha-beta T cell nu... 1 | 12
decreased anxiety-related resp... 1 | 12
decreased body weight 1 | 174
decreased caudal vertebrae num... 1 | 49
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased circulating bilirubi... 1 | 14
decreased circulating calcium ... 1 | 33
decreased circulating creatini... 1 | 31
decreased circulating phosphat... 1 | 15
decreased circulating thyroxin... 1 | 5
decreased dendritic cell numbe... 1 | 3
decreased heart weight 1 | 44
decreased lumbar vertebrae num... 1 | 62
decreased prepulse inhibition 1 | 52
decreased startle reflex 1 | 48
decreased total body fat amoun... 1 | 186
decreased vertical activity 1 | 22
hyperactivity 1 | 108
impaired pupillary reflex 1 | 14
increased KLRG1-positive gamma... 1 | 2
increased blood urea nitrogen ... 1 | 44
increased blood uric acid leve... 1 | 5
increased circulating alkaline... 1 | 119
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating serum al... 1 | 25
increased effector memory CD8-... 1 | 14
increased effector memory T-he... 1 | 5
increased fasted circulating g... 1 | 68
increased gamma-delta T cell n... 1 | 16
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 25
increased monocyte cell number 1 | 27
increased myeloid cell number 1 | 2
increased sacral vertebrae num... 1 | 62
increased thoracic vertebrae n... 1 | 8
increased total body fat amoun... 1 | 57
mydriasis 1 | 9
premature death 1 | 5
short tail 1 | 4
short tibia 1 | 82
small kidney 1 | 10
small superior vagus ganglion 1 | 20

Disease

psoriasis 105 | 6,685
medulloblastoma, large-cell 86 | 6,234
osteosarcoma 84 | 7,933
glioblastoma 78 | 5,572
ovarian cancer 76 | 8,484
pilocytic astrocytoma 64 | 3,086
lung cancer 61 | 4,466
lung carcinoma 60 | 2,844
Cancer 54 | 2,346
interstitial cystitis 54 | 2,299
atypical teratoid / rhabdoid tumor 53 | 4,369
ulcerative colitis 53 | 2,087
invasive ductal carcinoma 48 | 2,950
lung adenocarcinoma 44 | 2,713
malignant mesothelioma 44 | 3,162
oligodendroglioma 44 | 2,849
non-small cell lung cancer 43 | 2,798
primitive neuroectodermal tumor 43 | 3,031
adult high grade glioma 41 | 2,148
intraductal papillary-mucinous carcinoma (IPMC) 41 | 2,988
pancreatic cancer 41 | 2,300
Breast cancer 38 | 3,094
intraductal papillary-mucinous adenoma (IPMA) 38 | 2,956
pediatric high grade glioma 36 | 2,712
astrocytic glioma 34 | 2,241
Obesity 33 | 616
posterior fossa group A ependymoma 33 | 1,511
tuberculosis 33 | 1,557
intraductal papillary-mucinous neoplasm (IPMN) 32 | 3,289
breast carcinoma 31 | 1,614
diabetes mellitus 30 | 1,663
ductal carcinoma in situ 30 | 1,745
pituitary cancer 30 | 1,972
ependymoma 29 | 2,514
primary Sjogren syndrome 29 | 789
subependymal giant cell astrocytoma 29 | 2,287
Schizophrenia 28 | 501
cutaneous lupus erythematosus 28 | 1,056
Carcinoma 27 | 2,147
colon cancer 27 | 1,475
medulloblastoma 27 | 1,524
Asthma 26 | 349
Multiple Sclerosis 25 | 498
Pick disease 25 | 1,893
Rheumatoid Arthritis 25 | 1,160
cystic fibrosis 24 | 1,665
astrocytoma 23 | 1,493
Epilepsy 22 | 346
group 3 medulloblastoma 22 | 2,254
group 4 medulloblastoma 21 | 1,875
Kidney disease 20 | 396
atypical teratoid/rhabdoid tumor 20 | 1,095
Alcohol dependence 19 | 107
gastric carcinoma 18 | 832
hepatocellular carcinoma 18 | 532
Pain 17 | 70
adrenocortical carcinoma 17 | 1,427
mucosa-associated lymphoid tissue lymphoma 17 | 480
Atherosclerosis 16 | 275
Hypersensitivity reaction type II disease 16 | 235
Parkinson's disease 16 | 364
juvenile dermatomyositis 16 | 1,189
posterior fossa group B ependymoma 16 | 1,530
Hypertensive disease 15 | 193
Major Depressive Disorder 15 | 106
Vascular disease 15 | 281
active Crohn's disease 15 | 918
sarcoidosis 15 | 358
Adenoma 14 | 165
Alzheimer's disease 14 | 644
Arthritis 14 | 248
Cerebrovascular disease 14 | 231
Hypertension 14 | 287
Migraine 14 | 79
Pain agnosia 14 | 99
Seizures 14 | 95
Substance Withdrawal Syndrome 14 | 52
periodontitis 14 | 269
Acromegaly 13 | 40
Atopic dermatitis 13 | 944
Cocaine-Related Disorders 13 | 88
Hypersensitivity 13 | 63
Pneumonia 13 | 133
Status Epilepticus 13 | 85
head and neck cancer 13 | 270
pancreatic carcinoma 13 | 567
Attention deficit hyperactivity disorder 12 | 156
Bipolar Disorder 12 | 266
Down syndrome 12 | 548
Hyperalgesia 12 | 71
Hypotension 12 | 53
Lung disease 12 | 132
Pituitary adenoma 12 | 35
head and neck cancer and chronic obstructive pulmonary disease 12 | 237
non primary Sjogren syndrome sicca 12 | 840
primary pancreatic ductal adenocarcinoma 12 | 1,271
sonic hedgehog group medulloblastoma 12 | 1,482
Autistic Disorder 11 | 320
Coronary artery disease 11 | 240
nasopharyngeal carcinoma 11 | 1,056

Tissue

Urinary Tract 235 | 18,444
Nervous System 233 | 18,561
Female tissues 232 | 18,647
Endocrine System 231 | 18,512
Digestive Tract 230 | 18,473
Skin and soft tissues 223 | 18,115
Liver and Pancreas 220 | 18,136
Blood and immune system 218 | 17,995
Cardiovascular System 217 | 17,958
Male tissues 211 | 17,969
Respiratory system 210 | 17,484

Target Family

GPCR 137 | 406
Non-IDG 99 | 11,971
Enzyme 9 | 4,146

Reactome Pathway

G alpha (i) signalling events 245 | 245
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Pro-neuropeptide Y NPY Tbio Non-IDG -3.81741 7285.3 401
Short-wave-sensitive opsin 1 OPN1SW Tbio GPCR -1.90084 81.3 15
Regulator of G-protein signaling 22 RGS22 Tbio Non-IDG -0.31702 2.73 99
Neuropeptides B/W receptor type 1 NPBWR1 Tchem GPCR -1.34565 19.5 151
Neuropeptides B/W receptor type 2 NPBWR2 Tbio GPCR -1.14202 8.84 57
Platelet factor 4 PF4 Tbio Non-IDG -3.28845 2045.5 243
Platelet basic protein PPBP Tbio Non-IDG -3.18113 1540.1 348
G-protein-signaling modulator 1 GPSM1 Tbio Non-IDG -1.32467 28.6 99
Regulator of G-protein signaling 16 RGS16 Tbio Non-IDG -1.59717 42.2 162