Development Level

Tbio 34 | 10,625
Tchem 7 | 1,890
Tclin 2 | 602

IMPC Phenotype

embryonic lethality prior to o... 2 | 148
embryonic lethality prior to t... 2 | 187
preweaning lethality, complete... 2 | 633
preweaning lethality, incomple... 2 | 260
abnormal retina morphology 1 | 100
abnormal retinal inner nuclear... 1 | 5
decreased grip strength 1 | 123
decreased total retina thickne... 1 | 20
increased circulating potassiu... 1 | 31
increased heart weight 1 | 37
increased mean corpuscular vol... 1 | 91

Disease

ovarian cancer 31 | 8,491
Cancer 22 | 2,346
osteosarcoma 20 | 7,933
lung cancer 19 | 4,473
Xeroderma pigmentosum 18 | 41
Cockayne syndrome 15 | 54
Photosensitive trichothiodystrophy 12 | 24
medulloblastoma, large-cell 12 | 6,234
psoriasis 12 | 6,685
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,289
Breast cancer 8 | 3,098
Peripheral Neuropathy 8 | 303
glioblastoma 8 | 5,572
Waldenstrons macroglobulinemia 7 | 764
atypical teratoid / rhabdoid tumor 7 | 4,369
ependymoma 6 | 2,514
malignant mesothelioma 6 | 3,163
Multiple myeloma 5 | 1,327
Pick disease 5 | 1,893
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,988
Arsenic Poisoning 4 | 59
Stomach Neoplasms 4 | 282
Xeroderma pigmentosum-Cockayne syndrome complex 4 | 4
acute myeloid leukemia 4 | 785
astrocytic glioma 4 | 2,241
astrocytoma 4 | 1,493
atypical teratoid/rhabdoid tumor 4 | 1,095
diabetes mellitus 4 | 1,663
group 3 medulloblastoma 4 | 2,254
pituitary cancer 4 | 1,972
tuberculosis and treatment for 6 months 4 | 686
CAMFAK syndrome 3 | 4
COFS syndrome 3 | 4
Carcinoma 3 | 2,147
Cerebrooculofacioskeletal Syndrome 1 3 | 4
Fanconi's anemia 3 | 50
Intellectual disability 3 | 573
Micronuclei, Chromosome-Defective 3 | 20
Pena Shokeir syndrome Type 2 3 | 4
Prostatic Neoplasms 3 | 471
Stevens-Johnson syndrome 3 | 91
Trichothiodystrophy 1, photosensitive 3 | 4
Trichothiodystrophy Syndromes 3 | 5
adult high grade glioma 3 | 2,148
dermatomyositis 3 | 966
hepatocellular carcinoma 3 | 550
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,956
invasive ductal carcinoma 3 | 2,950
nasopharyngeal carcinoma 3 | 1,056
non-small cell lung cancer 3 | 2,798
oligodendroglioma 3 | 2,849
pancreatic cancer 3 | 2,300
pediatric high grade glioma 3 | 2,712
progressive supranuclear palsy 3 | 674
subependymal giant cell astrocytoma 3 | 2,287
Adenocarcinoma of lung (disorder) 2 | 48
Animal Mammary Neoplasms 2 | 135
Baller-Gerold syndrome 2 | 14
Bladder Neoplasm 2 | 109
Brain Ischemia 2 | 87
Carcinoma in situ of fallopian tube 2 | 2
Cataract 2 | 104
Cerebro-oculo-facio-skeletal syndrome 2 | 3
Cerebrovascular disease 2 | 231
Chromosome Aberrations 2 | 15
Dermatologic disorders 2 | 65
Disease Progression 2 | 125
Epithelial tumor of ovary 2 | 3
Malignant epithelial tumor of ovary 2 | 3
Malignant tumor of ovary 2 | 25
Malignant tumor of peritoneum 2 | 4
Mammary Neoplasms, Experimental 2 | 149
Melanoma 2 | 261
Myofibrillar myopathy 1 2 | 6
Myofibrillar myopathy 3 2 | 5
Neoplasm Metastasis 2 | 138
Neoplasms, Germ Cell and Embryonal 2 | 13
Neurodegenerative disease 2 | 383
Obesity 2 | 616
Pick's disease 2 | 14
Progeria 2 | 22
Rothmund-Thomson syndrome 2 | 22
Skin Neoplasms 2 | 49
Skin benign neoplasm 2 | 5
Testicular Neoplasms 2 | 5
Uterine Cervical Neoplasm 2 | 21
Xeroderma Pigmentosum, Complementation Group a 2 | 2
gastric cancer 2 | 436
glioblastoma multiforme 2 | 347
lung adenocarcinoma 2 | 2,714
non primary Sjogren syndrome sicca 2 | 840
pancreatic carcinoma 2 | 567
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
posterior fossa group B ependymoma 2 | 1,530
sonic hedgehog group medulloblastoma 2 | 1,482
spina bifida 2 | 1,064
Chloracne 1 | 32
Cholera 1 | 33
Malignant neoplasm of lung 1 | 16
Pertussis 1 | 17

Tissue

Blood and immune system 43 | 17,994
Cardiovascular System 43 | 17,957
Digestive Tract 43 | 18,472
Endocrine System 43 | 18,511
Female tissues 43 | 18,646
Liver and Pancreas 43 | 18,135
Male tissues 43 | 17,968
Nervous System 43 | 18,560
Respiratory system 43 | 17,483
Skin and soft tissues 43 | 18,114
Urinary Tract 43 | 18,443

Target Family

Non-IDG 29 | 11,969
Enzyme 11 | 4,146
Transcription Factor 2 | 1,400
Kinase 1 | 634

Reactome Pathway

Formation of Incision Complex ... 43 | 43
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA repair protein complementing XP-C cells XPC Tbio Non-IDG -2.18675 151.0 193
E3 ubiquitin-protein ligase Arkadia RNF111 Tbio Enzyme -1.35799 23.9 89
Small ubiquitin-related modifier 1 SUMO1 Tbio Non-IDG -2.69416 474.2 685
General transcription factor IIH subunit 3 GTF2H3 Tbio Non-IDG -0.87291 6.02 65
General transcription factor IIH subunit 2 GTF2H2 Tbio Non-IDG -1.31733 6.84 120
E3 SUMO-protein ligase PIAS3 PIAS3 Tbio Transcription Factor -1.72690 50.8 156
DNA repair protein complementing XP-G cells ERCC5 Tchem Enzyme -2.05009 296.8 215
General transcription factor IIH subunit 1 GTF2H1 Tbio Non-IDG -1.64263 41.9 218
DNA excision repair protein ERCC-1 ERCC1 Tbio Non-IDG -3.01167 969.9 606
Ubiquitin carboxyl-terminal hydrolase 45 USP45 Tbio Enzyme -1.27684 17.3 96