Development Level

Tbio 36 | 11,445
Tdark 10 | 6,588
Tchem 9 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 8 | 979
abnormal embryo size 2 | 220
abnormal eye morphology 2 | 68
cataract 2 | 92
decreased lymphocyte cell numb... 2 | 83
increased bone mineral density 2 | 72
abnormal body wall morphology 1 | 9
abnormal bone mineralization 1 | 38
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal embryo development 1 | 7
abnormal eyelid fusion 1 | 3
abnormal facial morphology 1 | 17
abnormal forelimb morphology 1 | 2
abnormal head morphology 1 | 10
abnormal head shape 1 | 10
abnormal heart morphology 1 | 162
abnormal hindbrain morphology 1 | 10
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal locomotor behavior 1 | 24
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal startle reflex 1 | 15
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased IgG2b level 1 | 4
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased body weight 1 | 161
decreased caudal vertebrae num... 1 | 53
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
edema 1 | 59
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
hydrometra 1 | 53
increased B cell number 1 | 9
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating magnesiu... 1 | 10
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
mammalian phenotype 1 | 17
microphthalmia 1 | 26
polydactyly 1 | 7
preweaning lethality, incomple... 1 | 499
protruding tongue 1 | 3
small superior vagus ganglion 1 | 74
syndactyly 1 | 23

Disease

Carcinoma 35 | 11,493
Breast cancer 27 | 3,578
ovarian cancer 26 | 8,520
lung cancer 25 | 4,740
psoriasis 24 | 6,694
Cancer 21 | 2,499
atypical teratoid / rhabdoid tumor 21 | 5,112
osteosarcoma 20 | 7,950
invasive ductal carcinoma 19 | 2,951
breast carcinoma 16 | 1,638
malignant mesothelioma 16 | 3,232
glioblastoma 15 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
ductal carcinoma in situ 13 | 1,745
lung adenocarcinoma 13 | 2,716
pancreatic cancer 13 | 2,398
ependymoma 12 | 4,679
primitive neuroectodermal tumor 12 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
medulloblastoma, large-cell 11 | 6,241
non-small cell lung cancer 11 | 2,890
Kidney cancer 10 | 2,613
Multiple myeloma 10 | 1,332
Schizophrenia 10 | 1,160
group 3 medulloblastoma 10 | 4,104
lung carcinoma 10 | 2,843
Breast Neoplasms 9 | 445
colon cancer 9 | 1,478
cystic fibrosis 9 | 1,696
Bipolar Disorder 8 | 666
Intellectual disability 8 | 1,016
Mammary Neoplasms 8 | 425
interstitial cystitis 8 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
Immune system cancer 7 | 140
Lymphoid leukemia 7 | 160
Small head 7 | 374
adrenocortical carcinoma 7 | 1,428
group 4 medulloblastoma 7 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
Astrocytoma, Pilocytic 6 | 3,081
Cleft Palate 6 | 271
Dull intelligence 6 | 645
Epilepsy 6 | 792
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Muscle hypotonia 6 | 571
Poor school performance 6 | 645
Seizures 6 | 596
Strabismus 6 | 270
astrocytoma 6 | 1,146
cutaneous lupus erythematosus 6 | 1,057
non-small cell lung carcinoma 6 | 317
pituitary cancer 6 | 1,972
subependymal giant cell astrocytoma 6 | 2,287
Adenocarcinoma 5 | 122
Adenoma 5 | 167
Bladder Neoplasm 5 | 112
Broad flat nasal bridge 5 | 236
Cognitive delay 5 | 608
Colonic Neoplasms 5 | 142
Cryptorchidism 5 | 296
Endometrial cancer 5 | 311
Global developmental delay 5 | 608
Melanoma 5 | 711
Mental and motor retardation 5 | 608
Nasal bridge wide 5 | 236
Ovarian Neoplasms 5 | 102
Short stature 5 | 531
Stomach Neoplasms 5 | 300
Urinary Bladder Neoplasms 5 | 114
Waldenstrons macroglobulinemia 5 | 765
acute myeloid leukemia 5 | 783
acute quadriplegic myopathy 5 | 1,158
astrocytic glioma 5 | 2,597
oligodendroglioma 5 | 2,850
ovarian neoplasm 5 | 99
pediatric high grade glioma 5 | 1,064
Acquired scoliosis 4 | 281
Adenocarcinoma of lung 4 | 142
Carcinoma, Hepatocellular 4 | 228
Chronic Lymphocytic Leukemia 4 | 262
Connective tissue disease 4 | 62
Curvature of spine 4 | 282
Failure to gain weight 4 | 365
Feeding difficulties in infancy 4 | 175
Liver cancer 4 | 604
Liver neoplasms 4 | 130
Lung Neoplasms 4 | 232
Pancreatic Neoplasm 4 | 85
Pancreatic Neoplasms 4 | 85
Pediatric failure to thrive 4 | 365
Pick disease 4 | 1,894
Prostatic Neoplasms 4 | 495
Rheumatoid arthritis 4 | 1,191
Skin cancer 4 | 469
dermatomyositis 4 | 966
diabetes mellitus 4 | 1,728
pancreatic carcinoma 4 | 562

Tissue

Endocrine System 55 | 18,159
Blood and immune system 54 | 16,909
Digestive Tract 54 | 17,369
Female tissues 53 | 17,400
Skin and soft tissues 53 | 17,230
Cardiovascular System 52 | 15,192
Liver and Pancreas 52 | 16,750
Male tissues 52 | 17,142
Nervous System 52 | 16,725
Respiratory system 52 | 16,393
Urinary Tract 52 | 16,678

Target Family

Non-IDG 39 | 12,091
Epigenetic 8 | 242
Transcription Factor 7 | 1,400
Enzyme 2 | 4,145

Reactome Pathway

Formation of the beta-catenin:... 56 | 56
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2B type 1-N HIST1H2BN Tbio Non-IDG -1.51422 30.2 60
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 48
Histone H2A type 1-B/E HIST1H2AB Tbio Non-IDG -1.27041 18.5 133
Histone H2A.J H2AFJ Tdark Non-IDG -0.00172 0.83 99
Histone H2A type 1-J HIST1H2AJ Tdark Non-IDG -0.13212 1.19 16
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.17 0.33 21
Histone H2B type 1-C/E/F/G/I HIST1H2BC Tbio Non-IDG -1.38165 22.7 117
Histone H2A.V H2AFV Tdark Non-IDG -1.18642 15.1 40
Histone H2B type F-S H2BFS Tbio Non-IDG -0.50219 4.04 68
Histone H2B type 3-B HIST3H2BB Tbio Non-IDG -0.72238 5.02 53