Development Level

Tbio 34 | 10,625
Tchem 7 | 1,890
Tclin 2 | 602

IMPC Term

embryonic lethality prior to o... 2 | 148
embryonic lethality prior to t... 2 | 187
preweaning lethality, complete... 2 | 633
preweaning lethality, incomple... 2 | 260
abnormal retina morphology 1 | 100
abnormal retinal inner nuclear... 1 | 5
decreased grip strength 1 | 123
decreased total retina thickne... 1 | 20
increased circulating potassiu... 1 | 31
increased heart weight 1 | 37
increased mean corpuscular vol... 1 | 91

Disease

ovarian cancer 31 | 8,484
Cancer 22 | 2,346
osteosarcoma 20 | 7,933
lung cancer 19 | 4,466
Xeroderma pigmentosum 18 | 41
Cockayne syndrome 15 | 54
Photosensitive trichothiodystrophy 12 | 24
medulloblastoma, large-cell 12 | 6,234
psoriasis 12 | 6,685
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,289
Breast cancer 8 | 3,094
Peripheral Neuropathy 8 | 303
glioblastoma 8 | 5,572
Waldenstrons macroglobulinemia 7 | 765
atypical teratoid / rhabdoid tumor 7 | 4,369
ependymoma 6 | 2,514
malignant mesothelioma 6 | 3,162
Multiple myeloma 5 | 1,327
Pick disease 5 | 1,893
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,988
Arsenic Poisoning 4 | 59
Stomach Neoplasms 4 | 282
acute myeloid leukemia 4 | 780
astrocytic glioma 4 | 2,241
astrocytoma 4 | 1,493
atypical teratoid/rhabdoid tumor 4 | 1,095
diabetes mellitus 4 | 1,663
group 3 medulloblastoma 4 | 2,254
pituitary cancer 4 | 1,972
tuberculosis and treatment for 6 months 4 | 686
CAMFAK syndrome 3 | 4
Carcinoma 3 | 2,147
Cerebrooculofacioskeletal Syndrome 1 3 | 4
Fanconi's anemia 3 | 50
Intellectual disability 3 | 573
Micronuclei, Chromosome-Defective 3 | 19
Pena Shokeir syndrome Type 2 3 | 4
Prostatic Neoplasms 3 | 471
Stevens-Johnson syndrome 3 | 78
Trichothiodystrophy Syndromes 3 | 5
adult high grade glioma 3 | 2,148
dermatomyositis 3 | 933
hepatocellular carcinoma 3 | 532
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,956
invasive ductal carcinoma 3 | 2,950
nasopharyngeal carcinoma 3 | 1,056
non-small cell lung cancer 3 | 2,798
oligodendroglioma 3 | 2,849
pancreatic cancer 3 | 2,300
pediatric high grade glioma 3 | 2,712
progressive supranuclear palsy 3 | 674
subependymal giant cell astrocytoma 3 | 2,287
Adenocarcinoma of lung (disorder) 2 | 48
Animal Mammary Neoplasms 2 | 136
Baller-Gerold syndrome 2 | 14
Bladder Neoplasm 2 | 109
Brain Ischemia 2 | 87
Carcinoma in situ of fallopian tube 2 | 2
Cataract 2 | 104
Cerebrovascular disease 2 | 231
Chromosome Aberrations 2 | 15
Dermatologic disorders 2 | 65
Disease Progression 2 | 125
Epithelial tumor of ovary 2 | 3
Malignant epithelial tumor of ovary 2 | 3
Malignant tumor of ovary 2 | 25
Malignant tumor of peritoneum 2 | 4
Mammary Neoplasms, Experimental 2 | 150
Melanoma 2 | 261
Myofibrillar myopathy 1 2 | 5
Myofibrillar myopathy 3 2 | 4
Neoplasm Metastasis 2 | 138
Neoplasms, Germ Cell and Embryonal 2 | 13
Neurodegenerative disease 2 | 383
Obesity 2 | 616
Pick's disease 2 | 14
Progeria 2 | 22
Rothmund-Thomson syndrome 2 | 22
Skin Neoplasms 2 | 49
Testicular Neoplasms 2 | 5
Uterine Cervical Neoplasm 2 | 21
gastric cancer 2 | 430
glioblastoma multiforme 2 | 347
lung adenocarcinoma 2 | 2,713
non primary Sjogren syndrome sicca 2 | 840
pancreatic carcinoma 2 | 567
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
posterior fossa group B ependymoma 2 | 1,530
sonic hedgehog group medulloblastoma 2 | 1,482
spina bifida 2 | 1,064
Body dysmorphic disorder 1 | 10
Craniofacial Abnormalities 1 | 147
Delusional disorder 1 | 10
Gaucher disease type 3 1 | 76
Muscular atrophy 1 | 67
Nijmegen breakage syndrome 1 | 23
Squamous cell carcinoma 1 | 94
interstitial lung disease 1 | 291
non-inflammatory breast cancer 1 | 208
thrombocytopenia-absent radius syndrome 1 | 15

Tissue

Blood and immune system 43 | 17,995
Cardiovascular System 43 | 17,958
Digestive Tract 43 | 18,473
Endocrine System 43 | 18,512
Female tissues 43 | 18,647
Liver and Pancreas 43 | 18,136
Male tissues 43 | 17,969
Nervous System 43 | 18,561
Respiratory system 43 | 17,484
Skin and soft tissues 43 | 18,115
Urinary Tract 43 | 18,444

Target Family

Non-IDG 29 | 11,971
Enzyme 11 | 4,146
Transcription Factor 2 | 1,400
Kinase 1 | 634

Reactome Pathway

Formation of Incision Complex ... 43 | 43
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.76828 59.7 468
General transcription factor IIH subunit 3 GTF2H3 Tbio Non-IDG -0.79392 6.02 65
General transcription factor IIH subunit 2 GTF2H2 Tbio Non-IDG -0.87357 6.84 120
Small ubiquitin-related modifier 1 SUMO1 Tbio Non-IDG -2.69547 474.2 685
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
Cyclin-dependent kinase 7 CDK7 Tchem Kinase -2.28652 191.1 505
Cyclin-H CCNH Tbio Non-IDG -1.98840 89.8 354
CDK-activating kinase assembly factor MAT1 MNAT1 Tbio Enzyme -2.07687 125.7 152
DNA repair protein complementing XP-A cells XPA Tbio Non-IDG -2.82887 674.6 301