Development Level

Tdark 71 | 6,588
Tbio 57 | 11,445
Tchem 24 | 1,598
Tclin 10 | 613

IMPC Phenotype

preweaning lethality, complete... 11 | 979
decreased body weight 4 | 161
preweaning lethality, incomple... 4 | 499
abnormal behavior 3 | 298
abnormal coat-hair pigmentatio... 3 | 64
abnormal cornea morphology 3 | 31
abnormal retina morphology 3 | 71
decreased circulating creatini... 3 | 39
embryonic lethality prior to t... 3 | 278
thrombocytopenia 3 | 56
abnormal bone structure 2 | 187
abnormal digit morphology 2 | 10
decreased circulating fructosa... 2 | 30
decreased circulating phosphat... 2 | 27
decreased circulating serum al... 2 | 82
decreased hemoglobin content 2 | 68
decreased total body fat amoun... 2 | 207
embryonic growth retardation 2 | 106
increased blood urea nitrogen ... 2 | 48
increased grip strength 2 | 41
increased lean body mass 2 | 172
increased leukocyte cell numbe... 2 | 47
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
increased neutrophil cell numb... 2 | 46
increased red blood cell distr... 2 | 34
increased spleen weight 2 | 10
increased total body fat amoun... 2 | 134
male infertility 2 | 123
small testis 2 | 58
abnormal bone mineralization 1 | 38
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal hair texture 1 | 4
abnormal heart morphology 1 | 162
abnormal iris morphology 1 | 13
abnormal iris pigmentation 1 | 4
abnormal maxilla morphology 1 | 17
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal snout morphology 1 | 23
abnormal stomach morphology 1 | 10
abnormal testis morphology 1 | 43
absent urinary bladder 1 | 1
anophthalmia 1 | 33
corneal opacity 1 | 32
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating potassiu... 1 | 20
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 50
decreased neutrophil cell numb... 1 | 42
decreased spleen weight 1 | 10
edema 1 | 59
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
enlarged kidney 1 | 14
fused cornea and lens 1 | 5
fused phalanges 1 | 1
fusion of vertebral arches 1 | 7
hyperactivity 1 | 148
impaired pupillary reflex 1 | 26
increased CD4-positive, alpha ... 1 | 4
increased T cell number 1 | 6
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating creatini... 1 | 38
increased circulating potassiu... 1 | 29
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased hemoglobin content 1 | 45
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
prolonged PR interval 1 | 15
short tibia 1 | 97
small epididymis 1 | 3
thin ventricular wall 1 | 24
vertebral fusion 1 | 23

Disease

osteosarcoma 67 | 7,950
Carcinoma 64 | 11,493
ovarian cancer 58 | 8,520
psoriasis 45 | 6,694
Cancer 39 | 2,499
medulloblastoma, large-cell 39 | 6,241
lung cancer 38 | 4,740
glioblastoma 37 | 5,792
interstitial cystitis 31 | 2,312
Breast cancer 30 | 3,578
atypical teratoid / rhabdoid tumor 30 | 5,112
Astrocytoma, Pilocytic 25 | 3,081
ependymoma 25 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,291
Kidney cancer 24 | 2,613
non-small cell lung cancer 24 | 2,890
pancreatic cancer 24 | 2,398
subependymal giant cell astrocytoma 24 | 2,287
tuberculosis 24 | 2,010
ulcerative colitis 24 | 1,819
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,955
lung carcinoma 23 | 2,843
lung adenocarcinoma 22 | 2,716
oligodendroglioma 22 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,989
invasive ductal carcinoma 21 | 2,951
adult high grade glioma 19 | 3,801
group 3 medulloblastoma 19 | 4,104
primitive neuroectodermal tumor 19 | 3,035
Multiple myeloma 18 | 1,332
Waldenstrons macroglobulinemia 17 | 765
juvenile dermatomyositis 17 | 1,187
cutaneous lupus erythematosus 16 | 1,057
astrocytic glioma 15 | 2,597
diabetes mellitus 15 | 1,728
malignant mesothelioma 15 | 3,232
primary Sjogren syndrome 15 | 735
Autosomal recessive predisposition 14 | 1,442
Schizophrenia 14 | 1,160
cystic fibrosis 14 | 1,696
group 4 medulloblastoma 14 | 1,855
Liver Cirrhosis, Experimental 13 | 769
Rheumatoid arthritis 13 | 1,191
breast carcinoma 13 | 1,638
periodontitis 13 | 293
primary pancreatic ductal adenocarcinoma 13 | 1,109
Pick disease 12 | 1,894
Wiskott-Aldrich syndrome 12 | 30
Intellectual disability 11 | 1,016
astrocytoma 11 | 1,146
colon cancer 11 | 1,478
ductal carcinoma in situ 11 | 1,745
esophageal adenocarcinoma 10 | 737
mucosa-associated lymphoid tissue lymphoma 10 | 484
Bipolar Disorder 9 | 666
Immunologic Deficiency Syndromes 9 | 113
chronic lymphosyte leukemia 9 | 204
pediatric high grade glioma 9 | 1,064
spina bifida 9 | 1,074
Kidney disease 8 | 430
Liver cancer 8 | 604
dermatomyositis 8 | 966
gastric carcinoma 8 | 807
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
pituitary cancer 8 | 1,972
Arthritis 7 | 290
Blastic phase chronic myeloid leukemia 7 | 58
Breast Neoplasms 7 | 445
Chronic Myelocytic Leukemia Accelerated Phase 7 | 59
Cognitive delay 7 | 608
Dull intelligence 7 | 645
Global developmental delay 7 | 608
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental and motor retardation 7 | 608
Mental deficiency 7 | 645
Neoplasm Invasiveness 7 | 161
Obesity 7 | 678
Poor school performance 7 | 645
acute quadriplegic myopathy 7 | 1,158
cystic fibrosis and chronic rhinosinusitis 7 | 214
pancreatic carcinoma 7 | 562
Alzheimer's disease 6 | 658
Chronic otitis media 6 | 52
Down syndrome 6 | 499
Fatigue 6 | 182
Mammary Neoplasms 6 | 425
Melanoma 6 | 711
Muscle hypotonia 6 | 571
Neoplasm Metastasis 6 | 168
Parkinson's disease 6 | 392
Seizures 6 | 596
Thrombocytopenia 6 | 197
acute myeloid leukemia 6 | 783
ear infection chronic 6 | 52
Attention deficit hyperactivity disorder 5 | 278
Chronic Lymphocytic Leukemia 5 | 262
Duchenne muscular dystrophy 5 | 601
Prostatic Neoplasms 5 | 495
Vascular disease 5 | 319

Tissue

Blood and immune system 85 | 16,909
Cardiovascular System 85 | 15,192
Digestive Tract 85 | 17,369
Endocrine System 85 | 18,159
Male tissues 85 | 17,142
Nervous System 85 | 16,725
Respiratory system 85 | 16,393
Skin and soft tissues 85 | 17,230
Urinary Tract 85 | 16,678
Female tissues 84 | 17,400
Liver and Pancreas 84 | 16,750

Target Family

Non-IDG 127 | 12,091
Kinase 19 | 634
Enzyme 13 | 4,145
Ion Channel 3 | 344

Reactome Pathway

Fcgamma receptor (FCGR) depend... 162 | 162
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myosin-2 MYH2 Tbio Non-IDG -2.14128 114.9 63
Immunoglobulin kappa variable 3-11 IGKV3-11 Tdark Non-IDG 0.00000 0
Immunoglobulin kappa variable 1-16 IGKV1-16 Tdark Non-IDG 0.00000 0
Immunoglobulin kappa variable 1D-39 IGKV1D-39 Tdark Non-IDG 0.00000 0
Unconventional myosin-X MYO10 Tbio Non-IDG -1.49855 36.4 47
Immunoglobulin kappa variable 1-17 IGKV1-17 Tdark Non-IDG 0.00000 0
Immunoglobulin kappa variable 1-39 IGKV1-39 Tdark Non-IDG 0.00000 0
Immunoglobulin kappa variable 1-33 IGKV1-33 Tdark Non-IDG 0.00000 0
Immunoglobulin kappa variable 1D-33 IGKV1D-33 Tdark Non-IDG 0.00000 0
Phospholipid phosphatase 5 PLPP5 Tbio Enzyme -0.73719 6.23 78