Development Level

Tdark 58 | 7,003
Tbio 52 | 10,625
Tchem 29 | 1,890
Tclin 9 | 602

Collection

Eligible Ion Channel Proteins 1 | 117

IMPC Term

decreased body weight 4 | 174
preweaning lethality, complete... 4 | 633
abnormal coat/hair pigmentatio... 3 | 54
decreased circulating creatini... 3 | 31
decreased mature B cell number 3 | 25
increased mean corpuscular hem... 3 | 93
abnormal behavior 2 | 226
abnormal cornea morphology 2 | 24
abnormal retina morphology 2 | 100
decreased NK T cell number 2 | 28
decreased circulating choleste... 2 | 85
decreased circulating fructosa... 2 | 31
decreased lean body mass 2 | 195
decreased lumbar vertebrae num... 2 | 62
decreased total body fat amoun... 2 | 186
embryonic lethality prior to t... 2 | 187
increased grip strength 2 | 83
increased leukocyte cell numbe... 2 | 37
increased red blood cell distr... 2 | 21
male infertility 2 | 62
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal digit morphology 1 | 13
abnormal embryo size 1 | 112
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 18
abnormal hair texture 1 | 4
abnormal hindbrain development 1 | 24
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
abnormal snout morphology 1 | 18
corneal opacity 1 | 25
decreased B cell number 1 | 30
decreased CD4-positive, CD25-p... 1 | 24
decreased Ly6C low monocyte nu... 1 | 23
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating HDL chol... 1 | 77
decreased circulating alkaline... 1 | 41
decreased circulating bilirubi... 1 | 14
decreased circulating free fat... 1 | 39
decreased circulating glucose ... 1 | 121
decreased circulating insulin ... 1 | 75
decreased circulating iron lev... 1 | 25
decreased circulating potassiu... 1 | 17
decreased circulating serum al... 1 | 79
decreased circulating total pr... 1 | 41
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased fasted circulating g... 1 | 49
decreased heart weight 1 | 44
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
fused cornea and lens 1 | 4
fused phalanges 1 | 1
fusion of vertebral arches 1 | 7
hyperactivity 1 | 108
impaired pupillary reflex 1 | 14
increased CD4-positive, alpha ... 1 | 15
increased IgG1 level 1 | 1
increased Ly6C high monocyte n... 1 | 12
increased T cell number 1 | 15
increased blood urea nitrogen ... 1 | 44
increased bone mineral content 1 | 92
increased circulating potassiu... 1 | 31
increased effector memory CD4-... 1 | 15
increased gamma-delta T cell n... 1 | 16
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 91
increased mean platelet volume 1 | 19
increased rib number 1 | 41
increased sacral vertebrae num... 1 | 62
persistence of hyaloid vascula... 1 | 22
preweaning lethality, incomple... 1 | 260
small epididymis 1 | 3
thrombocytopenia 1 | 46
vertebral fusion 1 | 23

Disease

osteosarcoma 65 | 7,933
ovarian cancer 57 | 8,484
psoriasis 43 | 6,685
medulloblastoma, large-cell 39 | 6,234
Cancer 37 | 2,346
lung cancer 37 | 4,466
glioblastoma 36 | 5,572
atypical teratoid / rhabdoid tumor 29 | 4,369
interstitial cystitis 29 | 2,299
Breast cancer 25 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,289
pilocytic astrocytoma 25 | 3,086
pancreatic cancer 24 | 2,300
subependymal giant cell astrocytoma 24 | 2,287
ulcerative colitis 24 | 2,087
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,956
lung carcinoma 23 | 2,844
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,988
non-small cell lung cancer 22 | 2,798
oligodendroglioma 22 | 2,849
Carcinoma 21 | 2,147
invasive ductal carcinoma 21 | 2,950
lung adenocarcinoma 21 | 2,713
ependymoma 20 | 2,514
tuberculosis 20 | 1,557
primitive neuroectodermal tumor 19 | 3,031
Multiple myeloma 18 | 1,327
Waldenstrons macroglobulinemia 18 | 765
juvenile dermatomyositis 18 | 1,189
pediatric high grade glioma 17 | 2,712
cutaneous lupus erythematosus 16 | 1,056
astrocytic glioma 15 | 2,241
primary Sjogren syndrome 15 | 789
primary pancreatic ductal adenocarcinoma 15 | 1,271
diabetes mellitus 14 | 1,663
malignant mesothelioma 14 | 3,162
medulloblastoma 14 | 1,524
Rheumatoid Arthritis 13 | 1,160
Pick disease 12 | 1,893
cystic fibrosis 12 | 1,665
group 4 medulloblastoma 12 | 1,875
periodontitis 12 | 269
IGA Glomerulonephritis 11 | 454
adult high grade glioma 11 | 2,148
astrocytoma 11 | 1,493
breast carcinoma 11 | 1,614
colon cancer 11 | 1,475
ductal carcinoma in situ 11 | 1,745
Wiskott-Aldrich syndrome 10 | 27
chronic lymphosyte leukemia 10 | 232
esophageal adenocarcinoma 10 | 737
dermatomyositis 9 | 933
mucosa-associated lymphoid tissue lymphoma 9 | 480
sonic hedgehog group medulloblastoma 9 | 1,482
spina bifida 9 | 1,064
Alzheimer's disease 8 | 644
gastric carcinoma 8 | 832
pituitary cancer 8 | 1,972
tuberculosis and treatment for 6 months 8 | 686
Amebiasis 7 | 22
Blastic phase chronic myeloid leukemia 7 | 58
Chronic Myelocytic Leukemia Accelerated Phase 7 | 59
Kidney disease 7 | 396
acute quadriplegic myopathy 7 | 1,157
cystic fibrosis and chronic rhinosinusitis 7 | 213
group 3 medulloblastoma 7 | 2,254
pancreatic carcinoma 7 | 567
Down syndrome 6 | 548
Intellectual disability 6 | 573
Leukemia 6 | 88
Mammary Neoplasms 6 | 410
Neoplasm Invasiveness 6 | 127
Obesity 6 | 616
Parkinson's disease 6 | 364
acute myeloid leukemia 6 | 780
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,795
Arthritis 5 | 248
Chronic phase chronic myeloid leukemia 5 | 45
Duchenne muscular dystrophy 5 | 602
Lymphoma 5 | 56
Neoplasm Metastasis 5 | 138
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 5 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 5 | 47
Prostatic Neoplasms 5 | 471
Vascular disease 5 | 281
adrenocortical carcinoma 5 | 1,427
atypical teratoid/rhabdoid tumor 5 | 1,095
non primary Sjogren syndrome sicca 5 | 840
non-small cell lung carcinoma 5 | 413
posterior fossa group A ependymoma 5 | 1,511
Animal Mammary Neoplasms 4 | 136
Asthma 4 | 349
Chronic Lymphocytic Leukemia 4 | 242
HIV Infections 4 | 100
Liver carcinoma 4 | 217
Lung Neoplasms 4 | 171
Multiple Sclerosis 4 | 498
Stomach Neoplasms 4 | 282
Thrombocytopenia 4 | 105
gastric cancer 4 | 430

Tissue

Blood and immune system 133 | 17,995
Digestive Tract 133 | 18,473
Female tissues 133 | 18,647
Respiratory system 133 | 17,484
Liver and Pancreas 132 | 18,136
Skin and soft tissues 132 | 18,115
Urinary Tract 132 | 18,444
Cardiovascular System 130 | 17,958
Endocrine System 129 | 18,512
Nervous System 129 | 18,561
Male tissues 127 | 17,969

Target Family

Non-IDG 113 | 11,971
Kinase 19 | 634
Enzyme 13 | 4,146
Ion Channel 3 | 341

Reactome Pathway

Fcgamma receptor (FCGR) depend... 148 | 148
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Immunoglobulin kappa variable 3-11 IGKV3-11 Tdark Non-IDG 0.00000 0
Wiskott-Aldrich syndrome protein family member 3 WASF3 Tbio Non-IDG -2.43045 280.1 123
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Adenosylhomocysteinase 2 AHCYL1 Tchem Enzyme -1.57893 43.2 102
Actin-related protein 2 ACTR2 Tchem Non-IDG -1.84526 72.5 184
Actin-related protein 3 ACTR3 Tbio Non-IDG -1.25542 16.8 169
Ig lambda-7 chain C region IGLC7 Tdark Non-IDG 228.7 0
Immunoglobulin lambda variable 1-44 IGLV1-44 Tdark Non-IDG 0.00000 0
High affinity immunoglobulin gamma Fc receptor I FCGR1A Tchem Non-IDG -2.98035 1006.3 583
Immunoglobulin heavy variable 1-2 IGHV1-2 Tdark Non-IDG 0.00000 0