Development Level

Tbio 47 | 11,445
Tdark 18 | 6,588
Tchem 9 | 1,598

IMPC Phenotype

preweaning lethality, complete... 5 | 979
preweaning lethality, incomple... 5 | 499
abnormal bone structure 3 | 187
abnormal embryo size 3 | 220
abnormal vibrissa morphology 2 | 25
decreased circulating glucose ... 2 | 126
decreased fasted circulating g... 2 | 65
decreased total body fat amoun... 2 | 207
embryonic growth retardation 2 | 106
embryonic lethality prior to t... 2 | 278
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal limb bud morphology 1 | 17
abnormal liver size 1 | 5
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal skin morphology 1 | 50
brachydactyly 1 | 19
cataract 1 | 92
convulsive seizures 1 | 13
corneal opacity 1 | 32
corneal vascularization 1 | 6
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased cardiac muscle contr... 1 | 11
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased coping response 1 | 8
decreased lean body mass 1 | 135
decreased vertical activity 1 | 208
dilated heart left ventricle 1 | 11
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
hyperactivity 1 | 148
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased total body fat amoun... 1 | 134
increased total retina thickne... 1 | 4
male infertility 1 | 123
narrow eye opening 1 | 12
pale liver 1 | 6
pale yolk sac 1 | 25
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
small kidney 1 | 16

Disease

psoriasis 42 | 6,694
Carcinoma 34 | 11,493
esophageal adenocarcinoma 21 | 737
lung cancer 19 | 4,740
ovarian cancer 19 | 8,520
cystic fibrosis 18 | 1,696
Breast cancer 17 | 3,578
non-small cell lung cancer 17 | 2,890
osteosarcoma 16 | 7,950
diabetes mellitus 15 | 1,728
Atopic dermatitis 14 | 952
interstitial cystitis 13 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
malignant mesothelioma 13 | 3,232
pancreatic cancer 13 | 2,398
Cancer 12 | 2,499
Kidney cancer 12 | 2,613
spina bifida 12 | 1,074
lung adenocarcinoma 11 | 2,716
medulloblastoma, large-cell 11 | 6,241
nasopharyngeal carcinoma 10 | 1,058
Autosomal recessive predisposition 9 | 1,442
Netherton syndrome 9 | 15
Congenital ichthyosiform erythroderma 8 | 28
Dermatitis 8 | 157
Hypotrichosis 8 | 47
Melanoma 8 | 711
Palmoplantar keratosis 8 | 74
Skin cancer 8 | 469
adult high grade glioma 8 | 3,801
atypical teratoid / rhabdoid tumor 8 | 5,112
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
Arrhythmogenic right ventricular cardiomyopathy 7 | 30
Ichthyosis 7 | 56
Peeling skin syndrome 7 | 17
Prostatic Neoplasms 7 | 495
breast carcinoma 7 | 1,638
ependymoma 7 | 4,679
glioblastoma 7 | 5,792
lung carcinoma 7 | 2,843
periodontitis 7 | 293
Ichthyosis vulgaris 6 | 11
Pemphigus 6 | 23
cutaneous lupus erythematosus 6 | 1,057
ductal carcinoma in situ 6 | 1,745
group 3 medulloblastoma 6 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
invasive ductal carcinoma 6 | 2,951
pituitary cancer 6 | 1,972
primitive neuroectodermal tumor 6 | 3,035
Asthma 5 | 385
Bullous pemphigoid 5 | 18
Cardiomyopathy 5 | 116
Cardiomyopathy, right ventricular 5 | 7
Dilated cardiomyopathy 5 | 56
Epidermolytic hyperkeratosis 5 | 14
Erythema 5 | 58
Flushing 5 | 60
Ichthyoses 5 | 41
Liver cancer 5 | 604
Ritter's disease 5 | 10
colon cancer 5 | 1,478
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
ulcerative colitis 5 | 1,819
Alopecia 4 | 115
Astrocytoma, Pilocytic 4 | 3,081
Congenital Nonbullous Ichthyosiform Erythroderma 4 | 16
Eczema 4 | 45
Failure to gain weight 4 | 365
Keratosis 4 | 37
Malaria 4 | 160
Nail Diseases 4 | 24
Nail abnormality 4 | 22
Pediatric failure to thrive 4 | 365
Rheumatoid arthritis 4 | 1,191
Squamous cell carcinoma 4 | 129
Sudden Cardiac Death 4 | 29
cystic fibrosis and chronic rhinosinusitis 4 | 214
oligodendroglioma 4 | 2,850
subependymal giant cell astrocytoma 4 | 2,287
Carcinoma, Squamous Cell 3 | 110
Cardiomyopathy, Dilated 3 | 83
DOID:2627 3 | 94
Endometrial cancer 3 | 311
Fragile skin 3 | 18
Pick disease 3 | 1,894
Pruritus 3 | 58
Reactive airway disease 3 | 21
Skin disease 3 | 66
Syncope 3 | 22
Ventricular arrhythmia 3 | 27
Wooly hair 3 | 17
acute myeloid leukemia 3 | 783
acute quadriplegic myopathy 3 | 1,158
astrocytic glioma 3 | 2,597
atypical teratoid/rhabdoid tumor 3 | 357
mucosa-associated lymphoid tissue lymphoma 3 | 484
posterior fossa group A ependymoma 3 | 468
primary pancreatic ductal adenocarcinoma 3 | 1,109
urothelial carcinoma 3 | 318

Tissue

Skin and soft tissues 72 | 17,230
Female tissues 68 | 17,400
Blood and immune system 63 | 16,909
Digestive Tract 63 | 17,369
Endocrine System 56 | 18,159
Liver and Pancreas 43 | 16,750
Male tissues 43 | 17,142
Urinary Tract 43 | 16,678
Nervous System 40 | 16,725
Respiratory system 37 | 16,393
Cardiovascular System 35 | 15,192

Target Family

Non-IDG 55 | 12,091
Enzyme 19 | 4,145

Reactome Pathway

Formation of the cornified env... 74 | 74
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Caspase-14 CASP14 Tchem Enzyme -1.81937 73.7 348
Plakophilin-2 PKP2 Tbio Non-IDG -2.10355 135.3 243
Suppressor of tumorigenicity 14 protein ST14 Tchem Non-IDG -2.50215 338.3 309
Kallikrein-12 KLK12 Tbio Enzyme -0.99694 11.0 111
Small proline-rich protein 2F SPRR2F Tbio Non-IDG 0.44 0.31 12
Plakophilin-3 PKP3 Tbio Non-IDG -1.37372 26.0 200
Small proline-rich protein 2G SPRR2G Tbio Non-IDG 0.39 0.31 1
Late cornified envelope protein 3D LCE3D Tdark Non-IDG -0.13175 1.11 0
Late cornified envelope protein 5A LCE5A Tdark Non-IDG 0.50 0.32 0
Plakophilin-1 PKP1 Tbio Non-IDG -1.86062 76.3 103