Development Level

Tbio 39 | 10,625
Tdark 21 | 7,003
Tchem 11 | 1,890

IMPC Term

abnormal bone structure 3 | 131
preweaning lethality, complete... 3 | 633
abnormal vibrissa morphology 2 | 17
decreased total body fat amoun... 2 | 186
improved glucose tolerance 2 | 56
abnormal cornea morphology 1 | 24
abnormal embryo size 1 | 112
abnormal sleep behavior 1 | 63
brachydactyly 1 | 2
convulsive seizures 1 | 11
corneal opacity 1 | 25
corneal vascularization 1 | 5
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 53
decreased circulating aspartat... 1 | 27
decreased circulating insulin ... 1 | 75
decreased circulating triglyce... 1 | 83
decreased coping response 1 | 5
decreased fasted circulating g... 1 | 49
edema 1 | 11
embryonic lethality prior to t... 1 | 187
impaired righting response 1 | 19
increased bone mineral content 1 | 92
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
male infertility 1 | 62
narrow eye opening 1 | 15
prenatal lethality 1 | 16
preweaning lethality, incomple... 1 | 260

Disease

psoriasis 42 | 6,685
esophageal adenocarcinoma 21 | 737
ovarian cancer 19 | 8,492
cystic fibrosis 18 | 1,670
lung cancer 18 | 4,473
non-small cell lung cancer 17 | 2,798
osteosarcoma 17 | 7,933
diabetes mellitus 16 | 1,663
Atopic dermatitis 15 | 944
interstitial cystitis 14 | 2,299
Breast cancer 13 | 3,099
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,289
malignant mesothelioma 13 | 3,163
Carcinoma 12 | 2,147
pancreatic cancer 12 | 2,300
spina bifida 12 | 1,064
Cancer 11 | 2,346
lung adenocarcinoma 11 | 2,714
medulloblastoma, large-cell 11 | 6,234
nasopharyngeal carcinoma 10 | 1,056
Netherton syndrome 9 | 14
atypical teratoid / rhabdoid tumor 9 | 4,369
Peeling skin syndrome 8 | 16
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,988
Arrhythmogenic right ventricular cardiomyopathy 7 | 27
Dermatitis 7 | 141
Prostatic Neoplasms 7 | 471
breast carcinoma 7 | 1,614
glioblastoma 7 | 5,572
periodontitis 7 | 269
posterior fossa group A ependymoma 7 | 1,511
Congenital ichthyosiform erythroderma 6 | 27
Hypotrichosis 6 | 29
Ichthyosis vulgaris 6 | 15
adult high grade glioma 6 | 2,148
cutaneous lupus erythematosus 6 | 1,056
ductal carcinoma in situ 6 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,956
invasive ductal carcinoma 6 | 2,950
lung carcinoma 6 | 2,844
pituitary cancer 6 | 1,972
primitive neuroectodermal tumor 6 | 3,031
Cardiomyopathy 5 | 110
Keratosis 5 | 34
Pemphigus 5 | 18
Ritter's disease 5 | 10
colon cancer 5 | 1,475
group 4 medulloblastoma 5 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
ulcerative colitis 5 | 2,087
Arrhythmogenic Right Ventricular Dysplasia 4 | 10
Bullous pemphigoid 4 | 17
Dilated cardiomyopathy 4 | 51
Epidermolytic hyperkeratosis 4 | 13
Palmoplantar keratosis 4 | 36
Rheumatoid Arthritis 4 | 1,171
Squamous cell carcinoma 4 | 96
oligodendroglioma 4 | 2,849
pilocytic astrocytoma 4 | 3,086
subependymal giant cell astrocytoma 4 | 2,287
Asthma 3 | 349
Cardiomyopathies 3 | 90
Eczema herpeticum 3 | 7
Irritant dermatitis 3 | 9
Lichen planus 3 | 17
Pick disease 3 | 1,893
Skin disease 3 | 65
acute myeloid leukemia 3 | 785
acute quadriplegic myopathy 3 | 1,157
astrocytic glioma 3 | 2,241
atypical teratoid/rhabdoid tumor 3 | 1,095
cystic fibrosis and chronic rhinosinusitis 3 | 213
medulloblastoma 3 | 1,524
mucosa-associated lymphoid tissue lymphoma 3 | 480
pediatric high grade glioma 3 | 2,712
posterior fossa group B ependymoma 3 | 1,530
primary pancreatic ductal adenocarcinoma 3 | 1,271
urothelial carcinoma 3 | 318
Alzheimer's disease 2 | 644
Contact Dermatitis 2 | 80
Down syndrome 2 | 548
Dry eye syndrome 2 | 14
Endometriosis 2 | 535
Eosinophilic esophagitis 2 | 31
Epidermolysis bullosa 2 | 21
Hypersensitivity reaction type II disease 2 | 235
IGA Glomerulonephritis 2 | 454
Ichthyosis linearis circumflexa 2 | 2
Liver diseases 2 | 66
Malaria 2 | 140
Melanoma 2 | 261
Multiple Sclerosis 2 | 498
Skin Neoplasms 2 | 49
active ulcerative colitis 2 | 477
dermatomyositis 2 | 967
facioscapulohumeral dystrophy 2 | 286
head and neck cancer 2 | 270
interstitial lung disease 2 | 292
primary Sjogren syndrome 2 | 789
pulmonary arterial hypertension 2 | 36

Tissue

Digestive Tract 69 | 18,473
Endocrine System 69 | 18,512
Female tissues 69 | 18,647
Skin and soft tissues 69 | 18,115
Nervous System 68 | 18,561
Urinary Tract 67 | 18,444
Blood and immune system 64 | 17,995
Cardiovascular System 64 | 17,958
Liver and Pancreas 61 | 18,136
Male tissues 58 | 17,969
Respiratory system 54 | 17,484

Target Family

Non-IDG 56 | 11,969
Enzyme 15 | 4,146

Reactome Pathway

Formation of the cornified env... 71 | 71
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Plakophilin-3 PKP3 Tbio Non-IDG -1.31567 24.3 165
Kallikrein-5 KLK5 Tchem Enzyme -1.84751 73.4 234
Small proline-rich protein 2G SPRR2G Tdark Non-IDG 0.39 0.31 0
Late cornified envelope protein 3D LCE3D Tdark Non-IDG 0.01 1.11 0
Calpain small subunit 1 CAPNS1 Tbio Non-IDG -2.88291 736.0 131
Suppressor of tumorigenicity 14 protein ST14 Tchem Non-IDG -2.48197 322.1 261
Kallikrein-12 KLK12 Tchem Enzyme -0.91839 10.7 96
Kallikrein-13 KLK13 Tchem Enzyme -1.21358 18.6 164
Small proline-rich protein 2F SPRR2F Tdark Non-IDG 0.44 0.31 9
Caspase-14 CASP14 Tbio Enzyme -1.81085 72.4 311